NAGAOKA Isao

J-GLOBAL         Last updated: Oct 1, 2019 at 18:06
 

Research Areas

 
 

Academic & Professional Experience

 
Dec 1994
 - 
Today
Professor, Host Defense and Biochemical Research, Juntendo University School of Medicine
 
Jan 1990
 - 
Nov 1994
Associate Professor, Biochemistry, Juntendo University School of Medicine
 
Apr 1988
 - 
Dec 1989
Biochemsitry, Juntendo University School of Medicine
 
Oct 1987
 - 
Sep 1989
Research Associate, NHLBI, Pulmonary Branch, National Institutes of Health, US
 
Jul 1983
 - 
Mar 1988
Assistant Professor, Physiological Chemistry, Juntendo University School of Medicine
 
Apr 1983
 - 
Jun 1983
Research Associate, Physiological Chemistry, Juntendo University School of Medicine
 

Education

 
Apr 1979
 - 
Mar 1983
Biochemistry, Graduate School of Medicine, Juntendo University
 
 
 - 
1983
Graduate School, Division of Medicine, Juntendo University
 
Apr 1973
 - 
Mar 1979
School of Medicine, JUntendo University
 
 
 - 
1979
Faculty of Medicine, Juntendo University
 

Awards & Honors

 
2016
"LL-37 affects macrophages and inhibits sepsis", In This Issue, Int Immunol 28: 210
Winner: Hu Z, Murakami T, Suzuki K, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Nagaoka I
 
2003
Medical Science Award, Tokyo Medical Association
 
1991
Alumni Scientific Award, Juntendo University School of Medicine
 

Research Grants & Projects

 
Functional analysis of antibacterial peptides
Project Year: 1998   
Expression of antibacterial proteins in granulocytes
Project Year: 1994   
Mechanism of superoxide generation
Project Year: 1994   
Modulation of neutrophil apoptosis by endogenous antimicrobial peptides.
Project Year: 2002   
Clinical application of antibacterial peptides for endotoxin shock.
Effect of functional foods on host defense

