原明 (Akira Hara) - マイポータル

基本情報

所属: 岐阜薬科大学岐阜薬科大学薬学部薬学科教授

学位: 博士(薬学)(岐阜薬科大学)

J-GLOBAL ID: 200901057760906409
researchmap会員ID: 1000054737

外部リンク: http://www.gifu-pu.ac.jp/lab/seika/index.html

研究キーワード

研究分野

経歴

1987年 - 1992年

岐阜薬科大学助教授
1987年 - 1992年

Assistant Professor, Gifu Pharmaceutical University.
1986年 - 1987年

岐阜薬科大学講師
1986年 - 1987年

Lecturer, Gifu Pharmaceutical University.
1975年 - 1985年

岐阜薬科大学助手
1975年 - 1985年

Research Associate, Gifu Pharmaceutical University.
1974年 - 1975年

徳島文理大学薬学助手
1974年 - 1975年

Research Associate, Tokushima University of Arts and Science.
1972年 - 1974年

岐阜大学医学部助手
1972年 - 1974年

Research Associate, Gifu University School of Medicine.

学歴

委員歴

1998年

日本薬物動態学会, 評議員
1992年

日本生化学会, 評議員

受賞

1983年

日本薬学会東海支部学術奨励賞

MISC

143

Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis

Krithika Sundaram, Urmi Dhagat, Satoshi Endo, Roland Chung, Toshiyuki Matsunaga, Akira Hara, Ossama El-Kabbani

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21(2) 801-804 2011年1月
Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10)

Satoshi Endo, Toshiyuki Matsunaga, Tsukasa Kuragano, Satoshi Ohno, Yukio Kitade, Kazuo Tajima, Ossama El-Kabbani, Akira Hara

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 503(2) 230-237 2010年11月
Structure-based optimization and biological evaluation of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors

Ossama El-Kabbani, Peter J. Scammells, Tom Day, Urmi Dhagat, Satoshi Endo, Toshiyuki Matsunaga, Midori Soda, Akira Hara

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 45(11) 5309-5317 2010年11月
Dimeric Crystal Structure of Rabbit L-Gulonate 3-Dehydrogenase/lambda-Crystallin: Insights into the Catalytic Mechanism

Yukuhiko Asada, Chizu Kuroishi, Yoko Ukita, Rie Sumii, Satoshi Endo, Toshiyuki Matsunaga, Akira Hara, Naoki Kunishima

JOURNAL OF MOLECULAR BIOLOGY 401(5) 906-920 2010年9月
Factorizing the role of a critical leucine residue in the binding of substrate to human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1): Molecular modeling and kinetic studies of the Leu308Val mutant enzyme

Urmi Dhagat, Satoshi Endo, Midori Soda, Akira Hara, Ossama El-Kabbani

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20(17) 5274-5276 2010年9月
Selectivity determinants of inhibitor binding to the tumour marker human aldose reductase-like protein (AKR1B10) discovered from molecular docking and database screening

Hai-Tao Zhao, Midori Soda, Satoshi Endo, Akira Hara, Ossama El-Kabbani

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 45(9) 4354-4357 2010年9月
Toxicity against gastric cancer cells by combined treatment with 5-fluorouracil and mitomycin c: implication in oxidative stress

Toshiyuki Matsunaga, Yoshitaka Tsuji, Kairyu Kaai, Saki Kohno, Renzo Hirayama, David H. Alpers, Tsugikazu Komoda, Akira Hara

CANCER CHEMOTHERAPY AND PHARMACOLOGY 66(3) 517-526 2010年8月
Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10

Satoshi Endo, Toshiyuki Matsunaga, Kazuo Kuwata, Hai-Tao Zhao, Ossama El-Kabbani, Yukio Kitade, Akira Hara

BIOORGANIC & MEDICINAL CHEMISTRY 18(7) 2485-2490 2010年4月
Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor

Vincenzo Carbone, Marco Giglio, Roland Chung, Trevor Huyton, Julian Adams, Rosanna Maccari, Rosaria Ottana, Akira Hara, Ossama El-Kabbani

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 45(3) 1140-1145 2010年3月
Direct and Simple Fluorescence Detection Method for Oxidized Lipoproteins

Takeshi Ikeda, Makoto Seo, Ikuo Inoue, Shigehiro Katayama, Toshiyuki Matsunaga, Akira Hara, Tsugikazu Komoda, Mari Tabuchi

ANALYTICAL CHEMISTRY 82(3) 1128-1132 2010年2月
Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme

