Naoto SUZUKI

Profile Information

Affiliation: Professor, School of Dentistry Department of Dentistry -, Nihon University

Other name(s) (e.g. nickname): Suzuki Naoto
Researcher number: 10226532
J-GLOBAL ID: 200901060329317022
researchmap Member ID: 1000085434

Research Interests

Research Areas

Research History

Apr, 2010 - Present

日本大学教授
Apr, 2007 - Mar, 2010

日本大学准教授
Jul, 2006 - Mar, 2007

日本大学助教授
1995 - Jun, 2006

日本大学講師
Sep, 1997 - Aug, 1999

トロント大学歯学部招聘教授
1990 - 1995

日本大学助手

Education

Committee Memberships

Apr, 2011 - Present

評議員, 日本歯科医学教育学会
Apr, 2008 - Present

理事, 硬組織再生生物学会
Jul, 2007 - Present

評議員, 歯科基礎医学会
Jul, 2006 - Present

評議員, 日本大学歯学会
Jul, 2006 - Present

理事, 日本大学歯学会

Awards

Papers

127

Co-Stimulation of AGEs and LPS Induces Inflammatory Mediators through PLCγ1/JNK/NF-κB Pathway in MC3T3-E1 Cells

Natsuko Tanabe, Keiko Tomita, Soichiro Manaka, Risa Ichikawa, Tadahiro Takayama, Takayuki Kawato, Misae Ono, Yuma Masai, Akihisa Utsu, Naoto Suzuki …

cells, 12(10), May 2, 2023 Peer-reviewedInvited
Atmospheric pressure plasma treatment with nitrogen induces osteoblast differentiation and reduce iNOS and COX-2 expressions

Sato R, Namura Y, Tanabe N, Sakai M, Utsu A, Tomita K, Suzuki N, Motoyoshi M

Journal of Hard Tissue Biology, 131-136, Apr 30, 2021 Peer-reviewed
Glucose transporter 4 mediates LPS-induced IL-6 production in osteoblasts under high glucose conditions

Shunichiro Kato, Natsuko Tanabe, Mayu Nagao, Jumpei Sekino, Keiko Tomita, Mayu Sakai, KImiko Abe, Naoto Suzuki and Koichiro Ueda

Journal of Oral Sciense, 62(4) 423-426, Oct, 2020 Peer-reviewed
PKY2 mediates BzATP-induced extracellular matrix proteins synthesis

Torigoe G, Tanabe, N, Manaka, S, Kariya T, Kawato, T, Sekino J, Kato S …

Biochem Biopys Res Commun, 494(3-4) 663-667, Oct 30, 2018 Peer-reviewed
MiR-200b attenuates IL-6 production through IKKβ and ZEB1 in human gingival fibroblasts.

Sari Matsui, Liming Zhou, Yohei Nakayama, Masaru Mezawa, Ayako Kato, Naoto Suzuki, NatsukoTanabe, Tomohiro Nakayama, Yuki Suzuki, Noriaki Kamio …

Inflammation Res, 67 956-793, Oct 30, 2018 Peer-reviewed
Low-intensity pulsed ultrasound induces cartilage matrix synthesis and reduced MMP13 expression in chondrocytes.

Jumpei Sekino, Mayu Nagao, Shunichiro Kato, Mayu Sakai, Kimiko Abe, Enri Nakayama, Mitsuyasu Sato, Yuki Nagashima, Haruka Hino, Natsuko Tanabe …

Biochemi Biophys Res Comm, 506 290-297, Oct 30, 2018 Peer-reviewed
Involvement of calcium-sensing receptor in mineral trioxide aggregate-induced osteogenic gene expression in murine MC3T3-E1 cells

Yasukawa T, Tanabe N, Tsuda H, suzuki Y, Kawato T, Suzuki N, Maeno M, Ogiso B

Dent Mater J, 36(4) 469-475, Jul 30, 2017 Peer-reviewed
Low-intensity pulsed ultrasound inhibits lipopolysaccharide-induced IL-6 and RANKL expression in osteoblasts

Mayu Nagao, Natsuko Tanabe, Soichiro Manaka, Tadahiro Takayama, Takayuki Kawato, Go Torigoe, Jumpei Sekino, Naoya Tsukune, Manami Ozaki, Masao Maeno …

JOURNAL OF ORAL SCIENCE, 59(2) 303-309, Jun, 2017 Peer-reviewed
Alkaline phosphatase determines polyphosphate-induced mineralization in a cell-type independent manner

Yoshikazu Mikami, Hiromasa Tsuda, Yuko Akiyama, Masaki Honda, Noriyoshi Shimizu, Naoto Suzuki, Kazuo Komiyama

