YAGITA Hideo

J-GLOBAL         Last updated: Nov 20, 2018 at 14:06
 
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Name
YAGITA Hideo
Affiliation
Juntendo University
Section
Faculty of Medicine
Degree
(BLANK)(Tohoku University), (BLANK)(Tohoku University)

Research Areas

 

Academic & Professional Experience

 
1985
 - 
1987
Research Associate,
 
 
   
 
Juntendo University, School of Medicine.
 
1987
 - 
1988
Assistant Professor,
 
 
   
 
Juntendo University, School of Medicine.
 

Education

 
 
 - 
1985
Graduate School, Division of Pharmaceutical Sciences, Tohoku University
 
 
 - 
1980
Faculty of Pharmaceutical Science, Tohoku University
 

Published Papers

 
Murai Shin, Yamaguchi Yoshifumi, Shirasaki Yoshitaka, Yamagishi Mai, Shindo Ryodai, Hildebrand Joanne M., Miura Ryosuke, Nakabayashi Osamu, Totsuka Mamoru, Tomida Taichiro, Adachi-Akahane Satomi, Uemura Sotaro, Silke John, Yagita Hideo, Miura Masayuki, Nakano Hiroyasu
NATURE COMMUNICATIONS   9    Oct 2018   [Refereed]
Kim Terresa, Kim Sol, Song Minju, Lee Cindy, Yagita Hideo, Williams Drake W., Sung Eric C., Hong Christine, Shin Ki-Hyuk, Kang Mo K., Park No-Hee, Kim Reuben H.
AMERICAN JOURNAL OF PATHOLOGY   188(10) 2318-2327   Oct 2018   [Refereed]
Gotot Janine, Dhana Ermanila, Yagita Hideo, Kaiser Romina, Ludwig-Portugall Isis, Kurts Christian
IMMUNOLOGY AND CELL BIOLOGY   96(8) 852-862   Sep 2018   [Refereed]
Brennan Amelia J., Law Ruby H. P., Conroy Paul J., Noori Tahereh, Lukoyanova Natalya, Saibil Helen, Yagita Hideo, Ciccone Annette, Verschoor Sandra, Whisstock James C., Trapani Joseph A., Voskoboinik Ilia
CELL DEATH AND DIFFERENTIATION   25(8) 1517-1529   Aug 2018   [Refereed]
Dufresne Sebastien S., Boulanger-Piette Antoine, Bosse Sabrina, Argaw Anteneh, Hamoudi Dounia, Marcadet Laetitia, Gamu Daniel, Fajardo Val A., Yagita Hideo, Penninger Josef M., Tupling A. Russell, Frenette Jerome
ACTA NEUROPATHOLOGICA COMMUNICATIONS   6    Apr 2018   [Refereed]
Isobe Masamichi, Izawa Kumi, Sugiuchi Masahiro, Sakanishi Tamami, Kaitani Ayako, Takamori Ayako, Maehara Akie, Matsukawa Toshihiro, Takahashi Mariko, Yamanishi Yoshinori, Oki Toshihiko, Uchida Shino, Uchida Koichiro, Ando Tomoaki, Maeda Keiko, Nakano Nobuhiro, Yagita Hideo, Takai Toshiyuki, Ogawa Hideoki, Okumura Ko, Kitamura Toshio, Kitaura Jiro
JOURNAL OF BIOLOGICAL CHEMISTRY   293(10) 3793-3805   Mar 2018   [Refereed]
Hashiramoto Akira, Konishi Yoshitake, Murayama Koichi, Kawasaki Hiroki, Yoshida Kohsuke, Tsumiyama Ken, Tanaka Kimie, Mizuhara Masaru, Shiotsuki Toshio, Kitamura Hitomi, Komai Koichiro, Kimura Tomoatsu, Yagita Hideo, Shiozawa Kazuko, Shiozawa Shunichi
JOURNAL OF BIOLOGICAL CHEMISTRY   293(6) 1933-1943   Feb 2018   [Refereed]
Ohtsuji Mareki, Lin Qingshun, Okazaki Hideki, Takahashi Kazuko, Amano Hirofumi, Yagita Hideo, Nishimura Hiroyuki, Hirose Sachiko
ARTHRITIS RESEARCH & THERAPY   20    Feb 2018   [Refereed]
Giwa Adebola, Ahmed Rizwan, Donner Thomas, Yagita Hideo, Hamad Abdel Rahim A.
FRONTIERS IN IMMUNOLOGY   8    Nov 2017   [Refereed]
Ahern Elizabeth, Harjunpaa Heidi, Barkauskas Deborah, Allen Stacey, Takeda Kazuyoshi, Yagita Hideo, Wyld David, Dougall William C., Teng Michele W. L., Smyth Mark J.
CLINICAL CANCER RESEARCH   23(19) 5789-5801   Oct 2017   [Refereed]