Urmi Dhagat, Satoshi Endo, Hiroaki Mamiya, Akira Hara, Ossama El-Kabbani

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 66 198-204 2010年2月
Nitric oxide mitigates apoptosis in human endothelial cells induced by 9,10-phenanthrenequinone: Role of proteasomal function

Toshiyuki Matsunaga, Marina Arakaki, Tetsuro Kamiya, Mariko Haga, Satoshi Endo, Ossama El-Kabbani, Akira Hara

TOXICOLOGY 268(3) 191-197 2010年2月
Rat Aldose Reductase-Like Protein (AKR1B14) Efficiently Reduces the Lipid Peroxidation Product 4-Oxo-2-nonenal

Biol Pharm Bull 33(11) 1886-1890 2010年
Selective Inhibition of the Tumor Marker AKR1B10 by Antiinflammatory N-Phenylanthranilic Acids and Glycyrrhetic Acid

Biol Pharm Bull 33(5) 886-890 2010年
Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: Probing the active site of the enzyme with molecular modeling and site-directed mutagenesis

Toshiyuki Matsunaga, Satoshi Endo, Midori Soda, Hai-Tao Zhao, Ossama El-Kabbani, Kazuo Tajima, Akira Hara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 389(1) 128-132 2009年11月
Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells

Toshiyuki Matsunaga, Marina Arakaki, Tetsuro Kamiya, Satoshi Endo, Ossama El-Kabbani, Akira Hara

CHEMICO-BIOLOGICAL INTERACTIONS 181(1) 52-60 2009年9月
Kinetic studies of AKR1B10, human aldose reductase-like protein: Endogenous substrates and inhibition by steroids

Satoshi Endo, Toshiyuki Matsunaga, Hiroaki Mamiya, Chisato Ohta, Midori Soda, Yukio Kitade, Kazuo Tajima, Hai-Tao Zhao, Ossama El-Kabbani, Akira Hara

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 487(1) 1-9 2009年7月
Expression Analysis of the Aldo-Keto Reductases Involved in the Novel Biosynthetic Pathway of Tetrahydrobiopterin in Human and Mouse Tissues

Haruka Hirakawa, Hiroshi Sawada, Yumi Yamahama, Shin-Ichiro Takikawa, Haruo Shintaku, Akira Hara, Keisuke Mase, Tomoyoshi Kondo, Teruhiko Iino

JOURNAL OF BIOCHEMISTRY 146(1) 51-60 2009年7月
Structure-Guided Design, Synthesis, and Evaluation of Salicylic Acid-Based Inhibitors Targeting a Selectivity Pocket in the Active Site of Human 20 alpha-Hydroxysteroid Dehydrogenase (AKR1C1)

Ossama El-Kabbani, Peter J. Scammells, Joshua Gosling, Urmi Dhagat, Satoshi Endo, Toshiyuki Matsunaga, Midori Soda, Akira Hara

JOURNAL OF MEDICINAL CHEMISTRY 52(10) 3259-3264 2009年5月
Structure/function analysis of a critical disulfide bond in the active site of l-xylulose reductase

H. -T. Zhao, S. Endo, S. Ishikura, R. Chung, P. J. Hogg, A. Hara, O. El-Kabbani

CELLULAR AND MOLECULAR LIFE SCIENCES 66(9) 1570-1579 2009年5月

もっとみる

書籍等出版物

Advances in Molecular Mechanisms and Pharmacology of Diabetic Complications

RESEARCH SIGNPOST 2010年
The HDL Handbook -Biological Functions and Clinical Implications

ACADEMIC PRESS 2010年
酵素ハンドブック（第3版）

朝倉書店 2008年
Enzymology and Molecular Biology of Carbonyl Metabolism 7 (共著)

Kluwer Academics/Plenum Publishers 1999年
Enzymology and Molecular Biology of Carbonyl Metabolism 6(共著)

Plenum Press 1997年
Enzymology and Molecular Biology of Carbonyl Metabolism 5(共著)

Plenum Press, 1995年
Enzymology and molecular biology of carbonyl metabolism 4(共著)

Plenum Press 1993年
Enzymology and Molecular Biology of Carbonyl Metabolism 3. (共著)

Plenum Press 1991年

原明

基本情報

研究キーワード

研究分野

経歴

学歴

委員歴

受賞

MISC

書籍等出版物

所属学協会

Works(作品等)

共同研究・競争的資金等の研究課題

メニュー