TSUTSUI Hiroko

J-GLOBAL         Last updated: Oct 1, 2013 at 10:47
 
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Name
TSUTSUI Hiroko
Affiliation
Hyogo College of Medicine
Section
Faculty of Medicine, Department of Microbiology
Job title
Professor
Degree
Medical Doctor(Osaka City University)

Research Areas

 
 

Academic & Professional Experience

 
1986
 - 
1988
Postdoctral Research Associate
 
 
   
 
      at Yale University
 

Education

 
 
 - 
1985
Medical School, Osaka City University
 
 
 - 
1985
生化学, Graduate School, Division of Medicine, Osaka City University
 
 
 - 
1981
Faculty of Medicine, Osaka City University
 

Published Papers

 
Kawashima T, Kosaka A, Yan H, Guo Z, Uchiyama R, Fukui R, Kaneko D, Kumagai Y, You DJ, Carreras J, Uematsu S, Jang MH, Takeuchi O, Kaisho T, Akira S, Miyake K, Tsutsui H, Saito T, Nishimura I, Tsuji NM
Immunity   38 1187-1197   Jun 2013   [Refereed]
Fujimoto Y, Shimoyama A, Saeki A, Kitayama N, Kasamatsu C, Tsutsui H, Fukase K
Molecular bioSystems   9 987-996   May 2013   [Refereed]
Uchiyama R, Yonehara S, Tsutsui H
Journal of immunology (Baltimore, Md. : 1950)   190 4245-4254   Apr 2013   [Refereed]
Kato J, Okamoto T, Motoyama H, Uchiyama R, Kirchhofer D, Van Rooijen N, Enomoto H, Nishiguchi S, Kawada N, Fujimoto J, Tsutsui H
Hepatology (Baltimore, Md.)   57 362-372   Jan 2013   [Refereed]
Tsutsui H, Nakanishi K
Immunotherapy   4 1883-1894   Dec 2012   [Refereed]

Misc

 
Drug-Specific T cells derived from patients with drug-induced allergic hepatitis (jointly worked)
Journal of Immunology   149    1992
There is no correlation between function and lymphokine production of HBs antigen-specific human CD4+-cloned T cells (jointly worked)
Scandinavian Journal of Immunology   34    1991
Importance of direct hepatocytolysis by liver macrophages in an experimental fulminant hepatitis (jointly worked)
Hepato-Gastroenterology   39    1992
Prostaglandins Leukotriens Essential Fatty Acids   40    1990

Books etc

 
Interleukin-18 [IL-1F4]
7. Okamura H., Lotze M. T., Tsutsui H., Kashiwamura S., Ueda H., Yoshimoto T. and Nakanishi K. (Part:Joint Work, "The Cytokine Handbook" 4th Edition, (Eds. Thomson, A. W. and Lotze, M. T.))
Elsevier Science Ltd   2003   
IL-18 and IL-18 receptor knockout mice in "Cytokine Knockouts 2nd Edition"
Humana Press Inc. Ttowa NJ   2003   
Interleukin-18 in "Encyclopedia of Hormones"
Academic Press   2003   
Measurement of human and mouse interleukin-18
"Current Protocols in Immunology" John Wiley & Sons, Inc.   2001   
Interleukin-18
"Cytokine Therapeutics in Infectious Diseases" Lippincott Williams & Wilkins   2001   

Works

 
Spontaneous development of atopic dermatitis in mice, over-expressing bioactive IL-18
1997
Molecularmechanisms of severe hepatitis in SOCS-1-deficient mice
1998
Impairment of listerial clearance in caspase-1-deficient mice
1997

Research Grants & Projects

 
Activation of inflammasome for IL-18/IL-1 beta release after microbial infection
Project Year: 2009   
Roles of endogenous interleukin-33 after microbial infection
Project Year: 2007   
IL-33 is produced as biologically inactive precursor following microbial infection. We have studied roles of IL-33 during the microbial infection
Molecular mechanisms underlying caspase-1 activation induced by microbial infection
Project Year: 1995   
Upon TLR3 and TLR4 engagement caspase-1 is activated depending on TRIF but not MyD88. This is also the case for caspase-1-dependent IL-18 release after infection with extracellular bacteria.
Study on endotoxin shock and multiple organ failure
Immunological disturbance underlying Plasmodium infection