Masafumi Mukamoto

Profile Information

Affiliation: Professor, Graduate School of Veterinary medicine, Osaka Metropolitan University

Degree: (BLANK)(Osaka Prefecture University)
(BLANK)(Osaka Prefecture University)

J-GLOBAL ID: 200901061919313908
researchmap Member ID: 1000057362

External link: http://www.vet.osakafu-u.ac.jp

Research Interests

Research Areas

Life sciences / Veterinary medicine /

Education

- Mar, 1983

Osaka Prefecture University
- Mar, 1981

Osaka Prefecture University
- 1959

Graduate School, Division of Agriculture, Osaka Prefecture University
- 1957

Faculty of Agriculture, Osaka Prefecture University

Committee Memberships

2013 - Present

委員, 兵庫県健康づくり審議会感染症対策専門員会
2013 - Present

委員, 近畿ブロック病性鑑定ネットワーク協議会
2013 - Present

委員, インフルエンザ・口蹄疫等対策専門関西広域防災計画策定委員会鳥インフル部会
2006 - Present

委員, 社団法人日本食鳥協会食鳥処理加工技能評価委員会
2003 - Present

委員, 兵庫県高病原性鳥インフルエンザ技術指導委員会
2011 - 2017

委員, 但馬牛遺伝資源保管対策検討会
2010 - 2014

技術専門員, 社団法人日本能率協会審査登録センター
2009 - 2013

研究アドバイザー, 兵庫県立健康生活科学研究所健康科学研究センター

Papers

Evaluation of immunochromatographic test of Shiga toxin 2e in enrichment cultures of swine edema disease clinical samples

Hideyuki ARIMITSU, Tomoko KOHDA, Masafumi MUKAMOTO, Masahiro KUSUMOTO

Journal of Veterinary Medical Science, 83(12) 1913-1917, 2021
Analysis of a plasmid encoding botulinum neurotoxin type G gene in Clostridium argentinense.

Yoshihiko Sakaguchi, Jumpei Uchiyama, Akira Také, Kazuyoshi Gotoh, Masakiyo Sakaguchi, Tomonori Suzuki, Yumiko Yamamoto, Koji Hosomi, Tomoko Kohda, Masafumi Mukamoto …

Anaerobe, 66 102281-102281, Dec, 2020
Translocation domain of botulinum neurotoxin A subtype 2 potently induces entry into neuronal cells

Tomoko Kohda, Kentaro Tsukamoto, Yasushi Torii, Shunji Kozaki, Masafumi Mukamoto

Microbiology and Immunology, 64(7) 502-511, Jul 1, 2020 Peer-reviewed
Response to "Standardized methods must be used to compare the properties of botulinum toxin serotypes"

Tomoko Kohda, Keiji Nakamura, Koji Hosomi, Yasushi Torii, Shunji Kozaki, Masafumi Mukamoto

MICROBIOLOGY AND IMMUNOLOGY, 61(12) 560-560, Dec, 2017 Peer-reviewed
Characterization of the functional activity of botulinum neurotoxin subtype B6

Tomoko Kohda, Keiji Nakamura, Koji Hosomi, Yasushi Torii, Shunji Kozaki, Masafumi Mukamoto

MICROBIOLOGY AND IMMUNOLOGY, 61(11) 482-489, Nov, 2017 Peer-reviewed
Development of a preliminary diagnostic measure for bovine leukosis in dairy cows using peripheral white blood cell and lymphocyte counts

Masao Nishiike, Michiyo Haoka, Takashi Doi, Tomoko Kohda, Masafumi Mukamoto

JOURNAL OF VETERINARY MEDICAL SCIENCE, 78(7) 1145-1151, Jul, 2016 Peer-reviewed
B型ボツリヌス菌が保有するCBB2_2914遺伝子の芽胞形成への関与(Characterization of CBB2_2914 gene associated with sporulation in Clostridium botulinum type B)

幸田知子, 細見晃司, 安木真世, 小崎俊司, 向本雅郁

日本細菌学雑誌, 71(1) 81-81, Feb, 2016
Morphological and genetic characterization of group I Clostridium botulinum type B strain 111 and the transcriptional regulator spoIIID gene knockout mutant in sporulation

