論文

査読有り
2011年6月

Characterization of Skin Inflammation Induced by Repeated Exposure of Toluene, Xylene, and Formaldehyde in Mice

ENVIRONMENTAL TOXICOLOGY
  • Asaka Saito
  • ,
  • Hiroyuki Tanaka
  • ,
  • Haruki Usuda
  • ,
  • Tomonori Shibata
  • ,
  • Sayaka Higashi
  • ,
  • Hirotaka Yamashita
  • ,
  • Naoki Inagaki
  • ,
  • Hiroichi Nagai

26
3
開始ページ
224
終了ページ
232
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/tox.20547
出版者・発行元
WILEY-BLACKWELL

Volatile organic compounds (VOCs) are considered the main cause of sick building syndrome and they are likely to irritate the skin, eyes, and mucous membrane; however, the toxic threshold and the mechanisms of cutaneous reaction induced by long-time VOC exposure have not been clarified. In the present study, we investigated the effect of repeated painting of VOCs onto mouse skin. Various concentrations of toluene, xylene, and formaldehyde (FA) were applied once a week for 5 weeks. While FA solution (2-10%) induced remarkable ear swelling and caused evident infiltration of inflammatory cells, high concentrations of toluene and xylene (50 or 100%) evoked mild ear swelling and marginal inflammatory cell invasion. In addition, FA exposure markedly increased the expression of interleukin-4 (IL-4), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and transient receptor potential vanilloid-1 (TRPV-1) mRNAs in the ears and IL-4 and NT-3 mRNAs in the cervical lymph nodes. Furthermore, capsazepine, a TRPV-1 antagonist, significantly suppressed ear swelling caused by repeated painting of 5% FA. These findings demonstrate that FA has more potent irritancy against skin than toluene or xylene and suggest that the Th2 response, neurotrophins and TRPV-1 play important roles in FA-induced skin inflammation. (C) 2009 Wiley Periodicals, Inc. Environ Toxicol 26:224-232, 2011.

リンク情報
DOI
https://doi.org/10.1002/tox.20547
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19904815
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000290489500002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/tox.20547
  • ISSN : 1520-4081
  • eISSN : 1522-7278
  • PubMed ID : 19904815
  • Web of Science ID : WOS:000290489500002

エクスポート
BibTeX RIS