安保明博 (Akihiro Ambo) - マイポータル - researchmap

基本情報

所属: 東北薬科大学薬学部衛生薬学科生化学教室講師

学位: 薬学修士(東北薬科大学)
薬学博士(東北薬科大学)

J-GLOBAL ID: 200901093849576824
researchmap会員ID: 1000062179

研究キーワード

2

研究分野

1

ライフサイエンス / 薬系化学、創薬科学 /

学歴

4

- 1989年

東北薬科大学, 薬学研究科, 衛生化学
- 1989年

Tohoku Pharmaceutical University, Graduate School, Division of Pharmaceutical Sciences
- 1987年

東北薬科大学, 薬学部, 薬学科
- 1987年

Tohoku Pharmaceutical University, Faculty of Pharmaceutical Science

MISC

13

Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities

A Ambo, H Niizuma, A Sasaki, H Kohara, Y Sasaki

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13(7) 1269-1272 2003年4月
Endomorphin 2 analogues containing Dmp residue as an aromatic amino acid surrogate with high mu-opioid receptor affinity and selectivity

Bioorganic & Medicinal Chemistry 11, 675-678 2003年
Novel [D-Arg(2)]dermorphin(1-4) analogs with mu-opioid receptor antagonist activity

A Ambo, T Terashima, Y Sasaki

CHEMICAL & PHARMACEUTICAL BULLETIN 50(10) 1401-1403 2002年10月
Dermorphin and deltorphin heptapeptide analogues: Replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity

A Ambo, H Murase, H Niizuma, H Ouchi, Y Yamamoto, Y Sasaki

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12(6) 879-881 2002年3月
Antinociceptive activity of deltorphin analogs in the formalin test

T Chiba, H Murase, A Ambo, Y Sasaki

LIFE SCIENCES 59(20) 1717-1722 1996年10月
SYNTHESIS AND OPIOID ACTIVITIES OF [D-LEU(8)]DYNORPHIN(1-8) ANALOGS CONTAINING A REDUCED PEPTIDE-BOND, PSI(CH2NH)

A AMBO, T ADACHI, Y SASAKI

CHEMICAL & PHARMACEUTICAL BULLETIN 43(9) 1547-1550 1995年9月
Synthesis and biological properties of quaternized N-methylation analogs of D-Arg-2-dermorphin tetrapeptides(共著)

Bioorg. Med. Chem. Lett. 4(16) 2049-2054 1994年
Synthesis of carboxyl-terminal extension analogs of dermorphin and evaluation of their opioid receptor-binding and opioid activities(共著)

Akihiro AMBO, Yusuke SASAKI, Kenji SUZUKI

Chem. Pharm. Bull. 42(4) 888-891 1994年
SOLID-PHASE SYNTHESIS AND OPIOID ACTIVITIES OF [D-ALA(2)]DELTORPHIN-II ANALOGS

Y SASAKI, A AMBO, K MIDORIKAWA, K SUZUKI

CHEMICAL & PHARMACEUTICAL BULLETIN 41(8) 1391-1394 1993年8月
Studies on analgesic oligopeptides. (]G0007[). Solid phase synthesis and biological properties of Tyr-D-Arg-Phe-βAla-NH₂ and its fluorinated aromatic amino acid derivatives

Chem. Pharm. Bull. 39(9) 2316-2318 1991年
[D-AlA²]Deltorphin (]G0002[) analogs with high affinity and selectivity for delta-opioid receptor

Biochem. Biophys. Res. Commun. 180(2) 822-827 1991年
Solid phase synthesis and opioid receptor binding properties of presumable dermorphin precursor derivatives

Yusuke SASAKI, Akihiro AMBO, Kenji SUZUKI

Chem. Pharm. Bull. 39(5) 1213-1216 1991年
Studies on analgesic oligopeptides. (]G0006[). Further studies of synthesis and biological properties of tripeptide alkylamide, Tyr-D-Arg-Phe-X

Chem. Pharm. Bull. 38(8) 2197-2200 1990年

所属学協会

2

共同研究・競争的資金等の研究課題

2