Sugai K, Kimura H, Miyaji Y, Tsukagoshi H, Yoshizumi M, Sasaki-Sakamoto T, Matsunaga S, Yamada Y, Kashiwakura JI, Noda M, Ikeda M, Kozawa K, Ryo A, Yoshihara S, Ogata H, Okayama Y
The Journal of allergy and clinical immunology Oct 2015 [Refereed]
Odajima H, Ebisawa M, Nagakura T, Fujisawa T, Akasawa A, Ito K, Doi S, Yamaguchi K, Katsunuma T, Kurihara K, Kondo N, Sugai K, Nambu M, Hoshioka A, Yoshihara S, Sato N, Seko N, Nishima S
Allergology international : official journal of the Japanese Society of Allergology 64(4) 364-370 Oct 2015 [Refereed]
Hamasaki Y, Kohno Y, Ebisawa M, Kondo N, Nishima S, Nishimuta T, Morikawa A, Aihara Y, Akasawa A, Adachi Y, Arakawa H, Ikebe T, Ichikawa K, Inoue T, Iwata T, Urisu A, Ohya Y, Okada K, Odajima H, Katsunuma T, Kameda M, Kurihara K, Sakamoto T, Shimojo N, Suehiro Y, Tokuyama K, Nambu M, Fujisawa T, Matsui T, Matsubara T, Mayumi M, Mochizuki H, Yamaguchi K, Yoshihara S
Pediatrics international : official journal of the Japan Pediatric Society 56(4) 441-450 Aug 2014 [Refereed]
Katsunuma T, Ohya Y, Fujisawa T, Akashi K, Imamura N, Ebisawa M, Daikoku K, Kondo N, Terada A, Doi S, Nishimuta T, Noma T, Hamasaki Y, Kurihara K, Masuda K, Yamada T, Yamada M, Yoshihara S, Watanabe K, Watanabe T, Kitabayashi T, Morikawa A, Nishima S, Protective Effect of Tulobuterol Patch on the Long-term Management of Asthma in Young Children Study Group
Allergy and asthma proceedings : the official journal of regional and state allergy societies 33(3) 28-34 May 2012 [Refereed]
[Pediatric asthma: novel examinations and tools useful for diagnosis].
Yoshihara S
Arerugi = [Allergy] 61(2) 159-167 Feb 2012 [Refereed]
Noguchi E, Sakamoto H, Hirota T, Ochiai K, Imoto Y, Sakashita M, Kurosaka F, Akasawa A, Yoshihara S, Kanno N, Yamada Y, Shimojo N, Kohno Y, Suzuki Y, Kang MJ, Kwon JW, Hong SJ, Inoue K, Goto Y, Yamashita F, Asada T, Hirose H, Saito I, Fujieda S, Hizawa N, Sakamoto T, Masuko H, Nakamura Y, Nomura I, Tamari M, Arinami T, Yoshida T, Saito H, Matsumoto K
Harada M, Hirota T, Jodo AI, Hitomi Y, Sakashita M, Tsunoda T, Miyagawa T, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Masuko H, Sakamoto T, Hizawa N, Suzuki Y, Yoshihara S, Adachi M, Ebisawa M, Saito H, Matsumoto K, Nakajima T, Mathias RA, Rafaels N, Barnes KC, Himes BE, Duan QL, Tantisira KG, Weiss ST, Nakamura Y, Ziegler SF, Tamari M
American journal of respiratory cell and molecular biology 44(6) 787-793 Jun 2011 [Refereed]
Harada M, Hirota T, Jodo AI, Hitomi Y, Sakashita M, Tsunoda T, Miyagawa T, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Masuko H, Sakamoto T, Hizawa N, Suzuki Y, Yoshihara S, Adachi M, Ebisawa M, Saito H, Matsumoto K, Nakajima T, Mathias RA, Rafaels N, Barnes KC, Himes BE, Duan QL, Tantisira KG, Weiss ST, Nakamura Y, Ziegler SF, Tamari M.
