Shigeyoshi Fujiwara

Profile Information

Degree: (BLANK)

J-GLOBAL ID: 200901082129676269
researchmap Member ID: 1000085033

Research Interests

Research Areas

Life sciences / Virology /

Education

- 1984

Hokkaido University
- 1984

Graduate School, Division of Medicine, Hokkaido University
- 1980

School of Medicine, Hokkaido University
- 1980

Faculty of Medicine, Hokkaido University

Papers

101

Rubella Virus Triggers Type I Interferon Antiviral Response in Cultured Human Neural Cells: Involvement in the Control of Viral Gene Expression and Infectious Progeny Production.

Sayuri Sakuragi, Huanan Liao, Kodai Yajima, Shigeyoshi Fujiwara, Hiroyuki Nakamura

International journal of molecular sciences, 23(17), Aug 29, 2022
Are Viral Infections Key Inducers of Autoimmune Diseases? Focus on Epstein-Barr Virus.

Masami Takei, Noboru Kitamura, Yosuke Nagasawa, Hiroshi Tsuzuki, Mitsuhiro Iwata, Yasuko Nagatsuka, Hideki Nakamura, Kenichi Imai, Shigeyoshi Fujiwara

Viruses, 14(9), Aug 27, 2022
Antineoplastic and anti-inflammatory effects of bortezomib on systemic chronic active EBV infection

Mayumi Yoshimori, Haruna Shibayama, Ken-Ichi Imadome, Fuyuko Kawano, Ayaka Ohashi, Miwako Nishio, Norio Shimizu, Morito Kurata, Shigeyoshi Fujiwara, Ayako Arai

Blood Advances, 5(7) 1805-1815, Apr 13, 2021
Human osteoclastogenesis in Epstein-Barr virus-induced erosive arthritis in humanized NOD/Shi-scid/IL-2Rγnull mice.

Yosuke Nagasawa, Masami Takei, Mitsuhiro Iwata, Yasuko Nagatsuka, Hiroshi Tsuzuki, Kenichi Imai, Ken-Ichi Imadome, Shigeyoshi Fujiwara, Noboru Kitamura

PloS one, 16(4) e0249340, 2021
Chronic Active Epstein-Barr Virus Infection: Is It Immunodeficiency, Malignancy, or Both?

Shigeyoshi Fujiwara, Hiroyuki Nakamura

Cancers, 12(11), Oct 30, 2020
Nationwide survey of systemic chronic active EBV infection in Japan in accordance with the new WHO classification.

Ichiro Yonese, Chizuko Sakashita, Ken-Ichi Imadome, Tohru Kobayashi, Masahide Yamamoto, Akihisa Sawada, Yoshinori Ito, Noriko Fukuhara, Asao Hirose, Yusuke Takeda …

Blood advances, 4(13) 2918-2926, Jul 14, 2020 Peer-reviewed
Animal Models for Gammaherpesvirus Infections: Recent Development in the Analysis of Virus-Induced Pathogenesis.

Shigeyoshi Fujiwara, Hiroyuki Nakamura

Pathogens (Basel, Switzerland), 9(2), Feb 12, 2020 Peer-reviewedLead authorCorresponding author
Editorial: Epstein-Barr Virus-Associated T/NK-Cell Lymphoproliferative Diseases

Fujiwara Shigeyoshi, Kimura Hiroshi

FRONTIERS IN PEDIATRICS, 7(JULY) 285, Jul 10, 2019 Lead authorCorresponding author
Defective Epstein-Barr virus in chronic active infection and haematological malignancy.

Yusuke Okuno, Takayuki Murata, Yoshitaka Sato, Hideki Muramatsu, Yoshinori Ito, Takahiro Watanabe, Tatsuya Okuno, Norihiro Murakami, Kenichi Yoshida, Akihisa Sawada …

Nature microbiology, 4(3) 404-413, Mar, 2019 Peer-reviewed
Publisher Correction: Defective Epstein-Barr virus in chronic active infection and haematological malignancy.