Misc

 
Expression of T cell/transmembrane, immunoglobulin, and mucin (TIM)-4 in normal cornea and corneal grafts
Takeda Ayaka, Taniguchi Hiroko, Kunishige Tomoyuki, Akiba Hisaya, Yagita Hideo, Hori Junko
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   59(9)    Jul 2018   [Refereed]
Uchida Koichiro, Yin Enzhi, Fujimoto Keiichi, Bashuda Hisashi, Takeda Kazuyoshi, Mejima Mio, Yagita Hideo, Okumura Ko
TRANSPLANTATION   102 S732   Jul 2018   [Refereed]
Cell death of activated lymphocytes and lymphoma/leukemia cells induced by MHC class I and II mAb. (Anapocosis)
Matsuoka Shuji, Mizutani Natsuko, Yagita Hideo, Takamatsu Hiroyuki, Hino Okio
CANCER SCIENCE   109 546   Jan 2018   [Refereed]
Sunitinib improves tumor microenvironment and augments the T cell infiltration and the effect of immunotherapy by DR-5
Tsukita Yoko, Okazaki Tatsuma, Sato Yasufumi, Yagita Hideo, Ichinose Masakazu
CANCER SCIENCE   109 120   Jan 2018   [Refereed]
Natural and induced iNKT regulation of intestinal tumor immunity
Wang Ying, Sedimbi Saikiran, Lofbom Linda, Singh Avadhesh K., Porcelli Steven A., Yagita Hideo, Cardell Susanna L.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY   86(4) 262   Oct 2017   [Refereed]
Schrand Brett, Verma Bhavna, Levay Agata, Patel Shradha, Castro Iris, Benaduce Ana Paula, Brenneman Randall, Umland Oliver, Yagita Hideo, Gilboa Eli, Ishkanian Adrian
CANCER RESEARCH   77    Jul 2017   [Refereed]
Role of B7-H3/TLT-2 pathway in immune privilege of corneal allografts
Taniguchi Hiroko, Hase Hidenori, Akiba Hisaya, Yagita Hideo, Azuma Miyuki, Hori Junko
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   58(8)    Jun 2017   [Refereed]
Tsukita Yoko, Okazaki Tatsuma, Komatsu Riyo, Nihei Mayumi, Kobayashi Makoto, Sato Yasufumi, Yagita Hideo, Ichinose Masakazu
JOURNAL OF CLINICAL ONCOLOGY   35    May 2017   [Refereed]
Muraoka Daisuke, Harada Naozumi, Seo Naohiro, Hayashi Tae, Fujii Keisuke, Yamaguchi Rui, Imoto Seiya, Miyano Satoru, Yagita Hideo, Akiyoshi Kazunari, Shiku Hiroshi
CANCER IMMUNOLOGY RESEARCH   5(3)    Mar 2017   [Refereed]
Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts
Taniguchi Hiroko, Kunishige Tomoyuki, Akiba Hisaya, Yagita Hideo, Abe Ryo, Hori Junko
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   57(12)    Sep 2016   [Refereed]
Anti-CD272 antibody (6B2) induced prolongation of fully MHC-mismatched murine cardiac allograft and generation of Foxp3+regulatory T cells
Uchiyama Masateru, Yin Enzhi, Jin Xiangyuan, Yanangisawa Takako, Mizuno Satoko, Yagita Hideo, Niimi Masanoti
TRANSPLANTATION   100(7) S499   Jul 2016   [Refereed]
Dual Blockade of OX40 and CD30 Signaling Reduces Memory Th2-driven Lung Inflammatory Responses to House Dust Mite Allergen
Gracias Donald Tom, Mehta Amit Kumar, Yagita Hideo, Croft Michael
JOURNAL OF IMMUNOLOGY   196    May 2016   [Refereed]
Field Cameron S., Hunn Martin K., Ferguson Peter M., Yagita Hideo, Hermans Ian F., Ancelet Lindsay R.
CANCER IMMUNOLOGY RESEARCH   4(1)    Jan 2016   [Refereed]
The Notch Ligand DLL4 Derived from Human Dendritic Cells Is Critical for Promoting T Helper (Th)1 and Th17 Cell Differentiation
Meng Lijun, Bai Zhenjiang, He Shan, Mochizuki Kazuhiro, Purushe Janaki, Sun Hongxing, Wang Jian, Yagita Hideo, Mineishi Shin, Fung Henry, Yanik Gregory A., Caricchio Roberto, Fan Xiaoxuan, Crisalli Lisa M., Reshef Ran, Zhang Yanyun, Zhang Yi
BLOOD   126(23)    Dec 2015   [Refereed]
Programming of Donor T Cells Using Allogeneic Delta-like Ligand 4-Positive Dendritic Cells to Reduce Gvhd but Retain GVL Activity
Mochizuki Kazuhiro, Meng Lijun, Mochizuki Izumi, Tong Qing, He Shan, Liu Yongnian, Purushe Janaki, Sun Hongxing, Fung Henry, Zaidi Raza, Reshef Ran, Blazar Bruce R., Yagita Hideo, Mineishi Shin, Zhang Yi
BLOOD   126(23)    Dec 2015   [Refereed]
PD-1 Signaling Has a Critical Role in Maintaining Regulatory T Cell Homeostasis; Implication for Treg Depletion Therapy By PD-1 Blockade