Koji Hosomi, Ritsuko Kuwana, Hiromu Takamatsu, Tomoko Kohda, Shunji Kozaki, Masafumi Mukamoto

ANAEROBE, 33 55-63, Jun, 2015 Peer-reviewed
C. botulinum B型の胞子形成の開始におけるオーファンヒスチジンキナーゼの関与(Involvement of an orphan histidine kinase in initiation of sporulation of C. botulinum type B)

細見晃司, 幸田知子, 桑名利津子, 高松宏治, 向本雅郁

日本細菌学雑誌, 70(1) 145-145, Feb, 2015
牛ボツリヌス症由来D型菌産生DCモザイク神経毒素の毒性発現機構の解析

大門和広, 幸田知子, 細見晃司, 中村佳司, 向本雅郁

日本細菌学雑誌, 70(1) 224-224, Feb, 2015
Genotyping and characterisation of the secretory lipolytic enzymes of Malassezia pachydermatis isolates collected from dogs.

Teramoto H, Kumeda Y, Yokoigawa K, Hosomi K, Kozaki S, Mukamoto M, Kohda T

Veterinary record open, 2(2) e000124, 2015 Peer-reviewed
Complete nucleotide sequence of a plasmid containing the botulinum neurotoxin gene in Clostridium botulinum type B strain 111 isolated from an infant patient in Japan

Koji Hosomi, Yoshihiko Sakaguchi, Tomoko Kohda, Kazuyoshi Gotoh, Daisuke Motooka, Shota Nakamura, Kaoru Umeda, Tetsuya Iida, Shunji Kozaki, Masafumi Mukamoto

MOLECULAR GENETICS AND GENOMICS, 289(6) 1267-1274, Dec, 2014 Peer-reviewed
Draft genome sequence of Clostridium botulinum type B strain Osaka05, isolated from an infant patient with botulism in Japan

Yoshihiko Sakaguchi, Koji Hosomi, Jumpei Uchiyama, Yoshitoshi Ogura, Kaoru Umeda, Masakiyo Sakaguchi, Tomoko Kohda, Masafumi Mukamoto, Naoaki Misawa, Shigenobu Matsuzaki …

Genome Announcements, 2(1), 2014 Peer-reviewed
Improved detection methods by genetic and immunological techniques for botulinum C/D and D/C mosaic neurotoxins

Keiji Nakamura, Tomoko Kohda, Yoshiyuki Seto, Masafumi Mukamoto, Shunji Kozaki

VETERINARY MICROBIOLOGY, 162(2-4) 881-890, Mar, 2013 Peer-reviewed
Analysis of tryptophan-rich region in Clostridium septicum alpha-toxin involved with binding to glycosylphosphatidylinositol-anchored proteins

Masafumi Mukamoto, Ryota Kimura, Mudenda B. Hang'ombe, Tomoko Kohda, Shunji Kozaki

Microbiology and Immunology, 57(3) 163-169, Mar, 2013 Peer-reviewed
変異D型神経毒素を産生するボツリヌス菌の遺伝学的解析

中村佳司, 幸田知子, 細見晃司, 向本雅郁, 小崎俊司

日本細菌学雑誌, 68(1) 125-125, Feb, 2013
Production of a Neutralizing Mouse-Human Chimeric Antibody against Botulinum Neurotoxin Serotype E

Masafumi Mukamoto, Hiroaki Maeda, Tomoko Kohda, Chikateru Nozaki, Motohide Takahashi, Shunji Kozaki

JAPANESE JOURNAL OF INFECTIOUS DISEASES, 66(1) 46-50, Jan, 2013 Peer-reviewed
Characterization of neutralizing mouse-human chimeric and shuffling antibodies against botulinum neurotoxin A

Masafumi Mukamoto, Hiroaki Maeda, Tomoko Kohda, Chikateru Nozaki, Motohide Takahashi, Shunji Kozaki

