2004年9月
Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/Biobran)
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
- ,
- 巻
- 17
- 号
- 3
- 開始ページ
- 283
- 終了ページ
- 292
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- BIOLIFE SAS
MGN-3/Biobran, modified arabinoxylan rice bran, has been shown to be a potent biological response modifier (BRM) as manifested by stimulation of different arms of the immune system such as NK, T and B cells; however, its effect on macrophages has not yet been studied. The effects of MGN-3 on macrophage function was examined in vitro using 3 models: human macrophage cell line U937, murine macrophage cell line RAW264.7, and murine peritoneal macrophages (P-Mphi). Treatment with MGN-3 resulted in an increase in the percentages of attachment and phagocytosis of yeast by macrophages. The effect depends on the type of macrophage and the dose of MGN-3 applied. Macrophages also demonstrated enhancement in their spreading ability, post treatment with MGN-3. Results also showed that MGN-3, in a dose-dependent manner (1, 10, 100 mug/ml), significantly induced high levels of production of cytokines: TNF-alpha and IL-6. In addition, MGN-3 significantly increased nitric oxide (NO) production. This data demonstrates that MGN-3 is a potent inducer of phagocytic function by macrophage, and may suggest that MGN-3 is a useful agent for fighting microbial infection.
- リンク情報
- ID情報
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- ISSN : 0394-6320
- Web of Science ID : WOS:000224919800008