Asano Takeru, Kishi Yuriko, Meguri Yusuke, Yoshioka Takanori, Iwamoto Miki, Maeda Yoshinobu, Yagita Hideo, Tanimoto Mitsune, Koreth John, Ritz Jerome, Matsuoka Ken-Ichi
BLOOD   126(23)    Dec 2015   [Refereed]
Navet Benjamin, Ando Kosei, Yagita Hideo, Mueller Christopher G., Heymann Dominique, Lezot Frederic
CANCER RESEARCH   75    Aug 2015   [Refereed]
Finnberg Niklas K., Gokare Prashanth, Navaraj Arunasalam, Kuhs Krystle A. Lang, Cerniglia George, Yagita Hideo, Takeda Kazuyoshi, Motoyama Noboru, El-Deiry Wafik S.
CANCER RESEARCH   75    Aug 2015   [Refereed]
Lezot Frederic P., Navet Benjamin, Choi YongWon, Yagita Hideo, Berdal Ariane, Mueller Christopher G., Redini Francoise, Heymann Dominique
CANCER RESEARCH   75    Aug 2015   [Refereed]
FasL-expressing B cells are major players in type 1 diabetes
Saxena Ankit, Xiao Zuoxiang, Yagita Hideo, Larman Ben, Donner Thomas, Hamad Abdel Rahim
JOURNAL OF IMMUNOLOGY   194    May 2015   [Refereed]
Type I interferons promote lupus through disruption of the lymphotoxin receptor mediated mechanosensing MKL1 pathway in marginal zone macrophages
Mountz John, Li Hao, Hsu Hui-Chen, Zhou Yong, Wu Qi, Yang PingAr, Li Jun, Luo Bao, Morel Laurence, Ware Carl, Fu Yang, Yagita Hideo
JOURNAL OF IMMUNOLOGY   194    May 2015   [Refereed]
Tumour necrosis factor-related apoptosis inducing ligand promotes the development of experimental chronic obstructive pulmonary disease
Hansbro Philip, Haw Tatt, Nair Prema, Hanish Irwan, Nguyen Duc, Liu Gang, Inman Mark, Kim Richard, Collison Adam, Knight Darryl, Yagita Hideo, Mattes Joerg, Horvat Jay, Starkey Malcolm
JOURNAL OF IMMUNOLOGY   194    May 2015   [Refereed]
Enhanced Expression of PD-1 Modulates CD4+Foxp3+Regulatory T Cell Homeostasis during Low-Dose IL-2 Therapy in Patients with Chronic Graft-Versus-Host Disease
Asano Takeru, Kim Haesook T., Koreth John, Soiffer Robert J., Meguri Yusuke, Yoshioka Takanori, Yagita Hideo, Tanimoto Mitsune, Ritz Jerome, Matsuoka Ken-ichi
BLOOD   124(21)    Dec 2014   [Refereed]
Marriott Clare L., Ferreira Cristina, Veldhoen Marc, Yagita Hideo, Withers David R.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY   80(3) 226   Sep 2014   [Refereed]
Combination immunotherapy with 4-1BB mAb and PD-1 mAb enhances antitumor efficacy in mouse subcutaneous model
新藤 芳太郎, 吉村 清, 倉増 敦朗, 伊藤 秀明, 小賀 厚徳, 前田 訓子, 吉野 茂文, 硲 彰一, 玉田 耕治, 八木田 秀雄, 岡 正朗
日本癌学会総会記事   73回 J-3045   Sep 2014
Therapeutic Anti-pan HLA class II mAb induce the Death of Leukemia/Lymphoma Cells via Large Pore Formation
松岡 周二, 水谷 奈津子, 八木田 秀雄, 樋野 興夫
日本癌学会総会記事   73回 P-3183   Sep 2014
Anti-tumor effects of mAb against a new immune-checkpoint molecule VISTA
近藤 雄太, 大野 建州, 張 晨陽, 八木田 秀雄, 原田 清, 東 みゆき
日本癌学会総会記事   73回 P-3194   Sep 2014
Amelioration of Adipose Inflammation and Insulin Resistance by Targeting Programmed Death 1+ adipose T Cells
白川 公亮, 佐野 元昭, 遠藤 仁, 玉城 香代子, 伊藤 健太郎, 山本 恒久, 勝俣 良紀, 安西 淳, 松橋 智弘, 福田 恵一, 森本 耕吉, 渡邊 光博, 八木田 秀雄, 新村 健
日本抗加齢医学会総会プログラム・抄録集   14回 315-315   Jun 2014
Condamine Thomas, Kumar Vinit, Ramachandran Indu, Youn Je-In, Celis Esteban, Finnberg Niklas, El-Deiry Wafik, Winograd Rafael, Vonderheide Robert, English Nickolas, Knight Stella, Yagita Hideo, Mccaffrey Judith, Antonia Scott, Hockstein Neil, Witt Robert, Masters Gregory, Bauer Thomas, Gabrilovich Dmitry
JOURNAL OF IMMUNOLOGY   192    May 2014   [Refereed]
TNF receptor superfamily costimulation couples TCR signal strength to thymic Treg differentiation
Farrar Michael, Mahmud Shawn, Manlove Luke, Schmltz Heather, Xing Yan, Wang Yanyan, Owen David, Schenkel Jason, Boomer Jonathan, Green Jonathan, Yagita Hideo, Chi Hongbo, Hogquist Kristin
JOURNAL OF IMMUNOLOGY   192    May 2014   [Refereed]
NOTCH2 SIGNALING AMELIORATES NEPHROSIS AND GLOMERULOSCLEROSIS
Eriko Tanaka, Katsuhiko Asanuma, Masatoshi Takagi, Akemi Koyanagi, Shuki Mizutani, Hideo Yagita, Yasuhiko Tomino
NEPHROLOGY   19 49   May 2014   [Refereed]
Suzui Masatoshi, Ichinose Masashi, Takeda Kazuyoshi, Yagita Hideo, Shek Pang N., Shephard Roy J., Okumura Ko
