2000年6月
Experimental study on liver regeneration after simultaneous partial hepatectomy and pancreatectomy
HEPATOLOGY RESEARCH
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- 巻
- 17
- 号
- 3
- 開始ページ
- 223
- 終了ページ
- 236
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S1386-6346(99)00078-9
- 出版者・発行元
- ELSEVIER SCI IRELAND LTD
In this study, we performed hepatectomy and pancreatectomy to assess the physiological contribution of the pancreas, especially in terms of endocrine function to hepatic regeneration. Group 1 Wistar rats underwent 70% hepatectomy and group 2 rats underwent 70% hepatectomy plus 50% pancreatectomy. The time course assessment of liver regeneration rates obtained by Fishback's formula demonstrated a difference in rates between the two groups as early as day 3 or day 7 after surgery. Since levels of both PCNA-positive cells and serum transforming growth factor-alpha (TGF-alpha) were significantly higher in the hepatectomy only group, we could prove the difference of liver regeneration between the two groups. We have concluded that pancreatectomy retards the liver regeneration initiation processes occurring from 24 h to 3 days after evisceration, Glucagon-insulin molar ratios most significantly differed between the two groups 3 days after evisceration in the present study. This result was due to increased glucagon level of group 2 at day 3 after evisceration. Our findings suggest that 50% partial pancreatectomy inhibits the rate of hepatic regeneration, thereby altering the supply of pancreatic hormones, especially glucagon. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/S1386-6346(99)00078-9
- ISSN : 1386-6346
- Web of Science ID : WOS:000087101000006