J-GLOBAL         Last updated: Aug 8, 2019 at 10:31
Meikai University
School of Dentistry
Job title
Professor,Director, Meikai-Pharmaco-Medical Laboratory (MPL),Chairman, International Exchange Committe, School of Dentistry,Director, Media Center
(BLANK)(The University of Tokyo), (BLANK)(Showa University)
Research funding number


I have following three major research projects
(1) Search for the compounds that selectively kill oral squamous cell carcinoma cell lines
(2) Pharmacological action of lignin-carbohydrate complex: identification of receptor and signaling pathway
(3) Saliva diagnostic markers: evidence for the biological efficacy of natural products against stomatitis
(4) Glycine as a marker of aging

Research Areas


Academic & Professional Experience

Apr 2017
Full-time professor, Meikai University School of Dentistry
Apr 2017
Director, Meikai University Research Institute of Odontoloty (M-RIO)
Apr 1999
Mar 2017
Head, Pharmaco-Medical Laboratory, Meikai University School of Dentistry
Apr 1997
Mar 2017
Chief Professor, Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
- Showa University, Research Assistant
Roswell Part Memorial Institute, Research Assistant
Showa University, Assistant Professor
Showa University, Associate Professor
- Meikai Univrtsity, Professor


Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
Faculty of Pharmaceutical Science, The University of Tokyo

Published Papers

Kobayashi M, Nihonmatsu S, Okawara T, Onuki H, Sakagami H, Nakajima H, Takeishi H, Shimada J
In Vivo   33(4) 1067-1079   Jul 2019   [Refereed]
Uchida S, Kobayashi K, Ohno S, Sakagami H, Kohase H, Nagasaka H
Anticancer Research   39(7) 3519-3529   Jul 2019   [Refereed]
Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H
Anticancer Research   39(7) 3507-3518   Jul 2019   [Refereed]
Tugrak M, Gul HI, Bandow K, Sakagami H, Gulcin I, Ozkay Y, Supuran CT
Bioorg Chem      Jun 2019   [Refereed]
Gul HI, Tugrak M, Gul M, Mazlumoglu S, Sakagami H, Gulcin I, Supuran CT
Bioorg Chem      Jun 2019   [Refereed]
Nagai J, Imamura M, Sakagami H and Uesawa Y
Medicines   6(2)    Apr 2019   [Refereed]
Kadokura H, Yamazaki T, Masuda Y, Kato Y, Hasegawa A, Sakagami H, Yokose S
In Vivo   33(2) 349-352   Mar 2019   [Refereed]
Photodynamic therapy to eliminate Enterococcus faecalis with alkaline extract of the leaves of Sasa senanensis Rehder and diode laser
Masuda Y, Sakagami H, Kadokura H, Tamazaki T, Hasegawa A and Yokose S
日歯内療誌   40(1) 20-25   Feb 2019   [Refereed]
Watanabe S, Toyama T, Sato T, Suzuki M, Morozumi A, Sakagami H and Hamada N
Medicines   6(1)    Feb 2019   [Refereed]
Hara Y, Shiratsuchi H, Kaneko T and Sakagami H
Medicines   6(1)    Jan 2019   [Refereed]
Ozmen Ozgun D, Gul HI, Yamali C, Sakagami H, Gulcin I, Sukuroglu M, Supuran CT.
Bioorg Chem   84 511-517   Dec 2018   [Refereed]
Sakagami H, Watanabe T, Hoshino T, Suda N, Mori K, Yasui T, Yamauchi N, Kashiwagi H, Gomi T, Oizumi T, Nagai J, Uesawa Y, Takao K, Sugita Y.
Medicines   6(1)    Dec 2018   [Refereed]
Sakagami H, Sugimoto M, Kanda Y, Murakami Y, Amano O, Saitoh J and Kochi A
Medicines   5    Nov 2018   [Refereed]
Sano A, Shi H, Suzuki R, Shirataki Y and Sakagami H
In Vivo   32(6) 1403-1408   Nov 2018   [Refereed]
Gul HI, Yamali C, Gunesacar G, Sakagami H, Okudaira N, Uesawa Y and Kagaya H
Medicinal Chemistry   27(10) 2366-2378   Oct 2018   [Refereed]
Tugrak M, Gul HI, Sakagami H, Gulcin I, Claudiu T and Supuran CT
Bioorganic Chemistry   81 433-439   Sep 2018   [Refereed]
Nagai J, Shi H, Kubota Y, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K and Sugita Y
Anticancer Research   38(8) 4449-4457   Aug 2018   [Refereed]
Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K and Sugita Y
Anticancer Resarch   38(8) 4459-4467   Aug 2018   [Refereed]
Sakagami H, Shi H, Bandow K, Tomomura M, Tomomura A, Horiuchi M, Fujisawa T and Oizmi T
Molecules   23(8)    Jul 2018   [Refereed]


