論文

2001年4月

Microsatellite polymorphism in intron 14 of the canine BRCA1 gene

JOURNAL OF VETERINARY MEDICAL SCIENCE
  • S Tsuchida
  • ,
  • S Ikemoto
  • ,
  • M Tagawa

63
4
開始ページ
479
終了ページ
481
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1292/jvms.63.479
出版者・発行元
JAPAN SOC VET SCI

Microsatellite polymorphism due to differences in CT dinucleotide repeats was demonstrated in intron 14 of the canine BRCA1 gene. Genotype analysis of 103 unrelated dogs from 30 different breeds detected the presence of five alleles, including 10 of the expected 15 genotypes. Gene frequencies were biased and all alleles with the exception of one were below 0.1. This polymorphism, which occurs at the intron of canine BRCA1 should prove to be a useful marker fur detecting the loss of heterozygosity (LOH). One of the more notable findings of the present study was the detection of homozygotes of rare alleles. This finding identified an accumulation of rare alleles in specific canine breeds and demonstrated the usefulness of this characteristic for the biological study of dog evolution.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1292/jvms.63.479
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000168439300022&DestApp=WOS_CPL
ID情報
  • DOI : 10.1292/jvms.63.479
  • ISSN : 0916-7250
  • Web of Science ID : WOS:000168439300022

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