1999年
Colony-promoting activity in mice kidneys with phenylhydrazine hemolytic anemia
RENAL FAILURE
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- 巻
- 21
- 号
- 6
- 開始ページ
- 615
- 終了ページ
- 625
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- MARCEL DEKKER INC
Aqueous anemic mice kidney extracts (MKE) were assessed colony-promoting activity (CPA) of hematopoietic progenitor cells in serum-free cultures stimulated by interleukin-3 and erythropoietin (Epo) Mice with hemolytic anemia followed by phenylhydorazine (PHZ) injection for 3 days showed a decrease in the hematocrit (25.4%) and an increase in serum Epo by 14-fold of the control on day 3 after the treatment At 3 clays, the total number of hematopoietic progenitor cells in the bone marrow of PHZ mice decreased by 67% of the control while these cells in the spleen increased to 22-fold of the control on day 3 and 55-fold on day 6. A significant increase in CPA was observed in MKE prepared from PHZ mice kidneys. Additionally, bone marrow suppressive anemia induced by 5-fluorouracil resulted in enhanced CPA the same as for PHZ mice, but in contrast anemia with suppression of Epo-production due to nephrotoxicity induced by cisplatin caused a decrease in CPA. These results suggest that CPA in MKE correlates with hematopoietic conditions, and may have a definite role in hematopoiesis through the function of the kidney.
- リンク情報
- ID情報
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- ISSN : 0886-022X
- Web of Science ID : WOS:000083847000004