School cafeteria in the world (4) – University of the Western Cape
Sakagami H, Katsumata A, Fujiwara S, Den I, Pheko M, Malan SF, Lamson D, Bawa U, Rhoda A, Gottgens P, Osman Y and Ohtomo K
New Food Industry   61(8) 637-647   Aug 2019
The effects of the Sasa senanensis rehder leaf extract (Sasahealth) on the rat cultured pulp cells.
Masuda Y, Yokose S and Sakagami H
New Food Industry   61(5) 365-369   May 2019   [Refereed]
Re-evaluation of neuroprotective activity and hormesis effect of alkaline extract of leaves of Sasa sp. and polyphenols ― Analysis with PC12 neuron model cells prepared by overlay method
61(2) 99-106   Feb 2019   [Refereed]
Looking back our recent publications of the tumor-specificity of chromone derivatives
Sakagami H, Haixia S, Nagai J, Uesawa Y, Takao K and Sugita Y
New Food Industry 61(1): 11-18, 2019   61(1) 11-18   Jan 2019   [Refereed]
Efficacy of traditional medicine "Kampo"
Sakagami H, Shirataki Y and Shi H
New Food Industry   60(10) 69-73   Oct 2018   [Refereed]
School cafeteria in the world (3)-Cafeterlas in Minhang Campus of Shanghai Jiao Tong University
Shi H, Yan Z, Wei B and Sakagami H
New Food Industry   60(9) 43-49   Sep 2018   [Refereed]
School cafeteria in the world (2) - Leon unit of the National Autonomous University of Mexico (UNAM)
New Food INdustry   60(8) 73-79   Aug 2018   [Refereed]
Neuroprotective action and clinical effects of Angelica shikokiana Makino
斎田圭子、斎田悟、八幡由花紫、三間修、青木晃、Zhangentkhan Abylaiuly、Bolshakova SB、Bogenbayeva GA、Dalenov ED、福地邦彦、坂上 宏
New Food Industry   60(7) 39-48   Jul 2018   [Refereed]
The importance of international communication skills (6) - Health management method in stress society
坂上宏、戴秋娟、肖黎、郑燕、大石隆介、神崎龍志、土田幸広、中井延美、ガルシア-コントレラス レネ
New Food Industry   60(6) 57-69   Jun 2018
Neuroprotective action of Miso
Kojima M, Sano A, Suzuki R, Shitaraki Y and Sakagami H
New Food Industry   60(5) 79-83   May 2018

Books etc

Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions
SAKAGAMI Hiroshi et al., (Part:Joint Work)
Lightning Source UK Ltd   Jun 2019   ISBN:978-3-03897-992-0
Oral health is general health. If the oral cavity is kept healthy, the whole body is always healthy. Bacteria in the oral cavity do not stay in the oral cavity, but rather travel throughout the body and induce various diseases. Periodontal pathoge...
Temas selectos de biomedicina en Ciencias de la Salud
Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Sakagami H and Nakajima H (Part:Joint Work, Capitulo I Area Odontologia, Efecto citotoxico de las nanoparticulas de TiO2 en cultivo de celulas orales, p31-42, 2017)
Capitulo I Area Odontologia, Efecto citotoxico de las nanoparticulas de TiO2 en cultivo de celulas orales, p31-42, 2017   Aug 2017   ISBN:978-607-9426-99-6
Biological Activities and Action Mechanisms of Licorice Ingredients
SAKAGAMI Hiroshi (Part:Editor, Chapter 1. Introductory Chapter: Future Prospect of Licorice, Popular Crude Drug and Food Sweetener. pp3-12;Chapter 6. Applicability of Licorice Extracts for Treatment of Oral Diseases, Evaluated by Simplified In Vitro Assay Systems. pp91-106)
INTECH   Apr 2017   ISBN:978-953-51-5195-1
Therapeutic potential of solubilized nanolignin against oral diseases.
Sakagami H, Sheng H, Yasui T, Fukuchi K, Oizumi T, Ohno H, Yamamoto M, Fukuda T, Kotohda K, Yoshida H, Kanamoto T, Terakubo S and Nakashima H (Part:Contributor, In Nanostructures for Oral Medicicne (Nanostructures in Therapeutic Medicine Series),)
Elsevier   Apr 2017   ISBN:978-0-323-47720-8
Volume XI: NanoBioMaterials in Dentistry. Applications of Nanobiomaterials Volume 11.
Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Masahiro Sugimoto M, Nakajima H and Sakagami H (Part:Joint Work, Chapter 3. Effect of titanium dioxide nanoparticle on proliferation, drug-sensitivity, inflammation and metabolomic profiling of human oral cells.)
Elsevier   Jul 2016   ISBN:978-0-323-42867-5

