NAKAKI Toshio

J-GLOBAL         Last updated: Sep 13, 2019 at 10:18
 
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Name
NAKAKI Toshio
URL
http://www.med.teikyo-u.ac.jp/~nakaki/nakaki.html
Affiliation
Teikyo University
Section
Faculty of Pharma-Science Department of Chemistry and Physics
Job title
Chairman and Professor
Degree
M.D., Ph.D.(Keio University)
Other affiliation
Teikyo Academic Research Center

Research Areas

 
 

Academic & Professional Experience

 
1983
 - 
1985
Postdoctoral Fellow, National Institute of Health (USA)
 
1983
 - 
1988
Assistant Keio University
 
1985
 - 
1996
Assistant Professor, Keio University
 
1996
 - 
2000
Associate Professor, Teikyo University
 
2000
   
 
Professor, Teikyo University
 

Education

 
 
 - 
1983
Graduate School, Division of Medicine, Keio University
 
 
 - 
1979
Faculty of Medicine, Keio University
 

Awards & Honors

 
1988
Sanshikai Award
 
1992
Kitasato Award
 
1992
Mitsukoshi Award
 

Published Papers

 
NAKAKI Toshio
Anal Biochem.   546 1-4   Apr 2018   [Refereed]
NAKAKI Toshio
Protein Expr Purif.   148 40-45   Mar 2018   [Refereed]
GTRAP3-18 regulates food intake and body weight by interacting with pro-opiomelanocortin.
NAKAKI Toshio
FASEB J   32(1) 330-341   Jan 2018   [Refereed]
Neuroprotection afforded by circadian regulation of intracellular glutathione levels: A key role for miRNAs.
NAKAKI Toshio
Free Radic Biol Med.   S0891-5849(17) 31227-31233   Dec 2017   [Refereed][Invited]
NAKAKI Toshio
Molecules   20(5) 8742-8758   2015   [Refereed]
Kinoshita, C. Aoyama, K. Matsumura, N. Kikuchi-Utsumi, K. Watabe, M. Nakaki, T.
Nature Communications   -5:3823 doi: 10.1038/ncomms4823   May 2014   [Refereed]
Aoyama K, Nakaki T
International journal of molecular sciences   14 21021-21044   Oct 2013   [Refereed]
Aoyama K, Nakaki T
Amino acids   45 133-142   Jul 2013   [Refereed]
Kikuchi-Utsumi K, Ishizaka M, Matsumura N, Nakaki T
Autonomic neuroscience : basic & clinical      May 2013   [Refereed]
Nitic oxide and natriuretic peptides
45(6) 1119-1124   Apr 2000   [Invited]
Soluble guanylyl cyclase
NAKAKI Toshio
Nippon Rinsho   58 230-234   Jan 2000   [Invited]
arginine paradox
Nakaki T, Hishikawa K
Folia Pharmacologica Japonica   7   [Refereed]
Matsumura N, Kikuchi-Utsumi K, Sakamaki K, Watabe M, Aoyama K, Nakaki T
Epilepsy research   104 203-216   May 2013   [Refereed]
Kikuchi-Utsumi, K. Ishizaka, M. Matsumura, N. Watabe, M. Aoyama, K. Sasakawa, N. Nakaki, T.
Neurotox Res   24(2) 130-138   2013   [Refereed]
Watabe M, Nakaki T
Communicative & integrative biology   5 278-280   May 2012   [Refereed]
Aoyama K, Wang F, Matsumura N, Kiyonari H, Shioi G, Tanaka K, Kinoshita C, Kikuchi-Utsumi K, Watabe M, Nakaki T
Neurobiology of disease   45 973-982   Mar 2012   [Refereed]
Aoyama K, Watabe M, Nakaki T
Amino acids   42 163-169   Jan 2012   [Refereed]
Aoyama K, Nakaki T
International journal of molecular sciences   13 12017-12035   2012   [Refereed]
Watabe M, Nakaki T
Journal of cell science   124 1519-1532   May 2011   [Refereed]
Aoyama K, Matsumura N, Watabe M, Wang F, Kikuchi-Utsumi K, Nakaki T.
Neuroscience   181 206-215   2011   [Refereed]
Koshio O, Tansho S, Ubagai T, Nakaki T, Ono Y
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   16 100-106   Apr 2010   [Refereed]
Ubagai T, Koshibu Y, Koshio O, Nakaki T, Ono Y
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   15 374-379   Dec 2009   [Refereed]
Zhang Q, Nakaki T, Iwami D, Niimi M, Shirasugi N
Transplantation   88 1360-1370   Dec 2009   [Refereed]
NAKAKI TOSHIO
ICUとCCU   32(12) 1071-1079   Dec 2008
Aoyama K, Watabe M, Nakaki T
Journal of pharmacological sciences   108 227-238   Nov 2008   [Refereed]
Watabe M, Aoyama K, Nakaki T
The Journal of neuroscience : the official journal of the Society for Neuroscience   28 9404-9413   Sep 2008   [Refereed]
Watabe M, Aoyama K and Nakaki T
J Neurosci   28 9404-9413   2008
Matsumura N, Kikuchi-Utsumi K and Nakaki T
J Pharmacol Exp Ther   325 357-362   2008
