YOSHIHARA Shigemi

J-GLOBAL         Last updated: Apr 17, 2018 at 12:40
 
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Name
YOSHIHARA Shigemi
Affiliation
Dokkyo Medical University
Section
School of Medicine, Department of Pediatrics
Job title
Associate Professor, Dept of Pediatrics, Dokkyo Univ. Sch. of Medicine
Degree
Doctor (Medicine)(Dokkyo Medical University)

Research Areas

 
 

Academic & Professional Experience

 
1993
 - 
1995
University of California, San Francisco, post doctoral fellow
 
1987
 - 
1989
University of Shizuoka, pharmacology, research fellow
 

Education

 
 
 - 
1989
Padiatrics, Graduate School, Division of Medicine, Dokkyo Medical University
 
 
 - 
1983
Medical School, Faculty of Medicine, Dokkyo Medical University
 

Committee Memberships

 
1995
   
 
European Respiratory Society  
 
1993
   
 
American Thoracic Society  
 

Awards & Honors

 
2005
Award of Dokkyo Univ. Sch. of Medicine
 
1999
Award of Dokkyo Univ. Sch. of Medicine
 
1998
Award of Japanese Society of Pediatric Allergy and Clinical Immunology
 

Published Papers

 
Sugai K, Kimura H, Miyaji Y, Tsukagoshi H, Yoshizumi M, Sasaki-Sakamoto T, Matsunaga S, Yamada Y, Kashiwakura JI, Noda M, Ikeda M, Kozawa K, Ryo A, Yoshihara S, Ogata H, Okayama Y
The Journal of allergy and clinical immunology      Oct 2015   [Refereed]
Yoshihara S, Kanno N, Fukuda H, Arisaka O, Arita M, Sekine K, Yamaguchi K, Tsuchida A, Yamada Y, Watanabe T, Shimizu T, Nishikawa K, Nishimuta T
Allergology international : official journal of the Japanese Society of Allergology   64(4) 371-376   Oct 2015   [Refereed]
Odajima H, Ebisawa M, Nagakura T, Fujisawa T, Akasawa A, Ito K, Doi S, Yamaguchi K, Katsunuma T, Kurihara K, Kondo N, Sugai K, Nambu M, Hoshioka A, Yoshihara S, Sato N, Seko N, Nishima S
Allergology international : official journal of the Japanese Society of Allergology   64(4) 364-370   Oct 2015   [Refereed]
Andelid K, Andersson A, Yoshihara S, Åhrén C, Jirholt P, Ekberg-Jansson A, Lindén A
International journal of chronic obstructive pulmonary disease   10 1253-1263   2015   [Refereed]
Hamasaki Y, Kohno Y, Ebisawa M, Kondo N, Nishima S, Nishimuta T, Morikawa A, Aihara Y, Akasawa A, Adachi Y, Arakawa H, Ikebe T, Ichikawa K, Inoue T, Iwata T, Urisu A, Ohya Y, Okada K, Odajima H, Katsunuma T, Kameda M, Kurihara K, Sakamoto T, Shimojo N, Suehiro Y, Tokuyama K, Nambu M, Fujisawa T, Matsui T, Matsubara T, Mayumi M, Mochizuki H, Yamaguchi K, Yoshihara S
Pediatrics international : official journal of the Japan Pediatric Society   56(4) 441-450   Aug 2014   [Refereed]
Yoshihara S, Yamada Y, Fukuda H, Tsuchiya T, Ono M, Fukuda N, Kanno N, Arisaka O
Allergology international : official journal of the Japanese Society of Allergology   63(2) 199-203   Jun 2014   [Refereed]
Yoshihara S, Kusuda S, Mochizuki H, Okada K, Nishima S, Simões EA, C-CREW Investigators
Pediatrics   132(5) 811-818   Nov 2013   [Refereed]
Imataka G, Sakamoto O, Yamanouchi H, Yoshihara S, Omura-Hasegawa Y, Tajima G, Arisaka O
Cell biochemistry and biophysics   67(1) 185-187   Sep 2013   [Refereed]
[Bronchial asthma: progress in diagnosis and treatments. Topics: III. Care and treatments; 1. Early intervention and out-grow for pediatric asthma].
Yoshihara S
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   102(6) 1384-1391   Jun 2013   [Refereed]
Yoshihara S, Fukuda H, Abe T, Nishida M, Yamada Y, Kanno N, Arisaka O
Allergology international : official journal of the Japanese Society of Allergology   61(3) 405-410   Sep 2012   [Refereed]
Katsunuma T, Ohya Y, Fujisawa T, Akashi K, Imamura N, Ebisawa M, Daikoku K, Kondo N, Terada A, Doi S, Nishimuta T, Noma T, Hamasaki Y, Kurihara K, Masuda K, Yamada T, Yamada M, Yoshihara S, Watanabe K, Watanabe T, Kitabayashi T, Morikawa A, Nishima S, Protective Effect of Tulobuterol Patch on the Long-term Management of Asthma in Young Children Study Group