JOURNAL OF BONE AND MINERAL METABOLISM, 34(6) 627-637, Nov, 2016 Peer-reviewed
Effect of a novel fluorapatite-forming calcium phosphate cement with calcium silicate on osteoblasts in comparison with mineral trioxide aggregate

Yusuke Suzuki, Makoto Hayashi, Natsuko Tanabe, Takuya Yasukawa, Yoriyuki Hirano, Shozo Takagi, Laurence C. Chow, Naoto Suzuki, Bunnai Ogiso

JOURNAL OF ORAL SCIENCE, 57(1) 25-30, Mar, 2015 Peer-reviewed
少人数テゥートリアル教育での成果発表の学生間の相互評価がテゥーターに対する評価に及ぼす影響-日本大学歯学部第2学年の生体基礎演習を振り返って-

酒井秀嗣, 三枝禎, 鈴木直人, 田中一, 桑田文幸

日本大学FD研究, (3) 9-12, Mar, 2015 Peer-reviewed
Tension Force-Induced ATP Promotes Osteogenesis Through P2X7 Receptor in Osteoblasts

Taro Kariya, Natsuko Tanabe, Chieko Shionome, Soichiro Manaka, Takayuki Kawato, Ning Zhao, Masao Maeno, Naoto Suzuki, Noriyoshi Shimizu

JOURNAL OF CELLULAR BIOCHEMISTRY, 116(1) 12-21, Jan, 2015 Peer-reviewed
Low-intensity pulsed ultrasound-induced ATP increases bone formation via the P2X7 receptor in osteoblast-like cells

Manaka S, Tanabe N, Kariya T, Naito M, Takayama T, Nagao M, Liu D, Ito K, Maeno M, Suzuki N …

FEBS Lett, 589 310-318, Dec 24, 2014 Peer-reviewed
BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells.

Tsuda H, Zhao N, Imai, K, Ochiai K, Otsuka K, Suzuki N

Bosn J Basic Med Sci, 13(4) 271-275, Nov 30, 2013 Peer-reviewed
Calcium ions released from mineral trioxide aggregate convert the differentiation pathway of C2C12 cells into osteoblast lineage

Matsumoto S, Hayashi M, Suzuki Y, Suzuki N. Maeno M, Ogiso B

J Endodontics, in press, Mar 30, 2013 Peer-reviewed
Calcium ions released from mineral trioxide aggregatae are taken up by C2C12 cells via L-type voltage-dipendent calcium channel

Matsumoto S, Hayashi M, Tanebe N, Suzuki Y, Kobayashi Y, Suzuki N, Maeno M, Ogiso, B

J Hard Tissue Biol, 22(1) 13-18-18, Mar 30, 2013 Peer-reviewed
受容体チロシンキナーゼ阻害剤による非外科的顎嚢胞治療法開発のための基礎的研究

山口洋子,石井輝彦,大木秀郎,大塚吉兵衛,鈴木直人

日大歯学, 86(3) 139-147-147, Dec 30, 2012 Peer-reviewed
Influence of Compressive Force and IL-1β on Metabolism of the Extracellular Matrix in Human Chondrocytes

Nakayama G, Aida Y, Watanabe Y, Honda K, Tanigawa S, Maeno M, Matsumura H

J Hard Tissue Biol, 21(3) 217-230-230, Sep, 2012 Peer-reviewedCorresponding author
Programmed cell death and its possible relationship with periodontal desease

Zhao N, Yamaguchi Y, Suzuki N

Journal of Oral Science, 54(2) 137-149-149, Apr, 2012 Peer-reviewed
Compressisve force induces the expression of bone remodeling-related proteins via interluekin-11 production in MC3T3-E1 cells

Chieko Shionome, Takayuki Kawato, Natsuko Tanabe, Taro Kariya, Rina Sanuki, Yuki Koyama, Naoto Suzuki, Noriyoshi Shimizu, Masao Maeno

J Haed Tissue BIol, 21(1) 65-74-74, Mar, 2012 Peer-reviewed

Misc.

LIPUS suppressed LPS-induced IL-1 alpha through the inhibition of NF-kappa B nuclear translocation via AT1-PLC beta pathway in MC3T3-E1 cells

Mayu Nagao, Natsuko Tanabe, Soichiro Manaka, Masako Naito, Jumpei Sekino, Tadahiro Takayama, Takayuki Kawato, Go Torigoe, Shunichiro Kato, Naoya Tsukune …

JOURNAL OF CELLULAR PHYSIOLOGY, 232(12) 3337-3346, Dec, 2017 Peer-reviewed
CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingiva epithelial cells.

