Toshima, Kazunobu

J-GLOBAL         Last updated: Jun 12, 2019 at 02:43
 
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Name
Toshima, Kazunobu
E-mail
toshimaapplc.keio.ac.jp
URL
http://www.applc.keio.ac.jp/~toshima/
Affiliation
Keio University
Section
Faculty of Science and Technology Department of Applied Chemistry
Job title
Professor
Degree
工学 (Keio University)
Research funding number
60217502

Research Areas

 
 

Academic & Professional Experience

 
Apr 1988
 - 
Mar 1989
ペンシルバニア大学化学科 ,博士研究員
 
Apr 1989
 - 
Mar 1994
慶應義塾大学(理工学部) ,助手
 
Apr 1994
 - 
Mar 1996
慶應義塾大学(理工学部) ,専任講師
 
Apr 1996
 - 
Mar 2003
慶應義塾大学理工学部(応用化学科),助教授
 
Apr 1997
 - 
Mar 1999
慶應義塾大学理工学応用化学科教室幹事
 

Education

 
Mar 1983
   
 
応用化学科, Faculty of Engineering, Keio University
 
Mar 1985
   
 
応用化学専攻, Graduate School, Division of Engineering, Keio University
 
Mar 1988
   
 
応用科学専攻, Graduate School, Division of Science and Engineeri, Keio University
 

Committee Memberships

 
Nov 2014
 - 
Today
GlycoTokyo  幹事
 
Apr 2014
 - 
Today
日本糖質学会  評議員
 
Apr 2007
 - 
Today
日本ケミカルバイオロジー学会  世話人
 
Apr 2006
 - 
Mar 2008
有機合成化学協会  関東支部常任幹事
 
Apr 2006
 - 
Mar 2008
有機合成化学協会  事業委員会委員
 

Awards & Honors

 
Feb 2016
SSOCJ Daiichi-Sankyo Award for Medicinal Organic Chemistry 2015
 
Mar 2015
日本化学会学術賞
 
May 1996
山下太郎学術研究奨励賞
 
Mar 1995
日本化学会進歩賞
 
Feb 1995
油脂技術優秀論文賞, 油脂工業会館
Winner: 戸嶋 一敦
 

Published Papers

 
Takashi Kitamura, Mai Okuyama, *Daisuke Takahashi, *Kazunobu Toshima
CHEMISTRY AN ASIAN JOURNAL   14(9) 1409-1412   Mar 2019   [Refereed]
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Purpose-designed 2-phenylquinoline (PQ)-sugar hybrids 1 and 2 were synthesized and evaluated for their photodegradation activities against an α-glucosidase target. The results indicated that PQ-m...
Nishi N., Sueoka K., Iijima K., Sawa R., Takahashi D., Toshima K.
Angewandte Chemie - International Edition   57(42) 13858-13862   Oct 2018
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Stereospecific β-l-rhamnopyranosylations were conducted using a 1,2-anhydro-l-rhamnopyranose donor and mono-ol or diol acceptors in the presence of a glycosyl-acceptor-derived borinic or boronic ...
Shota Sotokawa, Takashi Kitamura, Daisuke Takahashi, *Kazunobu Toshima
CHEMICAL COMMUNICATIONS   54(75) 10614-10617   Aug 2018   [Refereed]
© 2018 The Royal Society of Chemistry. A purpose-designed anthraquinone-horseradish peroxidase (HRP)-cell penetrating peptide hybrid 1 showed high and effective cell permeability. Furthermore, 1 exhibited enzymatic activity without photo-irradiati...
Shuhei Kosono, Akihiro Kasai, Sumika Komaba, Teruhiko Matsubara, Toshinori Sato, *Daisuke Takahashi, *Kazunobu Toshima
CHEMICAL COMMUNICATIONS   54(54) 7467-7470   Jun 2018   [Refereed]
© 2018 The Royal Society of Chemistry. Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a design...
Junki Nashida, Nobuya Nishi, Yoshiaki Takahashi, Chigusa Hayashi, Masayuki Igarashi, *Daisuke Takahashi,* Kazunobu Toshima*
THE JOURNAL OF ORGANIC CHEMISTRY   83(13) 7281-7289   Mar 2018   [Refereed][Invited]