Am J Respir Cell Mol Biol 44(6) 787-793 2011 [Refereed]
Riise GC, Ericson P, Bozinovski S, Yoshihara S, Anderson GP, Lindén A
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 29(7) 800-807 Jul 2010 [Refereed]
Kondo N, Nishimuta T, Nishima S, Morikawa A, Aihara Y, Akasaka T, Akasawa A, Adachi Y, Arakawa H, Ikarashi T, Ikebe T, Inoue T, Iwata T, Urisu A, Ebisawa M, Ohya Y, Okada K, Odajima H, Katsunuma T, Kameda M, Kurihara K, Kohno Y, Sakamoto T, Shimojo N, Suehiro Y, Tokuyama K, Nambu M, Hamasaki Y, Fujisawa T, Matsui T, Matsubara T, Mayumi M, Mukoyama T, Mochizuki H, Yamaguchi K, Yoshihara S, Japanese Society of Pediatric Allergy and Clinical Immunology
Pediatrics international : official journal of the Japan Pediatric Society 52(2) 319-326 Apr 2010 [Refereed]
Early intervention for infantile and childhood asthma
YOSHIHARA Shigemi
Expert Rev Clin Immunol 6(2) 247-255 Mar 2010 [Refereed]
[Impact of inhaled corticosteroid prescription at discharge from the emergency room on exacerbations of asthma in Japanese hospital].
Chohnabayashi N, Sugiyama K, Kato M, Kimura T, Mochiduki H, Yasuba H, Yoshihara S, Fukuda T, Morikawa A, Adachi M
Arerugi = [Allergy] 59(2) 123-136 Feb 2010 [Refereed]
[Investigation of factors childhood asthma persisting into adulthood].
Kanno N, Yoshihara S, Arisaka O, Noda M
Arerugi = [Allergy] 59(1) 25-36 Jan 2010 [Refereed]
Imada Y, Fujimoto M, Hirata K, Hirota T, Suzuki Y, Saito H, Matsumoto K, Akazawa A, Katsunuma T, Yoshihara S, Ebisawa M, Shibasaki M, Arinami T, Tamari M, Noguchi E
Harada M, Hirota T, Jodo AI, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Yoshihara S, Ebisawa M, Saito H, Matsumoto K, Nakamura Y, Ziegler SF, Tamari M
American journal of respiratory cell and molecular biology 40(3) 368-374 Mar 2009 [Refereed]
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 99(4) 380-381 Oct 2007 [Refereed]
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 96(6) 879-880 Jun 2006 [Refereed]
Nakashima K, Hirota T, Obara K, Shimizu M, Doi S, Fujita K, Shirakawa T, Enomoto T, Yoshihara S, Ebisawa M, Matsumoto K, Saito H, Suzuki Y, Nakamura Y, Tamari M
Biochemical and biophysical research communications 344(1) 300-307 May 2006 [Refereed]
Nakashima K, Hirota T, Suzuki Y, Akahoshi M, Shimizu M, Jodo A, Doi S, Fujita K, Ebisawa M, Yoshihara S, Enomoto T, Shirakawa T, Kishi F, Nakamura Y, Tamari M
Allergology international : official journal of the Japanese Society of Allergology 55(1) 77-83 Mar 2006 [Refereed]
In 2011, the American Thoracic Society (ATS) has announced the guidelines of Interpretation of Exhaled Nitric Oxide (eNO) for clinical applications, in which eNO values were classified into three zones of low eNO, intermediate eNO and high eNo. Ho...
The histamine release test is in vivo inspection using the basophil. Unlike a food challenge test, there is not the risk of the anaphylactic shock. This test is inspection to evaluate the release of the chemical mediator by the degranulation throu...
Background: Virus infection is an important risk factor for aggravation of childhood asthma. The objective of this study was to examine the effect of drugs on aggravation of asthma induced by a common cold. Methods: Asthma control was examined in ...
In infants and young children, early intervention for asthma, including both environment improvement and medication, is important for preventing disease onset and progress of airway remodeling. Environment improvements include reducing allergen ex...
A boy of 8-year-old with severe atopic asthma was hospitalized for treatment and attending special-needs school. Asthmatic symptoms were relieved soon after hospitalization. So, poor compliance and chronic exposure to indoor allergens were suspect...
Background: Little is known about differences in the characteristics of and problems associated with school lunch provision for food allergy among day nurseries, kindergartens, elementary schools, and junior high schools. Objectives and Methods: F...
It is considered that a therapeutic guideline is essential for the provision of improved care to asthmatics. In Japan, a novel Japanese Pediatric asthma Guideline (JPGL) and Asthma Handbook (HB) have been published in the last 2 years. However, th...