Murofushi T, Tsuda H, Mikami Y, Yamaguchi Y, Suzuki N

J Oral Sci, 59(3) 415-423, Oct 30, 2017 Peer-reviewed
A collagen membrane containing osteogenic protein-1 facilitates bone regeneration in a rat mandibular bone defect

Ozaki M, Takayama T, Yamamoto T, Ozawa Y, Nagao M, Tanabe N, Nakajima A, Suzuki N, Maeno M, Yamano S …

Arch Oral Biol, 84 19-28, Sep 30, 2017 Peer-reviewed
Combined effects of starvation and butyrate on autophagy-dependent gingival epithelial cell death

M. Evans, T. Murofushi, H. Tsuda, Y. Mikami, N. Zhao, K. Ochiai, T. Kurita-Ochiai, M. Yamamoto, K. Otsuka, N. Suzuki

JOURNAL OF PERIODONTAL RESEARCH, 52(3) 522-531, Jun, 2017
Chaetocin inhibits RANKL-induced osteoclast differentiation through reduction of Blimp1 in Raw264.7 cells.

Zhao N, Tsuda H, Murofushi T, Imai K, Ochiai K, Yang P, Suzuki N

Life Sci, 143(1) 1-7, Oct 26, 2015 Peer-reviewed
Tension force-induced ATP promotes osteoblast differentiation-related transcription factors and osteogenesis through P2X7 receptor in osteoblasts.

Natsuko Tanabe, Taro Kariya, Chieko Shionome, Takayuki Kawato, Masao Maeno, Noriyoshi Shimizu, Naoto Suzuki

JOURNAL OF BONE AND MINERAL RESEARCH, 29 S275-S275, Feb, 2014

Books and Other Publications

スタンダード生化学・口腔生化学第4版

荒川俊哉, 池尾隆, 加藤靖正, 古株彰一郎, 近藤信夫, 自見英治郎, 鈴木直人, 半田慶介, 板東健二郎, 平塚浩一 (Role: Joint editor)

学建書院, Mar 30, 2023 (ISBN: 9784762436338)
スタンダード生化学・口腔生化学, 第３版

池尾隆, 加藤靖正, 近藤信夫, 自見英治郎, 鈴木直人, 友村明人, 平塚浩一 (Role: Editor, 180-243) (Original Author(s): 池尾隆, 加藤靖正, 近藤信夫, 自見英治郎, 鈴木直人, 友村明人, 平塚浩一)

学建書院, Mar 1, 2016
スタンダード生化学・口腔生化学, 第2版

神谷真子, 亀山泰永, 城座映明, 田村功, 前野正夫, 八代耕児, 池尾隆, 大塚吉兵衛, 近藤信夫, 自見英次郎, 友村明人, 藤田厚 (Role: Joint author, 192-233) (Original Author(s): 神谷真子, 亀山泰永, 城座映明, 田村功, 前野正夫, 八代耕児安孫子宜光, 池尾隆, 大塚吉兵衛, 近藤信夫, 自見英次郎, 友村明人, 藤田厚)

学建書院, Mar 30, 2009
A novel KRAB/C2H2 zinc finger transcription factor is a negative regulator of chondrogenesis

Nishiyama T, Takada T, Ito-Kato E, Jheon AH, Sodek J, Otsuka K (Role: Joint author, 214) (Original Author(s): Nishiyama T, Takada T, Ito-Kato E, Jheon AH, Sodek J, Otsuka K)

The Chemistry and Biology of Mineralized Tissue, Oct, 2004
Effects of aging and IL-1 on expression of MMP-1 and TIMP-1 mRNA by human bone cells

Maeno M, Akiba M, Nishiyama T, Katayama I, Kasamo Y, Otsuka K (Role: Joint author, 415-416) (Original Author(s): Maeno M, Akiba M, Nishiyama T, Katayama I, Kasamo Y, Otsuka K)

The Chemistry and Biology of Mineralized Tissue, Jul 30, 2000
Effects of aging and IL-1 on expression of MMP-1 and TIMP-1 mRNA by human bone cells

Maeno M, Akiba M, Nishiyama T, Katayama I, Kasamo Y, Otsuka K (Role: Joint author, 415-416) (Original Author(s): Maeno M, Akiba M, Nishiyama T, Katayama I, Kasamo Y, Otsuka K)

The Chemistry and Biology of Mineralized Tissue, Jul 30, 2000
Cloning and Characterization of a novel gene,AJ-18, involved in osteogenetic differentiation