Patents

 
特許US 7452856 : Antibacterial peptide
Nagaoka I, Okuda T, Yomogida S, Tamura H

Published Papers

 
Reich J, Alexander Weyer F, Tamura H, Nagaoka I, Motschmann H
Int J Mol Sci   20(4)    2019   [Refereed]
Reich J, Tamura H, Nagaoka I, Motschmann H
Biologicals   53 1-9   2018   [Refereed]
Murakami T, Suzuki K, Niyonsaba F, Tada H, Reich J, Tamura H, Nagaoka I Isao
Mol Med Reports   4951-4959   2018   [Refereed]
Iba T, Hirota T, Sato K, Nagaoka I
Int J Hematol   107 528-534   2018   [Refereed]
Iba T, Levy JH, Hirota T, Hiki M, Sato K, Murakami T, Nagaoka I
Thromb Res   171 1-6   2018   [Refereed]
Takehara K, Murakami T, Kuwahara-Arai K, Iba T, Nagaoka I, Sakamoto K
Exp Ther Med   13 2969-2674   2017   [Refereed]
Iba T, Sasaki T, Ohshima K, Sato K, Nagaoka I, Thachil J
TH Open   01(01) e3-e10   2017   [Refereed]
Hosoda H, Nakamura K, Hu Z, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoaka I
Mol Med Reports   16 5618-5626   2017   [Refereed]
Hu Z, Murakami T, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoka I
Int J Mol Med   39 549-558   2017   [Refereed]
Murakami T, Hu Z, Tamura H, Nagaoka I
Mol Med Rep   13 3115-3120   2016   [Refereed]
Iba T, Hamakubo T, Nagaoka I, Sato K, Thachil J
Microcirculation   23 240-247   2016   [Refereed]
Tada H, Shimizu T, Nagaoka I, Takada H:
Biomed Res   37 199-206   2016   [Refereed]
Hu Z, Murakami T, Suzuki K, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Nagaoka I
Int Immunol   28 245-253   2016   [Refereed]
Suzuki K, Murakami T, Hu Z, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I
J Immunol   196 1338-1347   2016   [Refereed]
Iba T, Hashiguchi N, Nagaoka I, Tabe Y, Kadota K, Sato K
Intensive Care Med Exp   3 36   2015   [Refereed]
Iba T, Nagaoka I, Yamada A, Nagayama M, Miki T
Int J Med Sci   11 255-261   2014   [Refereed]
Hu Z, Murakami T, Suzuki K, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I
PLOS ONE   9(1) e85765-doi:10.1371/journal.pone.00857   2014   [Refereed]
Iba T, Miki T, Hashiguchi N, Tabe Y, Nagaoka I
Thromb Res   134 169-173   2014   [Refereed]
Murakami. T, Suzuki K, Tamura H, Nagaoka I
Exp Ther Med   2 57-61   2011   [Refereed]
Suzuki K, Murakami T, Kuwahara-Arai K, Tamura H, Hiramatsu K, Nagaoka I
Int Immunol   23 185-193   2011   [Refereed]
Hosoda H, Tamura H, Kida S, Nagaoka I
Life Sci   89 115-121   2011   [Refereed]
Yamaguchi K, Kawahara T, Kumakura S, Hua J, Kugimiya T, Nagaoka I, Inada E
Shock   33 436-441   2010
Nagaoka I, Suzuki K, Murakami T, Niyonsaba F, Tamura H, Hirata M
Int J Mol Med   260 925-934   2010
Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K
J Immunol   184(7) 3526-3534   2010
Naito K, Watari T, Muta T, Furuhata A, Iwase H, Igarashi M, Kurosawa H, Nagaoka I, Kaneko K
J Orthop Res   28 361-369   2010
Okuda D, Yomogida S, Kuwahara-Arai K, Hitamatsu K, Tamura H, Nagaoka I
Int J Mol Med   23 501-508   2009
Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa H, Okumura K
Br J Dermatol   160 243-249   2009
Murakami T, Obata T, Kuwahara-Arai K, Tamura H, Hiramatsu K, Nagaoka I
Int Immunol   21(8) 905-912   2009
Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H
Immunology   124(357) 367   2008   [Refereed]
Nagaoka I, Niyonsaba F, Tsutsumi-Ishii Y, Tamura H, Hirata M
