KAMO Masaharu

J-GLOBAL         Last updated: Apr 11, 2019 at 18:45
KAMO Masaharu
Iwate Medical University
School of Dentistry
Job title
Associate Professor
Doctor of Science(Tokyo University of Science)

Research Areas


Academic & Professional Experience

Research Associate, Research Institute for
Biological Sciences, Sciece University of Tokyo


Graduate School, Division of Natural Science, Tokyo University of Science
Faculty of Science, Tokyo University of Science

Published Papers

Akira Ishisaki, Seiko Kyakumoto, Seiji Yokota, Masaharu Kamo, Naoyuki Chosa
Ochanomizu Igaku Zasshi   66(2) 247-258   Oct 2018   [Refereed]
Mesenchymal stem cells(MSCs),which are able to differentiate into osteoblasts,adipocytes,and chondroblasts,are known as somatic stem cells.Previous studies have demonstrated that MSCs reside in the bone marrow,adipose tissue,and Wharton’s jelly in...
Molecular mechanism of transforming growth factor-β1-induced cell migration and invasion of HSC-4 human squamous cell carcinoma cells
Masaharu Kamo, Daishi Saito, Masafumi Hino, Takahiro Chiba, Hiroyuki Yamada, and Akira Ishisaki
Dent J Iwate Med Univ   43(2) 107-121   Oct 2018   [Refereed]
Maiko Ohta, Naoyuki Chosa, Seiko Kyakumoto, Seiji Yokota, Naoto Okubo, Akira Nemoto, Masaharu Kamo, Shigeharu Joh, Kenichi Satoh, Akira Ishisaki
International Journal of Molecular Medicine   42(3) 1484-1494   Jun 2018   [Refereed]
Mechanosensitive (MS) neurons in the periodontal ligament (PDL) pass information to the trigeminal ganglion when excited by mechanical stimulation of the tooth. During occlusal tooth trauma of PDL tissues, MS neurons are injured, resulting in atro...
Ohta, M., Nemoto, A., Chosa, N., Kyakumoto, S., Yokota, S., Kamo, M., Shibata, T., Joh, S., Sato, K. and Ishisaki, A.
Dent J Iwate Med Univ   43(1) 61-73   May 2018   [Refereed]
Sensory neurons in the periodontal ligament (PDL) transmit the impulses, which are generated by the mechanical stimulation of the tooth, into the trigeminal ganglion, resulting in the excitement of the nucleus ventralis posteromedialis of the thal...
Nemoto A, Chosa N, Kyakumoto S, Yokota S, Kamo M, Noda M, Ishisaki A
Molecular medicine reports   17(3) 3448-3454   Mar 2018   [Refereed]
Surface pre-reacted glass‑ionomer (S‑PRG)-containing dental materials, including composite and coating resins have been used for the restoration and/or prevention of dental cavities. S‑PRG is known to have the ability to release aluminum, boron, f...
Ibi M, Horie S, Kyakumoto S, Chosa N, Yoshida M, Kamo M, Ohtsuka M, Ishisaki A.
Bioscience Reports   38(2)    2018   [Refereed]
Many inflammatory cells are known to be home to inflamed temporomandibular joint (TMJ) tissues by stimulation with cytokines and chemokines produced by inflammatory lesions in the TMJ. However, how the inflammatory cells affect the progression of ...
Takizawa N, Okubo N, Kamo M, Chosa N, Mikami T, Suzuki K, Yokota S, Ibi M, Ohtsuka M, Taira M, Yaegashi T, Ishisaki A, Kyakumoto S
Experimental cell research   358(2) 411-420   Sep 2017   [Refereed]
Immunosuppressive/anti-inflammatory macrophage (Mφ), M2-Mφ that expressed the typical M2-Mφs marker, CD206, and anti-inflammatory cytokine, interleukin (IL)-10, is beneficial and expected tool for the cytotherapy against inflammatory diseases. Her...
Yokota S, Chosa N, Kyakumoto S, Kimura H, Ibi M, Kamo M, Satoh K, Ishisaki A
International journal of molecular medicine   39(4) 799-808   Apr 2017   [Refereed]
Malocclusion caused by abnormal jaw development or muscle overuse during mastication results in abnormal mechanical stress to the tissues surrounding the temporomandibular joint (TMJ). Excessive mechanical stress against soft and hard tissues arou...
Chiba T, Ishisaki A, Kyakumoto S, Shibata T, Yamada H, Kamo M
Oncology reports   37(2) 713-720   Feb 2017   [Refereed]
Squamous cell carcinoma is the most common cancer in the oral cavity. We previously demonstrated that transforming growth factor-β1 (TGF-β1) promotes the epithelial-mesenchymal transition (EMT) of human oral squamous cell carcinoma (hOSCC) cells; ...
Komatsu Y, Ibi M, Chosa N, Kyakumoto S, Kamo M, Shibata T, Sugiyama Y, Ishisaki A