(Role: Joint author, 101)

Okayama University and Japan Society for the Promotion of Science, 2000
Identification of different forms of collagen α-1(I)pN-propeptide in adult rabbit alveolar bone

Maeno M, Otsuka K, Omori Y, Suzuki K (Role: Joint author, 889) (Original Author(s): Maeno M, Otsuka K, Omori Y, Suzuki K)

The Chemistry and Biology of Mineralized Tissue, Oct 30, 1989

Presentations

244

口腔内細菌の代謝産物が抜歯窩治癒不全時の骨添加および炎症の遅延を起こす可能性

浅山雄之, 津田啓方, 鈴木直人

第65回歯科基礎医学会学術大会, Sep 16, 2023
ヒト歯肉上皮癌細胞株Ca9-22細胞が上皮バリヤ機能に及ぼすAGEsの影響

市川理沙, 田邉奈津子, 富田景子, 小野美紗穂, 間中総一郎, 鈴木直人, 佐藤秀一

第75回日本大学歯学会, May 21, 2023
口腔内細菌代謝産物が破骨細胞分化に及ぼす影響

朝山雄之,津田啓方,生木俊輔,鈴木直人,米原啓之

第74回日本大学歯学会, Apr 30, 2022, 日本大学歯学会
低出力超音波刺激がPYK2を介した骨芽細胞の分化に及ぼす影響

宇津暁久,田邉奈津子,長尾麻由,鈴木直人,本吉満

第74回日本大学歯学会, Apr 30, 2022, 日本大学歯学会
歯肉上皮細胞の短鎖脂肪酸誘導細胞死には活性酸素によるオートファジー誘導が必要である

三宅希和,津田啓方,篠塚啓二,鈴木直人,外木守雄

第74回日本大学歯学会, Apr 23, 2022, 日本大学歯学会
Advanced glycation end productsは骨芽細胞のCOX2発現を促進させる

富田景子,田邉奈津子,鈴木直人,佐藤秀一

第72回日本大学歯学会総会, May 17, 2020
トランスプリプトーム解析による短鎖脂肪酸誘導細胞死の誘導メカニズムの検索

室伏貴久,津田啓方,鈴木直人

第61回歯科基礎医学会学術大会, Oct 13, 2019, 歯科基礎医学会
短鎖脂肪酸誘導歯肉上皮細胞死にはヒストンアセチルトランスフェラーゼ活性優位の状況が必要である

津田啓方,鈴木直人

第61回歯科基礎医学会学術大会, Oct 13, 2019, 歯科基礎医学会
糖尿病が骨芽細胞のLPS誘導性サイトカインに及ぼす影響

加藤駿一郞,田邉奈津子, 昔農淳平,酒井真悠,阿部仁子,鈴木直人,植田耕一郎

第71回日本大学歯学会学術大会, May 19, 2019, 日本大学歯学会
最終糖化産物AGEsが骨芽細胞の骨形成に及ぼす影響

酒井真悠、富田景子、加藤駿一郞、田邉奈津子、鈴木直人、植田耕一郎

第71回日本大学歯学会総会・学術大会, May 19, 2019
ヒト歯肉線維芽細胞におけるIL-6発現へのmiR-200bの影響

小方頼昌,中山洋平,目澤優,加藤彩子,板井丈治,鈴木直人,田邉奈津子,中山智宏,鈴木由紀,神尾宜昌,高井英樹,松井沙莉

第61回春季日本歯周病学会学術学会, May 31, 2018, 日本歯周病学会
終末糖化産物AGEsが骨芽細胞の骨形成に及ぼす影響

酒井真悠,富田景子,加藤駿一郞,田邉奈津子,鈴木直人,植田耕一郎

第70会日本大学歯学会学術大会, May 20, 2018, 日本大学歯学会歯学会
The intensity of low-intensity pulsed ultrasound influences chondrocyte differentiation

Sekino J, Tanabe N, Abe K, Manaka S, Nagao M, Suzuki N, Maeno M, Ueda K

95th IADR, Mar 24, 2017
The collagen membrane containing with osteogenic protein-1 facilitates bone regeneration

Takayama T, Ozaki M, Yamamoto T, Ozawa Y, Suzuki D, Iguchi S, Sato N, Nakajima A, Suzuki N, Maeno M, Sato S