MICROBIOLOGY AND IMMUNOLOGY, 56(11) 748-755, Nov, 2012 Peer-reviewed
Unique Biological Activity of Botulinum D/C Mosaic Neurotoxin in Murine Species

Keiji Nakamura, Tomoko Kohda, Yuto Shibata, Kentaro Tsukamoto, Hideyuki Arimitsu, Mitsunori Hayashi, Masafumi Mukamoto, Nobuyuki Sasakawa, Shunji Kozaki

INFECTION AND IMMUNITY, 80(8) 2886-2893, Aug, 2012 Peer-reviewed
Stability of toxigenicity in proteolytic Clostridium botulinum type B upon serial passage.

Umeda K, Seto Y, Kohda T, Mukamoto M, Kozaki S

Microbiology and immunology, 56(5) 338-341, May, 2012 Peer-reviewed

Misc.

B6型ボツリヌス毒素遺伝子をコードするプラスミドの解析(Analysis of botulinum neurotoxin type B6 gene-encoding plasmid in Clostridium botulinum type B)

阪口義彦, 内山淳平, 細見晃司, 幸田知子, 小椋義俊, 林哲也, 林俊治, 小崎俊司, 向本雅郁

日本細菌学雑誌, 72(1) 127-127, Feb, 2017
B6型ボツリヌス毒素遺伝子をコードするプラスミドの解析(Analysis of botulinum neurotoxin type B6 gene-encoding plasmid in Clostridium botulinum type B)

阪口義彦, 内山淳平, 細見晃司, 幸田知子, 小椋義俊, 林哲也, 林俊治, 小崎俊司, 向本雅郁

日本細菌学雑誌, 72(1) 127-127, Feb, 2017
B型ボツリヌス菌のボツリヌス毒素遺伝子をコードするプラスミド解析(Analysis of botulinum neurotoxin type B6 gene-encoding plasmid in Clostridium botulinum type B)

阪口義彦, 内山淳平, 細見晃司, 幸田知子, 松崎茂展, 小椋義俊, 林哲也, 林俊治, 小崎俊司, 向本雅郁

日本細菌学雑誌, 70(1) 178-178, Feb, 2015
ボツリヌスB型神経毒素のサブタイプ間での毒性発現機構の解析

田中千暁, 幸田知子, 細見晃司, 中村佳司, 小崎俊司, 向本雅郁

日本細菌学雑誌, 69(1) 171-171, Feb, 2014
乳児ボツリヌス症由来B型菌Osaka05株と既知のプラスミドの比較

細見晃司, 幸田知子, 向本雅郁, 小崎俊司

日本獣医学会学術集会講演要旨集, 152回 216-216, Aug, 2011
ボツリヌスD/Cモザイク神経毒素の特性

中村佳司, 幸田知子, 塚本健太郎, 向本雅郁, 小崎俊司

日本細菌学雑誌, 65(1) 139, Feb 25, 2010
Compensatory Renal Growth in Uninephrectomized Immature Rats: Proliferative Activity and Epidermal Growth Factor

OKADA Toshiya, OMOTO-KITAO Mika, MUKAMOTO Masafumi, NAKAMURA Jun, MINO Masaki, KONDO Tomohiro, TAKESHITA Ai, KUSAKABE Ken Takeshi, KATO Keiko

The Japanese Journal of Veterinary Science, 72(8) 975-80, 2010
A new BoNT/B subtype detected from infant botulism in Japan

Kaoru Umeda, Tomoko Kohda, Yoshiyuki Seto, Masafumi Mukamoto, Shunji Kozaki

TOXICON, 51 54-54, Jun, 2008
Pathogenicity of botulinum C center dot D mosaic toxins in animals

Shunji Kozaki, Keiji Nakamura, Tomoko Kohda, Masafumi Mukamoto

TOXICON, 51 48-49, Jun, 2008
我が国で分離された Corynebacterium ulcerans が産生するジフテリア様毒素の性状について

