知久馬敏幸 (Toshiyuki Chikuma) - マイポータル

基本情報

所属: 昭和薬科大学薬学部薬品分析化学研究室教授

学位: 理学博士(東京工業大学)

J-GLOBAL ID: 200901042241629301
researchmap会員ID: 1000074538

研究キーワード

研究分野

MISC

Effects of memantine on soluble Aβ25-35 induced changes in peptidergic and glial cells in Alzheimer's disease model rat brai regions

M. Arif, T. Chikuma, M.M. Ahmed, M. Nakazato, M.A. Smith, T. Kato

Neuroscience 164(3) 1199-1209 2009年12月
Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex

Ayako Yawata, Yuko Matsuhashi, Hanako Kato, Keiko Uemura, Genjiro Kusano, Junko Ito, Toshiyuki Chikuma, Hiroshi Hojo

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 38(4) 355-361 2009年11月
Effect of Memantine on the Levels of Neuropeptides and Microglial Cells in the Brain Regions of Rats with Neuropathic Pain

Katsumichi Takeda, Mai Muramatsu, Toshiyuki Chikuma, Takeshi Kato

JOURNAL OF MOLECULAR NEUROSCIENCE 39(3) 380-390 2009年11月
Interleukin-6 Induces Prostaglandin E-2 Synthesis in Mouse Astrocytes

Toshiyuki Chikuma, Tetsuya Yoshimoto, Masahiro Ohba, Makoto Sawada, Takeshi Kato, Tomoaki Sakamoto, Yukio Hiyama, Hiroshi Hojo

JOURNAL OF MOLECULAR NEUROSCIENCE 39(1-2) 175-184 2009年9月
Up-regulation of hepatic heme oxygenase-1 expression by locally induced interleukin-6 in rats administered carbon tetrachloride intraperitoneally

Kenzaburo Yamaji, Yosuke Ochiai, Ken-ichi Ohnishi, Ayako Yawata, Toshiyuki Chikuma, Hiroshi Hojo

TOXICOLOGY LETTERS 179(3) 124-129 2008年7月
Interleukin-6 production by peritoneal inflammatory factors in mesothelial cells and its regulation by rats administered carbon tetrachloride intraperitoneally

Kenzaburo Yamaji, Ken-ichi Ohnishi, Ryii Zuinen, Yosuke Ochial, Toshiyuki Chikuma, Hiroshi Hojo

TOXICOLOGY AND APPLIED PHARMACOLOGY 226(1) 38-45 2008年1月
4-hydroxy-2-nonenal-modified glyceraldehyde-3-phosphate dehydrogenase is degraded by cathepsin G

Yukihiro Tsuchiya, Yasutaka Okuno, Kayoko Hishinuma, Asami Ezaki, Go Okada, Mitsune Yamaguchi, Toshlyuki Chikuma, Hiroshi Hojo

FREE RADICAL BIOLOGY AND MEDICINE 43(12) 1604-1615 2007年12月
Involvement of the protein kinase Cγ isoform in development of tolerance to nitrous oxide-induced antinociception in mice

Y. Matsushita, M. Ishikawa, K. Abe, I. Utsunomiya, T. Chikuma, H. Hojo, K. Hoshi, R.M. Quock, K. Taguchi

Neuroscience 148(2) 541-547 2007年8月
Early induced, high-level interleukin-6 expression in the rat peritoneal cavity into which a hepatotoxicant carbon tetrachloride was administered

Ryoji Zuinen, Kenzaburo Yamaji, Miho Aoki, Toshiyuki Chikuma, Hiroshi Hojo

TOXICOLOGY LETTERS 170(1) 42-48 2007年4月
Suppressive effect of clozapine but not haloperidol on the increases of neuropeptide-degrading enzymes and glial cells in MK-801-treated rat brain regions

Mohammad Arif, Toshiyuki Chikuma, Md. Mahiuddin Ahmed, Shunsuke Yoshida, Takeshi Kato

NEUROSCIENCE RESEARCH 57(2) 248-258 2007年2月
Axonal transports of tripeptidyl peptidase II in rat sciatic nerves

Toshiyuki Chikuma, Maki Shimizu, Yukihiro Tsuchiya, Takeshi Kato, Hiroshi Hojo

NEUROCHEMISTRY INTERNATIONAL 50(1) 236-242 2007年1月
Clozapine but not haloperidol suppresses the changes in the levels of neuropeptides in MK-801-treated rat brain regions

Mohammad Arif, Md. Mahiuddin Ahmed, Yukiko Kumabe, Hajime Hoshino, Toshiyuki Chikuma, Takeshi Kato

NEUROCHEMISTRY INTERNATIONAL 49(3) 304-311 2006年8月
Pentylenetetrazol-induced seizures affect the levels of prolyl oligopeptidase, thimet oligopeptidase and glial proteins in rat brain regions, and attenuation by MK-801 pretreatment

MM Ahmed, M Arif, T Chikuma, T Kato

NEUROCHEMISTRY INTERNATIONAL 47(4) 248-259 2005年9月
Degradation of glyceraldehyde-3-phosphate dehydrogenase triggered by 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal

Y Tsuchiya, M Yamaguchi, T Chikuma, H Hojo

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 438(2) 217-222 2005年6月
A highly sensitive and stable detection of acetylcholine by HPLC-osmium-horseradish peroxidase redox polymer electrode coated on a gold radial flow ring disk

K Yamamoto, K Sato, T Chikuma, T Kato

ANALYTICA CHIMICA ACTA 521(2) 209-213 2004年9月
Improved determination of bovine glutaminyl cyclase activity using precolumn derivatization and reversed-phase high-performance liquid chromatography with ultraviolet detection

T Chikuma, K Taguchi, M Yamaguchi, H Hojo, T Kato

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 806(2) 113-118 2004年7月
Preparation of monoclonal antibodies reactive to a hallucinogenic drug, psilocin

M. Yamaguchi, T. Saito, Y. Horiguchi, K. Ogawa, Y. Tsuchiya, K. Hishimuma, T. Chikuma, Y. Makino, H. Hojo

J. Health Sci. 50(6) 600-604 2004年
Effect of memantine on the levels of glial cells, neuropeptides, and peptide-degrading enzymes in rat brain regions of ibotenic acid-treated Alzheimer's disease model

MM Ahmed, H Hoshino, T Chikuma, M Yamada, T Kato

NEUROSCIENCE 126(3) 639-649 2004年
Characterization of muscarinic receptor subtypes in the rostral ventrolateral medulla and effects on morphine-induced antinociception in rats

K Abe, K Taguchi, M Kato, Utsunomiya, I, T Chikuma, H Hojyo, T Miyatake

EUROPEAN JOURNAL OF PHARMACOLOGY 465(3) 237-249 2003年4月
Anterograde axonal transport of endopeptidase 24.15 in rat sciatic nerves

M Yamamoto, T Chikuma, A Yamashita, M Yamaguchi, H Hojo, Y Ozeki, M Ahmed, T Kato

NEUROCHEMISTRY INTERNATIONAL 42(3) 231-237 2003年2月

もっとみる

所属学協会

共同研究・競争的資金等の研究課題

精神・神経疾患の病態と治療

2009年
neuropsychiatric disorders and therapy

2009年