中西信夫 (Nobuo Nakanishi) - マイポータル - researchmap

基本情報

所属: 明海大学歯学部歯学科口腔生化学講座講師

学位: 理学博士(東京都立大学)
理学修士(東京都立大学)

J-GLOBAL ID: 200901036633529097
researchmap会員ID: 1000065533

研究キーワード

6

研究分野

3

経歴

10

1985年 - 1988年

城西歯科大学講師(口腔生化学)
1985年 - 1988年

Dept of Biochemistry, Josai Dental University
1988年

- 明海大学・歯学部講師(口腔生化学)
1988年

- Dept of Biochemistry, Meikai University School of Dentistry
1983年 - 1985年

米国国立衛生研究所(NIH) 客員研究員
1983年 - 1985年

National Institue of Child Health and Human Development, NIH, USA, Visiting Fellow
1979年 - 1983年

城西歯科大学講師(口腔生化学)
1979年 - 1983年

Dept of Biochemistry, Josai Dental University
1978年 - 1979年

城西歯科大学(現明海大学歯学部) 助手(口腔生化学)
1978年 - 1979年

Dept of Biochemistry, Josai Dental University

学歴

4

MISC

203

Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knovkout mice. （共著）

Hattori Y, Hattori S, Wang X, Satoh H, Nakanishi N, Kasai K

Arteriosclerosis, Thrombosis, and Vascular Biology 27(4) 865-870 2007年4月
Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice

Yoshiyuki Hattori, Sachiko Hattori, Xi Wang, Hiroko Satoh, Nobuo Nakanishi, Kikuo Kasai

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 27(4) 865-870 2007年4月
Buthionine sulfoximine causes endothelium dependent hyper-relaxation and hypoadiponectinemia. （共著）

Iwata C, Wang X, Uchida K, Nakanishi N, Hattori Y

Life Sciences 80(9) 873-878 2007年2月
Buthionine sulfoximine causes endothelium dependent hyper-relaxation and hypoadiponectinemia

Chigusa Iwata, Xi Wang, Kohsuke Uchida, Nobuo Nakanishi, Yoshiyuki Hattori

LIFE SCIENCES 80(9) 873-878 2007年2月
Statin increases GTP cyclohydrolase I mRNA and 5,6,7,8-tetrahydrobiopterin in vascular endothelial cells. （共著）

Hattori Y, Nakanishi N

Pteridines 17(3) 65-68 2006年9月
Statin increases GTP cyclohydrolase I mRNA and 5,6,7,8-tetrahydrobiopterin in vascular endothelial cells.“jointly worked”

Hattori Y, Nakanishi N

Pteridies 17 65-68 2006年
Cellular accumulation of tetrahydrobiopterin following its administration is mediated by two different processes; direct uptake and indirect uptake mediated by a methotrexate-sensitive process. （共著）

Sawabe K, Suetake Y, Nakanishi N, Wakasugi KO, Hasegawa H

Molecular Genetics and Metabolism 86 S133-S138 2005年12月
Delivery of exogenous tetrahydrobiopterin (BH4) to cells of target organs: role of salvage pathway and uptake of its precursor in effective elevation of tissue BH4.（共著）

Hasegawa H, Sawabe K, Nakanishi N, Wakasugi KO

Molecular Genetics and Metabolism 86 S2-S10 2005年12月
Cellular accumulation of tetrahydroblopterin following its administration is mediated by two different processes; direct uptake and indirect uptake mediated by a methotrexate-sensitive process

K Sawabe, Y Suetake, N Nakanishi, KO Wakasugi, H Hasegawa

MOLECULAR GENETICS AND METABOLISM 86 S133-S138 2005年12月
Delivery of exogenous tetrahydrobiopterin (BH4) to cells of target organs: Role of salvage pathway and uptake of its precursor in effective elevation of tissue BH4

H Hasegawa, K Sawabe, N Nakanishi, OK Wakasugi

MOLECULAR GENETICS AND METABOLISM 86 S2-S10 2005年12月
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.（共著）

Journal of Hypertension 23(7) 1375-1382 2005年7月
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress

H Kase, Y Hashikabe, K Uchida, N Nakanishi, Y Hattori

JOURNAL OF HYPERTENSION 23(7) 1375-1382 2005年7月
Increase in tetrahydrobiopterin release from PC12 cells under hypotonic culture conditions is inhibited by HgCl2.（共著）

Pteridines 16(1) 1-5 2005年3月
Increase in tetrahydrobiopterin release from PC12 cells under hypotonic culture conditions is inhibited by HgCl2. “jointly worked”

Pteridines 16 1-5 2005年
Exogenous biopterin requirment for iNOS function in vascular smooth muscle cells.（共著）

Journal of Cardiovascular Pharmacology 42(2) 197-203 2003年8月
Specific expression of an A-kinase anchoring protein subtype, AKAP-150, and specific regulatory mechanism for Na+, K+ -ATPase via protein kinase A in the parotid gland among the three major salivary glands of the rat.（共著）

Biochemical Pharmacology 66(2) 239-250 2003年7月
Specific expression of an A-kinase anchoring protein subtype, AKAP-150, and specific regulatory mechanism for Na+,K+-ATPase via protein kinase A in the parotid gland among the three major salivary glands of the rat

K Kurihara, N Nakanishi, O Amano, M Yamamoto, S Iseki

BIOCHEMICAL PHARMACOLOGY 66(2) 239-250 2003年7月
HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells.（共著）

Arteriosclerosis, Thrombosis, and Vascular Biology 23(2) 176-182 2003年2月
HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells

