柴山修哉 (Naoya Shibayama) - マイポータル

基本情報

所属: 自治医科大学医学部生理学講座生物物理学部門教授

学位: 工学博士(大阪大学)

研究者番号: 20196439
J-GLOBAL ID: 200901080671475544
researchmap会員ID: 1000063201

外部リンク: http://www.jichi.ac.jp/divbio/index.html

研究キーワード

研究分野

経歴

自治医科大学（JMU）, 教授

学歴

委員歴

2010年1月 - 現在

日本生物物理学会, 分野別専門委員（アロステリズム）

論文

Novel insights into the ULK2-FIP200-AMPK-mediated regulation of autophagy and BCR::ABL degradation in chronic myeloid leukemia

Daisuke Koyama, Naoki Yamamoto, Takaaki Abe, Kengo Suzuki, Yuki Sato, Manabu Suzuki, Naoya Shibayama, Takayuki Ikezoe

Biochemical and Biophysical Research Communications 2025年9月
Analysis of β‐C‐terminal salt bridges in T‐state hemoglobin by trapping tertiary conformations in silica gels

Naoya Shibayama

Protein Science 2025年7月
Effects of allosteric effectors on oxygen binding to crystals of hemoglobin in the R‐quaternary structure

Naoya Shibayama

Protein Science 2025年1月
Development of serial X-ray fluorescence holography for radiation-sensitive protein crystals.

Artoni Kevin R Ang, Yasufumi Umena, Ayana Sato-Tomita, Naoya Shibayama, Naohisa Happo, Riho Marumi, Yuta Yamamoto, Koji Kimura, Naomi Kawamura, Yu Takano …

Journal of synchrotron radiation 30(Pt 2) 368-378 2023年3月1日
Tracking the Structural Development of Amyloid Precursors in the Insulin B Chain and the Inhibition Effect by Fibrinogen

Naoki Yamamoto, Rintaro Inoue, Yoshiteru Makino, Hiroshi Sekiguchi, Naoya Shibayama, Akira Naito, Masaaki Sugiyama, Eri Chatani

The Journal of Physical Chemistry B 126(51) 10797-10812 2022年12月29日
X-ray fluorescence holography of biological metal sites: Application to myoglobin

Ayana Sato-Tomita, Artoni Kevin R. Ang, Koji Kimura, Riho Marumi, Naohisa Happo, Tomohiro Matsushita, Sam-Yong Park, Naoya Shibayama, Yuji C. Sasaki, Kouichi Hayashi

Biochemical and Biophysical Research Communications 635 277-282 2022年12月
Heme-bound tyrosine vibrations in hemoglobin M: resonance Raman, crystallography and DFT calculation.

Nagatomo, S, Shoji, M, Terada, T, Nakatani, K, Shigeta, Y, Hirota, S, Yanagisawa, S, Kubo, M, Kitagawa, T, Nagai, M …

Biophys. J. 121(14) 2767-2780 2022年6月査読有り
Fast in-vitro screening of FLT3-ITD inhibitors using silkworm-baculovirus protein expression system

Naoki Yamamoto, Jiro Kikuchi, Yusuke Furukawa, Naoya Shibayama

PLOS ONE 17(5) e0261699-e0261699 2022年5月5日
Freezable and Unfreezable Hydration Water: Distinct Contributions to Protein Dynamics Revealed by Neutron Scattering

Naoki Yamamoto, Maiko Kofu, Kenji Nakajima, Hiroshi Nakagawa, Naoya Shibayama

The Journal of Physical Chemistry Letters 12(xxxx) 2172-2176 2021年2月25日査読有り
Direct observation of ligand migration within human hemoglobin at work

Naoya Shibayama, Ayana Sato-Tomita, Mio Ohki, Kouhei Ichiyanagi, Sam-Yong Park

Proceedings of the National Academy of Sciences 117(9) 4741-4748 2020年3月3日査読有り
Pumping mechanism of NM-R3, a light-driven bacterial chloride importer in the rhodopsin family

Ji-Hye Yun, Mio Ohki, Jae-Hyun Park, Naito Ishimoto, Ayana Sato-Tomita, Wonbin Lee, Zeyu Jin, Jeremy R. H. Tame, Naoya Shibayama, Sam-Yong Park …

Science Advances 6(6) eaay2042-eaay2042 2020年2月
Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages

Tadayoshi Karasawa, Akira Kawashima, Fumitake Usui-Kawanishi, Sachiko Watanabe, Hiroaki Kimura, Ryo Kamata, Koumei Shirasuna, Yutaro Koyama, Ayana Sato-Tomita, Takashi Matsuzaka …

Arteriosclerosis, Thrombosis, and Vascular Biology 38(4) 744-756 2018年4月1日査読有り
Valence Sensitive X-ray Fluorescence Holography of Fe3O4

A. K. R. Ang, T. Matsushita, Y. Hashimoto, N. Happo, Y. Yamamoto, M. Mizuguchi, A. Sato-Tomita, N. Shibayama, Y. C. Sasaki, K. Kimura …

Physica Status Solidi (b) 2018年査読有り
Direct observation of conformational population shifts in crystalline human hemoglobin

Naoya Shibayama, Mio Ohki, Jeremy R. H. Tame, Sam-Yong Park

JOURNAL OF BIOLOGICAL CHEMISTRY 292(44) 18258-18269 2017年11月査読有り
Size and Shape Controlled Crystallization of Hemoglobin for Advanced Crystallography

Ayana Sato-Tomita, Naoya Shibayama

CRYSTALS 7(9) 2017年9月査読有り
Molecular mechanism of photoactivation of a light-regulated adenylate cyclase

Mio Ohki, Ayana Sato-Tomita, Shigeru Matsunaga, Mineo Iseki, Jeremy R. H. Tame, Naoya Shibayama, Sam-Yong Park

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114(32) 8562-8567 2017年8月査読有り
Ligation-Dependent Picosecond Dynamics in Human Hemoglobin As Revealed by Quasielastic Neutron Scattering

Satoru Fujiwara, Toshiyuki Chatake, Tatsuhito Matsuo, Fumiaki Kono, Taiki Tominaga, Kaoru Shibata, Ayana Sato-Tomita, Naoya Shibayama

JOURNAL OF PHYSICAL CHEMISTRY B 121(34) 8069-8077 2017年8月査読有り
X-Ray Fluorescence Holography for Proteins: Application to Hemoglobin and Myoglobin

Ayana Sato-Tomita, Naohisa Happo, Sam-Yong Park, Koichi Hayashi, Yuji C. Sasaki, Naoya Shibayama

BIOPHYSICAL JOURNAL 112(3) 579A-579A 2017年2月
Structural insight into photoactivation of an adenylate cyclase from a photosynthetic cyanobacterium

Mio Ohki, Kanako Sugiyama, Fumihiro Kawai, Hitomi Tanaka, Yuuki Nihei, Satoru Unzai, Masumi Takebe, Shigeru Matsunaga, Shin-ichi Adachi, Naoya Shibayama …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113(24) 6659-6664 2016年6月査読有り
Development of an X-ray fluorescence holographic measurement system for protein crystals

Ayana Sato-Tomita, Naoya Shibayama, Naohisa Happo, Koji Kimura, Takahiro Okabe, Tomohiro Matsushita, Sam-Yong Park, Yuji C. Sasaki, Kouichi Hayashi

REVIEW OF SCIENTIFIC INSTRUMENTS 87(6) 063707 2016年6月査読有り