MISC

1998年2月20日

Effects of an endothelin ET(A)-receptor antagonist, S-0139, on cerebral vasospasm and behavioral changes in dogs intracisternally administered endothelin-1

Life Sciences
  • Shigeru Sato
  • ,
  • Yukio Yonetani
  • ,
  • Masafumi Fujimoto
  • ,
  • Taizo Kita
  • ,
  • Kaoru Kubo
  • ,
  • Toshikatsu Nakashima

62
13
開始ページ
PL191
終了ページ
PL197
記述言語
英語
掲載種別
DOI
10.1016/S0024-3205(98)00050-2

The effects of an endothelin ETA-receptor selective antagonist, S-0139, were examined using dogs given endothelin-1 (ET-1) into the subarachnoid space. ET-1 at 40 pmol apparently constricted the basilar artery in anesthetized dogs and caused various grades of ataxia, facial clonus, nystagmus and other features in conscious dogs, partially mimicking those which have been reported for conscious rats. S-0139 could completely inhibit both the vasoconstriction and behavioral changes. It could also alleviate the behavioral changes caused by ET-1 in conscious dogs when given after the severe ataxia. We concluded that ET-1 in the subarachnoid space produces behavioral changes via endothelin ETA-receptor mediation similar to its cerebral vasoconstricting action, at least, in dogs.

リンク情報
DOI
https://doi.org/10.1016/S0024-3205(98)00050-2
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9519805
ID情報
  • DOI : 10.1016/S0024-3205(98)00050-2
  • ISSN : 0024-3205
  • PubMed ID : 9519805
  • SCOPUS ID : 0008901574

エクスポート
BibTeX RIS