Misc

 
*Daisuke Takahashi, Masamichi Tanaka, *Kazunobu Toshima
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY   30(174) E55-E62   May 2018   [Refereed][Invited]
© 2018 FCCA (Forum: Carbohydrates Coming of Age) Development of regio- and stereoselective glycosylations leading to a specific hydroxyl group among several free hydroxyl groups is a challenging and long-standing research subject in carbohydrate c...
D. Takahashi, M. Tanaka, N. Nishi, K. Toshima
Carbohydrate Research   452 64-77   Nov 2017   [Refereed][Invited]
Toshima Kazunobu,Takahashi Daisuke
Glycoconjugate Journal   32(7) 475-482   Oct 2015   [Refereed]
アルツハイマー病原因物質アミロイドβを光分解する生体機能光制御分子の創製と応用
平林 歩、石田 康則、高橋 大介、戸嶋 一敦
ケミカルバイオロジー   7 2-5   Jun 2014   [Invited]

Books etc

 
標的糖鎖光分解用生体機能分子、糖鎖の新機能開発・応用ハンドブック
TAKAHASHI DAISUKE,TOSHIMA KAZUNOBU (Part:Joint Work, 377-379)
エヌ・ティー・エス   Aug 2015   
環境調和型グリコシル化反応、 糖鎖の新機能開発・応用ハンドブック
SASAKI KANAME,TAKAHASHI DAISUKE,TOSHIMA KAZUNOBU (Part:Joint Work, 339-342)
エヌ・ティー・エス   Aug 2015   
Stereoselective formation of 2-deoxyglycosidic bonds in biologically active natural products
TAKAHASHI DAISUKE, TOSHIMA KAZUNOBU (Part:Joint Work, 1137-1171)
Wiley   2013   
Green Solvents Ⅱ
SASAKI KANAME, TAKAHASHI DAISUKE, TOSHIMA KAZUNOBU (Part:Joint Work, 67-78)
Springer   2012   
進化を続ける有機触媒―有機合成を革新する第三の触媒
TOSHIMA KAZUNOBU
化学同人   Jul 2009   

Conference Activities & Talks

 
Structure-Activity Relationship Study of Vineomycin A1
Yuka Matsumoto, Momoko Funakoshi, Yuko Kanno,Daisuke Takahashi, Kazunobu Toshima
The 99th CSJ Annual Meeting   19 Mar 2019   The Chemical Society of Japan
Development and Mechanistic Study of Stereospecific β-Rhamnosylation Using Organoboron Reagents
Nobuya Nishi, Kazuhiro Sueoka, Daisuke Takahashi,Kazunobu Toshima
The 99th CSJ Annual Meeting   18 Mar 2019   The Chemical Society of Japan
Synthetic Study on a Natural Glycolipid, Terpioside B
Masato Endo, Kazuki Inaba, Naoto Iibuchi, Daisuke Takahashi, Kazunobu Toshima
The 99th CSJ Annual Meeting   17 Mar 2019   The Chemical Society of Japan
Boronic acid catalyzed desymmetric 1,2-cis-glycosylation of meso-diols
Masamichi Tanaka, Koji Sato, Ryoki Yoshida, Daisuke Takahashi, Kazunobu Toshima
The 99th CSJ Annual Meeting   17 Mar 2019   The Chemical Society of Japan
Selective Induction of Cancer Cell Death through Complement-Dependent Cytotoxicity by Cell Surface Glycoengineering
Shingo Yoshikami, Takumi Shimura, Daisuke Takahashi, Kazunobu Toshima
The 99th CSJ Annual Meeting   17 Mar 2019   The Chemical Society of Japan

Research Grants & Projects

 
機能複合化による生体機能光制御中分子の創製
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2018    Investigator(s): 戸嶋 一敦
Creation of agents that selectively photo-degrade certain proteins and oligosaccharides and its application to control of cell functions
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2014 - Mar 2017    Investigator(s): 戸嶋 一敦
Several agents, that target-selectively photo-degrade certain disease-related proteins and oligosaccharides, were designed and synthesized. Furthermore, it was found the agents thus developed work not only in test tube but also in disease-related ...

Patents

 
特願2013-150907 : 抗腫瘍活性を有する硫酸化オリゴフコシド類
戸嶋一敦、高橋大介、小柴望
特許第5046029号 : 光増感剤、タンパク質切断剤、タンパク質切断方法、糖分子切断剤、糖分子切断方法、及び光線力学治療剤
戸嶋一敦