J-GLOBAL         Last updated: May 11, 2019 at 12:30
Tokyo Metropolitan University
Job title
Doctor of Phylosophy(Jikei University)

Research Areas


Academic & Professional Experience

Apr 2010
Professor, Tokyo Metropolitan University
Apr 2000
Mar 2010
Lecturer, Tokyo Medical University
Apr 1995
Mar 2000
Lecturer, The Jikei University School of Medicine
Apr 1986
Mar 1995
Assistant Professor, The Jikei University School of Medicine


Faculty of Medicine, The Jikei University School of Medicine

Published Papers

Inhibitory effects of rubratoxin A, a potent inhibitor of protein phosphatase 2, on the Ca2+-dependent contraction of skinned carotid artery from guinea pig.
NARAKI Yasunobu, WATANABE Masaru, ISHIDA Yukisato
Jounral of Smooth Muscle Research   55(1) 14-21   Apr 2019   [Refereed]
Protein phosphatases 1 and 2A and their naturally occurring inhibitors: current topics in smooth muscle physiology and chemical biology
Takai A, Eto M, Hirano K, Takeya K, Wakimoto T, Watanabe M.
The Journal of Physiological Sciences   9 1-17   Jul 2017   [Refereed][Invited]
Omori H, Otsu M, Suzuki A, Nakayama T, Akama K, Watanabe M, Inoue N
Neuroscience research   79 13-21   Feb 2014   [Refereed]
Omori H, Otsu M, Suzuki A, Nakayama T, Akama,K, Watanabe M, Inoue N.
Neurosci Res   79 1-12   Jan 2014   [Refereed]
Thatcher SE, Fultz ME, Tanaka H, Hagiwara H, Zhang HL, Zhang Y, Hayakawa K, Yoshiyama S, Nakamura A, Wang HH, Katayama T, Watanabe M, Lin Y, Wright GL, Kohama K
J Pharmacol Sci   116(1) 116-127   Jun 2011   [Refereed]
Watanabe M, Yumoto M, Tanaka H, Wang HH, Katayama T, Yoshiyama S, Black J, Thatcher SE, Kohama K
Am J Physiol Cell Physiol   298(5) C1118-C1126   May 2010   [Refereed]
Katayama T, Watanabe M, Tanaka H, Hino M, Miyakawa T, Ohki T, Ye LH, Xie C, Yoshiyama S, Nakamura A, Ishikawa R, Tanokura M, Oiwa K, Kohama K
Am J Physiol Heart Circ Physiol   298(2) H505-H514   Feb 2010   [Refereed]
Watanabe M, Kobirumaki F, Yumoto M.
Nihon Yakurigaku Zasshi   133(3) 130-133   Mar 2009   [Refereed][Invited]
A potential role of actin filament polymerization/depolymerization in smooth muscle contraction
Watanabe M, Ishiwata S, Liou Y-M
Adaptive Medicine   2 20-28   2010   [Refereed]
Liou YM, Watanabe M, Yumoto M, Ishiwata S.
Am J Physiol Cell Physiol   296(5) 1024-1033   May 2009   [Refereed]
Hashimoto R, Yumoto M, Watanabe M, Konishi M, Haraoka J, Miki T.
J Smooth Musc Res 2009; 45: 55-62.   45(1) 63-74   Feb 2009   [Refereed]
Mechanisms of the inhibitory effects of a phenoxazine compound, 2-amino-4,4 alpha-dihydro-4 alpha-7-dimethyl-3H-phenoxazine-3-one, on the contraction of the smooth muscle of the guinea pig taenia cecum.
Musha S, Watanabe M, Tomoda A, Konishi M
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi   43(1) 15-24   Feb 2007   [Refereed]
Watanabe M, Konishi M, Ohkido I, Matsufuji S
American journal of physiology. Renal physiology   289(4) F742-8   Oct 2005   [Refereed]
Sakurai W, Watanabe M, Yamashina A, Konishi M
The Japanese journal of physiology   53(6) 471-474   Dec 2003   [Refereed]
[Urate transport mechanism of mammalian cell membrane].
Watanabe M
Nihon rinsho. Japanese journal of clinical medicine   61 Suppl 1 124-128   Jan 2003   [Refereed]