Matsushita T, Inoue S, Tanaka R, Kondo M, Takahashi Y,Miyamoto M, Kurumatani H and Nakaki T
Fisheries Sci   74 214-216   2008
Aoyama K, Matsumura N, Watabe M and Nakaki T
Eur J Neurosci   27 20-30   2008
Watabe M, Aoyama K and Nakaki T
Mol Pharmacol   72 1103-1100   2007
Shimojima N, Nakaki T, Morikawa Y, Hoshino K, Ozaki H, Hori M and Kitajima M
J Surg Res   135 255-261   2006
Plasma nitrate levels in deficit vs nondeficit forms of schizophrenia
Rev Psychiatr Neurosci   28: 288-292    2003
NF-kB as a therapeutic target for cardiovascular disease
Heart Drug   2: 303-311    2003
Plasma nitrate levels in deficit vs nondeficit forms of schizophrenia.n
J Psychiat Neurosci   28:288-292    2003
Biochem. Biochim. Acta’   1649:30-39.    2003
Neurosci Res Commun   30: 63-70    2002
Naunyn-Schmiedeberg's Arch Pharmacol   366: 30-32    2002
J Affect Disord   63 221-224   2001
Static pressure regulates connective tissue growth factor expression in human mesangial cells.
J.Biol.Chem.   276 16798-19803   2001
Overexpression of connective tissue growth factor gene induces apoptosis in human aortic smooth muscle cells
Circulation   100 2108-2112   1999
Nakaki, T. Fujii, T.
Folia Pharmacologica Japonica   112(3) 161-168   1998   [Refereed]
Nitric Oxide and Neurodegenerative Diseases. (共著)
Current Topics Pharmacol.   3 157-163   1997
Dexamethason and nitric oxide synthase gene expression in brain(共著)
Journal of Psychiatry and Neurosciences   22 105-110   1997
Endothelin-1 inhibits induction of nitric oxide synthase and GTP cyclohydrolase-1 in rat mesangial cells. (共著)
Pharmacology   53 241-249   1996
Nitric oxide in vascular remodeling (共著)
Jpn.H.J   37 1-15   1996
J.Biol.Chem.(共著)   271 13561-13565   1996
Tranilast inhibits the effect of platelert-derived growth factor on cell proliferation and induction of nitric oxide(共著)
Eur.J.Pharmacol.-Pharmacol.   291 435-438   1996
Role of interleukin-1 in stress responses : A putative neurotransmitter(共著)
MOl.Neurobiol.   10 47-71   1995
Natriuretic peptide-augmented induction of nitric oxide synthase through cyclic GMP in vascular smooth muscle cells(共著)
Endocrinology   136 2135-2142   1995
Involvement of interleukin-1 in immobilization-induced increase in plasma adrenocorticotropic hormone and in release of hypothalamic monoamines in the rat(共著)
Journal of Neuroscience   15 1961-1970   1995
Cyclosporin A inhibitis nitric oxide synthase induction in vascular smooth muscle cells(共著)
Hypertension   25 764-768   1995
Role of interleukin-1 in stress responses : A putative neurotransmitter(共著)
Molecular Neurobiology   10 47-71   1995
Affinity of neuroleptics for D1 receptor of human brain striatum
Kanba, S. Suzuki, E. Nomura, S. Nakaki, T. Yagi, G. Asai, M. Richelson, E.
J Psychiatry Neurosci   19(4) 265-269   Jul 1994   [Refereed]
Jpn.J.Pharmacol.   66 167-171   1994
Physiological and clinical significance of L-arginine(共著)
Keio J. Med.   43 15-26   1994
Inhibition by lithium of cyclic GMP formation without inhibition of nitric oxide generation in the mouse neuroblastoma cell(N1E-115)(共著)
Neuropsychopharmacology   11 119-124   1994
Measurement by in vivo brain microdialysis of nitric oxide release in the rat cerebellum(共著)
Journal of Psychiatry Neurosciences   19 217-221   1994
Pressure promotes DNA synthesis in rat cultured vascular smooth muscle cells(共著)
Journal of Clinical Investigations   93 1975-1980   1994
Arachidonic acid blocks gap junctions between retinal horizontal cells(共著)
Neuroreport   5,485-488    1994
Characterization of inositol phosphate by high performance liquid chromatography (共著)
Lipid metabolism in signaling systems   18(213-223)    1993
Progress in Neuro-Psychopharmacology and Biological Psychiatry   17 825-834   1993
Pressure-induced endothelin release from human dendthelial cells(共著)
Hypertension   22 437   1993
Differential effects of bacterial lipopolysaccharide on interleukin-1β-and tumor necrosis factor-α-induced production of nitrite/nitrate in vascular smooth muscle cells(共著)
Pharmacological Communications   3 193-200   1993