Yusuke Okuno, Takayuki Murata, Yoshitaka Sato, Hideki Muramatsu, Yoshinori Ito, Takahiro Watanabe, Tatsuya Okuno, Norihiro Murakami, Kenichi Yoshida, Akihisa Sawada …

Nature microbiology, 4(3) 544-544, Mar, 2019 Peer-reviewed
STAT3 is constitutively activated in chronic active Epstein-Barr virus infection and can be a therapeutic target

Erika Onozawa, Haruna Shibayama, Honami Takada, Ken-Ichi Imadome, Sho Aoki, Mayumi Yoshimori, Norio Shimizu, Shigeyoshi Fujiwara, Takatoshi Koyama, Osamu Miura …

Oncotarget, 9(57) 31077-31089, Jul 24, 2018 Peer-reviewed
Animal Models of Human Gammaherpesvirus Infections

Shigeyoshi Fujiwara

Adv Exp Med Biol, 1045 413-436, Jun, 2018 Peer-reviewedLead authorLast authorCorresponding author
Humanized mice: A brief overview on their diverse applications in biomedical research

Shigeyoshi Fujiwara

J Cell Physiol, 233(4) 2889-2901, Apr, 2018 Peer-reviewedLead authorLast authorCorresponding author
Overview of EBV-Associated T/NK-Cell Lymphoproliferative Diseases.

Kimura H, Fujiwara S

Frontiers in pediatrics, 6 417, 2018 Peer-reviewedLast author
Para-psychobiotic Lactobacillus gasseri CP2305 ameliorates stress-related symptoms and sleep quality

K. Nishida, D. Sawada, T. Kawai, Y. Kuwano, S. Fujiwara, K. Rokutan

JOURNAL OF APPLIED MICROBIOLOGY, 123(6) 1561-1570, Dec, 2017 Peer-reviewed
EBV induces persistent NF-kappa B activation and contributes to survival of EBV-positive neoplastic T- or NK-cells

Honami Takada, Ken-Ichi Imadome, Haruna Shibayama, Mayumi Yoshimori, Ludan Wang, Yasunori Saitoh, Shin Uota, Shoji Yamaoka, Takatoshi Koyama, Norio Shimizu …

PLOS ONE, 12(3) e0174136, Mar, 2017 Peer-reviewed
EBV induces persistent NF-kappa B activation and contributes to survival of EBV-positive neoplastic T- or NK-cells

Honami Takada, Ken-Ichi Imadome, Haruna Shibayama, Mayumi Yoshimori, Ludan Wang, Yasunori Saitoh, Shin Uota, Shoji Yamaoka, Takatoshi Koyama, Norio Shimizu …

PLOS ONE, 12(3) e0182682, Mar, 2017 Peer-reviewed
Human cytomegalovirus downregulates SLITRK6 expression through IE2

Huanan Liao, Haruna Sato, Ryosuke Chiba, Tomoko Kawai, Kazuhiko Nakabayashi, Kenichiro Hata, Hidenori Akutsu, Shigeyoshi Fujiwara, Hiroyuki Nakamura

JOURNAL OF NEUROVIROLOGY, 23(1) 79-86, Feb, 2017 Peer-reviewed
Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course

Sawada, D., Kawai, T., Nishida, K., Kuwano, Y., Fujiwara, S., Rokutan, K.

Journal of Functional Foods, 31 188-197, 2017 Peer-reviewed
Generation and analysis of humanized mouse model of EBV infection

Ken-Ichi Imadome, Shigeyoshi Fujiwara

Methods in Molecular Biology, 1532 241-254, 2017 Peer-reviewedLast authorCorresponding author

Misc.

