沼澤光輝 (Mitsuteru Numazawa) - マイポータル - researchmap

基本情報

所属: 東北薬科大学薬学部薬学科臨床分析化学教授

学位: 薬学博士(東北大学)
薬学修士(東北大学)

J-GLOBAL ID: 200901011598080810
researchmap会員ID: 1000062085

研究キーワード

6

研究分野

3

経歴

4

1980年 - 1981年

東北薬科大学,助教授
1980年 - 1981年

Tohoku Pharmaceutical University, Assistant Professor
1972年 - 1979年

東北大学助手
1972年 - 1979年

Tohoku University, Research Assistant

学歴

4

委員歴

2

1985年

日本薬物動態学会, 評議員
1984年

日本分析化学会, 常議員

受賞

1

1998年

宮田専治学術賞

MISC

74

C(10)-C(19) Bond Cleavage Reaction of 19-Oxygenated Androst-4-eve-3, 6-dione Steroids under Various Conditions(jointly worked)

Chemical & Pharmaceutical Bulletin 52, 983-985 2004年
Stereochemistry of NaBH4 Reduction of a 19-Carbonyl Group of 3-Deoxy Androgens. Synthesis of [195-3H]- and [19-R-3H]-Labeled Aromatase Inhibitors Having a 19-Hydroxy Group(jointly worked)

Chemical & Pharmaceutical Bulletin 52, 722-726 2004年
Structure-activity relationships of 3-deoxy androgens as aromatase inhibitors. synthesis and biochemical studies of 4-substituted 4-ene and 5-ene steroids

M Nagaoka, Y Watari, H Yajima, K Tsukioka, Y Muroi, K Yamada, M Numazawa

STEROIDS 68(6) 533-542 2003年8月
Probing the active site of aromatase with 2-methyl-substituted androstenedione analogs

M Numazawa, Y Watari, K Yamada, N Umemura, W Handa

STEROIDS 68(6) 503-513 2003年8月
Kinetic analysis of reversible inhibition of 16α- hydroxyandrostenedione aromatization in human placental microsomes by suicide substrates of androstenedione aromatization0

Mitsuteru Numazawa, Ayako Mutsumi, Mii Tachibana, Akiko Yoshimura

Biological and Pharmaceutical Bulletin 26(6) 890-892 2003年
Kinetic Analysis of Reversible Inhibition of 16d-Hydroxy and rostenedione Aromatization in Human Placental Microsomes by Suicide Substrates of Androstene

Mitsuteru Numazawa, Ayako Mutsumi, Mii Tachibana, Akiko Yoshimura

Biological and Pharmaceutical Bulletin 26(6) 890-892 2003年
Aromatase Inhibition by 4β, 5β Epoxides of 16α-hydroxy and rostendione and its 19-oxygenated Analogs, Potential Precursors of Estriol Production in the Feto-placental Unit

Biological and Pharmaceutical Bulletin 25(12) 1566-1569 2002年12月
Aromatase inhibition by 4 beta,5 beta-epoxides of 16 alpha-hydroxyandrostenedione and its 19-oxygenated analogs, potential precursors of estriol production in the feto-placental unit

M Numazawa, A Yoshimura, Y Watari, H Matsuzaki

BIOLOGICAL & PHARMACEUTICAL BULLETIN 25(12) 1566-1569 2002年12月
Studies on the catalytic function of aromatase: aromatization of 6-alkoxy-substituted androgens

M Numazawa, M Ando, R Zennyoji

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 82(1) 65-73 2002年9月
Aromatization of 16α-hydroxyandrostenedione by human placental microsomes : effect of preincubation with suicide substrates of androstenedione aromatization（共著）

Journal of Steroid Biochemistry and Molecular Biology 81, 165-172 2002年
Inhibition of aromatase activity by green tea extract catechins and their endcrinological effects of oral administration in rats（共著）

Food and Chemical Toxicology 40, 925-933 2002年
Gastric Parietal Cells : Potent Endocrine Role in Secreting Estrogen as a Possible Regulator of Gastro - Hepatis Axis（共著）

Endocrinology 143(8) 3162-3170 2002年
Improved Synthesis and Mokecular Modeling of 4β,19-Dinydroxy and rost-5-en-17-one, an Excellent Inhibitor of Aromatase（共著）

Chemical and Pharmaceutical Bulletin 50(5) 703-705 2002年
Time-dependent aromatase inactivation by 4,5-epoxides of the natural substrate and rostenedione and its 19-oxygenated analogs（共著）

NUMAZAWA M, YOSHIMURA A, TACHIBANA M, SHELANGOUSKI M, ISHIKAWA M

Steroids 67(3/4) 185-193 2002年
Aromatization of 16α-hydroxyandrostenedione by human placental microsomes : effect of preincubation with suicide substrates of androstenedione aromatization（共著）

Journal of Steroid Biochemistry and Molecular Biology 81, 165-172 2002年
Inhibition of aromatase activity by green tea extract catechins and their endcrinological effects of oral administration in rats（共著）

Food and Chemical Toxicology 40, 925-933 2002年
Gastric Parietal Cells : Potent Endocrine Role in Secreting Estrogen as a Possible Regulator of Gastro - Hepatis Axis（共著）

Endocrinology 143(8) 3162-3170 2002年
Improved Synthesis and Mokecular Modeling of 4β,19-Dinydroxy and rost-5-en-17-one, an Excellent Inhibitor of Aromatase（共著）

Mitsuteru Numazawa, Keiko Yamada, Yoko Watari, Momoko Ando

Chemical and Pharmaceutical Bulletin 50(5) 703-705 2002年
Time-dependent aromatase inactivation by 4,5-epoxides of the natural substrate and rostenedione and its 19-oxygenated analogs（共著）

Steroids 67(3/4) 185-193 2002年
Role of Gydrophilic Intrection in Binding of Hydroxylated 3-Deoxy C19 Steroids to the Active site of Aromatase（共著）

NUMAZAWA M, YAMADA K, NITTA S, SASAKI C, KIDOKORO K

Journal of Medicinal Chemistry 44(24) 4277-4283 2001年11月

もっとみる

所属学協会

7

Works(作品等)

4

共同研究・競争的資金等の研究課題

4