SHIBATA Nobuyuki

Last updated: Jun 19, 2019 at 19:00

Name	SHIBATA Nobuyuki
Affiliation	Tohoku Medical and Pharmaceutical University
Section	Faculty of Pharmaceutical Sciences　Department of Hygienic Pharmacentical Science
Job title	Associate Professor
Degree	Doctor of Pharmacy(Tohoku Pharmaceutical University)

Research Interests

Enzyme(158) , Pathogenicity(21) , Polysaccharide(33) , Antigen(8)

Research Areas

Agricultural chemistry / Applied biochemistry /
Pharmacy / Biological pharmacy /
Basic medicine / Bacteriology (including mycology) /

Academic & Professional Experience

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1981

1991

Tohoku Pharmaceutical University, Research

1991

2000

Tohoku Pharmaceutical University, Lecturer

2000

2003

Tohoku Pharmaceutical University, Associate

Apr 2011

Today

Tohoku Medical and Pharmaceutical University, Professor

Education

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1981

Carbohydrate Chemistry, Graduate School, Division of Pharmaceutical Sciences, Tohoku Pharmaceutical University

1979

Faculty of Pharmaceutical Science, Tohoku Pharmaceutical University

Published Papers

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Identification of Two Mannosyltransferases Contributing to Biosynthesis of the Fungal-type Galactomannan α-Core-Mannan Structure in Aspergillus fumigatus.

Onoue T, Tanaka Y, Hagiwara D, Ekino K, Watanabe A, Ohta K, Kamei K, Shibata N, Goto M, Oka T

Scientific reports 8(1) 16918 Nov 2018 [Refereed]

Cooperation between ER stress and calcineurin signaling contributes to the maintenance of cell wall integrity in Candida glabrata.

Tanaka Y, Sasaki M, Ito F, Aoyama T, Sato-Okamoto M, Takahashi-Nakaguchi A, Chibana H, Shibata N

Fungal biology 122(1) 19-33 Jan 2018 [Refereed]

GfsA is a β1,5-galactofuranosyltransferase involved in the biosynthesis of the galactofuran side chain of fungal-type galactomannan in Aspergillus fumigatus.

Katafuchi Y, Li Q, Tanaka Y, Shinozuka S, Kawamitsu Y, Izumi M, Ekino K, Mizuki K, Takegawa K, Shibata N, Goto M, Nomura Y, Ohta K, Oka T

Glycobiology 27(6) 568-581 Jun 2017 [Refereed]

KRE5 Suppression Induces Cell Wall Stress and Alternative ER Stress Response Required for Maintaining Cell Wall Integrity in Candida glabrata.

Tanaka Y, Sasaki M, Ito F, Aoyama T, Sato-Okamoto M, Takahashi-Nakaguchi A, Chibana H, Shibata N

PloS one 11(8) e0161371 2016 [Refereed]

Significant structural change in both O- and N-linked carbohydrate moieties of the antigenic galactomannan from Aspergillus fumigatus grown under different culture conditions.

Kudoh A, Okawa Y, Shibata N

Glycobiology 25(1) 74-87 Jan 2015 [Refereed]

Misc

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Existence of Branched Side Chains in the Cell Wall Mannan of Pathogenic Yeast, ┣DBCandida albicans(/)-┫DB. Structure-Antigenicity Relationship Between the Cell Wall Mannans of ┣DBCandida albicans(/)-┫DB and ┣DBCandida parapsilosis(/)-┫DB(共著)

The Journal of Biological Chemistry 270(3), 1113-1122 1995

Existence of Novel Branched Side Chains Containing β-1, 2 and α-1, 6 Linkages Corresponding to Antigenic Factor 9 in the Mannan of ┣DBCandida guilliermondii(/)-┫DB(共著)

The Journal of Biological Chemistry 271(16), 9259 1996

Characterization of β-1,2-mannosyltransferase in ┣DBCandida guilliermondii(/)-┫DB, and its utilization in the synthesis of novel oligosaccharides(共著)

The Journal of Biological Chemistry 272(27), 16822 1997

Immunochemical studies of the mannans of Saccharomyces cerevisiae X2180-1A-5 and Saccharomyces cerevisiae 4484-24D-1 mutnt strains, with special reference to their phosphate content(共著)

Journal of Bacteriology 144 92 1980

Immunochemical study on bakers' yeast mannan prepared by fractional precipitation with cetyltrimethylammonium bromide(共著)

Archives of biochemistry and Biophysics 212(1) 204-215 1981

Books etc

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Fungal Cell Wall and Immune Response(共著)

Springer-Verlag 1991

Novel structures found in the mannans of ┣DBCandida albicans(/)-┫DB and ┣DBCandida guilliermondii(/)-┫DB(共著)

Fungal Cells in Biodefense Mechanism 1997

Research Grants & Projects

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Structural Study of Yeast Cell Wall Mannan

Project Year: 1979

Conformational Study of Oligosaccharide

Project Year: 1993

Study of the Pathogenicity of Fungi

Project Year: 1999