瀬戸幸路, 幸田知子, 向本雅郁, 小宮貴子, 岩城正昭, 高橋元秀, 小崎俊司

日本細菌学雑誌, 62(1) 110-110, Feb 25, 2007
牛ボツリヌス症由来菌株の神経毒素の性状について

幸田知子, 中村佳司, 向本雅郁, 小崎俊司

日本細菌学雑誌, 62(1) 110-110, Feb 25, 2007
ボツリヌスC型およびD型神経毒素分子内の受容体結合領域について

塚本健太郎, 幸田知子, 向本雅郁, 越智定幸, 有満秀幸, 辻孝雄, 小崎俊司

日本細菌学雑誌, 62(1) 111-111, Feb 25, 2007
ボツリヌス菌C型およびD型神経毒素の受容体認識に関与するアミノ酸残基の検索

塚本健太郎, 幸田知子, 向本雅郁, 小崎俊司

日本細菌学雑誌, 61(1) 160, Feb 25, 2006
ボツリヌスC・Dモザイク神経毒素産生菌の病原性について

幸田知子, 塚本健太郎, 向本雅郁, 小崎俊司

日本細菌学雑誌, 61(1) 160, Feb 25, 2006
ボツリヌスC,D型神経毒素受容体としてのガングリオシドおよびリン脂質の役割

塚本健太郎, 幸田知子, 向本雅郁, 小崎俊司

日本獣医学会学術集会講演要旨集, 140th 120, Aug 31, 2005
ボツリヌスD神経毒素はガングリオシド非依存的に作用する

塚本健太郎, 幸田知子, 向本雅郁, 小崎俊司

日本細菌学雑誌, 60(1) 99, Feb 25, 2005
Effects of nitric oxide on the exocytotic release of glutamate in rat cerebellum granule cells

H Tsutsuki, H Ihara, T Kohda, M Mukamoto, S Kozaki

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 11(1) 109-109, Aug, 2004
Sequence of the gene for Clostridium botulinum type B neurotoxin associated with infant botulism, expression of the C-terminal half of heavy chain and its binding activity

H Ihara, T Kohda, F Morimoto, K Tsukamoto, T Karasawa, S Nakamura, M Mukamoto, S Kozaki

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1625(1) 19-26, Jan, 2003
Mutation analysis of receptor binding activity of Clostridiun botulinum type B neurotoxin fragment by use of site-directed mutagenesis

T Kohda, M Mukamoto, N Sugimoto, S Kozaki

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 365 R26-R26, Jun, 2002
C型ボツリヌス神経毒素のラット脳シナプトソームへの結合活性と受容体結合領域のクローニング

塚本健太郎, 竹田正人, 幸田知子, 向本雅郁, 小崎俊司

日本獣医学会学術集会講演要旨集, 132nd 170, Sep 7, 2001

Books and Other Publications

臨床獣医

向本雅郁 (Role: Contributor, ボツリヌス毒素に対するカビ毒吸着剤の吸着作用)

緑書房, Jan, 2016
Companion Animal Practice

MUKAMOTO Masafumi (Role: Contributor)

Mar, 2012
防菌防黴

向本雅郁 (Role: Contributor, 注目されるウイルス感染症と制御対策 ③口蹄疫)

日本防菌防黴学会, Jul, 2011
動薬研究

向本雅郁 (Role: Contributor, ヒノキチオールの生物活性)

バイエル薬品株式会社, Jun, 2011
Journal of environmental control technique

MUKAMOTO Masafumi (Role: Contributor)

Jun, 2011
微生物胞子

向本雅郁 (Role: Contributor, 第5章胞子形性細菌の分離同定)

株式会社サイエンスフォーラム, May, 2011
大阪府獣医師会報

向本雅郁 (Role: Contributor, 口蹄疫の発生原因と防疫対策)

大阪府獣医師会, Dec, 2010
都市問題

向本雅郁 (Role: Contributor, 家畜伝染病対策におけるリスクマネジメント)

東京市政調査会, Oct, 2010
医科細菌学

向本雅郁 (Role: Contributor, 第11章人獣共通感染症)

南江堂, Jul, 2008
平成１９年宮崎県での発生における現地対応事例

向本雅郁

社団法人日本食鳥協会, Mar, 2008
職種別研修テキスト「食鳥処理加工」

向本雅郁 (Role: Contributor)

