2002年10月
Phytoestrogen concentrations in serum from Japanese men and women over forty years of age
JOURNAL OF NUTRITION
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- 巻
- 132
- 号
- 10
- 開始ページ
- 3168
- 終了ページ
- 3171
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- AMER INST NUTRITION
Asian individuals have much lower incidences of prostate and breast cancer than populations from Western developed countries. They also consume a lower fat, higher fiber diet, with a large intake of phytoestrogens. These phytoestrogens may protect against hormone-dependent cancers and other diseases. Our study used established gas chromatography-mass spectrometry (GCMS) methodologies to measure the concentrations of four phytoestrogens (daidzein, genistein, equol and enterolactone) in serum samples obtained from Japanese men (n = 102) and women (n = 125) > 40 y old. The results were compared with those obtained with samples from the UK. The Japanese men and women had higher (P < 0.001) concentrations of circulating daidzein, genistein and equol than individuals from the UK. The mean concentration of genistein in Japanese men, for example, was 492.7 nmol/L, compared with 33.2 nmol/L in men from the UK. The two populations, however, had similar serum concentrations of enterolactone. Furthermore, 58% of the Japanese men and 38% of the Japanese women had equol concentrations > 20 nmol/L, compared with none of the UK men and 2.2% of the UK women. These results support previously published GC-MS results from studies with low numbers of samples.
- リンク情報
- ID情報
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- ISSN : 0022-3166
- Web of Science ID : WOS:000178447600031