Int Immunol   20(4) 543-553   2008
Tsutsumi-Ishii Y, Shimada K, Daida H, Toman R, Nagaoka I
Int Immunol   20(2) 199-208   2008
Murakami T, Yomogida S, Someya A, Kuwahara-Arai K, Tamura H, Nagaoka I
FEBS Lett   581(1) 140-144   2007
Chen X, Niyonsaba F, Ushio H, Hara M, Yokoi H, Matsumoto K, Saito H, Nagaoka I, Ikeda S, Okumura K, Ogawa H
Eur J Immunol   37 434-444   2007   [Refereed]
Zheng Y, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H
Br J Dermatol   157 1124-1134   2007   [Refereed]
Okuda D, Yomogida S, Tamura H, Nagaoka I
Antimicrob Agents Chemother   50 2602-2607   2006   [Refereed]
Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H
J Invest Dermatol   127 594-604   2006   [Refereed]
Niyonsaba F, Nagaoka I, Ogawa H
Crit Rev Immunol   26 545-576   2006   [Refereed]
Nagaoka I, Kuwahara-Arai K, Tamura H, Hiramatsu K, Hirata M
Inflamm Res   54 66-73   2005
Sampanthanarak P, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H
J Dermatol Sci   37 188-191   2005
Fukumoto K, Nagaoka I, Yamataka A, Kobayashi H, Yanai T, Kato Y, Miyano T
Pediatr Surg Int   21 20-24   2005
Chen X, Niyonsaba F, Ushio H, Okuda D, Nagaoka I, Ikeda S, Okumura K, Ogawa H
J Dermatol Sci   40 123-132   2005   [Refereed]
Niyonsaba F, Iwabuchi K, Someya A, Hirata M, Matsuda H, Ogawa H, Nagaoka I
Immunology   106 20-26   2002
Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Heumann D
J Immunol   167, 3329-3338    2001
agaoka I, Hirota S, Yomogida S, Ohwada A, Hirata M
Inflamm Res   49(2) 73-79   2000
Nagaoka I, Hirata M, Sugimoto K, Tsutsumi-Ishii Y, Someya A, Saionji K, Igari J
J Leukoc Biol   64 845-852   1998
Yomogida S, Nagaoka I, Saito K, Yamashita T
Inflamm Res   45(2) 62-67   1996
Yomogida S, Nagaoka I, Yamashita T
Arch Biochem Biophys   328(2) 219-226   1996
Nagaoka I, Honma S, Someya A, Iwabuchi K, Yamashita T
Comp Biochem Physiol B   103 349-356   1992   [Refereed]
Nagaoka I, Someya A, Iwabuchi K, Yamashita T
FEBS Lett   303 31-35   1992   [Refereed]
Nagaoka I, Yomogida S, Nakamura S, Someya A, Iwabuchi K, Yamashita T
FEBS Lett   302 279-283   1992   [Refereed]
Nagaoka I, Someya A, Iwabuchi K, Yamashita T
FEBS Lett   280 79-83   1991   [Refereed]
Nagaoka I, Someya A, Iwabuchi K, Yamashita T
FEBS Lett   280 287-291   1991   [Refereed]
Nagaoka I, Someya A, Iwabuchi K, Yamashita T
Comp Biochem Physiol B   100 313-319   1991   [Refereed]
Nagaoka I, Trapnell BC, Crystal RG
J Clin Invest   85 448-455   1990
Nagaoka I, Yamada M, Kira S, Yamashita T
Comp Biochem Physiol B   89 375-380   1988   [Refereed]
Nagaoka I, Yamashita T
Biochem Biophys Res Commun   147 282-287   1987   [Refereed]
Nagaoka I, Yamashita T
Biochim Biophys Acta   888 263-269   1986   [Refereed]
Nagaoka I, Yamashita T
Biochim Biophys Acta   886 231-242   1986   [Refereed]
Nagaoka I, Yamashita T
Biochim Biophys Acta   847 67-76   1985   [Refereed]
Nagaoka I, Yamashita T
Biochim Biophys Acta   804 176-180   1984   [Refereed]
Nagaoka I, Yamashita T
Comp Biochem Physiol B   79 147-151   1984   [Refereed]
Nagaoka I, Yamashita T
Histochemistry   81 273-278   1984   [Refereed]
Nagaoka I, Yamashita T
Biochim Biophys Acta   678 342-351   1981   [Refereed]
Nagaoka I, Yamashita T
Biochim Biophys Acta   598 169-172   1980   [Refereed]