International journal of molecular medicine   38(1) 139-147   Jul 2016   [Refereed]
Bisphosphonates (BPs) are analogues of pyrophosphate that are known to prevent bone resorption by inhibiting osteoclast activity. Nitrogen-containing BPs, such as zoledronic acid (ZA), are widely used in the treatment of osteoporosis and bone meta...
Hino M, Kamo M, Saito D, Kyakumoto S, Shibata T, Mizuki H, Ishisaki A
Journal of biochemistry   159(6) 631-640   Feb 2016   [Refereed]
Molecular mechanism underlying the invasion of oral cancer cells remains to be clarified. We previously demonstrated that transforming growth factor-β1 (TGF-β1) induces the expression of mesenchymal markers in human oral squamous cell carcinoma HS...
Kuramitsu-Fujimoto S, Ariyoshi W, Saito N, Okinaga T, Kamo M, Ishisaki A, Takata T, Yamaguchi K, Nishihara T
Journal of applied oral science : revista FOB   23(1) 49-55   Jan 2015   [Refereed]
Objective: Enamel matrix derivative (EMD) is used clinically to promote periodontal tissue regeneration. However, the effects of EMD on gingival epithelial cells during regeneration of periodontal tissues are unclear. In this in vitro study, we pu...
Asano T, Taoka M, Yamauchi Y, Craig Everroad R, Seto Y, Isobe T, Kamo M, Chosa N
Insect biochemistry and molecular biology   55 61-69   Oct 2014   [Refereed]
The laccase in the pupal cuticle of the silkworm, Bombyx mori, is thought to accumulate as an inactive precursor that can be activated stage-dependently. In this study we isolated an 81-kDa laccase from cuticular extract of B. mori that was prepar...
Saito D, Kyakumoto S, Chosa N, Ibi M, Takahashi N, Okubo N, Sawada S, Ishisaki A, Kamo M
Journal of biochemistry   153(3) 303-315   Mar 2013   [Refereed]
We investigated whether transforming growth factor-β1 (TGF-β1) promoted the epithelial-mesenchymal transition (EMT) and migration of human oral squamous cell carcinoma (hOSCC) cells. Among the 6 hOSCC cell lines investigated, Smad2 phosphorylation...
Kimura H, Okubo N, Chosa N, Kyakumoto S, Kamo M, Miura H, Ishisaki A
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology   32(4) 899-914   2013   [Refereed]
Background/Aims: Remodeling of fibrous and vascular tissues in the periodontal ligament (PDL) around the tooth root was observed during tooth movement by orthodontic force application. We previously demonstrated that a single cell-derived culture ...
Takahashi M, Okubo N, Chosa N, Takahashi N, Ibi M, Kamo M, Mizuki H, Ishisaki A, Kyakumoto S
International journal of molecular medicine   29(3) 357-364   Mar 2012   [Refereed]
The periodontal ligament (PDL) is a fibrous connective tissue located between the tooth root and the alveolar bone. We previously demonstrated that a single cell-derived culture of primarily cultured PDL fibroblasts has the potential to construct ...
Shenton MR, Berberich T, Kamo M, Yamashita T, Taira H, Terauchi R
Journal of plant research   125(2) 311-316   Mar 2012   [Refereed]
Early interactions between invading penetration hyphae of the pathogenic fungus Magnaporthe oryzae and rice cells occur at the apoplast, the free diffusional space outside the plasma membrane of leaves. After initial colonization, intercellular hy...
Yoshida M, Okubo N, Chosa N, Hasegawa T, Ibi M, Kamo M, Kyakumoto S, Ishisaki A
International journal of biological sciences   8(7) 1062-1074   2012   [Refereed]
TAKAHASHI Daisuke, FURUTO Akari, MINAMI Anzu, KAMO Masaharu, YAMASHITA Tetsuro, UEMURA Matsuo
Cryobiology and cryotechnology   57(1) 95-99   Apr 2011
Cold acclimation (CA) results in alterations of plasma membrane (PM) lipid and protein compositions in plants, which is critical to increase their freezing tolerance. Recent studies indicate that PM is considered not homogeneous and contains stero...
Yoshida Y, Ito S, Kamo M, Kezuka Y, Tamura H, Kunimatsu K, Kato H
Microbiology (Reading, England)   156(7) 2260-2269   Jul 2010   [Refereed]
Fusobacterium nucleatum produces a large amount of the toxic metabolite hydrogen sulfide in the oral cavity. Here, we report the molecular basis of F. nucleatum H(2)S production, which is associated with two different enzymes: the previously repor...