Conference Activities & Talks

Searching the possibility of Joint Research between MU and UWC [Invited]
Presentation in University of Western Cape   27 May 2019   
Application of natural resources to treatment of oral diseases [Invited]
30th Japanese Society of Pediatric Oral and Maxillofacial Surgery   24 Nov 2018   
Meikai University Research Institute of Odontology (M-RIO) searches for anti-oral disease agents with lower adverse effects
Sakagami H, Tomomura M and Masuda Y
Japanese Association for Oral Biology   18 Sep 2017   
Search for Anti-HIV and Anti-Oral Disease Substances from Natural Resources [Invited]
Hiroshi Sakagami
The 3rd SAJU Forum   15 Jul 2017   
Professor Hiroshi Sakagami's Retiring Commemoration publication
15 Apr 2017   
Professor retirement final lecture
Aiming at exploring new drugs targeted to oral diseases   23 Mar 2017   

Association Memberships



Anti-HIV Chumon immunodeficiency virus activity
1989 - 1991
Antiviral activity and apoptosis-inducing activity of tannin and related compounds
1989 - 2001
Antitumor activity of sodium benzylidene ascorbate
1997 - 1998
Effect of Sodium benzylidene ascorbate on transplanted tumor in nude mice
2002 - 2003

Research Grants & Projects

Approach from the peripheral and central to the pain of tooth movement by orthodontic treatment
Grants-in Aids for Scientific Research: Grants-in-Aid for Scientific Research (C) (General)
Project Year: Apr 2018 - Mar 2021    Investigator(s): SUDA Naoto
Improvement of body function by underwater movement and influence on saliva aging marker
Grants-in-Aid for Scientific Research: Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2017 - Mar 2020    Investigator(s): Tamura Nobuaki
Basic research of possibility of newly synthesized 3-styrylchromone derivatives as chemotherapeutic drugs against oral carcinoma
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (C) (General)
Project Year: Apr 2016 - Mar 2019    Investigator(s): SAKAGAMI Hiroshi
Polyphenols of functional foods as materials effective on tumor cells
Ministry of Education, Culture, Sports and Technology: 
Project Year: Apr 2013 - Mar 2016    Investigator(s): HATANO Tsutomu
Ministry of Education, Culture, Sports and Technology of Japan: Challenging Exploratory Research
Project Year: Apr 2013 - Mar 2015    Investigator(s): SAKAGAMI Hiroshi


特願2011-016195 : Newly synthesized tannin derivatives
Tsutomu Hatano, Yasuo Takeuchi, Hiroshi Sakagami
Antitumor polysaccharide
No. 251941
Antiviral agent
No. 2923660
New utilization method of lignin
New utilization method of polycafenol

Social Contribution

Collaboration and joint research between Meikai, Josai, Nihon Institute of Medical Science and Meiji Pharmaceutical Universities
[Editor, Informant, Report writing]  Meikai University Research Institute of Odontoloty  20 Oct 2018 - Today
Joint research with Shanghai Jiaton University
[Editor, Informant, Planner, Report writing]  Meikai University Research Institute of Odontology (M-RIO)  25 Feb 2018 - Today
Japan-China joint writing activities for stimulating the international communication capability and establishing friendly relationship between two countires
[Editor, Planner]  2014 - Today
Storyline of newly arrived western novels in Media Center of Meikai University Urayasu campus
[Informant, Contribution]  S52N270315H  29 Jul 2013 - Today
List of all publications
[Informant]  1977 - Today
MPL founding 18 anniversary magazine
[Editor, Planner, Report writing]  S52N270315H  Jan 2017