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   46(5) 917   May 2014   [Refereed]
McGrath Martina, Guleria Indira, Tripathi Sudipta, Yeung Melissa, Dakle Pranal, Chabtini Lola, Smith Brian, Najafian Nader, Akiba Hisaya, Yagita Hideo
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY   210(1) S397   Jan 2014   [Refereed]
Clostridium butyricum Induces Intestinal IL-10-Produincg Macrophages to Suppress Acute Colitis
Hayashi Atsushi, Kanai Takanori, Mikami Yohei, Sujino Tomohisa, Mizuno Shinta, Handa Tango, Matsumoto Atsuhiro, Matsuoka Katsuyoshi, Sato Toshiro, Hisamatsu Tadakazu, Yagita Hideo, Hibi Toshifumi
DIGESTION   89(1) 84-85   2014   [Refereed]
Host Tissue PD-1 Pathway Contribute To Murine Chronic Graft-Versus-Host Disease Via Th1+Th17+Cells
Fujiwara Hideaki, Maeda Yoshinobu, Kobayashi Koichiro, Nishimori Hisakazu, Matsuoka Ken-ichi, Azuma Miyuki, Yagita Hideo, Chen Lieping, Tanimoto Mitsune
BLOOD   122(21)    Nov 2013   [Refereed]
Activation of autophagy by TIM4-AMPK-α1 interaction in tumor-associated macrophages suppresses antitumor immunity
地主 将久, バグダディー・ムハマド, 米田 明弘, 吉山 裕規, 八木田 秀雄
日本癌学会総会記事   72回 145-145   Oct 2013
Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established tumors
バグダーディ・ムハンマド, 吉山 裕規, 八木田 秀雄, 秋田 弘俊, 地主 将久
日本癌学会総会記事   72回 149-149   Oct 2013
Notch2 ameliorates nephrosis and glomerulosclerosis through Akt pathway
Tanaka Eriko, Asanuma Katsuhiko, Kim Eunhee, Oliva Trejo Juan Alejandro, Nonaka Kanae, Koyanagi Akemi, Takagi Msatoshi, Mizutani Shuki, Yagita Hideo, Tomino Yasuhiko
PEDIATRIC NEPHROLOGY   28(8) 1438-1439   Aug 2013   [Refereed]
Dual functions of PD-1 in CD4+T cell responses by sublingual mucosa-mediated antigen application
Ohno Tatsukuni, Zhang Chenyang, Yagita Hideo, Azuma Miyuki
JOURNAL OF IMMUNOLOGY   190    May 2013   [Refereed]
Clostridium Butyricum Regulates IL-10 Production in Normal and Inflammatory Conditions Through Different Target Cells
Hayashi Atsushi, Kanai Takanori, Sato Toshiro, Mikami Yohei, Matsuoka Katsuyoshi, Hisamatsu Tadakazu, Yoshimura Akihiko, Kamada Nobuhiko, Yagita Hideo, Hibi Toshifumi
GASTROENTEROLOGY   144(5) S895   May 2013   [Refereed]
Effect Of OLL 1073R-1 Yogurt Intake On NK Cell Receptors During Intense Training
Suzui Masatoshi, Takeda Kazuyoshi, Nagatomi Ryoichi, Yagita Hideo, Okumura Ko, Ikegami Shuji, Ito Hiroyuki, Shek Pang N., Shephard Roy J.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   45(5) 469   May 2013   [Refereed]
Bransi Ali, Yagita Hideo, Knuth Alexander, van den Broek Maries
CANCER RESEARCH   73    Jan 2013   [Refereed]
Gupta Anurag K., Probst Hans Christian, Van Vuong, Landshammer Alexandro, Muth Sabine, Yagita Hideo, Schwendener Reto, Pruschy Martin, Knuth Alexander, van den Broek Maries
CANCER RESEARCH   73    Jan 2013   [Refereed]
Radiotherapy combined with multiple immune-modulatory antibodies ('radio-immunotherapy') cures mice bearing established mammary tumours
Verbrugge Inge, Hagekyriakou Jim, Sharp Leslie L., Galli Mara, West Alison, McLaughlin Nicole M., Duret Helene, Yagita Hideo, Johnstone Ricky W., Smyth Mark J., Haynes Nicole M.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE   32 S19   2013   [Refereed]
Notch Signaling by Delta-Like 4 In Macrophages Contributes to Lesion Formation after Vascular Injury
Fukuda Daiju, Yagita Hideo, Aikawa Masanori
CIRCULATION   126(21)    Nov 2012   [Refereed]
Identification of Previously Uncharacterized Delta 4-Positive Inflammatory Plasmacytoid Dendritic Cells That Play Important Roles in Eliciting Graft-Versus-Host Disease in Mice
Mochizuki Kazuhiro, Xie Fang, He Shan, Tong Qing, Liu Yongnian, Guo Yajun, Kato Koji, Yagita Hideo, Mineishi Shin, Zhang Yi
BLOOD   120(21)    Nov 2012   [Refereed]
Regulatory T Cells and Myeloid-derived Suppressor Cells in the Tumor Microenvironment Undergo FAS-dependent Cell Death During IL-2/ACD40 Therapy
