Hiroichi Nagai

Profile Information

Affiliation: 教授,学長, 看護学部専門教育臨床薬理学, 岐阜保健大学
: 非常勤講師, 医学部医学教育開発研究センター, 岐阜大学

Degree: (BLANK)(Kyushu University)

J-GLOBAL ID: 200901058375278347
researchmap Member ID: 1000054719

External link: http://www.gifu-pu.ac.jp

Research Interests

Research Areas

Research History

Jul, 2016 - Present

Gifu University of Health Science Junior College
Apr, 2010 - Jun, 2016

Gifu Junior college of health science

Education

Committee Memberships

Awards

Papers

243

Analysis for a lack of oral tolerance for food allergy

Yamashita Hirotaka, Kuromaru Takahiro, Tanaka Hiroyuki, Nagai Hiroichi, Inagaki Naoki

JOURNAL OF PHARMACOLOGICAL SCIENCES, 121 104P, 2013 Peer-reviewed
Overcoming food allergy through acquired tolerance conferred by transfer of Tregs in a murine model

H. Yamashita, K. Takahashi, H. Tanaka, H. Nagai, N. Inagaki

ALLERGY, 67(2) 201-209, Feb, 2012 Peer-reviewed
Recent research and developmental strategy of anti-asthma drugs

Hiroichi Nagai

Pharmacology and Therapeutics, 133(1) 70-78, Jan, 2012 Peer-reviewed
Characterization of Skin Inflammation Induced by Repeated Exposure of Toluene, Xylene, and Formaldehyde in Mice

Asaka Saito, Hiroyuki Tanaka, Haruki Usuda, Tomonori Shibata, Sayaka Higashi, Hirotaka Yamashita, Naoki Inagaki, Hiroichi Nagai

ENVIRONMENTAL TOXICOLOGY, 26(3) 224-232, Jun, 2011 Peer-reviewed
Development and analysis of food allergy model using mice

Yamashita Hirotaka, Takahashi Keita, Tanaka Hiroyuki, Nagai Hiroichi, Inagaki Naoki

JOURNAL OF PHARMACOLOGICAL SCIENCES, 115 84P, 2011 Peer-reviewed
Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

K. Hyakkoku, J. Hamanaka, K. Tsuruma, M. Shimazawa, H. Tanaka, S. Uematsu, S. Akira, N. Inagaki, H. Nagai, H. Hara

Neuroscience, 171(1) 258-267, Nov 24, 2010 Peer-reviewed
Comparison of the efficacy of tacrolimus and cyclosporine A in a murine model of dinitrofluorobenzene-induced atopic dermatitis

Hirotaka Yamashita, Tomokazu Ito, Hideo Kato, Shusei Asai, Hiroyuki Tanaka, Hiroichi Nagai, Naoki Inagaki

EUROPEAN JOURNAL OF PHARMACOLOGY, 645(1-3) 171-176, Oct, 2010 Peer-reviewed
Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells

Hidetomo Matsushita, Shoichiro Ohta, Hiroshi Shiraishi, Shoichi Suzuki, Kazuhiko Arima, Shuji Toda, Hiroyuki Tanaka, Hiroichi Nagai, Masao Kimoto, Akira Inokuchi …

INTERNATIONAL IMMUNOLOGY, 22(9) 739-747, Sep, 2010 Peer-reviewed
カルシニューリン阻害薬の掻破行動抑制作用機序

加藤秀雄, 浅井秀星, 山下弘高, 田中宏幸, 永井博弌, 稲垣直樹

日本薬理学雑誌, 135(3) 19P-19P, Mar, 2010
Depletion of substance P, a mechanism for inhibition of mouse scratching behavior by tacrolimus

Naoki Inagaki, Noriko Shiraishi, Katsuhiro Igeta, Masafumi Nagao, John Fan Kim, Takao Chikumoto, Tomokazu Itoh, Hideo Katoh, Hiroyuki Tanaka, Hiroichi Nagai

EUROPEAN JOURNAL OF PHARMACOLOGY, 626(2-3) 283-289, Jan, 2010 Peer-reviewed
Involvement of transient receptor potential vanilloid-1 (TRPV1) in the skin inflammation induced by formaldehyde (FA) in mice

Tanaka Hiroyuki, Usuda Haruki, Endo Takumi, Shimouchi Ayumi, Saito Asaka, Yamashita Hirotaka, Inagaki Naoki, Nagai Hiroichi

