Papers

Oct, 2004

Transient increase of TUNEL-positive cells on postnatal day 20 in the developing rat olfactory bulb

NEUROSCIENCE RESEARCH
  • K Saito
  • S Saito
  • K Taniguchi
  • N Kobayashi
  • T Terashita
  • T Shimokawa
  • K Mominoki
  • K Miyawaki
  • J Chen
  • SY Gao
  • CY Li
  • S Matsuda
  • Display all

Volume
50
Number
2
First page
219
Last page
225
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1016/j.neures.2004.07.001
Publisher
ELSEVIER SCI IRELAND LTD

In the developing central nervous system, apoptosis plays an important role in the normal organization of the neuronal circuit. The timing of neurogenesis, proliferation, and migration of the neurons in the developing olfactory bulb (OB) is well studied; however, the involvement of apoptosis in this process is not fully understood. In this study, we examined the changes in the distribution and the number of apoptotic cells in the rat OB during embryonic and postnatal periods, by using terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end-labeling (TUNEL) staining. Although the number of TUNEL-positive cells was relatively small during the embryonic period, it gradually increased after birth, and peaked on postnatal day 20 with statistical significance, especially in the granule cell layer of the main OB. This transient increase of TUNEL-positive cells on postnatal day 20 may be involved in a critical event during maturation of the OB. (C) 2004 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

Link information
DOI
https://doi.org/10.1016/j.neures.2004.07.001
CiNii Articles
http://ci.nii.ac.jp/naid/10014233761
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/15380329
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000224597000009&DestApp=WOS_CPL
ID information
  • DOI : 10.1016/j.neures.2004.07.001
  • ISSN : 0168-0102
  • CiNii Articles ID : 10014233761
  • Pubmed ID : 15380329
  • Web of Science ID : WOS:000224597000009

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