Weiss Jonathan M., Subleski Jeff J., Back Tim, Chen Xin, Watkins Stephanie K., Yagita Hideo, Sayers Thomas J., Murphy William J., Wiltrout Robert H.
JOURNAL OF IMMUNOTHERAPY   35(9) 753   Nov 2012   [Refereed]
ROR gamma t-dependent Pathological NKT Cells and Protective Innate Lymphoid Cells Regulate Hepatic Immune Responses in the Development of the Acute Hepatitis
Matsumoto Atsuhiro, Kanai Takanori, Mikami Yohei, Nakamoto Nobuhiro, Chu Po-sung, Ebinuma Hirotoshi, Sato Toshiro, Yagita Hideo, Hibi Toshifumi
HEPATOLOGY   56 245A-246A   Oct 2012   [Refereed]
CONTEXT- AND CELL-DEPENDENT DLL4 BLOCKADE EFFECTS IN THE BONE MARROW MICROENVIRONMENT
Remedio Leonor, Carvalho Tania, Caiado Francisco, Bastos Ana, Duarte Antonio, Yagita Hideo, Dias Sergio
EXPERIMENTAL HEMATOLOGY   40(8) S96   Aug 2012   [Refereed]
TIM-4 blockade augments therapeutic efficacy of chemotherapy by immune-mediated mechanisms
Haghdadi Muhammad, 千葉 殖幹, 吉山 裕規, 秋葉 久弥, 八木田 秀雄, 地主 将久
日本癌学会総会記事   71回 112-112   Aug 2012
Tumor associated dendritic cell suppresses the nucleic acids-mediated innate immune response in a TIM-3-dependent manner
千葉 殖幹, ムハンマド・バグダーディー, 秋葉 久弥, 吉山 裕規, 上出 利光, 高岡 晃教, 八木田 秀雄, 地主 将久
日本癌学会総会記事   71回 113-113   Aug 2012
Simultaneous blockade of PD-1 and VEGFR-2 induces synergistic antitumor effect
安田 里司, 庄 雅之, 山戸 一郎, 八木田 秀雄, 中島 祥介
日本癌学会総会記事   71回 147-147   Aug 2012
Therapeutic effect of cytolytic anti-pan HLA class II mAb on Hodgkin, Non Hodgkin Lymphoma and Adult T cell leukemia
松岡 周二, 石井 保之, 八木田 秀雄, 増谷 弘, 前田 道之, 杉本 耕一, 荒瀬 尚, 大辻 奈穂美, 阿部 雅明, 樋野 興夫
日本癌学会総会記事   71回 300-300   Aug 2012
Impact of Acute Exercise on Natural Killer Cell Subset Distributions in Selected Mouse Tissues
Suzui Masatoshi, Takeda Kazuyoshi, Hayakawa Yoshihiro, Yagita Hideo, Okumura Ko, Shek Pang N., Shephard Roy J.
JOURNAL OF GENERAL INTERNAL MEDICINE   27 684-685   Jul 2012   [Refereed]
RANK-ligand activates stroma in postnatal lymph node growth
Mueller Christopher, Hess Estelle, Golub Rachel, Choi Yongwon, Hideo Yagita
JOURNAL OF IMMUNOLOGY   188    May 2012   [Refereed]
Enhanced CD8 T cell expansion and protective immunity during VSV infection by agonistic anti-CD40 is dependent on CD70 and accessory signals
Zickovich Julianne, Yagita Hideo, Obar Joshua
JOURNAL OF IMMUNOLOGY   188    May 2012   [Refereed]
The role of ICOS co-stimulation on CD8 T cell differentiation during infection.
Mouries Juliette, Yagita Hideo, Lefrancois Leo
JOURNAL OF IMMUNOLOGY   188    May 2012   [Refereed]
Rival Claudia, Samy Eileen, Setiady Yulius, Sun Yuefang, Sparks Joshua, Yagita Hideo, Tung Kenneth
JOURNAL OF IMMUNOLOGY   188    May 2012   [Refereed]
Effects of Acute Exercise on Expressions of Natural Killer Cell Receptors
Suzui Masatoshi, Takeda Kazuyoshi, Yagita Hideo, Okumura Ko, Shek Pang N., Shephard Roy J.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   44 822   May 2012   [Refereed]
Zhou Hong, Ekmekcioglu Suhendan, Marks John W., Asrani Kaushal, Phillips Keeley K., Brown Sharron, Cheng Emily, Weiss Michele B., Hittelman Walter N., Tran Nhan L., Yagita Hideo, Winkles Jeffrey A., Rosenblum Michael G.
CANCER RESEARCH   72    Apr 2012   [Refereed]
Peng Weiyi, Liu Chenwen, Xu Chunyu, Chen Jieqin, Lou Yanyan, Overwijk Willem, Lizee Gregory, Yagita Hideo, Hwu Patrick
CANCER RESEARCH   72    Apr 2012   [Refereed]
Kato Kazunori, Takenouchi Makoto, Sakuragi Naoya, Yagita Hideo
CANCER RESEARCH   72    Apr 2012   [Refereed]
Hotta Kiyohiko, Sho Masayuki, Yamato Ichiro, Harada Hiroshi, Yagita Hideo, Nakajima Yoshiyuki, Nonomura Katsuya
JOURNAL OF UROLOGY   187(4) E912-E913   Apr 2012   [Refereed]
Blockade of Delta-Like 4 Prevents Lesion Formation After Vascular Injury
Fukuda Daiju, Yagita Hideo, Aikawa Masanori
CIRCULATION   124(21)    Nov 2011   [Refereed]
Dll4 Blockade Modifies the Bone Marrow Vascular Niche and Improves Donor Bone Marrow Cells for Bone Marrow Transplant
Remedio Leonor, Carvalho Tania, Caiado Francisco, Carvalho Ana Bastos, Duarte Antonio, Yagita Hideo, Dias Sergio
