論文

査読有り 国際誌
2014年10月6日

A pulse radiolysis study of the dynamics of ascorbic acid free radicals within a liposomal environment.

Chemphyschem : a European journal of chemical physics and physical chemistry
  • Kazuo Kobayashi
  • ,
  • Yumiko Seike
  • ,
  • Akinori Saeki
  • ,
  • Takahiro Kozawa
  • ,
  • Fusako Takeuchi
  • ,
  • Motonari Tsubaki

15
14
開始ページ
2994
終了ページ
7
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/cphc.201402297
出版者・発行元
Wiley-VCH Verlag GmbH & Co.

The dynamics of free-radical species in a model cellular system are examined by measuring the formation and decay of ascorbate radicals within a liposome with pulse radiolysis techniques. Upon pulse radiolysis of an N2O-saturated aqueous solution containing ascorbate-loaded liposome vesicles, ascorbate radicals are formed by the reaction of OH(·) radicals with ascorbate in unilamellar vesicles exclusively, irrespective of the presence of vesicle lipids. The radicals are found to decay rapidly compared with the decay kinetics in an aqueous solution. The distinct radical reaction kinetics in the vesicles and in bulk solution are characterized, and the kinetic data are analyzed.

リンク情報
DOI
https://doi.org/10.1002/cphc.201402297
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25056365