Sataro Goto

Profile Information

Affiliation: collaboration researcher, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Degree: Doctor of Philosophy(The University of Tokyo)
Doctorem Honoris Causa(Semmeweis University)

J-GLOBAL ID: 200901099208575583
researchmap Member ID: 1000082808

External link: http://www.mnc.toho-u.ac.jp/v-lab/aging/

Research Interests

Research Areas

Research History

2007 - Present

Collaborating researcher, Tokyo Metropolitan Institute of Gerontology
2005 - Present

Visiting professor, Graduate School of Physical Education and Sports, Semmelweis University
2005 - Present

Visiting Professor, Semmelweis University Graduate School
2007 - Mar, 2022

Visiting professor, Institute of Health and Sports Science & Medicine, Juntendo University
1979 - 2007

Professor (currently, Professor Emeritus), Faculty of Pharmaceutical Sciences, Toho University
1979 - 2007

Professor, Toho University
1998 - 2003

Visiting professor, Faculty of Medicine, Shinshu University
1998 - 2003

Visiting Professor, Shinshu University
1992 - 1997

Faculty of Medicine, University of Tokyo
1992 - 1997

Part time Lecture, University of Tokyo
1970 - 1979

Research associate, Faculty of Pharmaceutical Sciences, University of Tokyo
1970 - 1979

Research Associate, University of Tokyo
1979

Faculty of Pharmaceutical Sciences, The University of Tokyo
1979

Associate Professor, University of Tokyo
1973 - 1975

Post doctoral fellow, Department of Molecular Biology, Institut Pasteur
1971 - 1973

Post doctoral fellow, Karolinska Institutet

Education

Committee Memberships

2009 - 2015

薬学研究奨励財団理事(2009-現在)
2006 - 2011

American Aging Association、Fellowship committee member (2006-2011)
1991 - 2005

理事, 国際老年学会(アジア・オセアニア地区)
1991 - 2005

国際老年学会理事・国際老年学会アジアオセアニア地区生物学部門議長（1991-2005）
1994 - 2003

日本学術会議癌・老化研究連絡委員会委員（1994-2003）
1992 - 1998

日本基礎老化学会理事（1992- 1998；2000 -2009）・同会長（2000-2006）日本老年学会理事（1995 -1998；2000 -現在）
1991 - 1998

理事,会長, 日本基礎老化学会
1992

評議員, 日本生化学会

Awards

2002

Semmelweis University Doctorem Honoris Causa (名誉博士）

Papers

Exercise effects on physiological function during aging

Zsolt Radak, Ferenc Torma, Istvan Berkes, Sataro Goto, Tatsuya Mimura, Aniko Posa, Laszlo Balogh, Istvan Boldogh, Katsuhiko Suzuki, Mitsuru Higuchi …

Free Radical Biology and Medicine, 132 33-41, Feb, 2019
Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

Melitta Pajk, Alexandra Cselko, Csaba Varga, Aniko Posa, Margareta Tokodi, Istvan Boldogh, Sataro Goto, Zsolt Radak

BIOGERONTOLOGY, 18(4) 593-600, Aug, 2017 Peer-reviewed
Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats

Mohammad Mosaferi Ziaaldini, Erika Koltai, Zsolt Csende, Sataro Goto, Istvan Boldogh, AlbertW. Taylor, Zsolt Radak

EXPERIMENTAL GERONTOLOGY, 67 9-14, Jul, 2015 Peer-reviewed
Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages

Yasunobu Aoki, Akiko H. Hashimoto, Yoshiki Sugawara, Kyoko Hiyoshi-Arai, Sataro Goto, Kenichi Masumura, Takehiko Nohmi

Genes and Environment, 37, Jan 1, 2015
Voluntary exercise can ameliorate insulin resistance by reducing iNOS-mediated S-nitrosylation of Akt in the liver in obese rats

Tsuzuki T, Shinozaki S, Nakamoto H, Kaneki M, Goto S, Shimokado K, Kobayashi H, Naito H, Andrews Z

PLoS ONE, 10(7), 2015 Peer-reviewed
Cardiorespiratory fitness, body mass index, and cancer mortality: a cohort study of Japanese men

Susumu S. Sawada, I-Min Lee, Hisashi Naito, Ryo Kakigi, Sataro Goto, Masaaki Kanazawa, Takashi Okamoto, Koji Tsukamoto, Takashi Muto, Hiroaki Tanaka …