Tashiro M, Tursun P, Miyazaki T, Watanabe M, Konishi M
Biophysical Journal   91 244-254   2006
American Journal of Physiology - Renal Physiology   289(4) F742-F748   2005
Biochemical and Biophysical Research Communications   307(2 pp. 236-240)    2003
Michiko Tashiro, Pulat Tursun, Takefumi Miyazaki, Masaru Watanabe, Masato Konishi
Japanese Journal of Physiology   52(6) 541-551   2002
Pfl(]E88DB[)gers-Archiv-European Journal of Physiology   442(1) 35-40   2001
Assesment of physiological conditions of smooth muscle specimens from rat uteri
Jikeikai medical journal   46 217-226   1999
Effect of okadaic acid on electromechanical coupling is realized via phosphoprotein phosphatase
Neurochemia(Moscow)   13(4) 292-296   1996
GTPγS-induced contraction in staphylococcus aureus α-toxin-treated uterine smooth muscle from pregnant rats
Jikeikai Medical Journal   43(3) 161-169   1996
Resting cytoplasmic free Ca2+concentration in frog skeletal muscle measured with fura-2 conjugated to high molecular weight dextran.
Journal of General Physiology   106 1123-1150   1995
Force-inhibiting effect of okadaic acid on skinned rat uterus permeabilized with α-foxin.
Pfliigers Archiv-European Journal of Physiology   430 754-6   1995
Molecular size-dependent leakage of intracellular molecules from frog skeletal muscle fibers permeabilized with β-escin
Pfl(]E88FB[)gers Archiv - European Journal of Physiology   429 598-600   1995
Current X-ray diffraction experiments using a synchrotron radiation source.
Adv Exp Med Biol   332,423-33    1993
Effects of 2,3-butanedione monoxime on smooth-muscle contraction of guinea-pig portal vein.
Pfl(]J1168[)gers Archiv : European Journal of Physiology   425,462-468    1993
Change in stiffness of skinned muscle fibres observed during slow and rapid contractions.
Jikeikai Medical Journal   40(1) 1-20   1993
X-ray diffraction study on mammalian visceral smooth muscles in resting and activated states
Journal of Musclar Research and Cell Motility   14,469-475    1993

Books etc

Cell membrane-transport of magnesium in cardiac myocytes and CCL39 cells expressing the sodium-calcium exchanger. in Advances in Magnesium Research: Nutrition and Health
John Libbey & Company   2001   
Cellular basis of magnesium transport. In New Perspectives in Magnesium Research.
Springer   2005   

Conference Activities & Talks

Effects of beta escin skinning on X-ray diffraction pattern of taenia cecum smooth muslce from guinea pig
The 95th annual meeting of the Physiological Society of Japan   29 Mar 2018   
Rubratoxin A, a specific protein phosphatase 2A inhibitor, suppresses smooth muscle contraction through myosin light chain phosphorylation dependent and independent pathway
3 rd Japan - Taiwan Bilateral Conference on Protein Phosphatase   19 Nov 2017   
Effects of beta escin skinning on X-ray diffraction patterns of guinea pig taenia cecum
59th Annual Meeting of Japan Soceiety of Smooth Muscle Research   24 Aug 2017   
Mechanisms of inhibitory effects of a protein phosphatase 2A inhibitor on the smooth muscle contraction
94th Annual Meeting of the Physiological Sosiety of Japan   29 Mar 2017   
Force suppressing effects of of a protein phophatase inhibitor on skinned taenia cecum
58th annual meeting of Japan Society of Smooth Muscle Research   19 Aug 2016   
Mechanisms of accelerating effect of protein phosphatase 2A inhibitors on smooth muscle relaxation
93rd annual meeting of Jpanase Physiological Society   22 Mar 2016   
Role of protein phosphatase 2A in smooth muscle contraction
57th Annual meeting of Japn Society of Smooth Muscle Reseach   26 Aug 2015   
Nucleotide dependence on the accelerating effects of myosin II inhibitors on the smooth muscle
92nd Annual Meeting of Japanese Physiological Society   21 Mar 2015   
Mechanisms of acclerating effects of myosin II inhibitors on the smooth muscle relaxation
56th Annual Meeting of Japan Society of Smooth Muscle Research   7 Aug 2014   

Research Grants & Projects

Regulatory mechanisms of protein phosphatase 2A induced mechano-chemical coupling in smooth muscle
Japan Society for the Promotion of Sciences: Grant-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2019    Investigator(s): WATANABE Masaru
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2007 - 2010    Investigator(s): Masaru WATANABE
To quantitatively evaluate the relation between myofilament remodeling and mechanical properties in vertebrate smooth muscle cells, by using electron microscopy, florescent resonance energy transfer (FRET) analysis and conventional electrophoresis...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2006    Investigator(s): Masaru WATANABE
1)Mechanism of the inhibitory effects of Phx-1 on the smooth muscle contraction To elucidate the mechanisms of relaxing effect of 2-amino-4,4 a-dihydro-4 a-7-dimethyl-3H-phenoxazine-3-one (Phx-1) on the smooth muscle preparations, we investigated ...
NMR Study on smooth muscle
Ordinary Research
Project Year: 2001   
Regulatory mechanisms of remodelling of contractile filaments in smooth muscle
Grant-in-Aid for Scientific Research
Project Year: 2001