Yoshihiko Shinohara - My portal - researchmap

Profile Information

Affiliation: Associate Professor, School of Pharmacy, Pathophysiology, Tokyo University of Pharmacy and Life Science

Degree: (BLANK)(Tokyo University of Pharmacy and Life Science)

J-GLOBAL ID: 200901091738489920
researchmap Member ID: 1000081469

Research Interests

4

Research Areas

2

Research History

6

1984 - 1991

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
1984 - 1991

Tokyo College of Pharmacy, Assistant Professor
1982 - 1984

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
1982 - 1984

Tokyo College of Pharmacy, Research Assistant
1980 - 1982

University of California, San Francisco
1980 - 1982

University of California (San Francisco), Research Fellow

Education

4

Misc.

39

Determination of D- and L-enantiomers of methionine and [H-2(3)]methionine in plasma by gas chromatography-mass spectrometry

H Hasegawa, Y Shinohara, K Akahane, T Hashimoto

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 823(2) 203-208, Sep, 2005
Metabolism of osaterone acetate in dogs and humans

K Minato, S Honma, Y Shinohara, T Hashimoto

STEROIDS, 70(9) 563-572, Aug, 2005
Direct detection ond evaluation of conversion of D-methionine into L-methionine in rats by stable isotope methodology

J. Nutr, 135: 2001-2005, 2005
Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine

Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara, Ryuichi Konno, Takao Hashimoto

American Journal of Physiology - Endocrinology and Metabolism, 287(1) E160-E165, Jul, 2004
Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine

Am J Physiol Endocrinol Metab, 287:E160-E165, 2004
Kinetics of sequential metabolism from D-leucine to L-leucine via ketoisocaproic acid in rat

Drug Metabolism and DispositionD, 30(12), 2002
Kinetics of Intramolecular Acyl Migration of 1β-O-Acyl Glucuronides of (R)- and (S)-2-Phenylpropionic Acids.

Biol. Pharm. Bull.,, 24, 852-855, 2001
Simultaneous Determination of Methionine and Total Homocysteine in Human Plasma by Gas Chromatography-Mass Spectrometry.

J. Chromatogr. B,, 758, 283-288, 2001
Pharmacokinetic Studies of Methionine in Rats using Deuterium-Labeled Methionine : Quantitative Assessment of Remethylation.

Life Sci., 70, 727-734, 2001
Gas Chromatographic-Mass Spectrometric Determination of α-Ketoisocaproic Acid and [²H₇]α-Ketoisocaproic Acid in Plasma after Derivatization with ┣DB N (/)-┫DB-Phenyl-1, 2-phenylenediamine.

Journal of Chromatography B, 751(2) 213-220, 2001
Simultaneous Determination of Methionine and Total Homocysteine in Human Plasma by Gas Chromatography-Mass Spectrometry.

J. Chromatogr. B,, 758, 283-288, 2001
Pharmacokinetic Studies of Methionine in Rats using Deuterium-Labeled Methionine : Quantitative Assessment of Remethylation.

Life Sci., 70, 727-734, 2001
Kinetics of Intramolecular Acyl Migration of 1β-O-Acyl Glucuronides of (R)- and (S)-2-Phenylpropionic Acids.

Biol. Pharm. Bull., 24, 852-855, 2001
Assessment of the metabolic chiral inversion of D-leucine in rat by gas chromatography-mass spectrometry combined with a stable isotope dilution analysis

H Hasegawa, T Matsukawa, Y Shinohara, T Hashimoto

DRUG METABOLISM AND DISPOSITION, 28(8) 920-924, Aug, 2000
Stable isotope dilution analysis of human urinary metabolites of 17 alpha-methyltestosterone

Y Shinohara, K Isurugi, T Hashimoto

JOURNAL OF CHROMATOGRAPHY B, 741(2) 271-278, May, 2000
Stereoselective internal acyl migration of 1 beta-O-acyl glucuronides of enantiomeric 2-phenylpropionic acids

K Akira, H Hasegawa, Y Shinohara, M Imachi, T Hashimoto

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 23(4) 506-510, Apr, 2000
Synthesis of L-[3, 3, 4, 4, S-Methyl-²H₇]Methionine for Use as a Substrate for the Methionine Loading Test.

Journal of Labelled Compounds and Radiopharmaceuticals, 44 21-30, 2000
Internal Acyl Migration of 1β-O-Acyl Glucuronides of Enantiomeric 2-Phenylpropionic Acids.

Biol. Pharm. Bull.,, 23, 506-510, 2000
Simultaneous determination of the enantiomers of leucine and [²H₇]leucine in plasma by capillary gas chromatography-mass spectrometry.

Journal of Chromatography B, 735(2) 141-149, 1999
Synthesis of (2S)-2-amino-3-(2 ',6 '-dibromo-4 '-hydroxy)phenyl-propionic acid (2,6-dibromo-L-tyrosine)

H Hasegawa, Y Shinohara

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, (2) 243-247, Jan, 1998

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Books and Other Publications

5

薬学生の物理化学

広川書店, 1993
薬学生の放射化学

広川書店, 1988
Radiochemistry for Students of Pharmacy

1988
質量分析法の新展開(現代化学・増刊15) 土屋正彦,大橋守,上野民夫編

東京化学同人
New Developments in Mass Spectrometry

Professional Memberships

6

Research Projects

8