Misc

 
Diminished No : A cause or an effect of hypertension (共著)
Proceedings of the 2nd and 3rd Annual Conferences of Blood Cell and Microvascular Research   71-76   1996
L-Arginine-induced changes in haemodynamics in man (共著)
The Biology of Nitric Oxide   351-352   1992
Two distinct subtypes of PEG1 receptors identified in neuroblastoma NE-115 : A high affinity receptor stimulatig and synthesis and a low-affinity receptor stimulating cGMP synthesis and PL cycle-Ca2+ (共著)
Adv.Sec.Mess.Phosphoprot.Res.   24 543   1990
Inositol pentakisphosphate accumulation by high K+ or nicotine stimulation in cultured adrenal chromaffin cells(共著)
Adv.Sec.Mess.Phosphoprot.Res.   24 585   1990
Inhibition by endothelium-derved relaxing factor and nitric oxide-producing vasodilators of DNA synthesis in vascular smooth muscle cells (共著)
Biosignalling in Cardiac and Vascular Systems   66-69   1989
Possible invovement of phospholipasse A2 activation and lipoxgenase product(s)in the mechanism of insulin secretoin(共著)
Advances in Prostaglandin,Thromboxane and Leukotriene   265-270   1983

Books etc

 
Side _Effects of Drugs Annual, 40th Edition
NAKAKI Toshio (Part:Contributor, Drugs that affect autonomic functions or the extrapyramidal system)
Elsevier   2018   
Side Effects of Drugs Annual, 39th Edition
NAKAKI Toshio (Part:Contributor, Drugs that affect autonomic functions or the extrapyramidal system)
Elsevier   2017   
Side Effects of Drugs Annual, 38th Edition
NAKAKI Toshio (Part:Contributor, Drugs that affect autonomic functions or the extrapyramidal system)
Elsevier   2016   
Side Effects of Drugs Annual, 37th Edition
NAKAKI Toshio (Part:Contributor, Drugs that affect autonomic functions or the extrapyramidal system)
Nov 2015   
Side Effects of Drugs Annual, 36th Edition
NAKAKI Toshio (Part:Contributor, Drugs that affect autonomic functions or the extrapyramidal system)
Elsevier   Nov 2014   

Conference Activities & Talks

 
Modulation of neuronal glutathione synthesis [Invited]
NAKAKI Toshio
11th National Sino-Western Joint Conference on Microcirculation   18 Jun 2011   
Regulation of neuronal glutathione level by GTRAP3-18 via EAAC1 in neurons in vitro and in vivo [Invited]
Nakaki, T., Aoyama, K., Watabe, M.
11th International Congress on Amino Acids, Peptides and Proteins   3 Aug 2009   
Crucial role of EAAC1, a member of glutathione transporter family, in cysteine uptake and glutathione level in the brain [Invited]
Aoyama, K., Swanson, R.A., Watabe, M., Nakaki, T.
11th International Congress on Amino Acids, Peptides and Proteins   3 Aug 2009   

Works

 
Arginine blocks gap junctions between retinal horizontal cells
1990
Serum interleukin-6 in schizophrenic patients
1991
Signal Transduction Systems of PGE1 Receptors
1991

Research Grants & Projects

 
Role of NO in central nervous system
New drugs for Pankinson's disease
Project Year: 2000   
1) Oxidative stress in the brain 2) Innovative drugs for Parkinson's disease

Patents

 
8,551,711 B2 : SCREENING METHOD OF GLUTATHIONE-INCREASING SUBSTANCE
Toshio Nakaki, Masahiko Watabe, and Koji Aoyama,