Allergy and asthma proceedings : the official journal of regional and state allergy societies   33(3) 28-34   May 2012   [Refereed]
[Pediatric asthma: novel examinations and tools useful for diagnosis].
Yoshihara S
Arerugi = [Allergy]   61(2) 159-167   Feb 2012   [Refereed]
Yoshihara S, Morimoto S, Momoi M, Eguchi M, Ihara M, Kanno N, Hirao J, Arisaka O
Arerugi = [Allergy]   61(1) 30-40   Jan 2012   [Refereed]
Yoshihara S, Kanno N, Fukuda H, Yamada Y, Fukuda N, Tsuchiya T, Arisaka O
Pediatr Allergy Immunol   22(7) 667-670   Nov 2011   [Refereed]
Noguchi E, Sakamoto H, Hirota T, Ochiai K, Imoto Y, Sakashita M, Kurosaka F, Akasawa A, Yoshihara S, Kanno N, Yamada Y, Shimojo N, Kohno Y, Suzuki Y, Kang MJ, Kwon JW, Hong SJ, Inoue K, Goto Y, Yamashita F, Asada T, Hirose H, Saito I, Fujieda S, Hizawa N, Sakamoto T, Masuko H, Nakamura Y, Nomura I, Tamari M, Arinami T, Yoshida T, Saito H, Matsumoto K
PLoS Genet   7(7) e1002170   Jul 2011   [Refereed]
Harada M, Hirota T, Jodo AI, Hitomi Y, Sakashita M, Tsunoda T, Miyagawa T, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Masuko H, Sakamoto T, Hizawa N, Suzuki Y, Yoshihara S, Adachi M, Ebisawa M, Saito H, Matsumoto K, Nakajima T, Mathias RA, Rafaels N, Barnes KC, Himes BE, Duan QL, Tantisira KG, Weiss ST, Nakamura Y, Ziegler SF, Tamari M
American journal of respiratory cell and molecular biology   44(6) 787-793   Jun 2011   [Refereed]
Harada M, Hirota T, Jodo AI, Hitomi Y, Sakashita M, Tsunoda T, Miyagawa T, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Masuko H, Sakamoto T, Hizawa N, Suzuki Y, Yoshihara S, Adachi M, Ebisawa M, Saito H, Matsumoto K, Nakajima T, Mathias RA, Rafaels N, Barnes KC, Himes BE, Duan QL, Tantisira KG, Weiss ST, Nakamura Y, Ziegler SF, Tamari M.
Am J Respir Cell Mol Biol   44(6) 787-793   2011   [Refereed]
Yamada Y, Matsumoto K, Hashimoto N, Saikusa M, Homma T, Yoshihara S, Saito H
Int Arch Allergy Immuno   154(3) 185-194   2011   [Refereed]
Yoshihara S, Fukuda H, Arisaka O
Arzneimittelforschung   61(7) 421-424   2011   [Refereed]
Yamada Y, Matsumoto K, Hashimoto N, Saikusa M, Homma T, Yoshihara S, Saito H
International archives of allergy and immunology   154(3) 185-194   2011   [Refereed]
Larsson S, Nordenson A, Glader P, Yoshihara S, Lind?n A, Slinde F
Int J Chron Obstruct Pulmon Dis   6 83-88   2011   [Refereed]
Yamada Y, Yoshihara S
Allergology international : official journal of the Japanese Society of Allergology   59(4) 375-380   Dec 2010   [Refereed]
Riise GC, Ericson P, Bozinovski S, Yoshihara S, Anderson GP, Lindén A
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation   29(7) 800-807   Jul 2010   [Refereed]
Kondo N, Nishimuta T, Nishima S, Morikawa A, Aihara Y, Akasaka T, Akasawa A, Adachi Y, Arakawa H, Ikarashi T, Ikebe T, Inoue T, Iwata T, Urisu A, Ebisawa M, Ohya Y, Okada K, Odajima H, Katsunuma T, Kameda M, Kurihara K, Kohno Y, Sakamoto T, Shimojo N, Suehiro Y, Tokuyama K, Nambu M, Hamasaki Y, Fujisawa T, Matsui T, Matsubara T, Mayumi M, Mukoyama T, Mochizuki H, Yamaguchi K, Yoshihara S, Japanese Society of Pediatric Allergy and Clinical Immunology
Pediatrics international : official journal of the Japan Pediatric Society   52(2) 319-326   Apr 2010   [Refereed]
Early intervention for infantile and childhood asthma
YOSHIHARA Shigemi
Expert Rev Clin Immunol   6(2) 247-255   Mar 2010   [Refereed]
[Impact of inhaled corticosteroid prescription at discharge from the emergency room on exacerbations of asthma in Japanese hospital].
Chohnabayashi N, Sugiyama K, Kato M, Kimura T, Mochiduki H, Yasuba H, Yoshihara S, Fukuda T, Morikawa A, Adachi M
Arerugi = [Allergy]   59(2) 123-136   Feb 2010   [Refereed]
[Investigation of factors childhood asthma persisting into adulthood].
Kanno N, Yoshihara S, Arisaka O, Noda M