JOURNAL OF PHARMACOLOGICAL SCIENCES, 112 84P, 2010 Peer-reviewed
Evaluation of irritancy of microbial organic compounds (MVOCs) to mouse skin

Usuda Haruki, Tanaka Hiroyuki, Endo Takumi, Yamashita Hirotaka, Inagaki Naoki, Nagai Hiroichi

JOURNAL OF PHARMACOLOGICAL SCIENCES, 112 84P, 2010 Peer-reviewed
Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment: Mouse Models for the Development of Remedies for Human Allergic Dermatitis

Naoki Inagaki, Hiroichi Nagai

JOURNAL OF PHARMACOLOGICAL SCIENCES, 110(3) 251-259, Jul, 2009 Peer-reviewed
The Effects of Inhaled KP-496, a Novel Dual Antagonist for Cysteinyl Leukotriene Receptor and Thromboxane A(2) Receptor, on Allergic Asthmatic Responses in Guinea Pigs

Masahiro Suda, Toshiaki Okuda, Masakazu Ishimura, Shigeo Kurokawa, Shota Tokuoka, Tsutomu Nakamura, Yoshimasa Takahashi, Hiroyuki Tanaka, Hiroichi Nagai

PHARMACOLOGY, 84(4) 249-256, 2009 Peer-reviewed
DEVELOPMENT OF A NOVEL MOUSE ATOPIC DERMATITIS MODEL INDUCED BY MITE FECAL ANTIGEN

Yamashita Hirotaka, Miyamoto Yoshihiro, Tanaka Hiroyuki, Nagai Hiroichi, Inagaki Naoki

ACTA DERMATO-VENEREOLOGICA, 89(6) 708, 2009 Peer-reviewed
Augmentation of antigen-stimulated allergic responses by a small amount of trichloroethylene ingestion from drinking water

Makoto Seo, Takeo Yamagiwa, Ryo Kobayashi, Koji Ikeda, Masahiko Satoh, Naoki Inagaki, Hiroichi Nagai, Hisamitsu Nagase

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 52(2) 140-146, Nov, 2008 Peer-reviewed
Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease

Isao Nakao, Sachiko Kanaji, Shoichiro Ohta, Hidetomo Matsushita, Kazuhiko Arima, Noriko Yuyama, Mutsuo Yamaya, Katsutoshi Nakayama, Hiroshi Kubo, Mika Watanabe …

JOURNAL OF IMMUNOLOGY, 180(9) 6262-6269, May, 2008 Peer-reviewed
Inhibitory effects of Piper betle on production of allergic mediators by bone marrow-derived mast cells and lung epithelial cells

Mali Wirotesangthong, Naoki Inagaki, Hiroyuki Tanaka, Witchuda Thanakijcharoenpath, Hiroichi Nagai

INTERNATIONAL IMMUNOPHARMACOLOGY, 8(3) 453-457, Mar, 2008 Peer-reviewed
A new murine model of allergic rhinitis by repeated intranasal Cry j 1 challenge

Masako Tsunematsu, Taketo Yamaji, Daisuke Kozutsumi, Rika Murakami, Hiroichi Nagai, Kohsuke Kino

Biomedical Research, 29(3) 119-123, 2008 Peer-reviewed
Immunomodulatory effects of CpG oligodeoxynucleotides on house dust mite-induced airway inflammation in mice

Izumi Hirose, Hiroyuki Tanaka, Go Takahashi, Keiko Wakahara, Mayumi Tamari, Tatsuo Sakamoto, Seiji Kojima, Naoki Inagaki, Hiroichi Nagai

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 147(1) 6-16, 2008 Peer-reviewed

Misc.

694

Enhancing effects of trichloroethylene and tetrachloroethylene on type I allergic responses in mice

Makoto Seo, Ryo Kobayashi, Tetsunori Okamura, Koji Ikeda, Masahiko Satoh, Naoki Inagaki, Hiroichi Nagai, Hisamitsu Nagase

JOURNAL OF TOXICOLOGICAL SCIENCES, 37(2) 439-445, Apr, 2012
Transient Receptor Potential Vanilloid 1-a Polymodal Nociceptive Receptor - Plays a Crucial Role in Formaldehyde-Induced Skin Inflammation in Mice

Haruki Usuda, Takumi Endo, Ayumi Shimouchi, Asaka Saito, Makoto Tominaga, Hirotaka Yamashita, Hiroichi Nagai, Naoki Inagaki, Hiroyuki Tanaka

JOURNAL OF PHARMACOLOGICAL SCIENCES, 118(2) 266-274, Feb, 2012
ダニ抗原誘発マウス気管支喘息発症におけるTLR9の意義

