2003年12月
Synthesis of acyclic nucleotide analogues possessing a difluoromethylene phosphonyl group at the side chain
TETRAHEDRON
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- 巻
- 59
- 号
- 51
- 開始ページ
- 10223
- 終了ページ
- 10230
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.tet.2003.10.064
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
A synthetic approach to a new type of acyclic nucleotide analogues 8 and 9 was examined. The design was based on acyclic modification of MRS 2179, a P2Y(1)-antagonist, and replacement of one of two phosphate groups characterized by MRS 2179 with an isosteric difluoromethylenephosphonyl group. The nucleotide analogues 8 and 9 were enantio-divergently prepared as their ester-protecting derivatives from a highly differentiated 1,5-pentanediol derivative possessing a difluoromethylenephosphonyl group at the 3-position. (C) 2003 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.tet.2003.10.064
- ISSN : 0040-4020
- Web of Science ID : WOS:000187013100012