EBウイルス関連疾患の発症メカニズム－なぜ一部の人が発症するのか？

藤原成悦, 中村浩幸

臨床免疫・アレルギー科, 72(4) 425-434, Oct, 2019 InvitedLead authorCorresponding author
【ヒト化マウスモデル】ヒト化マウスの基本事項とさまざまな応用序に代えて

藤原成悦

臨床免疫・アレルギー科, 68(3) 243-248, Sep, 2017 Invited
Epstein-Barr Virus-Induced Expression of Receptor Activator Nuclear Factor-kappa b Ligand on B Cells Is Possibly Responsible for Erosive Arthritis in Epstein-Barr Virus-Infected Humanized Nonobese Diabetic/Shi-Scid/gamma cnull Mice

Mitsuhiro Iwata, Yosuke Nagasawa, Noboru Kitamura, Takamasa Nozaki, Eiko Ishizuka, Ken-Ichi Imadome, Shigeyoshi Fujiwara, Masami Takei

ARTHRITIS & RHEUMATOLOGY, 68, Oct, 2016
CLONAL DYNAMICS OF TWO DISTINCT CLONES IN LEUKEMIC TRANSFORMATION FROM MDS WITH ISOLATED DEL(5Q) HARBORING TP53 MUTATION

H. Tsukamoto, Y. Watatani, K. Yoshida, Y. Yamashita, H. Tanaka, K. Chiba, Y. Shiraishi, Y. Kawaguchi, S. Fujiwara, N. Kabasawa …

HAEMATOLOGICA, 101 496-497, Jun, 2016
EBウイルス感染モデルマウス種の壁をどう乗り越えるか?

藤原成悦

西日本皮膚科, 78(3) 281-281, Jun, 2016
疾病モデルを用いた病態の解明獣医臨床研究におけるNOGマウスの有用性を考える人医療からヒト化マウスをもちいたEBウイルス関連疾患モデル

藤原成悦

獣医臨床病理, 14(1) 63-63, Dec, 2015
【ウイルス感染関連造血器疾患の病態・治療研究の進歩】 EBV関連リンパ増殖性疾患疾患概念と病態解析研究

今留謙一, 藤原成悦, 大賀正一

血液内科, 71(2) 187-193, Aug, 2015
ヒト化マウスを用いるウイルス感染症研究病態の再現から予防・治療法の評価まで

藤原成悦, 今留謙一, 武井正美

臨床免疫・アレルギー科, 63(3) 263-270, Mar, 2015
EBウイルスと関節リウマチ

岩田光浩, 長澤洋介, 藤原成悦, 武井正美

臨床免疫・アレルギー科, 63(1) 96-101, Jan, 2015
STAT3 Is Activated By EBV in T or NK Cells Leading to Development of EBV-T/NK-Lymphoproliferative Disorders

Honami Komatsu, Ken-Ichi Imadome, Haruna Shibayama, Tomotaka Yada, Momoko Yamada, Kouhei Yamamoto, Takatoshi Koyama, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai

BLOOD, 124(21), Dec, 2014
Human Osteoclasts Are Mobilized in Erosive Arthritis of Epstein-Barr Virus-Infected Humanized NOD/Shi-Scid/IL-2R gamma(null) Mice.

Yosuke Nagasawa, Natsumi Ikumi, Takamasa Nozaki, Hirotake Inomata, Kenichi Imadome, Noboru Kitamura, Mitsuhiro Iwata, Shigeyoshi Fujiwara, Masami Takei

ARTHRITIS & RHEUMATOLOGY, 66 S1020-S1021, Oct, 2014
Epstein-Barr Virus Induces Activation-Induced Cytidine Deaminase Expression in T or NK Cells Leading to Mutagenesis and Development of Lymphoma

Ayako Arai, Masato Horino, Ken-Ichi Imadome, Kohsuke Mai, Honami Komatsu, Ludan Wang, Go Matsuda, Kasumi Hamazaki, Morito Kurata, Tetsuya Kurosu …

BLOOD, 122(21), Nov, 2013
感染がん・炎症がんの分子基盤 EBVはT、NK細胞に感染後AID発現とそれによる遺伝子変異蓄積をもたらし腫瘍発症に寄与する(Molecular mechanisms for infection- and inflammation-associated carcinogenesis EBV induces AID expression in T or NK cells leading to mutagenesis and development of lymphoma)

