論文

査読有り
2013年9月

Ingestion of Low Dose Pyroglutamyl Leucine Improves Dextran Sulfate Sodium-Induced Colitis and Intestinal Microbiota in Mice

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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回数 : 281
  • Sayori Wada
  • Kenji Sato
  • Ryoko Ohta
  • Eri Wada
  • Yukiho Bou
  • Miki Fujiwara
  • Tamami Kiyono
  • Eun Young Park
  • Wataru Aoi
  • Tomohisa Takagi
  • Yuji Naito
  • Toshikazu Yoshikawa
  • 全て表示

61
37
開始ページ
8807
終了ページ
8813
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/jf402515a
出版者・発行元
AMER CHEMICAL SOC

Inflammatory bowel diseases (IBD) are based on chronic inflammation in the gastrointestinal tract. We previously found anti-inflammatory peptide pyroGlu-Leu in the enzymatic hydrolysate of wheat gluten. The objective of present study is to elucidate improvement of colitis by oral administration of pyroGlu-Leu in an animal model. Acute colitis was induced by dextran sulfate sodium (DSS), and various concentrations of pyroGlu-Leu were administrated by oral gavage for 7 days. A dose of 0.1 mg/kg body weight/day showed the most significant improvement. The pyroGlu-Leu concentration was significantly increased 24 h after oral administration both in the small intestine and the colon compared with the baseline. It was 20-fold higher in the small intestine than the colon. Administration of pyroGlu-Leu normalized population of Bacteroidetes and Firmicutes in the colon. These results indicate that pyroGlu-Leu has a potential therapeutic effect against IBD at a practical dose.

リンク情報
DOI
https://doi.org/10.1021/jf402515a
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000330096300012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1021/jf402515a
  • ISSN : 0021-8561
  • eISSN : 1520-5118
  • Web of Science ID : WOS:000330096300012

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