田中宏幸, 升田雄士, 江崎友哉, 村田健司, 山下弘高, 植松智, 審良静男, 稲垣直樹, 永井博弌

日本薬学会年会要旨集, 131年会(3) 80-80, Mar, 2011
Toll-like receptor (TLR) 9 is involved in the onset of Dermatophagoides farinae (Der f)-induced asthma in mice

Yuji Masuta, Hiroyuki Tanaka, Yuya Ezaki, Takeshi Murata, Naoki Inagaki, Hiroichi Nagai

JOURNAL OF PHARMACOLOGICAL SCIENCES, 115 103P-103P, 2011
MS5-4 ウィルス様刺激による喘息発症促進機構におけるIL-13およびCD8^+T細胞の意義(MS5 気管支喘息動物モデル,ミニシンポジウム,第61回日本アレルギー学会秋季学術大会)

井上奏子, 田中宏幸, 梶原悠, 土性千恵, 永井博弌, 稲垣直樹

アレルギー, 60(9) 1328-1328, 2011
MS5-7 ダニ抗原誘発マウス喘息様病態形成におけるTLR9の意義(MS5 気管支喘息動物モデル,ミニシンポジウム,第61回日本アレルギー学会秋季学術大会)

升田雄士, 田中宏幸, 江崎友哉, 村田健司, 永井博弌, 稲垣直樹

アレルギー, 60(9) 1329-1329, 2011
O12-4 ダニ抗原誘発マウス気道炎症に及ぼすウィルス感染様刺激の影響(O12 気管支喘息病態生理3 in vitro,マウス,口演,第61回日本アレルギー学会秋季学術大会)

生木庸寛, 田中宏幸, 若原恵子, 土性千恵, 梶原悠, 柳楽庸史, 永井博弌, 稲垣直樹

アレルギー, 60(9) 1379-1379, 2011
O47-8 ダニ抗原反復塗布により誘発されるマウス皮膚炎におけるopioid receptorの関与に関する検討(O47 免疫療法・アレルギー治療薬,口演,第61回日本アレルギー学会秋季学術大会)

佐田建, 山下弘高, 田中宏幸, 永井博弌, 稲垣直樹

アレルギー, 60(9) 1434-1434, 2011
Enhancement of immediate allergic reactions by trichloroethylene ingestion via drinking water in mice

Ryo Kobayashi, Tadayoshi Ikemoto, Makoto Seo, Masahiko Satoh, Naoki Inagaki, Hiroichi Nagai, Hisamitsu Nagase

JOURNAL OF TOXICOLOGICAL SCIENCES, 35(5) 699-707, Oct, 2010
Orally supplemented Lactobacillus acidophilus strain L-92 inhibits passive and active cutaneous anaphylaxis as well as 2,4-dinitroflurobenzene and mite fecal antigen induced atopic dermatitis-like skin lesions in mice

Mohammad Monir Shah, Yoshihiro Miyamoto, Yoshihito Yamada, Hirotaka Yamashita, Hiroyuki Tanaka, Takayuki Ezaki, Hiroichi Nagai, Naoki Inagaki

MICROBIOLOGY AND IMMUNOLOGY, 54(9) 523-533, Sep, 2010
アレルギー疾患における脂質メディエーターの役割 ―アレルギー疾患治療薬の標的分子として―

永井博弌, ナガイヒロイチ, Hiroichi NAGAI

岐阜薬科大学紀要 = The annual proceedings of Gifu Pharmaceutical University, 59 1-7, Jun 30, 2010
ホルムアルデヒド誘発マウス皮膚炎モデルにおける侵害刺激受容体の意義

田中宏幸, 臼田春樹, 遠藤拓未, 升田雄士, 山下弘高, 稲垣直樹, 永井博弌

日本薬学会年会要旨集, 130th(3) 100-100, Mar 5, 2010
Effect of Diesel Exhaust Particles on House Dust Mite-Induced Airway Eosinophilic Inflammation and Remodeling in Mice

Go Takahashi, Hiroyuki Tanaka, Keiko Wakahara, Reishi Nasu, Mikiko Hashimoto, Kosuke Miyoshi, Hirohisa Takano, Hirotaka Yamashita, Naoki Inagaki, Hiroichi Nagai

JOURNAL OF PHARMACOLOGICAL SCIENCES, 112(2) 192-202, Feb, 2010
A Novel CC-Chemokine.Receptor 3 Antagonist, Kil9003, Inhibits Airway Eosinophilia and Subepithelial/Peribronchial Fibrosis Induced by Repeated Antigen Challenge in Mice