新井文子, 倉田盛人, 藤原成悦, 三浦修

日本癌学会総会記事, 72回 34-34, Oct, 2013
先入性サイトメガロウイルス感染におけるウイルス型の解析

生田和史, 錫谷達夫, 浅野仁覚, 石橋啓, 今村孝, 峰松俊夫, 井上直樹, 久保隆彦, 藤原成悦, 中井英剛 …

福島医学雑誌, 63(3) 170-170, Sep, 2013
難治性EBウイルス関連T/NKリンパ増殖性疾患モデルマウスを用いた新規薬剤の評価研究

原口摩耶, 今留謙一, 新井文子, 小山高敏, 藤原成悦

臨床病理, 61(補冊) 182-182, Sep, 2013
サイトメガロウイルス血清型・DNA型に基づく先天感染例の検討

生田和史, 峰松俊夫, 石岡賢, 佐藤友香, 石橋啓, 今村孝, 藤原成悦, 久保隆彦, 中井英剛, 吉川哲史 …

日本ウイルス学会学術集会プログラム・抄録集, 61st, 2013
ウイルスと自己免疫疾患原因としてのEpstein-Barrウイルスの可能性

武井正美, 野崎高正, 猪股弘武, 桑名慶和, 北村登, 白岩秀隆, 井汲菜摘, 長澤洋介, 澤田滋正, 矢島美彩子 …

日大医学雑誌, 71(5) 302-310, Oct, 2012
EBV関連難治性疾患における感染細胞産生sFasの役割についての検討

山田千尋, 今留謙一, 小山高敏, 藤原成悦

臨床病理, 60(補冊) 273-273, Oct, 2012
ヒト化マウスを用いたEBウイルス感染細胞と肝機能障害の関連についての検討

浜崎霞, 千葉祐規乃, 山田千尋, 松田剛, 小山高敏, 藤原成悦, 今留謙一

臨床病理, 60(補冊) 274-274, Oct, 2012
疾患モデルによる免疫病態の解明 EBウイルス誘発ビラン性関節炎のヒト免疫化マウスモデル

武井正美, 矢島美彩子, 今留謙一, 桑名慶和, 猪股弘武, 野崎高正, 井汲菜摘, 白岩秀隆, 北村登, 澤田滋正 …

日本臨床免疫学会会誌, 35(4) 316-316, Aug, 2012

Books and Other Publications

EBウイルス改訂第3版

藤原成悦 (Role: Contributor, 動物モデル)

診断と治療社, Sep, 2015 (ISBN: 9784787821546)
EBウイルス改訂第2版

藤原成悦 (Role: Contributor, 動物モデル)

診断と治療社, Aug, 2008 (ISBN: 9784787816603)
検査値のみかた : 付パニック値・警戒値

藤原成悦, 岡野素彦 (Role: Contributor, EBウイルス抗原・抗体)

中外医学社, Jun, 2006 (ISBN: 9784498011366)
検査値のみかた : 付パニック値・警戒値

藤原成悦, 岡野素彦 (Role: Contributor, EBウイルスの核酸診断)

中外医学社, Jun, 2006 (ISBN: 9784498011366)
EBウイルス

藤原成悦 (Role: Contributor, Bリンパ球不死化)

診断と治療社, Jul, 2003 (ISBN: 4787812351)
Advances in Applied Biotechnology: Gene Regulation/Oncogenesis/AIDS

Schweinfest, C. W, Jorcyk, C. L, Fujiwara, S, Lau, L. F, Papas, T. S (Role: Contributor, Regulation of G0/G1 transition genes by c-myc)

Gulf Publishing Co, Houston, 1990
The ┣DBets(/)-┫DB family of nuclear oncoproteins : identification and characterization

Fisher, R. J, Fujiwara, S, Koizumi, S, Bhat, N. K, Papas, T. S (Role: Contributor)

Advances in Applied Biotechnology: Gene Regulation/Oncogenesis/AIDS, Gulf Publishing Co, 1990
Molecular Genetics of Chromosome 21 and Down Syndrome