BMC PUBLIC HEALTH, 14(1), Sep, 2014 Peer-reviewed
The redox-associated adaptive response of brain to physical exercise

Z. Radak, F. Ihasz, E. Koltai, S. Goto, A. W. Taylor, I. Boldogh

FREE RADICAL RESEARCH, 48(1) 84-92, Jan, 2014 Peer-reviewed
Effects of regular exercise on neutrophil functions, oxidative stress parameters and antibody responses against 4-hydroxy-2-nonenal adducts in middle aged humans

Soichiro Sasaki, Takayuki Matsuura, Rei Takahashi, Takuya Iwasa, Hitoshi Watanabe, Kouji Shirai, Hideko Nakamoto, Sataro Goto, Shinya Akita, Yoshiro Kobayashi

EXERCISE IMMUNOLOGY REVIEW, 19 60-71, 2013 Peer-reviewed
Dietary Restriction Increases Protein Acetylation in the Livers of Aged Rats

Akihiro Nakamura, Kyojiro Kawakami, Fuyuki Kametani, Sataro Goto

GERONTOLOGY, 59(6) 542-548, 2013 Peer-reviewed
Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training

Erika Koltai, Nikolett Hart, Albert W. Taylor, Sataro Goto, Jenny K. Ngo, Kelvin J. A. Davies, Zsolt Radak

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 303(2) R127-R134, Jul, 2012 Peer-reviewed
Nitric oxide: Is it the cause of muscle soreness?

Zsolt Radak, Hisashi Naito, Albert W. Taylor, Sataro Goto

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 26(2) 89-94, Feb, 2012 Peer-reviewed
Dietary restriction increases site-specific histone H3 acetylation in rat liver: Possible modulation by sirtuins

Kyojiro Kawakami, Akihiro Nakamura, Sataro Goto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 418(4) 836-840, Feb, 2012 Peer-reviewed
Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA

Zsolt Radak, Zhongfu Zhao, Sataro Goto, Erika Koltai

MOLECULAR ASPECTS OF MEDICINE, 32(4-6) 305-315, Aug, 2011 Peer-reviewed
Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats

Orsolya Marton, Erika Koltai, Csaba Nyakas, Tibor Bakonyi, Tania Zenteno-Savin, Shuzo Kumagai, Sataro Goto, Zsolt Radak

BIOGERONTOLOGY, 11(6) 679-686, Dec, 2010 Peer-reviewed
Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice

Kengo Koike, Yoshitaka Kondo, Mitsuaki Sekiya, Yasunori Sato, Kazunori Tobino, Shin-iciro Iwakami, Sataro Goto, Kazuhisa Takahashi, Naoki Maruyama, Kuniaki Seyama …

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 298(6) L784-L792, Jun, 2010 Peer-reviewed
HORMETIC EFFECTS OF REACTIVE OXYGEN SPECIES BY EXERCISE: A VIEW FROM ANIMAL STUDIES FOR SUCCESSFUL AGING IN HUMAN

Sataro Goto, Zsolt Radak

DOSE-RESPONSE, 8(1) 68-72, 2010 Peer-reviewed
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

Erika Koltai, Zsofia Szabo, Mustafa Atalay, Istvan Boldogh, Hisashi Naito, Sataro Goto, Csaba Nyakas, Zsolt Radak

MECHANISMS OF AGEING AND DEVELOPMENT, 131(1) 21-28, Jan, 2010 Peer-reviewed
[A strategy for successful late life based on biomedical findings in gerontology].

Goto S

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 47 107-109, 2010 Peer-reviewed
Biological significance of protein modifications in aging and calorie restriction

Akihiro Nakamura, Kyojiro Kawakami, Fuyuki Kametani, Hideko Nakamoto, Sataro Goto

AGING, CANCER, AND AGE-RELATED DISEASES: COMMON MECHANISM?, 1197 33-39, 2010 Peer-reviewed
抗酸化剤摂取はSenescence-accelerated mice(SAM)P1の老化を抑制するか?

小池建吾, 瀬山邦明, 袁益明, 秋吉妙子, 岩間水輝, 天野晶子, 佐藤安訓, 近藤嘉高, 石神昭人, 後藤佐多良 …

順天堂医学, 55(3) 370-370, Sep, 2009

Misc.

