論文

国際誌
2008年9月

The teleost Oryzias latipes shows telomere shortening with age despite considerable telomerase activity throughout life.

Mechanisms of ageing and development
  • Hitoshi Hatakeyama
  • ,
  • Ken-Ichi Nakamura
  • ,
  • Naotaka Izumiyama-Shimomura
  • ,
  • Akio Ishii
  • ,
  • Shuichi Tsuchida
  • ,
  • Kaiyo Takubo
  • ,
  • Naoshi Ishikawa

129
9
開始ページ
550
終了ページ
7
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.mad.2008.05.006

Previous studies of telomeres and telomerase have focused mostly on mammals, and data for other vertebrates are limited. We analyzed both telomere length (terminal restriction fragment length) and telomerase activity in a small freshwater teleost fish, the medaka (Oryzias latipes), and found that the telomeres shorten during ageing despite the fact that a considerable amount of telomerase activity is ubiquitously detectable throughout the life of the fish. Since the telomere attrition rate during development was greater than that in adulthood, telomere length is inversely correlated with the increase in body length. The difference in telomere length among medaka individuals was similar to that in humans, and the individual specific differences were evident even at the earliest embryonic stage. Telomerase activity was ubiquitously detectable not only in the body of the embryo but also in the systemic organs of mature individuals throughout their entire life span. These data suggest that telomere attrition during ageing in medaka, which is similar to that in humans, may be a major factor determining their mortality, and that telomere maintenance through strong telomerase activity may be required for the characteristic lifelong continuous growth of this fish.

リンク情報
DOI
https://doi.org/10.1016/j.mad.2008.05.006
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18597819
ID情報
  • DOI : 10.1016/j.mad.2008.05.006
  • PubMed ID : 18597819

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