Arerugi = [Allergy]   59(1) 25-36   Jan 2010   [Refereed]
Yamada Y, Matsumoto K, Hashimoto N, Saikusa M, Homma T, Yoshihara S, Saito H
Int Arch Allergy Immunol   154(3) 185-194   2010   [Refereed]
Fukuda H, Abe T, Yoshihara S
Int Arch Allergy Immunol   152(3) 295-300   2010   [Refereed]
Yoshihara S, Fukuda H, Abe T, Arisaka O
Biological & pharmaceutical bulletin   33(10) 1763-1765   2010   [Refereed]
Yoshihara S, Ono M, Yamada Y, Fukuda H, Abe T, Arisaka O
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology   20(5) 486-492   Aug 2009   [Refereed]
[Endpoint for therapy in allergic diseases: pediatric asthma].
Yoshihara S
Arerugi = [Allergy]   58(7) 739-44; quiz 745, 752   Jul 2009   [Refereed]
Imada Y, Fujimoto M, Hirata K, Hirota T, Suzuki Y, Saito H, Matsumoto K, Akazawa A, Katsunuma T, Yoshihara S, Ebisawa M, Shibasaki M, Arinami T, Tamari M, Noguchi E
BMC research notes   20 54   Mar 2009   [Refereed]
Harada M, Hirota T, Jodo AI, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Yoshihara S, Ebisawa M, Saito H, Matsumoto K, Nakamura Y, Ziegler SF, Tamari M
American journal of respiratory cell and molecular biology   40(3) 368-374   Mar 2009   [Refereed]
Yoshihara S, Yoshida T, Kurosaka F, Arisaka O, Furusho K
Pediatrics international : official journal of the Japan Pediatric Society   50(4) 495-499   Aug 2008   [Refereed]
Nitta A, Nishikura K, Fukuda H, Yoshihara S, Hirao J, Arisaka O, Matsuda H
The Journal of pediatrics   152(3) 445-446   Mar 2008   [Refereed]
Hirota T, Harada M, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Noguchi E, Saito H, Nakamura Y, Tamari M
The Journal of allergy and clinical immunology   121(3) 769-770   Mar 2008   [Refereed]
Yoshihara S, Yoshida T, Kurosaka F, Arisaka O, Furusho K
Pediatric International   50(4) 495-499   2008   [Refereed]
[Case of infant with anaphylaxis due to macadamia nuts].
Yamada H, Shimizu A, Tsuchiya T, Yoshihara S
Arerugi = [Allergy]   56(10) 1306   Oct 2007   [Refereed]
Yamada Y, Yoshihara S, Arisaka O
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology   99(4) 380-381   Oct 2007   [Refereed]
Hatsushika K, Hirota T, Harada M, Sakashita M, Kanzaki M, Takano S, Doi S, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Sagara H, Fukuda T, Masuyama K, Katoh R, Matsumoto K, Saito H, Ogawa H, Tamari M, Nakao A
Clin Exp Allergy   37 1165-1174   2007   [Refereed]
Yoshihara S, Yamada Y, Abe T, Arisaka O
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology   96(6) 879-880   Jun 2006   [Refereed]
Nitta A, Nishikura K, Hirao J, Suzumura H, Yoshihara S, Arisaka O
The Journal of pediatrics   148(5) 708-709   May 2006   [Refereed]
Nakashima K, Hirota T, Obara K, Shimizu M, Doi S, Fujita K, Shirakawa T, Enomoto T, Yoshihara S, Ebisawa M, Matsumoto K, Saito H, Suzuki Y, Nakamura Y, Tamari M
Biochemical and biophysical research communications   344(1) 300-307   May 2006   [Refereed]
Nakashima K, Hirota T, Suzuki Y, Akahoshi M, Shimizu M, Jodo A, Doi S, Fujita K, Ebisawa M, Yoshihara S, Enomoto T, Shirakawa T, Kishi F, Nakamura Y, Tamari M
Allergology international : official journal of the Japanese Society of Allergology   55(1) 77-83   Mar 2006   [Refereed]
Nitta A, Suzumura H, Tsuboi Y, Yoshihara S, Arisaka O
The Journal of pediatrics   148(2) 282   Feb 2006   [Refereed]
Nitta A, Nishikura K, Hirao J, Suzumura H, Yoshihara S, Arisaka O
J Pediatrics   148 708-709   2006   [Refereed]
Yoshihara S, Kanno N, Yamada Y, Ono M, Fukuda N, Numata M, Abe T, Arisaka O
Lung   184 63-72   2006   [Refereed]
Yoshihara S, Yamada Y, Abe T, Lind?n A, Arisaka O
Clin Exp Immunol   144 212-216   2006   [Refereed]
The use of a patch formulation of tulobuterol, a long-acting ?2-adrenoreceptor agonist, in the treatment of severe pediatric asthma.
Yoshihara S, Yamada Y, Abe T, Arisaka O
Ann Allergy Asthma Immunol   96 879-880   2006   [Refereed]