Masato Komai, Hiroyuki Tanaka, Koichi Nagao, Masayuki Ishizaki, Daisuke Kajiwara, Toru Miura, Hiroshi Ohashi, Tomoko Haba, Kazuki Kawakami, Eiji Sawa …

JOURNAL OF PHARMACOLOGICAL SCIENCES, 112(2) 203-213, Feb, 2010
O32-1 マウス食物アレルギーモデルを用いた経口免疫寛容の検討(O32 食物アレルギー・治療,口演,第60回日本アレルギー学会秋季学術大会)

山下弘高, 高橋慶多, 田中宏幸, 永井博弌, 稲垣直樹

アレルギー, 59(9) 1406-1406, 2010
P22-4 ICRマウスの特徴を有するヘアレスマウスのヒスタミン感受性の検討(P22 皮膚基礎研究他,ポスター,第60回日本アレルギー学会秋季学術大会)

樋口順哉, 山下弘高, 田中宏幸, 永井博弌, 稲垣直樹

アレルギー, 59(9) 1461-1461, 2010
アレルゲン・抗原と症例微生物由来揮発性有機化合物の皮膚に及ぼす影響に関する基礎的研究

臼田春樹, 田中宏幸, 遠藤拓未, 山下弘高, 稲垣直樹, 永井博弌

アレルギー, 58(8-9) 1304-1304, Sep, 2009
アレルゲン・抗原と症例ホルムアルデヒド誘発マウス皮膚炎モデルにおけるtransient receptor potential vanilloid1(TRPV1)の意義

遠藤拓未, 田中宏幸, 臼田春樹, 下内鮎美, 山下弘高, 稲垣直樹, 永井博弌

アレルギー, 58(8-9) 1304-1304, Sep, 2009
Mechanisms of the development of allergen-induced airway remodeling: from mouse studies

Clinical immunology & allergology, 52(1) 58-63, Jul, 2009
Pharmacogenomics in the Treatment of Asthma

Hiroichi NAGAI

58 1-7, Jun 30, 2009

Books and Other Publications

もうアレルギーに苦しまない

(社)日本薬学会編, 丸善出版, 2000
呼吸器作用薬、免疫・アレルギー・抗炎症薬、薬物中毒と解毒

コメディカルの薬理学廣川書店, 1996
サイトカインと気道過敏性モデル動物における検討

喘息'94 メディカルレビュー, 1994
アレルギーの理論とその展開-新しい概念に向けて-特に新しい抗アレルギー薬

医薬ジャーナル社, 1992
機能形態学--呼吸器系--

広川書店, 1992
The theoretical and practical therapy of allergic diseases-------Anti-allergic drugs

1992
Anatomical physiology----Respiratory system

1992

Professional Memberships

Research Projects

Clarification of the underlying mechanism of allergic diseases targeting the signal pathways of the involved cytokines

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

IZUHARA Kenji, KANAJI Sachiko, OHTA Shoichiro, SHIRAISHI Hiroshi, NAGAI Hiroichi, INOUE Makoto
キノコからの生体機能分子の探索とその作用機構解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

河岸洋和, 永井博弌, 稲垣直樹, 徳山真治
キノコからの生体機能分子の探策とその作用機構解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2005 - 2005

河岸洋和, 徳山真治, 上野勝, 永井博弌, 稲垣直樹
Clarification of the mechanism of allergic diseases based on the analyses of the mechanism of signal transduction of interleukin-4 and-13

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

IZUHARA Kenji, ARIMA Kazuhiko, KANAJI Sachiko, KANJI Taisuke, MASUMOTO Kiyonari, NAGAI Hiroichi
Basic research for the onset and modulation of allergic diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1998 - 2000

NAGAI Hiroichi
A study on the reality of Japanese cedar pollinosis in children and students : An evaluation from clinical and preclinical viewpoints

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1998 - 2000

IIKURA Yoji, ITO Yukiko, HOSOI Susumu, HATA Daishi, NAGAI Hirokazu, KITABAYASHI Taeru
Basic reseach for a remedy to allergic tissue inflammation

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1993 - 1994

NAGAI Hiroichi
アレルギー疾患および自己免疫疾患の発症機序

1967
アレルギー疾患おび自己免疫疾患治療薬についての研究
Pharmacological studies of the remedy for allergic and autoimmune disease
The mechanism of the onset and development of allergic and autoimmune disease

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