128

一過性の持久的運動は2型糖尿病ラットの骨格筋における核内のNrf2量を増加させる

都築孝允, 吉原利典, 後藤佐多良, 内藤久士

基礎老化研究, 40(Suppl.) 63-63, May, 2016
運動が2型糖尿病ラットのレドックス調節機構に与える影響

都築孝允, 吉原利典, 後藤佐多良, 内藤久士

順天堂スポーツ健康科学研究, 7(Suppl.) 6-6, Mar, 2016
運動による肥満ラットの肝臓S‐ニトロソ化Aktの減少はインスリン抵抗性の改善に関与する

都築孝允, 篠崎昇平, 中本英子, 金木正夫, 後藤佐多良, 下門顕太郎, 小林裕幸, 内藤久士

基礎老化研究, 39(2) 57, May 29, 2015
運動による肥満ラットの肝臓S-ニトロソ化Aktの減少はインスリン抵抗性の改善に関与する

都築孝允, 篠崎昇平, 中本英子, 金木正夫, 後藤佐多良, 下門顕太郎, 小林裕幸, 内藤久士

日本老年医学会雑誌, 52(Suppl.) 150-150, May, 2015
Elevated oxidative stress in type 2 diabetic OLETF rat liver

Tsuzuki T, Nakamoto H, Kobayashi H, Goto S, Ichinoseki-Sekine N, Naito H

FASEB J, 29, Apr, 2015 Peer-reviewed
定期的な運動は2型糖尿病ラットの肝臓S‐ニトロソ化Aktを軽減する

都築孝允, 篠崎昇平, 中本英子, 小林裕幸, 後藤佐多良, 金木正夫, 内藤久士

体力科学, 63(6) 603, Dec 1, 2014
Implications of oxidative damage to proteins and DNA in aging and its intervention by caloric restriction and exercise

Sataro Goto, Zsolt Radak

JOURNAL OF SPORT AND HEALTH SCIENCE, 2(2) 75-80, Jun, 2013
The complex role of physical exercise and reactive oxygen species on brain

Zsolt Radak, Orsolya Marton, Eniko Nagy, Erika Koltai, Sataro Goto

JOURNAL OF SPORT AND HEALTH SCIENCE, 2(2) 87-93, Jun, 2013
Redox-regulating sirtuins in aging, caloric restriction, and exercise

Zsolt Radak, Erika Koltai, Albert W. Taylor, Mitsuru Higuchi, Shuzo Kumagai, Hideki Ohno, Sataro Goto, Istvan Boldogh

Free Radical Biology and Medicine, 58 87-97, May, 2013 Peer-reviewed
Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training

303(1,Pt.2) R127-R134, Jul, 2012
Age-associated Declines In Mitochondrial Biogenesis And Protein Quality Control Are Minimized By Exercise Training

Erika Koltai, Nikolett Hart, Albert W. Taylor, Sataro Goto, Jenny K. Ngo, Kelvin J. A. Davies, Zsolt Radak

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 44 349-349, May, 2012
Dietary restriction increases site-specific histone H3 acetylation in rat liver: Possible modulation by sirtuins

418(4) 836-840, Feb 24, 2012
Nitric oxide: Is it the cause of muscle soreness?

Zsolt Radak, Hisashi Naito, Albert W. Taylor, Sataro Goto

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 26(2) 89-94, Feb, 2012
ビタミンC摂取によるCOPD発症リスク軽減効果の検討

小池建吾, 後藤佐多良

順天堂医学, 57(2) 187-188, Apr, 2011
The Effects of Aging and Exercise on Protein Acetylation/Deacetylation: Role of Sirtuins

RADAK Zsolt, MARTON Orsolya, KOLTAI Erika, GOTO Sataro, NAITO Hisashi

順天堂医学, 56(3) 257-259, Jun 30, 2010
Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice

298(6,Pt.1) L784-L792, Jun, 2010
ビタミンC摂取によるCOPD発症リスク軽減効果の検討

小池建吾, 後藤佐多良

順天堂医学, 56(2) 139-139, Apr, 2010
Age associated increase in SIRT1 and SIRT6 content attenuated by exercise in rat skeletal muscle

E. Koltai, Z. Szabo, I. Boldogh, S. Goto, Z. Radak

FREE RADICAL RESEARCH, 43 71-71, 2009
Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia

295(4,Pt.2) R1231-R1237, Oct, 2008
Beneficial effect of regular exercise on hepatic nuclear and mitochondrial DNA oxidation in old rats