Misc

 
Hu Z, Nagaoka I
Juntendo Med J   62 98-104   2016
Suzuki K, Nagaoka I
Juntendo Med J   62 105-111   2016
Tamura H, Reich J, Nagaoka I
Juntendo Med J   62 132-140   2016
Iba T, Yamada A, Hashiguchi N, Nagaoka I
Pol Arch Med Wewn   124 321-328   2014
Iba T, Miki T, Hashiguchi N, Tabe Y, Nagaoka I
Crit Care   18 230   2014
Iba T, Murai M, Nagaoka I, Tabe Y
Acute Med Surg   1 2-9   2014   [Refereed]
Iba T, Hashiguchi N, Nagaoka I, Tabe Y, Murai M
J Intensive Care   1 13   2013   [Refereed]
Iba T, Nagaoka I, Boulat M
Thromb Res   131 383-389   2013   [Refereed]
Nagaoka I, Suzuki K, Niyonsaba F, Tamura H, Hirata M
SRN Microbiol   2012 345791   2012   [Refereed]
Suzuki K, Nagaoka I
Inflamm Regener   31 375-381   2011
Naito K, Watari T, Muta T, Furuhata A, Iwase H, Igarashi M, Kurosawa H, Nagaoka I, Kaneko K.
J. Orthop. Res.   28 361-369   2010
Nagaoka, I., Nabeshima, K., Murakami, S., Yamamoto, T., Watanabe, K., Tomonaga, A., Yamaguchi, H.
Exp. Ther. Med.   1 817-827   2010
Niyonsaba F, Nagaoka I, Ogawa H, Okumura K
Curr Pharm Des   15 2393-2413   2009
Yomogida S, Kojima Y, Tsutsumi-Ishii Y, Hua J, Sakamoto K, Nagaoka I
Int J Mol Med   22 317-323   2008
Ju Y, Hua J, Sakamoto K, Ogawa H, Nagaoka I
Int J Mol Med   22: 809-815, 2008.    2008
Functional effects of NAD(P)H oxidase p22phox C242T mutation in human leukocytes and association with thrombotic cerebral infarction.
Atherosclerosis   175: 109-115    2004
Iwabuchi K, Komayashi T, Ishii K, Makino A, Kaga N, Murayama K, Nagaoka I
23 223-230   2003
Hua J, Suguro S, Ishii-Tsutsumi Y, Iwabuchi K, Sakamoto K, Nagaoka I
Inflamm Regener   23 164-169   2003
Niyonsaba F, Hirata M, Ogawa H, Nagaoka I
Curr Drug Targets Inflamm Allergy   2 224-231   2003
Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils.(共著)
Journal of Leukocyte Biology   71, 632-640    2002
Lactosylceramide-enriched glycosphingolipid signaling domain mediates superoxide generation from human neutrophils.(共著)
Blood   100, 1454-1464    2002
Nagaoka I, Sakamoto K
Inflamm Regener   22 461-468   2002
Nagaoka I, Hirota S, Niyonsaba F, Tamura H, Tanaka S, HIrata M
Inflamm Regener   22 131-138   2002
Involvement of cytosolic prolyl endopeptidase in degradation of p40-phox splice variant protein in myeloid cells.(共著)
Journal of Leukocyte Biology   69, 963-968    2001
Niyonsaba F, Hirata M, Nagaoka I
Inflamm Regener   21 109-115   2001
Ishii-Tsutsumi Y, Yaguchi H, Nagaoka I
21 219-226   2001
Evaluation of the expression of NADPH oxidase components during maturation of HL-60 cells to neutrophil lineage. (共著)
Journal of Leukocyte Biology   68 216-224   2000
Nagaoka I, Horota S, Sasagawa A, Ohwada A, Hirata M
Ensho   20 131-136   2000
DNA vaccination against HuD antigen elicits antitumor activity in a small-cell lung cancer murine model. (共著)
American Journal of Respiratory Cell and Molecular Biology   21 37-43   1999
Short exposure of intestinal epithelial cells to TNF-α and histamine induces Mac-1-mediated neutrophil adhesion independent of protein synthesis. (共著)
Journal of Leukocyte Biology   66 437-446   1999
Phosphorylation of p40-phox during activation of neutrophil NADPH oxidase. (共著)
Journal of Leukocyte Biology   66 851-857   1999
Iwabuchi K, Nagaoka I, Yamashita T
Seikagaku   71 353-358   1999
Effect of erythromycin of otitis media with effusion in experimental rat model(共著)
Acta Otolaryngology   539 57-60   1998
Modulation of neutrophil adherence to endothelial cells by platelet-derived adherence-inhibiting factor through interactions with selectin molecules(共著)
Journal of Leukocyte Biology   63 500-508   1998
Chemotactic activity of soluble Fas ligand against phagocytes(共著)
Journal of Immunology   161 4484-4488   1998
Transplantation Proceedings   30 2982-2983   1998
Altered surface expression of effector cell molecules on neutrophils in myelodysplastic syndromes(共著)