Y Hattori, N Nakanishi, K Akimoto, M Yoshida, K Kasai

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 23(2) 176-182 2003年2月
Na+-K+-2Cl-共輸送およびアミン輸送の調節：cAMPの作用［総説］（共著）

日本唾液腺学会誌 44 1-14 2003年

もっとみる

書籍等出版物

37

Increase in the biopterin pool after tetrahydrobiopterin administration is due to uptake of an oxidation product dihydrobiopterin and its conversion to the reduced state.（共著）

Pterines, Folates and Neurotransmitters in Molecular Medicine.(Blau, N. and Thöny, B. eds. ) SPS Publications, Heilbronn, Germany 2003年
Regulatory effect of cyclic AMP on transport of biogenic amines and of inorganic ions.（共著）

Recent Research Development in Biochemistry, Research Signpost, Kerala, India 2003年
Regulation of Na+, K+ -ATPase by cAMP -dependent protein kinase anchored on membrane via A-kinase anchoring protein subtype, AKAP-150, in rat parotid gland.（共著）

Annals of the New York Academy of Sciences 2003年
Increase in the biopterin pool after tetrahydrobiopterin administration is due to uptake of an oxidation product dihydrobiopterin and its conversion to the reduced state.“jointly worked”

Pterines, Folates and Neurotransmitters in Molecular Medicine.(Blau, N. and Thöny, B. eds. ) SPS Publications, Heilbronn, Germany 2003年
Regulatory effect of cyclic AMP on transport of biogenic amines and of inorganic ions. "jointly worked"

In: Recent Research Developments in Biochemistry, 2003年
Regulation of Na+, K+ -ATPase by cAMP -dependent protein kinase anchored on membrane via A-kinase anchoring protein subtype, AKAP-150, in rat parotid gland.“jointly worked”

Annals of the New York Academy of Sciences 2003年
Cells take up BH4, oxidize it and the oxidized biopterin is preferentially released. （共著）

Chemistry and Biology of Pteridines and Folates 2001 2001年
Cells take up BH4, oxidize it and the oxidized biopterin is preferentially released. “jointly worked”

Chemistry and Biology of Pteridines and Folates 2001 2001年
Cellular uptake of tetrahydrobiopterin by PC12 cells and its release: inhibition of the outward flow by reserpine. （共著）

Chemistry and Biology of Pteridines and Folates 1997, Blackwell Wiss.-Verl., Berlin 1997年
Uptake of tetrahydrobiopterin by cells in monolayer cultures of RBL2H3 and PC12 cells. （共著）

Chemistry and Biology of Pteridines and Folates 1997, Blackwell Wiss.-Verl., Berlin 1997年
Cellular uptake of tetrahydrobiopterin by PC12 cells and its release : inhibition of the outward flow by reserpine. “jointly worked”

Chemistry and Biology of Pteridines and Folates 1997, Blackwell Science, Berlin 1997年
Uptake of tetrahydrobiopterin by cells in monolayer cultures of RBL2H3 and PC12 cells. “jointly worked”

Chemistry and Biology of Pteridines and Folates 1997, Blackwell Science, Berlin 1997年
Induction of nitric oxide syntase in human thyrocytes. （共著）

The Biology of Nitric Oxide Part 5, Portland Press, London 1996年
The role of nuclear factor kB in immunostimulant-induced GTP-cyclohydrolase I gene expression and tetrahydrobiopterin synthesis inrat vascular smooth muscle: relation to nitric oxide synthase. （共著）

The Biology of Nitric Oxide Part 5, Portland Press, London 1996年
Induction of nitric oxide syntase in human thyrocytes. (jointly authered)

The Biology of Nitric Oxede Part 5, Portland Press, London 1996年
The role of nuclear factor kB in immunostimulant-induced GTP-cyclohydrolase I gene expression and tetrahydrobiopterin synthesis in rat vascular smooth muscle : relation to nitric oxide synthase. “jointly worked”

The Biology of Nitric Oxide Part 5, Portland Press, London 1996年
Long-term treatment of PC12 pheochromocytoma with dibutyryl cyclic AMP increases biopterin content in the cells but decreases that in the medium. （共著）

Chemistry and Biology of Pteridines and Folates, Plenum Press, New York 1993年
Long-term treatment of PC12 pheochromocytoma with dibutyryl cyclic AMP increases biopterin content in the cells but decreases that in the medium. “jointly worked”

Chemistry and Biology of Pteridines and Folates, Plenum Press 1993年
Effect of cyclic AMP on the synthesis and transport of catecholamines in PC12h pheochromocytoma cells. （共著）

Pteridines and Related Biogenic Amines and Folates, Hanrim Publishing Co., Seoul 1992年
Effect of cyclic AMP on the synthesis and transport of catecholamines in PC12h pheochromocytoma cells. (In : pteridines and Related Biogenic Amines and Folates). “jointly worked”

Hanrim publishing 1992年

もっとみる

講演・口頭発表等

2

Naturally occurring antisense RNA of GTP cyclohydrolase I in PC12 cells: Stimulation of both sense and antisense RNAs of the enzyme by nerve growth factor, dibutyryl cAMP and phorbol ester, PMA

International Meeting on “Tetrahydrobiopterin and Alternative Treatments in Phenylketonurea (PKU), Cardiovascular Diseases, and Diabetes” 2006年
Naturally occurring antisense RNA of GTP cyclohydrolase I in PC12 cells: Stimulation of both sense and antisense RNAs of the enzyme by nerve growth factor, dibutyryl cAMP and phorbol ester, PMA

International Meeting on “Tetrahydrobiopterin and Alternative Treatments in Phenylketonurea (PKU), Cardiovascular Diseases, and Diabetes” 2006年

所属学協会

2

Works(作品等)

12

共同研究・競争的資金等の研究課題

10