95th IADR, Mar 24, 2017
骨芽細胞のLPS誘導生IL-1a産生はLIPUS刺激の抗炎症作用によって抑制される

長尾麻由,田邉奈津子,間中総一郎,内藤昌子,昔濃淳平,鈴木直人,前野正夫,佐藤秀一

第15回日本超音波治療研究会, Nov 12, 2016, 日本超音波治療研究会
LIPUSの出力が軟骨細胞の細胞外マトリックスタンパク発現に及ぼす影響

昔濃淳平,田邉奈津子,阿部仁子,間中総一郎,長尾麻由,鈴木直人,前野正夫,植田耕一郎

第15回日本超音波治療研究会, Nov 12, 2016, 日本超音波治療研究会
酪酸刺激誘導nerosis様細胞死によるDAMPｓ及びリウマチ関連因子の放出

津田啓方,室伏貴久,山口洋子,鈴木直人

第58回歯科基礎医学会, Aug 25, 2016
酪酸刺激誘導NETosis様細胞死によるDAMPｓ及びリウマチ関連因子の放出

津田啓方, 室伏貴久, 山口洋子, 鈴木直人

第58回歯科基礎医学会, Aug 25, 2016
Osteogenic protein-1添加コラーゲン膜がラット下顎角骨欠損の骨再生に及ぼす影響

尾崎愛美,髙山忠裕,山本崇申,小澤康正,井口慎也,鈴木大悟,長尾麻由,中島晃昭,田邉奈津子,鈴木直人,前野正夫,佐藤秀一

第25回硬組織再生生物学会, Aug 20, 2016
LIPUS刺激は骨芽細胞のATP-P2X7受容体を介してコラーゲン代謝を促進する

間中総一郎,田邉奈津子,長尾麻由,鈴木直人,前野正夫,佐藤秀一

第25回硬組織再生生物学会, Aug 20, 2016

Professional Memberships

Research Projects

Effects of AGEs on the relationship of exacerbation of periodontal disease and impairment of gingival epithelial barrier function.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
糖尿病での歯周病の進行・難治化における終末糖化産物の関与を調べる基礎研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

田邉奈津子, 鈴木直人
A study of the possibility of an aggravating factor for periodontal disease that excessive fructose intake in diabetes mellitus.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

TANABE Natsuko
The mechanism of pupil dilation response during cold pressor test

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

OKA Shunichi, SUZUKI Naoto, OKADA Akiko, NAKAJIMA Ichiro, OI Yoshiyuki
Application of New Generation Respiratory Pathogens Detection System to Elderly in Aspiration Pneumonia Prevention

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

SEKI Mitsuko, HAGIWARA Yoshiyuki, SUZUKI Naoto, MORINO Tomoko, OHNISHI Makoto, TAKAHASHI Hideyuki, OOKAWA Katsumasa, KILGORE Paul, Evan, KIM Dong, Wook, KIM Soon
The elucidation of the molecular mechanism in bone and cartilage destruction by IL-17supposing temporomandibular joint disorder

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

MAENO Masao, SUZUKI Naoto, KAWATO Takayuki
Clarification of molecular mechanism that deteriorates periodontitis with alveolar bone resorption by nicotine and lipopolysaccharide.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

MAENO Masao, SUZUKI Naoto, TANABE Natsuko, TANAKA Hideki
β-alanyl-L-histidinato zinc inhibits bone resorption

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2008

SUZUKI Naoto, MAENO Masao, TANABE Natsuko
Clarification of molecular mechanism of the extension of dental radicular cysts with osteoclast formation after inflammatory cytokine is stimulated

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2006

MAENO Masao, OGISO Bunnai, MOTOHASHI Masafumi, SUZUKI Naoto, TANABE Natsuko
The elucidation of action mechanism of enamel matrix derivative on the reconstruction of alveolar bone.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2003

MAENO Masao, SUZUKI Naoto, ITO Koichi, OTSUKA Kichibee, YAMAGUCHI Yoko
Dynamic phase of Alveolar Bone-derived Osteoblasts at High Calcium Ion Concentration with Bone Resorption Accentuation.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1999 - 2000

MAENO Masao, SUZUKI Naoto, ITO Koich, OTSUKA Kichibee, ITO Emi, OHSHIMA Mitsuhiro
加齢に伴うヒト歯槽骨リモデリング機構の変動の解明(歯槽骨由来の骨芽細胞様細胞のコラーゲン代謝に及ぼす骨吸収因子の影響)

科学研究費助成事業, 一般研究(C), 日本学術振興会, 1995 - 1995

前野正夫, 鈴木直人, 笠茂幸嗣, 片山一郎

Industrial Property Rights

特願2007-160816 日本特許登録抗菌剤 Nubic1111

鈴木直人,川戸貴行,浜理薬品工業株式会社
特願2004-331444 咀嚼訓練具

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Research History

Education

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Awards

Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

Research Projects

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