MISC

2003年10月

Expression of histone acetyltransferases was down-regulated in poly(ADP-ribose) polymerase-1-deficient murine cells

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • K Ota
  • ,
  • M Kameoka
  • ,
  • Y Tanaka
  • ,
  • A Itaya
  • ,
  • K Yoshihara

310
2
開始ページ
312
終了ページ
317
記述言語
英語
掲載種別
DOI
10.1016/j.bbrc.2003.08.146
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

NF-kappaB-dependent, as well as human immunodeficiency virus type-1 (HIV-1) long terminal repeat (LT R)-dependent, reporter gene expression was significantly impaired in cells derived from poly(ADP-ribose) polymerase-1 (PARP-1)-knockout (PARP-1 -/-) mice. In addition, the level of protein acetylation was markedly lower in PARP-1 -/- cells than control (PARP-1 +/+) cells. Surprisingly, the expression levels of historic acetyltransferases (HATs), p300, cAMP response element-binding protein-binding protein (CBP), and p300/CBP-associated factor (PCAF), were significantly reduced in PARP-1 -/- cells, as compared with PARP-1 +/+ cells. These results suggest that PARP-I is required for the proper expression of particular HATs. Since p300 and CBP are coactivators of NF-kappaB, we propose here that PARP-1 participates in NF-kappaB-dependent transcription by means of maintaining the expression of HATs. (C) 2003 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 12

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2003.08.146
CiNii Articles
http://ci.nii.ac.jp/naid/80016237994
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/14521911
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000185904300010&DestApp=WOS_CPL

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