Papas, T. S, Blair, D. G, Watson, D. K, Yuan, C. C, Ruscetti, S. K, Fujiwara, S, Seth, A. K, Fisher, R. J, Bhat, N. K, Mavrothalassitis, G, Koizumi, S, Jorcyk, C. L, Schweinfest, C. W, Ascione, R (Role: Contributor, The ETS family of genes: structural analysis, gene products, and involvement in neoplasia and other pathologies)

Wiley-Liss, 1990
Infection and oncogenesis by ubiquitous human Epstein-Barr virus : uncontrolled lympho proliferation and risk factors

Osato, T, Mizuno, F, Aya, T, Fujiwara, S, Koizumi, S, Imai, S, Matsuura, A, Kinoshita, T, Sugiura, M, Kyi, H, Kikuta, H, Okano, M, Matsumoto, S, Abo, W, Yamanaka, T, Chiba, S, Nakao, T, Miyazaki, T, Miwa, M, Ohigashi, H, Koshimizu, K, Ito, Y, Harabuchi, Y, Kataura, A (Role: Contributor)

"Oncogenic Herpesviruses: Recent Advances in Japan" Hokkaido University School of Medicine, 1989
Vector systems for the high-level expression of oncogenes, HTLV-1, and HIV polypeptides

Papas, T. S, Samuel, K. P, Lautenberger, J. A, Dubois, G. C, Zweig, M, Showalter, S. D, Seth, A, Fisher, R. J, Fujiwara, S, Schweinfest, C. W, Shih, T. Y, Ascione, R (Role: Contributor)

"Molecular Probes: Technology and Medical Application" Raven Press, 1989
c-┣DBets(/)-┫DB -2 and the mitogenic signal pathway

Haematology and Blood Transfusion 32: Modern Trends in Human Leukemia (]G0008[), 1989
The ets oncogene

Papas, T. S, Blair, D. G, Fisher, R. J, Watson, D. K, Sacchi, N, Fujiwara, S, Bhat, N. K, Ascione, R (Role: Contributor)

"The oncogene handbook", Elsevier, 1988
Molecular Mechanisms in the Regulation of Cell Behavior

Papas, T. S, Bhat, N. K, Fujiwara, S, Ascione, R, Fisher, R. J (Role: Contributor, Temporal regulation of ets gene expression in murine tissues)

"Molecular Mechanisms in the 'Regulation of Cell Behavior" Alan Liss, 1987
The ┣DBets(/)-┫DB genes in cells and viruses : implications for leukemics and other human diseases

"Normal and Neoplastic Blood Cells: From Genes to Therapy" New York Academy of Sciences, 1987
Viral ┣DBmyc(/)-┫DB genes and their cellular homologs

"Gene Amplification and Analysis: Oncogenes" Elsevier, 1986
Human Epstein-Barr virus and cancer

Osato, T, Mizuno, F, Fujiwara, S, Koizumi, S (Role: Contributor)

"The Human Oncogenic Viruses: Molecular Analysis and Diagnosis" Human Press, 1986

Professional Memberships

日本ウィルス学会

Research Projects

Analysis on the role of SLITRK6 in congenital CMV infection

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Fujiwara Shigeyoshi
Analysis of native immune responses to Epstein-Barr virus in the virus-infected humanized mice

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

FUJIWARA Shigeyoshi, IMADOME Ken-ichi
New functions of the Epstein-Barr virus nuclear protein 2 revealed by gene transfer with a tetracycline-regulated expression vector

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1999 - 2000

FUJIWARA Shigeyoshi
Development of novel experimental systems for persistent Epstein-Barr virus infection

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1996 - 1997

FUJIWARA Shigeyoshi, ONO Yasushi
Epstein-Barr virus mutagenesis by homologous recombination

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1993 - 1994

FUJIWARA Shigeyoshi, ONO Yasushi
Characterization of Epstein-Barr viral proteins by using monoclonal antibodies
Experimental infection of human T lymphocytes with recombinant Epstein-Barr viruses
ヒト化マウスをもちいたウイルス特異的原発性免疫不全症の疾患モデル

藤原成悦
慢性活動性EBウイルス感染症とその類縁疾患に対する革新的治療薬を実現するための統合的研究体制の構築

藤原成悦

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