Kazutaka Tanizawa - My portal - researchmap

Profile Information

Affiliation: Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Health Sciences University of Hokkaido

Degree: Ph.D(Hokkaido University)

J-GLOBAL ID: 200901050867535590
researchmap Member ID: 1000060330

Research Interests

4

Research Areas

3

Research History

4

1975 - 1992

Faculty of Pharmaceutical Sciences, Hokkaido University
1975 - 1992

Hokkaido University, Assistant Professor
1966 - 1975

Faculty of Pharmaceutical Sciences, Hokkaido University
1966 - 1975

Hokkaido University, Research Assistant

Education

4

- 1965

Hokkaido University
- 1965

Graduate School, Division of Pharmaceutical Sciences, Hokkaido University
- 1963

Faculty of Pharmaceutical Sciences, Hokkaido University
- 1963

Faculty of Pharmaceutical Science, Hokkaido University

Committee Memberships

2

2003

北海道支部長, 日本薬学会
1983

北海道支部幹事, 日本薬学会

Awards

1

1984

日本薬学会奨励賞

Misc.

35

Photoregulation of deacylation rate of acyl trypsin derived from photoresponsive inverse substrate

H Sekizaki, A Kumagai, K Itoh, E Toyota, K Horita, Y Noguchi, K Tanizawa

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 13(21) 3809-3812, Nov, 2003
Photoregulation of deacylation rate of acyl trypsin derived from photoresponsive inverse substrate

H Sekizaki, A Kumagai, K Itoh, E Toyota, K Horita, Y Noguchi, K Tanizawa

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 13(21) 3809-3812, Nov, 2003
Synthesis and evaluating of guahiaine-containing schift base copper(II), zinc(II), and iron(III) chelates as trypsin inhibitors

TOYOTA E, SEKIZAKI H, ITOH K, TANIZAWA K

Chem. Pharm. Bull., 51(6) 625-629, 2003
Synthesis and evaluating of guahiaine-containing schift base copper(II), zinc(II), and iron(III) chelates as trypsin inhibitors

Chem. Pharm. Bull., 51(6) 625-629, 2003
A facil synthesis of benzofuran derivatives: a useful synthon for preparation of trypsin inhibitor

Heterocycles, 529 237–243, 2003
Crystal structure and nucleotide sequence of an anionic trypsin from chum salmon (Oncorhynchus keta) in comparison with Atlantic salmon (Salmo salar) and bovine trypsin

E Toyota, KKS Ng, S Kuninaga, H Sekizaki, K Itoh, K Tanizawa, MNG James

JOURNAL OF MOLECULAR BIOLOGY, 324(3) 391-397, Nov, 2002
Trypsin-catalyzed synthesis of oligopeptide amides: comparison of catalytic efficiency among trypsins different origin (bovine, streptomyces griseuse, and chum salmon)

J. Peptide Sci., 21 521-528., 2002
Chum salmon trypsin-catalyzed preferential formation of peptide containing D-amino acid

Amino Acids, 21 175-184., 2001
X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates

E Toyota, KKS Ng, H Sekizaki, K Itoh, K Tanizawa, MNG James

JOURNAL OF MOLECULAR BIOLOGY, 305(3) 471-479, Jan, 2001
Chum salmon trypsin-catalyzed peptide synthesis with inverse substrates as acyl donor components at low temperature

Haruo Sekizaki, Masami Murakami, Kunihiko Itoh, Eiko Toyota, Kazutaka Tanizawa

Journal of Molecular Catalysis - B Enzymatic, 11(1) 23-28, Nov 30, 2000
Anionic trypsin from chum salmon: activity with p-amidinophenyl ester and comparison with bovine and Streptomyces griseus trypsins

H Sekizaki, K Itoh, M Murakami, E Toyota, K Tanizawa

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 127(3) 337-346, Nov, 2000
Trypsin-catalyzed peptide synthesis with m-guanidinophenyl and m-(guanidinomethyl)phenyl esters as acyl donor component

H Sekizaki, K Itoh, E Toyota, K Tanizawa

AMINO ACIDS, 17(3) 285-291, 1999
Application of Various Inverse Substrates to Thrombin-Catalyzed Peptode Synthesis

Chem. Pharm. Bull., 47(3) 444-447, 1999
Application of Schiff Base Copper((]G0002[)) and Iron((]G0003[)) Chelates to Site-Specific Cleavage of a Trypsin

Eiko TOYOTA, Hiromitsu MIYAZAKI, Kunihiko ITOH, Haruo SEKIZAKI, Kazutaka TANIZAWA

Chem. Pharm. Bull., 47(1) 116-119, 1999
The Structural Requirements for an Inverse Substrate for Enzymatic Peptide Synthesis : Position Isomers of Guanidinonaphthyl Esters as the Acyl Dnor Component

Haruo SEKIZAKI, Kunihiko ITOH, Eiko TOYOTA, Kazutaka TANIZAWA

Chem. Pharm. Bull., 47(1) 104-110, 1999
Biologically Selective Pottasium Channel Openers Having 1,1-Diethylpropyl Group

Bioorg. Med. Chem. Lett., 8(23) 3397-3402, 1998
Enzymatic Peptide Synthesis with p-(Guanidinomethyl)phenyl Esters as Acyl Donors

Haruo SEKIZAKI, Kunihiko ITHO, Eiko TOYOTA, Kazutaka TANIZAWA

Chem. Pharm. Bull., 46(5) 846-849, 1998
Enzymatic coupling of alpha,alpha-dialkyl amino acids using inverse substrates as acyl donors

H Sekizaki, K Itoh, E Toyota, K Tanizawa

TETRAHEDRON LETTERS, 38(10) 1777-1780, Mar, 1997
Methyltrypsin-catalyzed peptide coupling: Comparison of alkyl ester and guanidinophenyl ester derivatives as acyl donor component

K Itoh, H Sekizaki, E Toyota, K Tanizawa

BIOORGANIC CHEMISTRY, 25(5-6) 307-319, 1997
Chromatographic Separation of Diastereomeric Schiff Base Copper(11), Nickel(11), and Zinc(11) Chelates from α-Amino Acid Racemates

Bioorganic Chemistry, 24(2) 150-158, 1996

More

Books and Other Publications

7

基礎薬学「物理化学スタデイガイド」(共著)

広川書店, 1999
基礎薬学「物理化学」(共著)

広川書店, 1997
酵素・生合成阻害剤のデザイン

生物活性物貭の分子設計(ソフトサイエンス社), 1991
タンパク貭の機能部位の検出,構造解析

日本生化学会編新生化学実験講座(東京化学同人), 1991
Design of Enzyme Inhibitors and Metabolic Inhibitors

1991
Analysis of Functional Sites of Protein

1991
Compounds Which Simulate Enzyme-Substrate Interaction

Topics in Current Chemistry(Springer-Verlag), 1986

Professional Memberships

2

Works

2

X-ray Crystallographic Analyses of Trypsin-inhibition Complex

2000 - 2003
トリプシン-阻害剤複合体のX線結晶解析

2000 - 2001

Research Projects

6