加茂 政晴, 平野 大輔, 松本 識野, 相原 恵子, 横田 聖司, 帖佐 直幸, 客本 齊子, 石崎 明
口腔組織培養学会誌   27(1) 39-40   Mar 2018
太田 麻衣子, 帖佐 直幸, 横田 聖司, 客本 齊子, 加茂 政晴, 深見 秀之, 成田 欣弥, 佐原 資謹, 石崎 明
口腔組織培養学会誌   27(1) 37-38   Mar 2018
根本 章, 清水 峻介, 青木 貴晃, 横田 聖司, 帖佐 直幸, 客本 齊子, 加茂 政晴, 櫻井 秀人, 志賀 華絵, 岡田 伸男, 浅野 明子, 野田 守, 石崎 明
口腔組織培養学会誌   27(1) 35-36   Mar 2018
横田聖司, 帖佐直幸, 客本齊子, 加茂政晴, 佐藤和朗, 石崎明
岩手医科大学歯学雑誌   42(2) 80   Oct 2017
太田麻衣子, 佐藤健一, 石崎明, 帖佐直幸, 客本齊子, 加茂政晴, 城茂治
岩手医科大学歯学雑誌   42(1) 49‐50   Jun 2017
根本章, 帖佐直幸, 客本齊子, 加茂政晴, 石崎明, 野田守
岩手医科大学歯学雑誌   42(1) 47‐48   Jun 2017
客本斉子, 滝沢尚希, 大久保直登, 加茂政晴, 帖佐直幸, 横田聖司, 大塚正人, 衣斐美歩, 石崎明
日本生化学会大会(Web)   90th ROMBUNNO.2LBA‐091 (WEB ONLY)-091]   Dec 2017
根本章, 根本章, 帖佐直幸, 客本齊子, 横田聖司, 加茂政晴, 野田守, 石崎明
日本生化学会大会(Web)   90th ROMBUNNO.2P‐0785 (WEB ONLY)-0785]   Dec 2017
太田麻衣子, 太田麻衣子, 帖佐直幸, 横田聖司, 客本斎子, 加茂政晴, 佐藤健一, 城茂治, 石崎明
日本生化学会大会(Web)   90th ROMBUNNO.2P‐0453 (WEB ONLY)   2017
松本識野, 松本識野, 横田聖司, 帖佐直幸, 菊池恵美子, 木村仁迪, 加茂政晴, 佐藤和朗, 石崎明
日本生化学会大会(Web)   90th ROMBUNNO.2P‐0454 (WEB ONLY)-0454]   Dec 2017

Books etc

2-D Proteome Analysis Protocols
Andrew J. Link (Part:Contributor, 2-D Electrophoresis of Plant Proteins/2-D Electrophoresis of Plant Proteins)
Humana Press   1999   
N-terminal amino acid sequencing of 2-DE spots(共著)
2-D Proteome Analysis Protocols, Humana Press   1999   
2-D Electrophoresis of Plant Proteins(共著)
2-D Proteome Analysis , Humana Press   1999   
Proceedings of 5th International Symposium on Rice Molecular Biology
Yi Hsien Publishing Co. Ltd.   Jun 1997   
World wide web of two-dimensional electrophoresis database ; relating database of spot image and sequenced data of rice and Arabidopsis(共著)
Proceedings of 5th International Symposium on Rice Molecular Biology   1997   