Sataro Goto, Hideko Nakamoto, Takao Kaneko, Zsolt Radak, Hisashi Naito

JOURNAL OF AGING AND PHYSICAL ACTIVITY, 16 S165-S165, Jul, 2008

Books and Other Publications

Dietary restriction initiated in late adulthood can reverse age-related alterations of protein and protein metabolism.In:Increasing the Healthy Life Span:Conventional Measures and Slwing the Innate Aging Process.(ed.Harman D)

Ann New York Acad Sci, 2002
日野原重明他監修｢看護のための最新医学講座」

第17巻｢老人の医療」第1章全体像を把握する。からだの老化。生化学からみた老化（中山書店）, 2001
「看護のための最新医学講座」第17巻「老人の医療」第一章全体像を把握する、からだの老化、生化学からみた老化

中山書店, 2001
Implications of Protein Degradation in Aging.

Healthy Aging for Functional Longevity : Molecular and Cellular Interactions in Senescence Ann. New York Acad. Sci., 2001
Oxidative modification of proteins and DNA.

Free Radicals in Exercise and Aging(Champaign, IL, USA), 2000
Ubiquitin/proteasome system of proteolysis : Effect of age and dietary restriction from early senescence in mice and rats.

Gerontological Approaches to care for the aged in the 21^st century, 2000
第2章老化の生物学タンパク質の加齢変化

「新老年学」(第2版、東京大学出版会), 1999
第5章老化の生物学老化制御

「新老年学」(第2版、東京大学出版会), 1999
The effects of exercise, aging and caloric restriction on protein oxidation and DNA damage in skeletal muscle.

Oxidative Stress in Skeletal Muscle. (ed. A. Z. Reznick, Birkh(]J1103[)user Verlag, Basel/Switzerland), 1998
老化の基礎-蛋白質から見た老化

「老年消化器病の現況と将来」(医学図書出版), 1997
Age-associated changes in protein turnover with special reference to the effect of oxidative modifications.

Molecular Biology of Development and Aging(ed. Kanungo, M. S. )New Age International Publishers, New Delhi., 1997
Pharmacological Intervention in Aging and age-associated disorders.

Ann. New York Acad. Sci., 1996
1老年医学総論1老化の生物学

「新老年病研修マニュアル」(メジカルレビュー社), 1995
Accumulation of ubiquitinated proteins in aging mouse brains.

Oxidative Stress and Aging, 1995
Age-associated changes of oxidative modification and turnover of proteins.

Oxidative Stress and Aging, 1995
老化とライソゾーム

「ライソゾームの基礎とライソゾーム病」(学際企画), 1994
栄養制限下における物質代謝

「老化と環境因子」(学会出版センター), 1994
1 老化の生理学。第一章老化の理論および機構 2:分子生物学から見た老化,2-3:蛋白質

「新老年学」東京大学出版会, 1992
第2章老化はなぜ起こるか

「一億人の化学:健やかに老いる」(大日本図書), 1992

Professional Memberships

Works

Research Projects

Do skeletal muscle fiber composition-related genetic polymorphisms predict future chronic diseases?

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Goto Sataro
Quantitative estimation of susceptibility of aged animal to a mutagen in ambient air.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2005 - 2006

AOKI Yasunobu, NOHMI Takehiko, GOTO Sataro, MATSUMOTO Michi
Roles of oxidatively modified proteins in the brain of aging animals : Intervention by moderate regular exercise

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2000 - 2001

GOTO Sataro
加齢に伴う蛋白質分解活性低下の分子機構

科学研究費助成事業, 一般研究(C), 日本学術振興会, 1992 - 1993

後藤佐夛良, 高橋良哉
Studies on Species-specific Expression of Uricase Gene

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1991 - 1992

MOTOJIMA Kiyoto, GOTO Sataro
Biochemical studies on the mechanism of Generation and accumulation of altered enzymes with age

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (B), Japan Society for the Promotion of Science, 1988 - 1989

GOTO Sataro, MOTOJIMA Kiyoto, TAKAHASHI Ryoya
老化研究のストラテジー

科学研究費助成事業, 総合研究(B), 日本学術振興会, 1987 - 1987

朝長正徳, 藤原美定, 竹田俊男, 後藤佐多良, 松尾光芳, 嶋昭紘
老化メカニズムの解明および健康長寿の実現

共同研究, 1967
老化と運動ホルミシス
老化とエピジェネティックス
Aging lntervention
Mechanism of Aging

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