2002年2月
Long-term treatment with nicardipine for severe pre-eclampsia
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
- ,
- ,
- 巻
- 76
- 号
- 2
- 開始ページ
- 135
- 終了ページ
- 141
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0020-7292(01)00569-0
- 出版者・発行元
- ELSEVIER SCI IRELAND LTD
Objective. To evaluate the safety of long-term nicardipine treatment in severely pre-eclamptic women and their fetuses/newborns. Methods: We divided 50 pregnant women into three groups according to the length of their treatment: short-term treatment of severely pre-eclamptic women (7 days or less, n = 20); medium-term treatment also of severely pre-eclamptic women (8-28 days, n, = 20); and long-term treatment of women with severe superimposed pre-eclampsia (29 days or more, n = 10). Results: Nicardipine significantly lowered both systolic (P < 0.01) and diastolic blood pressures (P < 0.025) in all three groups. The incidence of delivery before 28 weeks of gestation was very low in all three groups. There were no maternal or fetal/neonatal adverse effects, Conclusion: Our results suggest that long-term treatment with nicardipine for severe pre-eclampsia is as effective and safe as a short- and medium-term treatment. (C) 2002 International Federation of Gynecology and Obstetrics.
- リンク情報
- ID情報
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- DOI : 10.1016/S0020-7292(01)00569-0
- ISSN : 0020-7292
- Web of Science ID : WOS:000174584800003