Misc

 
YOSHIHARA SHIGEMI, AKUTSU SATORU, OMORI KAZUE, FUKUDA HIRONOBU, ARISAKA OSAMU
日本小児科学会雑誌   119(9) 1400   Sep 2015
YOSHIHARA SHIGEMI, ANDO YUSUKE
こどもケア   10(3) 2-8   Aug 2015
TSUKADA KEIKO, IMATAKA JOJI, YAMAZAKI YUZURU, NISHIDA MITSUHIRO, YOSHIHARA SHIGEMI, ARISAKA OSAMU
小児科臨床   68(7) 1399-1402   Jul 2015
YOSHIHARA SHIGEMI
日本小児呼吸器学会雑誌   26(1) 120-126   Jun 2015
YOSHIHARA SHIGEMI
月刊アレルギーの臨床   (472) 537-541   Jun 2015
SUGAI KAZUKO, YOSHIHARA SHIGEMI, IKEDA MASANORI, NODA MASAHIRO
臨床とウイルス   43(2) S93   May 2015
FUKUDA HIRONOBU, FUKUDA HIRONOBU, YOSHIHARA SHIGEMI, TAMURA MOTOKO, TAMURA MOTOKO, ARISAKA OSAMU
日本小児難治ぜん息・アレルギー疾患学会誌   13(2) 176   May 2015
Shigemi Yoshihara, Shigemi Yoshihara, Sonomjants Munkhbayarlakh, Sohei Makino, Clyde Ito, Narantsetseg Logii, Sarangerel Dashdemberel, Hironori Sagara, Hironori Sagara, Takeshi Fukuda, Takeshi Fukuda, Osamu Arisaka
Allergology International      Jan 2015
© 2015 The Authors. Background: Bronchial asthma is a common but important chronic disease in children in all over the world. To take measures against prevalence of childhood asthma, many researchers have surveyed the actual statuses of childhood ...
吉原 重美
Dokkyo journal of medical sciences   41(3) 277-284   Oct 2014
Nishida Mitsuhiro, Yajima Shuhei, Kuwako Miyuki, Sakai Akira, Kuroda Kiyoko, Miyagi Yoshihumi, Miyamoto Takeshi, Yoshihara Shigemi
JJACI   28(5) 787-795   2014
In 2011, the American Thoracic Society (ATS) has announced the guidelines of Interpretation of Exhaled Nitric Oxide (eNO) for clinical applications, in which eNO values were classified into three zones of low eNO, intermediate eNO and high eNo. Ho...
Abe Toshio, Yoshihara Shigemi
JJACI   28(5) 860-866   2014
The histamine release test is in vivo inspection using the basophil. Unlike a food challenge test, there is not the risk of the anaphylactic shock. This test is inspection to evaluate the release of the chemical mediator by the degranulation throu...
吉原 重美
日本医師会雑誌   142(6) 1279-1283   Sep 2013
吉原 重美
日本内科学会雑誌   102(6) 1384-1391   Jun 2013
Pranlukast hydrate in the treatment of pediatric bronchial asthma
YOSHIHARA Shigemi
Pediatric Health Medicine and Therapeutics   2013(4) 55-63   2013   [Refereed]
YOSHIHARA Shigemi
日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology   26(5) 762-768   Dec 2012
NISHIDA Mitsuhiro, YOSHIHARA Shigemi
日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology   26(5) 740-746   Dec 2012
Shigemi Yoshihara, Hironobu Fukuda, Toshio Abe, Mitsuhiro Nishida, Yumi Yamada, Noriko Kanno, Osamu Arisaka
Allergology International   61 405-410   Oct 2012
Background: Virus infection is an important risk factor for aggravation of childhood asthma. The objective of this study was to examine the effect of drugs on aggravation of asthma induced by a common cold. Methods: Asthma control was examined in ...
山田 裕美, 吉原 重美
臨床免疫・アレルギー科   58(4) 425-428   Oct 2012
吉原 重美
臨床免疫・アレルギー科   57(4) 411-417   Apr 2012
Yoshihara Shigemi
JJACI   26(1) 168-175   2012
In infants and young children, early intervention for asthma, including both environment improvement and medication, is important for preventing disease onset and progress of airway remodeling. Environment improvements include reducing allergen ex...
Nishida Mitsuhiro, Yoshihara Shigemi
JJACI   26(5) 740-746   2012
A boy of 8-year-old with severe atopic asthma was hospitalized for treatment and attending special-needs school. Asthmatic symptoms were relieved soon after hospitalization. So, poor compliance and chronic exposure to indoor allergens were suspect...
阿部 利夫, 吉原 重美
小児科診療   74(12) 1975-1977   Dec 2011