財団法人国際研修協力機構, 2008
韓国における高病原性鳥インフルエンザ対策に関する調査報告書－緊急時対応マニュアル作成の手引き－

向本雅郁

社団法人日本食鳥協会, Sep, 2007
消費者情報

向本雅郁 (Role: Contributor, 2005年何が起きたか「鳥インフルエンザ」)

関西消費者協会, Feb, 2006
鶏肉小売店のための衛生管理マニュアル

向本雅郁

全国食鳥肉販売業生活衛生同業組合連合会, Feb, 2006

Teaching Experience

Professional Memberships

Research Projects

ウェルシュ菌産生壊死毒素(NetB)の鶏壊死性腸炎発症に関与する宿主側因子の特定

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

向本雅郁
Mechanisms of pathogenicities of virulence factors produced by Clostridium perfringens involved in the pathogenesis of chicken necrotic enteritis.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

MUKAMOTO Masafumi
Investigation of mechanisms of chicken necrotic enterlitis onset by Clostridium perfringens producing necrosis toxin (NetB)

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

MUKAMOTO Masafumi
Development of new cataract model animals: A Study on the lens rupture and endophthalmitis suppression

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

OKADA Toshiya, MUKAMOTO Masafumi, NAKAGAWA Hiroshi, KONDO Tomohiro, MATSUYAMA Satoshi
ウエルシュ菌に起因する鶏壊死性腸炎の新規病原因子NetB の病原性発現機構の解明

科学研究費補助金基盤研究（C), 日本学術振興会, Apr, 2012 - Mar, 2015

向本雅郁
ガス壊疽菌産生壊死毒素による急性心原性ショックの病態生理機構の解明

科学研究費補助金基盤研究（C), 日本学術振興会, Apr, 2009 - Mar, 2012

向本雅郁
悪性水腫および気腫疽の発症に関わるガス壊疽菌群産生毒素の病原性発現機構の解明

科学研究費補助金基盤研究（C), 日本学術振興会, Apr, 2007 - Mar, 2009

向本雅郁
抗毒素製剤の効率的製造方法の開発に関する研究

医薬品等医療技術リスク評価研究事業, 厚生労働省, Apr, 2003 - Mar, 2009

向本雅郁
Characterization of CF-1 cataract mouse as a new animal model

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

OKADA Toshiya, MUKAMOTO Masafumi, MATSUYAMA Satoshi
ガス壊疽菌が産生する壊死毒の作用発現機構の解明

科学研究費補助金基盤研究（C), 日本学術振興会, Apr, 2004 - Mar, 2006

向本雅郁
Characterization of ddY cataract mouse as a new animal model

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

OKADA Toshiya, MUKAMOTO Masafumi, MATSUYAMA Satoshi
Effects of maternal chronic uremia on the development of fetal kidney : expression of growth factors and genes

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1998 - 2000

OKADA Toshiya, MUKAMOTO Masafumi
Study on structure and function of toxins produced by Clostridium septicum

Ordinary Research, 2000
Immune Responses and Roles of Cytokines at the Feto-material Interface during Successful Pregnancy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1997 - 1999

KISO Yasuo, OKADA Toshiya, YAMATE Jyoji, MAKITA Takashi, MUKAMOTO Masaya, KANNAN Yukiko

Industrial Property Rights

特開WO2009096162 A型ボツリヌス毒素中和組成物及びヒト抗A型ボツリヌス毒素抗体

向本雅郁
特許第5004154号組換え抗ボツリヌス神経毒素抗体

向本雅郁
特開2007-274924 抗E型ボツリヌス神経毒素抗体

向本雅郁
特開2005-145864 コロナウイルス用消毒剤

向本雅郁
特開2005-082558 小型球形ウイルスの高感度検出法

向本雅郁

Profile Information

Research Interests

Research Areas

Education

Committee Memberships

Papers

Misc.

Books and Other Publications

Teaching Experience

Professional Memberships

Research Projects

Industrial Property Rights

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