BLOOD   118(21) 583   Nov 2011   [Refereed]
BCR-ABL Regulates Death Receptor Expression for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Philadelphia Chromosome-Positive Leukemia
Kuroda Itaru, Inukai Takeshi, Zhang Xiaochun, Kikuchi Jiro, Furukawa Yusuke, Nemoto Atsushi, Akahane Koshi, Hirose Kinuko, Honna-Oshiro Hiroko, Goi Kumiko, Kagami Keiko, Yagita Hideo, Tauchi Tetsuzo, Maeda Yasuhiro, Sugita Kanji
BLOOD   118(21) 1178-1179   Nov 2011   [Refereed]
Blockade of Delta-like1 Suppresses Osteoclastgenesis and Arthritis
Sekine Chiyoko, Koyanagi Akemi, Koyama Noriko, Hozumi Katsuto, Chiba Shigeru, Yagita Hideo
ARTHRITIS AND RHEUMATISM   63(10) S705   Oct 2011   [Refereed]
APC-derived TIM3 is a novel target for stimulating innate and adaptive antitumor immunity
ムハンマド・バグダーディー, 千葉 殖幹, クラン・マイケル, アリソン・ジェームス, 八木田 秀雄, 秋田 弘俊, 高岡 晃教, 地主 将久
日本癌学会総会記事   70回 80-80   Sep 2011
Tumor-associated dendritic cells suppress nucleic acids-mediated innate immune recognition in an TIM-3-dependent manner
千葉 殖幹, ムハンマド・バグダーディー, 八木田 秀雄, 吉山 裕規, 高岡 晃教, 上出 利光, 地主 将久
日本癌学会総会記事   70回 217-217   Sep 2011
ATM-mediated DNA damage signals suppress antitumor immunity by integrin-αvβ3-dependent mechanisms
地主 将久, 千葉 殖幹, 高岡 晃教, 上出 利光, 八木田 秀雄
日本癌学会総会記事   70回 271-271   Sep 2011
NON-MYELOABLATIVE TRANSPLANTATION OF SELF-ANTIGEN EXPRESSING BONE MARROW PREVENTS AUTOIMMUNE DISEASE BY PERIPHERAL TOLERANCE MECHANISM
Chan James, Hosseini Hamid, Oh Ding Yuan, Chan Siow T., Chen Xiang T., Yagita Hideo, Alderuccio Frank, Toh Ban-Hock
JOURNAL OF GENE MEDICINE   13(43289) 423-424   Jul 2011   [Refereed]
Suzui Masatoshi, Takeda Kazuyoshi, Hayakawa Yoshihiro, Yagita Hideo, Okumura Ko, Shek Pang N., Shephard Roy J.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   43(5) 684-685   May 2011   [Refereed]
Zhou Hong, Marks John W., Ekmekcioglu Suhendan, Hittelman Walter N., Nhan Tran, Yagita Hideo, Winkles Jeffrey A., Rosenblum Michael G.
CANCER RESEARCH   71    Apr 2011   [Refereed]
A marked expansion of villous M cells occurs in the terminal ileum of B cell- and IgA-deficient mice that requires both the commensal microflora and RANKL
Knoop Kathryn A., Butler Betsy R., Yagita Hideo, Williams Ifor R.
FASEB JOURNAL   25    Apr 2011   [Refereed]
Functionally impaired memory CD8 T cells are generated after vesicular stomatitis virus infection
Obar Joshua, Zickovich Julianne, Meyer Susan, Yagita Hideo, Noelle Randolph
JOURNAL OF IMMUNOLOGY   186    Apr 2011   [Refereed]
The elucidation of the oral/respiratory axis in inducing protective immunity against Francisella tularensis
Signarovitz Aimee, Yu Jieh-Juen, Ray Heather, Guentze M. Neal, Williams Ifor, Yagita Hideo, Berton Michael, Klose Karl, Arulanandam Bernard
JOURNAL OF IMMUNOLOGY   186    Apr 2011   [Refereed]
INDUCTION OF PRIMARY SCLEROSING CHOLANGITIS-LIKE DISEASE BY DR5-MEDIATED APOPTOSIS
Takeda Kazuyoshi, Kojima Yuko, Yagita Hideo, Smyth Mark J., Okumura Ko
ADVANCES IN TNF FAMILY RESEARCH   691 782   2011   [Refereed]
The role of PD-1/PD-L pathway in the development of Theiler's Murine Encephalomyelitis Virus - Induced dymyelinating disease
Sho Takizawa, Tomoaki Kaneyama, Naoya Takeichi, Satoshi Yanagisawa, Hideo Yagita, Byung S Kim, Chang-Sung Koh
JOURNAL OF NEUROIMMUNOLOGY   228(43102) 202-203   Nov 2010   [Refereed]
The principles of tumor immunology
八木田 秀雄
日本癌学会総会記事   69回 381-381   Aug 2010
The fibrinolytic system regulates tumor growth via MMP-9: implications for novel therapeutic target
石原 誠人, 山本 玲, 八木田 秀雄, 奥村 康, ハイジッヒ・ベアテ, 服部 浩一
日本癌学会総会記事   69回 399-400   Aug 2010
Antibody therapy Epigenetic modulation enhances therapeutic effect of anti-IL13R alpha 2 antibody in human mesothelioma xenografts
竹之内 信, 桜木 直也, 平井 幸恵, 八木田 秀雄, 濱田 洋文, 加藤 和則
日本癌学会総会記事   69回 425-425   Aug 2010
Suzui Masatoshi, Takeda Kazuyoshi, Taga Tsuneo, Yagita Hideo, Okumura Ko, Shek Pang N., Shephard Roy J.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   42(5) 367   May 2010   [Refereed]