吉原 重美, 小野 三佳
小児科診療   74(12) 1949-1952   Dec 2011
山田 裕美, 吉原 重美
小児科診療   74(12) 1943-1945   Dec 2011
吉原 重美
小児科診療   74(12) 1953-1957   Dec 2011
YAMADA Yumi, YOSHIHARA Shigemi
日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology   25(4) 692-699   Oct 2011
西田 光宏, 山崎 弦, 吉原 重美
Japanese journal of pediatrics   64(7) 1679-1684   Jul 2011
山田 裕美, 吉原 重美
The Japanese journal of acute medicine   35(5) 582-586   May 2011
山田 裕美, 吉原 重美
The Journal of pediatric practice   74(0) 186-188   2011
Yamada Yumi, Yoshihara Shigemi
JJACI   25(4) 692-699   2011
Background: Little is known about differences in the characteristics of and problems associated with school lunch provision for food allergy among day nurseries, kindergartens, elementary schools, and junior high schools. Objectives and Methods: F...
YOSHIHARA Shigemi
日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology   24(5) 659-668   Dec 2010
吉原 重美
The Journal of pediatric practice   73(10) 1753-1758   Oct 2010
近藤 直実, 吉原 重美, Kim Chang Keun
International review of asthma & COPD   12(3) 6-27   Aug 2010
吉原 重美
The Journal of pediatric practice   73(7) 1167-1173   Jul 2010
吉原 重美
医学のあゆみ   233(1) 99-105   Apr 2010
吉原 重美
The Journal of pediatric practice   73(0) 239-242   2010
吉原 重美
The Journal of pediatric practice   72(7) 1271-1275   Jul 2009
西田 光宏, 山崎 弦, 吉原 重美
Japanese journal of pediatrics   62(3) 451-455   Mar 2009
吉原 重美
Respiration and circulation   56(1) 919-924   Sep 2008
YOSHIHARA Shigemi
日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology   21(5) 635-648   Dec 2007
吉原 重美
The Journal of pediatric practice   70(8) 1267-1271   Aug 2007
YOSHIHARA Shigemi
日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology   21(1) 14-20   Mar 2007
Fukuda Norimasa, Yoshihara Shigemi, Tsuchiya Takayoshi, Yamada Yumi, Ono Mika, Arisaka Osamu
JJACI   21(2) 205-212   2007
It is considered that a therapeutic guideline is essential for the provision of improved care to asthmatics. In Japan, a novel Japanese Pediatric asthma Guideline (JPGL) and Asthma Handbook (HB) have been published in the last 2 years. However, th...
YOSHIHARA Shigemi, KANNO Noriko, YAMADA Yumi, ONO Mika, FUKUDA Norimasa, NUMATA Michio, ABE Toshio, ARISA.KA Osamu
JJACI   19(1) 53-59   Mar 2005
This article describes a retrospective study assessing the effect of early intervention with inhaled sodium cromoglycate in childhood asthma. The study was performed using the records of 54 severe asthmatic children treated with inhaled sodium cro...
TOKUYAMA K, UMENO E, KATSUNUMA T, KAMEDA M, SAKAMOTO T, HAMASAKI Y, MASUDA K, YOSHIHARA S
JJACI   18: 270-278(3) 270-278   Aug 2004
In Japan, the strategy for the proper use of anticholinergic drugs in the management of childhood asthma is not established. Thus, we wanted to know how anticholinergic agents were used in the clinical practice. For the purpose, we prepared a ques...
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JJPP   15, 13-16(1) 13-16   Jun 2004
We report a case of a girl with the severe obstructive sleep apnea syndrome (OSAS) caused by adenotonsillar hypertrophy with obesity.The patient had an excess overweight of+84.3% and sleep apnea, snoring, daytime somnolence, adenotonsillar hypertr...
ONO Mika, YOSHIHARA Shigemi, FUKUDA Norimasa, YAMADA Yumi, ABE Toshio, HIRAO Junichi, ARISAKA Osamu
JJPP   14(2) 161-167   Dec 2003
We report a case of 1-year-6-month-old boy with post-infectious bronchiolitis obliterans (BO) diagnosed on the basis of his clinical course and a CT examination of his chest.Measurements of the concentrations of some inflammatory mediators in seru...