This article describes a retrospective study assessing the effect of early intervention with inhaled sodium cromoglycate in childhood asthma. The study was performed using the records of 54 severe asthmatic children treated with inhaled sodium cro...
TOKUYAMA K, UMENO E, KATSUNUMA T, KAMEDA M, SAKAMOTO T, HAMASAKI Y, MASUDA K, YOSHIHARA S
JJACI 18: 270-278(3) 270-278 Aug 2004
In Japan, the strategy for the proper use of anticholinergic drugs in the management of childhood asthma is not established. Thus, we wanted to know how anticholinergic agents were used in the clinical practice. For the purpose, we prepared a ques...
We report a case of a girl with the severe obstructive sleep apnea syndrome (OSAS) caused by adenotonsillar hypertrophy with obesity.The patient had an excess overweight of+84.3% and sleep apnea, snoring, daytime somnolence, adenotonsillar hypertr...
We report a case of 1-year-6-month-old boy with post-infectious bronchiolitis obliterans (BO) diagnosed on the basis of his clinical course and a CT examination of his chest.Measurements of the concentrations of some inflammatory mediators in seru...
EMB Task Force Guideline Committee of the Japanes, Nishima Sankei, Furusho Kenshi, , , , , , , , , , , , , , , ,
JJACI 17(2) 204-209 2003
A multicenter, double-blind comparative study of the tulobuterol patch was conducted to evaluate the effects of continuous use of this agent on airway hypersensitivity and its safety. The participants were a total of 43 children (30 males and 13 f...
We reported a case of an infant, who developed acquired subglottic stenosis after endotracheal intubation for relatively short period of 11 days. Tracheotomy and operation to enlarge glottis were performed, and she required long-term hospitalizati...
The aquaporins (water channels) are novel molecular transporters that permit water to across the epithelial and endothelial plasma membrane. Recent studies strongly suggest that an important contribution of aquaporin in the respiratory pathophysio...
Igaku Kyoiku / Medical Education (Japan) 32(1) 39-45 2001
We investigated the effects on medical education of early exposure of undergraduate students to a summer camp for children with asthma. An objective evaluation by the editorial staff found final improvements in the following areas (in descending o...
The aquaporins (water channels) are novel molecular watertransporters that permit water to across the epithelial and endothelial plasma membrane. Several recent studies strongly suggest that important roles of aquaporins in different pathological ...
We reported a case of infant was noted respiratory and sucking distress that have diagnosed congenital nasal stenosis without treatment. Since nasopharyngeal tube was retained for the treatment, respiratory distress was soon improved and body weig...
Japanese Journal of Allergology 43(1) 55-61 Jan 1994
Chromogranin A like immunoreactivity (CGA-IR) was measured by a specific radioimmunoassay using N-terminal specific antiserum R-0763 in respiratory tissues of guinea pigs. All guinea pig were actively immunized by recurrent Ovalbumin (OA)-inhalati...
Chromogranin A like immunoreactivity (CGA-IR) was measured by a specific radioimmunoassay using N-terminal specific antiserum R-0763 in respiratory tissues of guinea pigs. All guinea pig were actively immunized by recurrent Ovalbumin (OA)-inhalati...
CAP RAST is a new assay system for measuring allergen specific IgE. The results were compared with those of RAST in 57 allergic children. The correlation between CAP RAST and RAST were very good. The discordant results between CAP RAST and RAST we...
Japanese Journal of Allergology 42(5) 643-648 May 1993
One hundred twenty five allergic patients ranging in age from 0 to 36 years old (mean age 9 years) were tested. Intradermal skin tests were performed on the volar surface of the forearm by injection of a five-fold dilution of histamine dihydrochlo...
Pediatric Otorhinolaryngology Japan 12(1) 50-53 1991
16 cases with febrile convulsion and 3 cases with acute recurrent cerevical lymphadenitis were studied as to the presence of allergic nasopharyngitis which is easily alleviated by treatment SCG nasal spray.<BR>All of cases had positive family hist...
Pediatric Otorhinolaryngology Japan 12(1) 54-57 1991
Using specific radioimmunoassay we tried to determine whether any neuropeptides, VIP or SP, may exist in adenoidal and palatine tonsillar tissues in human.<BR>Adenoidal tissues of 8 cases (hypertrophic adenoids of patients aged 5 to 13 years,4 mal...
