論文

査読有り
2015年12月27日

The effect of Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon) and its derived ingredient methylthioacetic acid on energy metabolism during aerobic exercise

SpringerPlus
  • Wataru Aoi
  • Kazuya Takeda
  • Azusa Sasaki
  • Yuki Hasegawa
  • Yasushi Nakamura
  • Eun Young Park
  • Kenji Sato
  • Masayo Iwasa
  • Airi Nakayama
  • Mizuki Minamikawa
  • Yukiko Kobayashi
  • Koji Shirota
  • Noboru Suetome
  • 全て表示

4
1
開始ページ
377
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s40064-015-1144-y
出版者・発行元
SpringerOpen

Purpose: We investigated the effect of Katsura-uri (Japanese pickling melon
Cucumis melo var. conomon) on energy metabolism during exercise in human and animal studies. Methods: Eight healthy men (mean age, 21.4 ± 0.7 years) participated in a single-blind, crossover study. Thirty minutes after ingesting the Katsura-uri drink or placebo drink, they exercised on a cycle ergometer at 40% maximal heart rate for 30 min. Respiratory gas analysis was performed during exercise to examine oxygen consumption and substrate utilization. Blood biochemical parameters were evaluated during exercise. In the animal study, the effect of methylthioacetic acid (MTA), a Katsura-uri derived component was examined in mice. Immediately after running at 25 m/min for 30 min, biochemical parameters in the hind limb muscle and blood of mice were measured. Results: Oxygen consumption during exercise was higher in the Katsura-uri condition (19.8 ± 3.5 mL/kg/min) than the placebo condition (18.6 ± 3.0 mL/kg/min) (P &lt
 0.05). The elevation of blood lactate was lower in the Katsura-uri condition (1.7 ± 0.4 mM) than the placebo condition (2.2 ± 0.6 mM) 15 min after beginning exercise (P &lt
 0.05). There was a higher positive correlation between lactate concentration and carbohydrate oxidation during exercise in the Katsura-uri condition (R&lt
sup&gt
2&lt
/sup&gt
 = 0.86) compared to the placebo condition (R&lt
sup&gt
2&lt
/sup&gt
 = 0.47). The decrease in intermuscular pH and the increase in blood lactate following exercise were prevented by MTA supplementation (250 ppm) with significant differences in the MTA-supplemented group compared to the control group. Conclusions: These results suggest that the ingestion of Katsura-uri and/or MTA improves glucose metabolism and acidification in skeletal muscles during exercise in human and animal studies.

リンク情報
DOI
https://doi.org/10.1186/s40064-015-1144-y
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26217554
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84938869383&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84938869383&origin=inward
ID情報
  • DOI : 10.1186/s40064-015-1144-y
  • ISSN : 2193-1801
  • eISSN : 2193-1801
  • PubMed ID : 26217554
  • SCOPUS ID : 84938869383

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