EMB Task Force Guideline Committee of the Japanes, Nishima Sankei, Furusho Kenshi, , , , , , , , , , , , , , , ,
JJACI   17(2) 204-209   2003
A multicenter, double-blind comparative study of the tulobuterol patch was conducted to evaluate the effects of continuous use of this agent on airway hypersensitivity and its safety. The participants were a total of 43 children (30 males and 13 f...
NUMATA Michio, YAMADA Yumi, YOSHIHARA Shigemi, HOSHI Megumi, KANAZAWA Sanae, ONO Mika, FUKUDA Norimasa, HIRAO Jun-ichi, ARISAKA Osamu, ,
JJPP   13, 37-40(1) 37-40   Jun 2002
We reported a case of an infant, who developed acquired subglottic stenosis after endotracheal intubation for relatively short period of 11 days. Tracheotomy and operation to enlarge glottis were performed, and she required long-term hospitalizati...
FUKUDA Norimasa, , ARISAKA Osamu
JJACI   15(1) 68-76   Apr 2001
The aquaporins (water channels) are novel molecular transporters that permit water to across the epithelial and endothelial plasma membrane. Recent studies strongly suggest that an important contribution of aquaporin in the respiratory pathophysio...
YOSHIHARA Shigemi, ABE Toshio, YAMADA Yumi, WATANABE Makoto, ONO Mika, OYAMA Mariko, KANAZAWA Sanae, NUMATA Michio, NISHIKURA Kiyoshi, NAKAJIMA Daisuke, HOSHI Megumi, FUKUDA Norimasa, ANDO Tamotsu, KANNO Noriko, ARISAKA Osamu, EGUCHI Mitsuoki
医学教育   32(1) 39-45   Feb 2001
YOSHIHARA Shigemi, ABE Toshio, YAMADA Yumi, WATANABE Makoto, ONO Mika, OYAMA Mariko, KANAZAWA Sanae, NUMATA Michio, NISHIKURA Kiyoshi, NAKAJIMA Daisuke, HOSHI Megumi, FUKUDA Norimasa, ANDO Tamotsu, KANNO Noriko, ARISAKA Osamu, EGUCHI Mitsuoki
Igaku Kyoiku / Medical Education (Japan)   32(1) 39-45   2001
We investigated the effects on medical education of early exposure of undergraduate students to a summer camp for children with asthma. An objective evaluation by the editorial staff found final improvements in the following areas (in descending o...
FUKUDA Norimasa, YOSHIHARA Shigemi, ARISAKA Osamu
JJPP   11(2) 114-126   Dec 2000
The aquaporins (water channels) are novel molecular watertransporters that permit water to across the epithelial and endothelial plasma membrane. Several recent studies strongly suggest that important roles of aquaporins in different pathological ...
YAMADA Yumi, ANDO Tamotsu, HIRAO Jun-ichi, KANAZAWA Sanae, ABE Toshio, SUZUMURA Hiroshi, YOSHIHARA Shigemi, ARISAKA Osamu
JJPP   10(1) 15-19   Jun 1999
We reported a case of infant was noted respiratory and sucking distress that have diagnosed congenital nasal stenosis without treatment. Since nasopharyngeal tube was retained for the treatment, respiratory distress was soon improved and body weig...
ICHIMURA Tohju, ANDO Tamotsu, HIBI Shigeki, YOSHIHARA Shigemi, KANO Kenichi
自律神経 = The Autonomic nervous system   33(3) 249-256   Jun 1996
IKADATSU Yumi, HIRAO Junichi, FUKUDA Norimasa, ABE Toshio, YOSHIHARA Shigemi, ICHIMURA Tohju
日本小児科学会雑誌   100(4) 798-801   Apr 1996
Fukuda Norimasa, Yoshihara Shigemi, Ichimura Tohju, Yanaihara Noboru
Japanese Journal of Allergology   43(1) 55-61   Jan 1994
Chromogranin A like immunoreactivity (CGA-IR) was measured by a specific radioimmunoassay using N-terminal specific antiserum R-0763 in respiratory tissues of guinea pigs. All guinea pig were actively immunized by recurrent Ovalbumin (OA)-inhalati...
N. Fukuda, S. Yoshihara, T. Ichimura
Japanese Journal of Allergology   43 55-61   Jan 1994
Chromogranin A like immunoreactivity (CGA-IR) was measured by a specific radioimmunoassay using N-terminal specific antiserum R-0763 in respiratory tissues of guinea pigs. All guinea pig were actively immunized by recurrent Ovalbumin (OA)-inhalati...
