Sugai, Takeshi

J-GLOBAL         Last updated: Aug 24, 2019 at 03:03
Sugai, Takeshi
Keio University
Faculty of Pharmacy Department of Pharmaceutical Sciences
Job title
農学(The University of Tokyo)
Research funding number

Research Areas


Academic & Professional Experience

Apr 1984
Mar 1988
Apr 1988
Mar 1993
Aug 1991
Sep 1992
Research Associate, The Scripps Research Institute
Apr 1993
Mar 1997
Oct 1994
Mar 1995


Mar 1981
農芸化学科, Faculty of Agriculture, The University of Tokyo
Mar 1983
農芸化学専門課程, Graduate School, Division of Agricultural Science, The University of Tokyo
Mar 1984
農芸化学専門課程, Graduate School, Division of Agricultural Science, The University of Tokyo

Committee Memberships

Jan 2003
Current Organic Synthesis  Editorial Advisory Board
Jan 2003
Mini-Reviews in Organic Chemistry  Editorial Advisory Board
Apr 2004
日本化学会  化学教育協議会大学入試21WG委員
Mar 2001
日本農芸化学会  日本農芸化学会誌編集幹事
Apr 1999
日本糖質学会  評議員

Awards & Honors

Jun 2000
Enzymes in Large-scale Organic Synthesis, Presidential 2000 Green Chemistry Challenge Award, as a co-recipient of the honoring C.-H. Wong, Department of Environmental Protection, USA,
Winner: Takeshi Sugai
Apr 1994
生体触媒を利用する不斉合成と物質生産への応用, 農芸化学奨励賞, 日本農芸化学会

Published Papers

Chemoenzymatic Synthesis of Hydroxytyrosol Monoesters and Their Suppression Effect on Nitric Oxide Production Stimulated by Lipopolysaccharides
A. Sakakura, M. Pauze, A. Namiki, M. Funakoshi-Tago, H. Tamura, K. Hanaya, S. Higashibayashi, T. Sugai
Biosci. Biotechnol. Biochem.   83 185-191   Feb 2019   [Refereed]
Synthesis of 5-Hydroxy-3’,4’,7-trimethoxyflavone (HTMF) and Related Compounds and Elucidation of Their Reversal Effects on BCRP/ABCG2-Mediated Anticancer Drug Resistance
R. Tsunekawa, K. Katayama,. K. Hanaya, S. Higashibayashi, Y. Sugimoto, T. Sugai
ChemBioChem   20 210-220   Jan 2019   [Refereed]
Preparation of Menisdaurigenin and Related Compounds
R. Shirakawa, S. Ishikawa; M. Takahashi, Y. Ueno, Y. Uekusa, Y. Narukawa. T. Sugai, F. Kiuchi
J. Nat. Med.   73 236-243   Jan 2019   [Refereed]
Dearomative Oxidative Rearrangement of [3]Cyclo-1,8-carbazolylene
M. Yasui, H. Ohtsu, M. Kawano, K. Hanaya, T. Sugai, S. Higashibayashi
Chem. Lett.   47 1357-1359   Nov 2018   [Refereed]
Synthesis of Trilobatin from Naringin via Prunin as the Key Intermediate: Acidic Hydrolysis of the α-Rhamnosidic Linkage in Naringin under Improved Conditions
K. Kurahayashi, K. Hanaya, S. Higashibayashi, T. Sugai
Biosci. Biotechnol. Biochem.   82 1463-1467   Sep 2018   [Refereed]

Books etc

“Future Directions in Biocatalysis (Second Edition)”
R. Tsunekawa, K. Hanaya, M. Shoji, T. Sugai (Part:Joint Work, 279–295)
T. Matsuda, ed., Elsevier   Aug 2017   
“Comprehensive Organic Synthesis II (Second Edition) Volume 2: Additions to C–X Π-Bonds, Part 2”
T. Sugai, K. Fushuku (Part:Joint Work, 512–522)
P. Knochel, G. A. Molander, eds., Elsevier   Jan 2014   
Practical Methods for Biocatalysis and Biotransformations
T. Sugai, A. Fujino, H. Yamaguchi, M. Ikunaka (Part:Joint Work, 190-198)
J. Whittal, P. W. Sutton, eds., Wiley   Dec 2009   
Glycoscience: Chemistry and Chemical Biology
T. Sugai, T. Kajimoto (Part:Joint Work, 907-1021)
Springer-Verlag GmbH, Berlin Heidelberg New York (B. O. Fraser-Reid, K. Tatsuta, J. Thiem eds.)   Dec 2001   
Enzymes in Nonaqueous Solvents; Methods and Protocols, Methods in Biotechnology
Springer   Oct 2001   

Conference Activities & Talks

New Entries for Transformation of Carbohydrates towards the Synthesis of Bioactive Compounds [Invited]
T. Sugai
2018 Frontiers in Chemical Biology   1 Aug 2018   
Enzyme-catalyzed Asymmetric Reduction of Cyclic Ketoesters and Application to Natural Product Synthesis [Invited]
T. Sugai, K. Kuwata, R. Tsunekawa, R. Fujita
The 13th Yonsei CBMH-Keio LCC Joint Symposium   13 Oct 2017   
The Complementary and Integrated Chemo-enzymatic Processes for Fine Chemical Syntheses (Invited Lecture) [Invited]
T. Sugai, Y. Yamashita, Y. Niitsu, M. Hamada, C. Hiraoka, T. Higashi, M. Shoji
The 14th Asia Pacific Confederation of Chemical Engineering   23 Feb 2012   
Chemo-enzymatic approaches towards both enatiomers of dehydroxymethylepoxy-quinomicin (DHMEQ) (Selected Oral Presentation)
T. Sugai, C. Hiraoka, M. Hamada, Y. Niitsu, R. Kobayashi, K. Nakagawara, T. Seki, M. Suzuki, Y. Yamashita, T. Higashi, M. Shoji, K. Umezawa
10th International Symposium on Biocatalysis and Biotransformations   6 Oct 2011   
Regio- and stereoselective lipase-catalyzed reactions on sugars and carbasugars (Invited Lecture) [Invited]
M. Hamada, Y. Ueda, N. Chishima, J. Calveras, T. Higashi, M. Shoji, T. Sugai
The International Chemical Congress of Pacific Basin Societies   19 Dec 2010   

Research Grants & Projects

MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2019 - Mar 2022    Investigator(s): 須貝 威
Efficient organic synthesis utilizing microbial enzyme catalysts
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2014 - Mar 2017    Investigator(s): 須貝 威
Complementary and synergistic utilization of enzyme-catalyzed reactions and chemical transformation was studied, toward the efficient synthesis of complex target molecules involving valuable natural and unnatural products. The achievements are sh...

Social Contribution

[]  Apr 2001 - Mar 2002