2007年11月
Microarray analysis of bisphenol A-induced changes in gene expression in human oral epithelial cells
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
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- 巻
- 39
- 号
- 11
- 開始ページ
- 879
- 終了ページ
- 884
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1111/j.1745-7270.2007.00351.x
- 出版者・発行元
- OXFORD UNIV PRESS
Bisphenol A (BPA) is a common ingredient in dental materials. However, its potential adverse effects on the oral cavity are unknown. The purpose of this study is to identify the genes responding to BPA in a human oral epithelial cell line using DNA microarray. Of the 10,368 genes examined, changes in mRNA levels were detected in seven genes: five were up-regulated and two were down-regulated. The expression levels of the calcium channel, voltage-dependent, L-type, alpha 1C subunit (CACNA1C), cell death activator CIDE-3 (CIDE-3), haptoglobin-related protein (HPR), importin 4 (IPO4), and POU domain, class 2 and transcription factor 3 (POU2F3) were significantly up-regulated in the cells exposed to 100 mu M BPA. The spermatogenesis-associated, serine-rich 2 (S PATS2) and HSPC049 protein (HSPC049) were significantly down-regulated. The detailed knowledge of the changes in gene expression obtained using microarray technology will provide a basis for further elucidating the molecular mechanisms of the toxic effects of BPA in the oral cavity.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1745-7270.2007.00351.x
- ISSN : 1672-9145
- eISSN : 1745-7270
- Web of Science ID : WOS:000251184600008