Abe Toshio, Andou Tamotsu, Fukuda Norimasa, Kanno Noriko, Yoshihara Shigemi, Ichimura Tohju
JJACI   8(3) 97-101   1994
CAP RAST is a new assay system for measuring allergen specific IgE. The results were compared with those of RAST in 57 allergic children. The correlation between CAP RAST and RAST were very good. The discordant results between CAP RAST and RAST we...
Kanno Noriko, Abe Toshio, Asai Hidemi, Yoshihara Shigemi, Ichimura Tohju
Japanese Journal of Allergology   42(5) 643-648   May 1993
One hundred twenty five allergic patients ranging in age from 0 to 36 years old (mean age 9 years) were tested. Intradermal skin tests were performed on the volar surface of the forearm by injection of a five-fold dilution of histamine dihydrochlo...
N. Kanno, T. Abe, H. Asai, S. Yoshihara, T. Ichimura
Japanese Journal of Allergology   42 643-648   Jan 1993
Jpn. J. Allergol.   42(5) 643-648   1993
Abe Toshio, Fukuda Norimasa, Asai Hidemi, Yoshihara Shigemi, Ichimura Tohju
Pediatric Otorhinolaryngology Japan   12(1) 50-53   1991
16 cases with febrile convulsion and 3 cases with acute recurrent cerevical lymphadenitis were studied as to the presence of allergic nasopharyngitis which is easily alleviated by treatment SCG nasal spray.<BR>All of cases had positive family hist...
Yoshihara Shigemi, Asai Hidemi, Abe Toshio, Fukuda Norimasa, Ami Kouichi, Ichimura Tohju
Pediatric Otorhinolaryngology Japan   12(1) 54-57   1991
Using specific radioimmunoassay we tried to determine whether any neuropeptides, VIP or SP, may exist in adenoidal and palatine tonsillar tissues in human.<BR>Adenoidal tissues of 8 cases (hypertrophic adenoids of patients aged 5 to 13 years,4 mal...
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Pediatric Otorhinolaryngology Japan   11(2) 27-30   1990
First Dept. of Pediatrics, Dokkyo Univ. School of Medicine, Tochigi We made the new classification of hypertrophy and/or swelling of palatine tonsils in inspection. and tried the palpation of possible lower parts of the palatine tonsils on 234 all...
S. Yoshihara, T. Ichimura, N. Yanaihara, K. Iguchi, T. Inoue
Japanese Journal of Allergology   38(7) 524-531   Jul 1989
Vasoactive intestinal polypeptide (VIP) has recently received widespread attention with respect to its control of airway constriction, and is now regarded as the most promising candidate as a neurotransmitter for nonadrenergic noncholinergic inhib...
Yoshihara shigemi
Japanese Journal of Allergology   37(12) 1161-1168   Dec 1988
Immunoreactive substance P(IR-SP)in the respiratory tract tissues of normal guinea pigs was measured with a specific radioimmunoassay using N-specific anti-serum R400. Male Hartley guinea pigs were passively sensitized with homologous anti-ovalbum...
S. Yoshihara
Japanese Journal of Allergology   37 1161-1168   Dec 1988
Ichimura Tohju, Yoshiwara Shigemi, Hirayama Takanori, Asai Hidemi
Japanese Journal of Allergology   35(5) 367-373   May 1986
It is nowaday very controversial whether nasomucosal stimulation (Ns・S) and also nasopharyngeal stimulation (Rp・S) cause bronchoconstriction or dilation in both healthy animals and humans. Neverthless, we recently found that peroral Rp・S evoked co...
Ichimura Tohju, Yoshiwara Shigemi, Asai Hidemi, Hyodo Haruo
Japanese Journal of Allergology   35(4) 295-300   Apr 1986
The authors found that mechanical stimulation applied perorally to the nasopharynx (Rp・S) could resolve or alleviate asthmatic attacks in child-asthmatics in about 15 seconds. On the other hand, the authors also found that the Rp・S very rarely did...

