MISC

2004年2月

Morphological characterization of ductular reactions in canine liver disease

JOURNAL OF COMPARATIVE PATHOLOGY
  • K Yoshioka
  • ,
  • S Enaga
  • ,
  • K Taniguchi
  • ,
  • U Fukushima
  • ,
  • M Uechi
  • ,
  • K Mutoh

130
2-3
開始ページ
92
終了ページ
98
記述言語
英語
掲載種別
DOI
10.1016/j.jcpa.2003.08.004
出版者・発行元
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD

Intrahepatic bile duct proliferation (ductular reaction) was examined histologically, immunohistochemically and ultrastructurally in four cases of canine liver disease, diagnosed as chronic hepatitis, liver fibrosis, cirrhosis and cholangiocellular carcinoma. Ductular reaction was a common finding in all cases. Most of the proliferated bile ducts were similar to normal bile ducts. In addition, duct-like structures occurred, consisting of hepatocytes and of intermediate cells that had phenotypic characteristics of both cholangiocytes and hepatocytes. The proliferated bile ducts were immunohistochemically negative for proliferating cell nuclear antigen (PCNA) and stem cell factor (SCF). The proliferated bile ducts in these four cases of canine liver disease thus showed both typical ductular reactions, such as elongation and tortuosity of the existing bile ducts, and atypical ductular reactions resulting from metaplasia of hepatocytes. (C) 2003 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 18

リンク情報
DOI
https://doi.org/10.1016/j.jcpa.2003.08.004
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000220155100002&DestApp=WOS_CPL