Pediatric Otorhinolaryngology Japan 11(2) 27-30 1990
First Dept. of Pediatrics, Dokkyo Univ. School of Medicine, Tochigi We made the new classification of hypertrophy and/or swelling of palatine tonsils in inspection. and tried the palpation of possible lower parts of the palatine tonsils on 234 all...
S. Yoshihara, T. Ichimura, N. Yanaihara, K. Iguchi, T. Inoue
Japanese Journal of Allergology 38(7) 524-531 Jul 1989
Vasoactive intestinal polypeptide (VIP) has recently received widespread attention with respect to its control of airway constriction, and is now regarded as the most promising candidate as a neurotransmitter for nonadrenergic noncholinergic inhib...
Japanese Journal of Allergology 37(12) 1161-1168 Dec 1988
Immunoreactive substance P(IR-SP)in the respiratory tract tissues of normal guinea pigs was measured with a specific radioimmunoassay using N-specific anti-serum R400. Male Hartley guinea pigs were passively sensitized with homologous anti-ovalbum...
Japanese Journal of Allergology 35(5) 367-373 May 1986
It is nowaday very controversial whether nasomucosal stimulation (Ns・S) and also nasopharyngeal stimulation (Rp・S) cause bronchoconstriction or dilation in both healthy animals and humans. Neverthless, we recently found that peroral Rp・S evoked co...
Japanese Journal of Allergology 35(4) 295-300 Apr 1986
The authors found that mechanical stimulation applied perorally to the nasopharynx (Rp・S) could resolve or alleviate asthmatic attacks in child-asthmatics in about 15 seconds. On the other hand, the authors also found that the Rp・S very rarely did...
Suplast tosilate for prophylaxis of pediatric allergy. Atopic dermatitis Edited by Esparza-Gordillo et al
Yoshihara S, Ono Y, Yamada Y, Fukuda H, Abe T, Arisaka O (Part:Contributor, 289-298)
InTech 2012
Grobal strategy for the diagnosis and management of asthma in children 5 years and younger
Bateman ED, Boulet LP, Cruz A, FitzGerald M, Haahtela T, Levy M, O’Byne P, Ohta K, Paggiaro P, Pedersen SE, Soto-Quiroz M, Tan WC, Wong GW, Yoshihara S et al
Global initiative for asthma(GINA),Medical Communications Resources,inc 2009
Chronic respiratory diseases in Japan. Ed by Sohei Makino
Akiyama K, Dobashi K, Fukuchi Y, Haida M, Kawashiro T, Keicho N, Kida K, Kohno Y, Ohta K, Okubo K, Fukuda T, Yoshihara S, Sagara H (Part:Contributor, 19-27)
Elsevier, Present status of prevalence and management of chronic respiratory disease in Asia-Pacific 2006
Childhood asthma. Ed by Sohei Makino
YOSHIHARA Shigemi (Part:Contributor, 79-81)
Elsevier, Present status of prevalence and management of chronic respiratory disease in Asia-Pacific 2006
Chronic respiratory diseases in Japan
Ed by Sohei Makino/ Elsevier/ Present status of prevalence and management of chronic respiratory disease in Asia-Pacific 2006
We investigated that Cannabinoid receptor agonist (WIN55212-2) inhibits antigen-induced plasma extravasation by in guinea pig airways. Plasma extravasation was assessed by the photometric measurement of the extravasated Evans blue after formamide ...
We compared the relaxant effect of pituitary adenylate cyclase activating peptide (PACAP) 1-27 with that of a newly developed PACAP 1-27 analogue, [Arg_<152021>Leu_<17>]-PACAP-Gly-Lys-Arg-NH_2, in human bronchi in vitro. In human bronchi precontra...
Airway remodeling and early intervention on anti-inflammatory drugs in childhood asthma
Project Year: 1999
Effect of bronchodilation in PACAP/VIP
Project Year: 1994
Therapy of tachykinin/Kinin antagonists in allergic diseases (Asthma, Atopic dermatitis)
Project Year: 1988
Cannabinoid receptor agonists and airway inflammation
Research on a cause of childhood asthma and viral infection in the airway