British Journal of Haematology   98 108-113   1997
Biochemical and Biophysical Research Communications   232(1) 198-203   1997
Transplant Immunology   5 237-239   1997
Kazuhisa Iwabuchi, Isao Nagaoka, Ryuko Miyata, Akimasa Someya, Tatsuhisa Yamashita
Japanese Journal of Inflammation   17(5) 477-481   1997
Isao Nagaoka, Yuko Tsutsumi-Ishii, Shin Yomogida, Tomoe Hayakawa, Tatsuhisa Yamashita
Japanese Journal of Inflammation   17(4) 367-374   1997
Type IV Collagen-binding Proteins of Neutrophils : Possible Involvement of L-Selectin in the Neutrophil binding to Type IV Collagen(共著)
BLOOD   87 365-372   1996
Regulation of cell adhesion by platelets(共著)
MOLECULAR MEDICINE   33 554-563   1996
BIOCHIMICA ET BIOPHYSICA ACTA   1277(3) 217-225   1996
Defensin(共著)
Clinical Immunology   27 229-236   1995
Isao Nagaoka, Noriko Ishihara, Akimasa Someya, Kazuhisa Iwabuchi, Shin Yomogida, Tatsuhisa Yamashita
Japanese Journal of Inflammation   15(1) 33-41   1995
Effect of a chemical or proteolytic modification on the biological activity og guinea-pig cationic peptide(共著)
Biochimica et Biophysica Acta   1243 295-299   1995
Effect of cigarette smoke on the mRNA and protein expression of carcinoembryonic antigen(CEA), a possible chemoattractant for neutrophils in human bronchioloalveolar tissues(共著)
THORAX   50 651-657   1995
Localization of Platelet-derived Growth Factor and Insulin-like Growth Factor I in the Fibrotic Lung(共著)
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   152 2084-2089   1995
Kazuhisa Iwabuchi, Isao Nagaoka, Akimasa Someya, Shin Yomogida, Tatsuhisa Yamashita
Japanese Journal of Inflammation   15(1) 27-32   1995
Analysis of the NADPH oxidase components during differentiation of HL-60 cells to eosinophilic lineage(共著)
Biochimica et Biophysica Acta   1224 11-16   1994
Granulocyte dysfunction and microbial infection
Juntendo Medical Journal   40 255-257   1994
Cytokines and inflammation-Involvement of PDGF in lung fibrosis(共著)
Infection, Inflammation and Immunity   24 137-142   1994
Biliary Glycoprotein mRNA Expression Is Increased in Primary Lung Cancer, Especially in Squamous Cell Carcinoma(共著)
American Journal of Respiratory Cell and Molecular Biology   11 214-220   1994
Comparative Biochemistry and Physiology   106(2) 387-390   1993
Purification of the antibacterial fragments of guinea-pig major basic protein (共著)
Biochimica et Biophysica Acta   1203,236-242    1993
Isolation and Characterization of the Neutrophil-Binding Proteins for Platelet-Derived Adherence-Inhibiting Factor(共著)
BLOOD   82 1884-1890   1993
Nagaoka I, Honma S, Someya A, Yamashita T
Ensho   13 113-118   1993
Differential expression of the platelet-derived growth factor-A and -B genes during maturation of monocytes to macrophages (共著)
Comparative Biochemistry and Physiology   103B,349-356    1992
Inhibition of the accumulation of macrophages and the generation of macrophage chemotactic activity by dexamethasone in concanavalin A-induced periotonitis of mice (共著)
Agents and Actions   25,156-163    1988
Biochemical and Biophysical Research Communications   147,282-287    1987
Studies on the leukotriene D4-metabolizing enzyme of rat leukocytes, which catalyzes the conversion of leukotriene D4 to leukotriene E4 (共著)
Biochimica et Biophysica Acta   922,8-17    1987

Books etc

 
Basic and Clinical Aspects of Pulmonary Fibrosis
Nagaoka I, Yamashita T (Part:Joint Work, Platelet-derived growth factor production by alveolar macrophages)
CRC Press   1994   
Platelet-derived growth factor production by alveolar macrophages(共著)
Basic and Clinical Aspects of Pulmonary Fibrosis CRC Press   1994   

Works

 
Biochemical studies of antibacterial peptides
2002
Biochemical studies of phagocytes
2002
Effects of glucosamine on inflammatory cells
2001