Conference Activities & Talks

TGF-beta;1 suppresses BMP-2-induced mesenchymal-epithelial transition in human oral squamous cell carcinoma cell HSC-4 through attenuation of BMP-2 signal
Masaharu Kamo, Seiko Kyakumoto, Akira Ishisaki
18 Sep 2017   
MSCs educate undifferentiated monocyte/macrophage to the CD206-positive immunosuppressive (M2) macrophages in the co-culture of mouse bone marrow cells
KAMO MasaharuKyakumoto S, Takizawa N, Kamo M, Chosa N, Suzuki K, Okubo N, Yaegashi T. and Ishisaki A.
BIT’s 6th World Gene Convention-2015   26 Nov 2015   
Establishment of a co-culture system for simultaneous proliferation of td-Tomato-expressing mouse bone marrow-derived mesenchymal stem cells and undifferentiated blood cells
Kyakumoto, S., Takizawa, N., Shima, A., Chosa, N., Kamo, M. Okubo, N., Ibi, M., Yaegashi, T. and Ishisaki, A.
12 Sep 2015   
Establishment of a co-culture system for simultaneous proliferation of td-Tomato-expressing mouse bone marrow-derived mesenchymal stem cells and undifferentiated blood cells
26 Nov 2014   
FLICE-inhibitory protein is a target of HSP90 and has an inhibitory role on Fas-induced apoptosis in human salivary gland cell line
89th Annual Meeting of the Endocrine Society   2007   
Galectin-1 mediates suppression of anoikis in human oral squamous cell carcinoma cells
Masaharu Kamo
The Impacts of OMICS-Iwate International Symposium on Biological Sciences   2007   
Characterization and functional analysis of a secreted cysteine-rich protein, scrapie responsive gene one
20th IUBMB International Congress of Biochemistry and Molecular Biology   2006   

Research Grants & Projects

Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2019 - Mar 2022    Investigator(s): Akutsu Hitomi
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2017 - Mar 2020    Investigator(s): KAMO Masaharu
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2020    Investigator(s): Akira Ishisaki
歯肉線維芽細胞(HGF)の機能の発現に重要な受容体やシグナル伝達分子の細胞内局在を制御する分子のうち、ゾレドロン酸(ZA)によりその機能が阻害される細胞内輸送分子を捉えるための研究基盤整備を実施した。ZA によりその細胞内局在が影響されるTGF-β受容体輸送体であるRabファミリーを制御するAddicsinとArl6ip1の細胞内動態を観察するための実験基盤の樹立を試みた。ZAが細胞内輸送分子の局在を変化させるのに適した刺激時間や刺激濃度設定のためには、ZAでその細胞内局在の変化させる分子...
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2010 - Mar 2013    Investigator(s): Masaharu Kamo
上皮由来の腫瘍細胞が転移を起こすには、アノイキスを回避する必要がある。ヒト口腔扁平上皮癌細胞(hOSCC)HSC-3では、ガレクチン-1が、アノイキスを抑制する因子であり、上皮成長因子受容体に結合して細胞の生存のシグナルを増強させて、アノイキスを抑制することが示された。一方、アノイキスの回避は上皮間葉転換により間葉系細胞の性質を得ることにより可能となる。 hOSCC細胞ではTGF-βへの反応性と上皮間葉転換の程度との間に相関性が認められた。最も顕著にTGF-βに反応したHSC-4細胞では、...
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2006 - Mar 2008    Investigator(s): Masaharu Kamo
1.上皮細胞において癌転移抑制遺伝子がその癌の転移能に関与していることが知られているが、Nm23の機能については十分理解されていないため相互作用するタンパク質の網羅的な解析を行った。2.発現ベクターを作製し、大腸菌およびHEK293細胞に導入させてそれぞれのタンパク質を発現させた。このNm23タンパク質を精製後、HEK293細胞を用いたpull-down assayを行い、相互作用タンパク質の精製を行った。これらのタンパク質についてSDS-PAGEにより分離した後、in-gel diges...


Method for Obtaining Peptide Fragments
European Patent 97310175.1-2116