Books etc

 
Suplast tosilate for prophylaxis of pediatric allergy. Atopic dermatitis Edited by Esparza-Gordillo et al
Yoshihara S, Ono Y, Yamada Y, Fukuda H, Abe T, Arisaka O (Part:Contributor, 289-298)
InTech   2012   
Grobal strategy for the diagnosis and management of asthma in children 5 years and younger
Bateman ED, Boulet LP, Cruz A, FitzGerald M, Haahtela T, Levy M, O’Byne P, Ohta K, Paggiaro P, Pedersen SE, Soto-Quiroz M, Tan WC, Wong GW, Yoshihara S et al
Global initiative for asthma(GINA),Medical Communications Resources,inc   2009   
Chronic respiratory diseases in Japan. Ed by Sohei Makino
Akiyama K, Dobashi K, Fukuchi Y, Haida M, Kawashiro T, Keicho N, Kida K, Kohno Y, Ohta K, Okubo K, Fukuda T, Yoshihara S, Sagara H (Part:Contributor, 19-27)
Elsevier, Present status of prevalence and management of chronic respiratory disease in Asia-Pacific    2006   
Childhood asthma. Ed by Sohei Makino
YOSHIHARA Shigemi (Part:Contributor, 79-81)
Elsevier, Present status of prevalence and management of chronic respiratory disease in Asia-Pacific   2006   
Chronic respiratory diseases in Japan
Ed by Sohei Makino/ Elsevier/ Present status of prevalence and management of chronic respiratory disease in Asia-Pacific   2006   

Conference Activities & Talks

 
The inhibitory effect of cannabinoid B2 receptor agonist on antigen-induced plasma extravasation
Fukuda H, Yoshihara S, Abe T, Arisaka O
Asia Pacific Association of Pediatric Allergy, Respirology & Immunology(APAPARI)   2011   
Asia Pacific Association of Pediatric Allergy, Respirology & Immunology(APAPARI)
YOSHIHARA Shigemi
Early intervention for infantile and young childhood asthma   2011   
Early intervention for infantile and young childhood asthma
Yoshihara S
Asia Pacific Association of Pediatric Allergy, Respirology & Immunology(APAPARI)   2011   
Positioning of Tulobuterol patches in pediatric asthma management in Japan 
Yoshihara S
The Korean academy of pediatric allergy and respiratory disease, Korea-Japan joint asthma meeting 2010   2010   
How pediatric asthma patients are approached in Japan -Based on Japanese guideline-
Yoshihara S
korea/Japan joint asthma meeting   2010   

Works

 
Investgation of sick house syndrome in Tochigi
2005
Joint of Research in the Cannabinoid receptor agonists
2003
Joint Research on Inhalation Therapy of Asthma in PACAP
2001
Joint Research on diagnosis in food allergy
2001
Joint Research on internal and external factor in allergic disease
2000

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2006 - 2007    Investigator(s): Yoshihara SHIGEMI
We investigated that Cannabinoid receptor agonist (WIN55212-2) inhibits antigen-induced plasma extravasation by in guinea pig airways. Plasma extravasation was assessed by the photometric measurement of the extravasated Evans blue after formamide ...
Cannabinoid receptor agonists inhibits airway inflammation
Project Year: 2003   
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2001 - 2002    Investigator(s): Shigemi YOSHIHARA
We compared the relaxant effect of pituitary adenylate cyclase activating peptide (PACAP) 1-27 with that of a newly developed PACAP 1-27 analogue, [Arg_<152021>Leu_<17>]-PACAP-Gly-Lys-Arg-NH_2, in human bronchi in vitro. In human bronchi precontra...
Airway remodeling and early intervention on anti-inflammatory drugs in childhood asthma
Project Year: 1999   
Effect of bronchodilation in PACAP/VIP
Project Year: 1994   
Therapy of tachykinin/Kinin antagonists in allergic diseases (Asthma, Atopic dermatitis)
Project Year: 1988   
Cannabinoid receptor agonists and airway inflammation
Research on a cause of childhood asthma and viral infection in the airway
Research on inflammatory marker in asthma
Research on airway remodeling in childhood asthma
Research on pathophysiology in infantile asthma