小倉健一郎 (Kenichiro Ogura) - マイポータル

基本情報

所属: 東京薬科大学薬学部医療薬学科薬物代謝安全性学教室准教授

学位: 薬学博士
Ph.D.(Tokyo University of Pharmacy and Life Science)

J-GLOBAL ID: 200901004140384961
researchmap会員ID: 1000081490

研究キーワード

研究分野

経歴

学歴

1984年4月 - 1986年3月

東京薬科大学, 薬学研究科, 博士課程前期課程
- 1986年

Tokyo University of Pharmacy and Life Science, Graduate School, Division of Pharmaceutical Sciences
1983年4月 - 1984年3月

東京薬科大学, 薬学部, 専攻科
1979年4月 - 1983年3月

東京薬科大学, 薬学部, 薬学科
- 1983年

Tokyo University of Pharmacy and Life Science, Faculty of Pharmaceutical Science

論文

Procyanidins from Cinnamomi Cortex promote proteasome-independent degradation of nuclear Nrf2 through phosphorylation of insulin-like growth factor-1 receptor in A549 cells.

Ohnuma T, Sakamoto K, Shinoda A, Takagi C, Ohno S, Nishiyama T, Ogura K, Hiratsuka A

Archives of biochemistry and biophysics 635 66-73 2017年12月査読有り
Selective antagonization of activated Nrf2 and inhibition of cancer cell proliferation by procyanidins from Cinnamomi Cortex extract

Tomokazu Ohnuma, Eri Anzai, Yohei Suzuki, Mai Shimoda, Shin Saito, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 585 17-24 2015年11月査読有り
5-Fluorouracil Chemotherapy for Dihydropyrimidine Dehydrogenase-deficient Patients: Potential of the Dose-escalation Method

Yoichiro Yoshida, Kenichiro Ogura, Akira Hiratsuka, Naoya Aisu, Teppei Yamada, Daibo Kojima, Syu Tanimura, Kentaro Ogata, Shuuji Hara, Ai Mogi …

ANTICANCER RESEARCH 35(9) 4881-4887 2015年9月査読有り
Significance of non-cytochrome P450 (non-P450) enzymes in basic science, clinical field and drug development Preface

Kenichiro Ogura, Yuji Ishii

DRUG METABOLISM AND PHARMACOKINETICS 30(1) 1-2 2015年2月査読有り
Formation and stability of 4-(hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronide, a stable form of reactive intermediate produced from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, in mice

Takahito Nishiyama, Nahoko Hayashi, Naoki Kakurai, Hiromi Yanagita, Ai Kuriyama, Chika Miyamoto, Yumi Ishihara, Kenichiro Ogura, Tomokazu Ohnuma, Akira Hiratsuka

JOURNAL OF TOXICOLOGICAL SCIENCES 39(4) 515-521 2014年8月査読有り
Tissue distributions of 4-(hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronide, a stable form of reactive intermediate produced from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, in the rat

Takahito Nishiyama, Kenichiro Ogura, Tomokazu Ohnuma, Akira Hiratsuka

JOURNAL OF TOXICOLOGICAL SCIENCES 39(2) 263-267 2014年4月査読有り
Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract

Tomokazu Ohnuma, Takashi Matsumoto, Ayano Itoi, Ayako Kawana, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 413(4) 623-629 2011年10月査読有り
Dietary Diacetylene Falcarindiol Induces Phase 2 Drug-Metabolizing Enzymes and Blocks Carbon Tetrachloride-Induced Hepatotoxicity in Mice through Suppression of Lipid Peroxidation

Tomokazu Ohnuma, Eisaburo Anan, Rika Hoashi, Yuika Takeda, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka

BIOLOGICAL & PHARMACEUTICAL BULLETIN 34(3) 371-378 2011年3月査読有り
Organic Anion-Transporting Polypeptide 1b2 (Oatp1b2) Is Important for the Hepatic Uptake of Unconjugated Bile Acids: Studies in Oatp1b2-Null Mice

Ivan L. Csanaky, Hong Lu, Youcai Zhang, Kenichiro Ogura, Supratim Choudhuri, Curtis D. Klaassen

HEPATOLOGY 53(1) 272-281 2011年1月査読有り
Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound

Tomokazu Ohnuma, Shinji Nakayama, Eisaburo Anan, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka

TOXICOLOGY AND APPLIED PHARMACOLOGY 244(1) 27-36 2010年4月査読有り
Cooperation of NAD(P)H:quinone oxidoreductase 1 and UDP-glucuronosyltransferases reduces menadione cytotoxicity in HEK293 cells

Takahito Nishiyama, Tadashi Izawa, Mami Usami, Tomokazu Ohnuma, Kenichiro Ogura, Akira Hiratsuka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 394(3) 459-463 2010年4月査読有り
Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress

Tomokazu Ohnuma, Takao Komatsu, Shinji Nakayama, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 488(1) 34-41 2009年8月査読有り
Inhibitory Effects of Herbal Extracts on the Activity of Human Sulfotransferase Isoform Sulfotransferase 1A3 (SULT1A3)

Marie Nagai, Takahiro Fukamachi, Masayuki Tsujimoto, Kenichiro Ogura, Akira Hiratsuka, Hisakazu Ohtani, Satoko Hori, Yasufumi Sawada

BIOLOGICAL & PHARMACEUTICAL BULLETIN 32(1) 105-109 2009年1月査読有り
Amino acid positions 69-132 of UGT1A9 are involved in the C-glucuronidation of phenylbutazone

Takahito Nishiyama, Miki Fujishima, Yasuhiro Masuda, Tadashi Izawa, Tomokazu Ohnuma, Kenichiro Ogura, Akira Hiratsuka

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 478(1) 75-80 2008年10月査読有り
Plasma profiling of intact isoflavone metabolites by high-performance liquid chromatography and mass spectrometric identification of flavone glycosides daidzin and genistin in human plasma after administration of kinako

Kaori Hosoda, Takashi Furuta, Akitomo Yokokawa, Kenichiro Ogura, Akira Hiratsuka, Kazuo Ishii

DRUG METABOLISM AND DISPOSITION 36(8) 1485-1495 2008年8月査読有り
UDP-glucuronosyltransferases 1A6 and 1A10 catalyze reduced menadione glucuronidation

Takahito Nishiyarna, Tornokazu Ohnuma, Yuu Inoue, Takehiko Kishi, Kenichiro Ogura, Akira Hiratsuka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 371(2) 247-250 2008年6月査読有り
Characterization of organic anion transporting polypeptide 1b2-null mice: Essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR

Hong Lu, Supratim Choudhuri, Kenichiro Ogura, Ivan L. Csanaky, Xiaohong Lei, Xingguo Cheng, Pei-Zhen Song, Curtis D. Klaassen

TOXICOLOGICAL SCIENCES 103(1) 35-45 2008年5月査読有り
Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3

Haruka Nishimuta, Hisakazu Ohtani, Masayuki Tsujimoto, Kenichiro Gura, Akira Hiratsuka, Yasufumi Sawada

BIOPHARMACEUTICS & DRUG DISPOSITION 28(9) 491-500 2007年12月査読有り
Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone

Takahito Nishiyama, Tomihiro Kobori, Kouji Arai, Kenichiro Ogura, Tomokazu Ohnuma, Kazuo Ishii, Kenichiro Hayashi, Akira Hiratsuka

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 454(1) 72-79 2006年10月査読有り
[Dihydropyrimidine dehydrogenase activity and its genetic aberrations].

Ogura K

Gan to kagaku ryoho. Cancer & chemotherapy 33(8) 1041-1048 2006年8月査読有り

もっとみる

所属学協会

共同研究・競争的資金等の研究課題

乳がん細胞の抗がん剤耐性化に関与する薬物代謝酵素の役割

科学研究費助成事業基盤研究（C） 2012年 - 2014年

小倉健一郎
乳がん治療薬タモキシフェン耐性腫瘍の耐性機構の解明

科学研究費助成事業基盤研究（C） 2005年 - 2007年

小倉健一郎
植物エストロゲンの硫酸ならびにグルクロン酸抱合反応による代謝

科学研究費助成事業基盤研究（C） 2002年 - 2004年

小倉健一郎
薬物代謝酵素の構造と機能に関する研究
Study on Structure and Function of Drug Metabolizing Enzymes