Immune Molecular Plasticity Links Viral Virulence to Protective T cell Vaccines
Salek-Ardakani Shahram, Flynn Rachel, Arens Ramon, Yagita Hideo, Smith Geoffrey, Borst Jannie, Schoenberger Stephen, Croft Michael
JOURNAL OF IMMUNOLOGY   184    Apr 2010   [Refereed]
NOVEL ROLE OF THE TIM-4 MOLECULE IN ALLOIMMUNITY
Yeung Melissa Y., Ueno Takuya, Akiba Hisaya, Yagita Hideo, Najafian Nader, Sayegh Mohamed
AMERICAN JOURNAL OF KIDNEY DISEASES   55(4) A113   Apr 2010   [Refereed]
Targeting Fibroblast Growth Factor-Inducible 14 Prevents Acute and Chronic Injury after Renal Ischemia Reperfusion
Hotta Kiyohiko, Sho Masayuki, Yamato Ichiro, Harada Hiroshi, Yagita Hideo, Nonomura Katsuya, Nakajima Yoshiyuki
AMERICAN JOURNAL OF TRANSPLANTATION   10 80   Apr 2010   [Refereed]
Jagged2 Signaling Antibody Precipitates Rejection in a Treg-Dependent Model through IL-6 Upregulation and Consequent Treg Malfunction.
Riella Leonardo V., Robles Susanne, Yang Jun, Boenisch Olaf, Yagita Hideo, Sayegh Mohamed H., Chandraker Anil
AMERICAN JOURNAL OF TRANSPLANTATION   10 98   Apr 2010   [Refereed]
TIM-4: A Key Molecule in Conversion of Naive CD4+T Cells into Regulatory T Cells.
Yeung Melissa Y., Ueno Takuya, Akiba Hisaya, Yagita Hideo, Najafian Nader, Sayegh Mohamed
AMERICAN JOURNAL OF TRANSPLANTATION   10 106   Apr 2010   [Refereed]
Central Role of Interleukin-6 in TIM-3: Galectin-9-Mediated Regulation of Alloimmunity
Boenisch Olaf, D'Addio Francesca, Watanabe Toshihiko, Yagita Hideo, Akiba Hisaya, Najafian Nader
AMERICAN JOURNAL OF TRANSPLANTATION   10 159   Apr 2010   [Refereed]
Targeting Notch Ligand Delta1 Can Promote Cardiac Allograft Survival
Riella Leonardo V., Ueno Takuya, Yang Jun, Yagita Hideo, Chandraker Anil, Najafian Nader
AMERICAN JOURNAL OF TRANSPLANTATION   10 182   Apr 2010   [Refereed]
Intact TIM-3: Galectin-9 Regulatory Pathway Is Crucial for the Induction of CTLA4-Ig-Mediated Acquired Tolerance
Watanabe Toshihiko, Boenisch Olaf, Yagita Hideo, Akiba Hisaya, Najafian Nader
AMERICAN JOURNAL OF TRANSPLANTATION   10 183   Apr 2010   [Refereed]
Hotta Kiyohiko, Sho Masayuki, Yamato Ichiro, Harada Hiroshi, Akahori Takahiro, Nakamura Shinji, Yagita Hideo, Nonomura Katsuya, Nakajima Yoshiyuki
JOURNAL OF UROLOGY   183(4) E803   Apr 2010   [Refereed]
Regulatory Function of Galectin-9 in Allograft Rejection and Acquired Tolerance
Watanabe Toshihiko, Boenisch Olaf, Yagita Hideo, Akiba Hisaya, Najafian Nader
AMERICAN JOURNAL OF TRANSPLANTATION   10 16   Jan 2010   [Refereed]
Elyaman Wassim, Bradshaw Elizabeth, Bassil Ribal, Lahoud Youmna, Zhu Bing, Yagita Hideo, Khoury Samia
CLINICAL IMMUNOLOGY   135 S123   2010   [Refereed]
Bassil Ribal, Lahoud Youmna, Zhu Bing, Yagita Hideo, Elyaman Wassim, Khoury Samia
CLINICAL IMMUNOLOGY   135 S125   2010   [Refereed]
Blockade of the Notch Ligand Delta-like 4 (DII4) Prevents the Cardiometabolic Syndrome
Fukuda Daiju, Aikawa Elena, Yamazaki Hiroyuki, Yagita Hideo, Aikawa Masanori
CIRCULATION   120(18) S1166   Nov 2009   [Refereed]
Protective role of ICOS/B7RP-1 pathway in acceptance of corneal allografts
堀 純子, 谷口 ヒロ子, 東 みゆき, 秋葉 久弥, 八木田 秀雄, 安部 良
日本免疫学会総会・学術集会記録   39 178-178   Nov 2009
Deletion of tnfri gene rescues severe inflammatory bowel disease in traf2-/- mice
Piao Jianghu, 長谷川 瑞穂, 猪原 直弘, 竹田 和由, 八木田 秀雄, 奥村 康, 中野 裕康
日本免疫学会総会・学術集会記録   39 188-188   Nov 2009
TIM4 regulates asthmatic response in a murine model of asthma
伊藤 潤, 牧野 文彦, アラ・フセイン, 八木田 秀雄, 奥村 康, 高橋 和久, 秋葉 久弥
日本免疫学会総会・学術集会記録   39 220-220   Nov 2009
Clinical significance and therapeutic potential of T cell negative regulatory pathway in gastrointestinal cancer
野見 武男, 庄 雅之, 山戸 一郎, 赤堀 宇広, 童 仁, 北東 大督, 山田 高嗣, 高 済峯, 金廣 裕道, 八木田 秀雄, 中島 祥介
日本癌学会総会記事   68回 389-389   Aug 2009
Clinical importance and therapeutic potential of targeting B7-H3 in pancreatic cancer
Yamato Ichiro, Sho Masayuki, Nomi Takeo, Akahori Takahiro, Kanehiro Hiromichi, Shimada Keiji, Konishi Noboru, Yagita Hideo, Nakajima Yoshiyuki
CANCER RESEARCH   69    May 2009   [Refereed]

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2005 - 2009    Investigator(s): Hideo YAGITA
By characterizing the molecular mechanism of tumor cell recognition and lysis by cytotoxic T cells and natural killer cells, we have developed the anti-DR5 therapy which mimics it. We have also developed novel strategies to augment anti-tumor immu...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2002 - 2004    Investigator(s): Hideo YAGITA
(1)We have identified a novel transcriptional activator named BSAC, which suppresses TNF-induced cell death. We have also revealed that TRAF-mediated NF-κB activation suppresses TNF-induced ROS accumulation, which leads to prolonged JNK activation...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究(C), 特定領域研究)
Project Year: 2001 - 2004    Investigator(s): Hideo YAGITA
(1) We have revealed that the anti-metastatic effect of a-GalCer, a specific activator of NKT cells, is not mediated by cytolytic activity of NKT cells but by IFN-γ, which secondarily activates NK cells to produce sustained IFN-γ. We have also rev...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1996 - 1998    Investigator(s): Hideo YAGITA
1, The cardiac allograft tolerance induced by the anti-LFA-l/ICAM-1 treatment was mainly mediated by the inactivation of allogeneic classi-reactive CD8^+ T cells, whereas that induced by anti-CD/fCD48 or anti-CD8O/CD86 was mediated by Th2 deviatio...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(B))
Project Year: 1993 - 1995    Investigator(s): Hideo YAGITA
1. We succeeded to establish monoclonal antibodies against mouse CD48 (CD2 ligand), CD80 (B7-1), CD86 (B7-2), CD29 (integrin beta1), CD49a (integrin alpha1), CD49b (alpha2), CD49e (alpha5), CD49f (alpha6), CD40, CD40 ligand, CD95 ligand, that agai...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(B))
Project Year: 1990 - 1992    Investigator(s): Hideo YAGITA
(1)We revealed that CD4 and CD8 regulate IL-2 response of T cells via activation of p56^<lck> associated with them.(2)We demonstrated that CD2-mediated signal plays an important role in T and NK cell activation.(3)We revealed that CD48 is the pred...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1988 - 1989    Investigator(s): Hideo YAGITA
1. We cloned and sequenced the murine CD2 cDNA and noted a highly conserved primary structure of its cytoplasmic region between human and mouse CD2.2. We established five rat anti-mouse CD2 mAbs by screening their reactivities to rat fibroblasts t...
tumor immunology
autoimmune disease
Transplantation immunology

Works

 
Molecular mechanisms that control NK cell-mediated tumor surveillance
2001 - 2003