SEKI Taiichiro

Last updated: May 8, 2019 at 03:07

Name	SEKI Taiichiro
E-mail	seki.taiichirounihon-u.ac.jp
Affiliation	Nihon University
Section	College of Bioresource Sciences, Department of Chemistry and Life Science
Job title	Professor
Degree	Master of Science(Nihon University), Ph.D.(The University of Tokyo)
Research funding number	20187834
ORCID ID	https://orcid.org/0000-0002-3507-067X

Research Interests

nutrition, physiology(6) , functional food(71) , life-style related diseases(23) , 肥満(8) , coagulation, fibrinolysis(2) , stem cell(138) , 増殖と分化(1) , differentiation(95) , 細胞療法(1) , cell biology(578) , fibrinolytic enzyme(2) , gene expression(155) , plasminogen activator(3) , liver(50) , regeneration(110) , functional food(71) , がん(4) , アポトーシス(2) , 食事(2)

Research Areas

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Boundary agriculture / Applied molecular and cellular biology / Applied Molecular Cell Biology
Agricultural chemistry / Food science / Food Science
Agricultural chemistry / Applied biochemistry / Applied Biochemistry
Biological Science / Molecular biology / Molecular Biology
Biological Science / Cell biology / Cell Biology

Academic & Professional Experience

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Jul 1994

Jan 1996

Postdoctral Research Fellow, Department of Human Genetics,The University of Michigan Medical School

Jan 2003

Mar 2003

お茶の水女子大学大学院人間文化研究科講師

Apr 2007

Sep 2007

東京農工大学農学府講師

Apr 2014

非常勤講師, 農学生命科学研究科, 東京大学大学院

Committee Memberships

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Mar 2016

International　Association for Traditional and Complementary Medicine (IATCM) Advisory Board Member

Oct 2015

7th International Congress on Food Factors (ICoFF 2019) Vice-president

Sep 2014

XXlllrd International Congress on Fibrinolysis & Proteolysis andXVlth International Workshop on Molecular and Cellular Biology of Plasminogen Activation. Organizing Committee Member

Aug 2013

Journal of Traditional and Complementary Medicine Associate Editor

Mar 2013

May 2015

The Nutrition Investigator Award supported by Nestle Research. Chair of Selection Committee

Awards & Honors

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May 2017

食品由来含硫化合物の生活習慣病予防に関する基礎的研究, 日本栄養・食糧学会　学会賞, 公益社団法人　日本栄養食糧学会

本学会賞は、栄養科学または食糧科学に関する分野において顕著な業績を有し、現在も活発に研究活動を行っている研究者に授与される

May 2011

Verification of antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes., Biosci Biotechnol Biochem. 論文賞 2010(日本農芸化学会)

Published Papers

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A novel function of thrombin-activatable fibrinolysis inhibitor during rat liver regeneration and in growth-promoted hepatocytes in primary culture.

Okumura N, Koh T, Hasebe Y, Seki T, Ariga T.

J Biol Chem 284(24) 16553-61 Apr 2009 [Refereed]

Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin.

Hosono T, Fukao T, Ogihara J, Ito Y, Shiba H, Seki T, Ariga T

J Biol Chem 280(50) 41487-41493 Dec 2005 [Refereed]

Reciprocal regulation of tissue-type and urokinase-type plasminogen activators in the differentiation of murine preadipocyte line 3T3-L1 and the hormonal regulation of fibrinolytic factor in the mature adipocytes.

Seki T, Miyasu T, Noguchi T, Hamasaki A, Sasaki R, Ozawa Y, Okukita K, Declerck PJ, Ariga T

Journal of Cellular Physiology 189(1) 72-78 Oct 2001 [Refereed]

Alkenyl group, but not alkyl group, is responsible for the anti-cancer effect of trisulfide, acting by disrupting microtubule network formation in human colon cancer cell line HT-29 cells.

T. Hosono, T. Hosono-Fukao, K. Inada, R. Tanaka, T. Seki, I. Hasegawa, T. Ariga

Carcinogenesis 29(7) 1400-6 Jul 2008 [Refereed]

Diallyl sulfides in garlic activate both TRPA1 and TRPV1. 1

Koizumi K, Iwasaki Y, Narukawa M, Izuka H, Fukao T, Seki T, Ariga T, Watanabe T.

Biochemical and Biophysical Research Communications 382(3) 545-548 May 2009 [Refereed]

Misc

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硫黄

細野　崇、関　泰一郎

成人病と生活習慣病 48(6) 696-700 2018 [Refereed][Invited]

ニンニクの食文化と機能性

関　泰一郎　　細野崇　　増澤（尾崎）依

Functional Food 32(11) 117-121 Dec 2017 [Refereed][Invited]

α2マクログロブリン（α2M）

関　泰一郎

一般社団法人　日本血栓止血学会監修　用語集（ホームページ） Nov 2015 [Refereed][Invited]

TAFI（thrombin activatable fibrinolysis inhibitor）

関泰一郎三浦　徳

一般社団法人　日本血栓止血学会　用語集（ホームページ） Nov 2015 [Refereed][Invited]

線溶とその制御部会

関　泰一郎

日本血栓止血学会誌 25(3) 423-424 Jun 2014

Books etc

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Chemistry of Korean Foods and Beverages

Seki, Taiichiro; Hosono, Takashi; Ozaki-Masuzawa, Yori (Part:Joint Work, Chemistry of Sulfur Containing Compounds derived from Garlic and their Functions)

ACS Books, American Chemical Society 2019

Functional Foods, Nutraceuticals and Natural Products-Concepts and Applications (edts; D.A. Vattem, V. Maitin)

T.Seki, T.Hosono, H.Kumagai, T.Ariga (Part:Joint Work, Allium: Garlic and Onion)

DEStech Publications, Inc. Oct 2015 ISBN:978-1-60595-101-0

新・血栓止血血管学-抗凝固と線溶（一瀬白帝他編集）

関　泰一郎、三浦　徳 (Part:Joint Work, TAFIの基礎と臨床)

金芳堂 Oct 2015 ISBN:978-4-7653-1650-7

食品因子による栄養機能制御（日本栄養・食糧学会監修）

関泰一郎、細野崇 (Part:Joint Work, 第6章　ネギ属植物の含硫成分の機能性)

建帛社 May 2015 ISBN:978-4-7679-6181-1

食品の保健機能と生理学

関　泰一郎 (Part:Joint Work, 血糖値の上昇を抑制する機能、血中の中性脂肪やコレステロールの上昇を抑制する機能、貧血を予防する機能、血栓を抑制する機能)

アイ・ケイコーポレーション Mar 2015 ISBN:978-4-87492-328-3

Conference Activities & Talks

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Anti-thrombotic effect of garlic attributes inhibition of platelet function and coagulation pathway by allyl sulfide. [Invited]

Taiichiro Seki,Takashi Hosono,Yori Ozaki-Masuzawa

256th American Chemical Society(ACS) National Meeting & Exposition, Division of Agricultural and Food Chemistry, Symposia Functional Foods-Their Novel Biofunctions & Underlying Mechanisms 19 Aug 2018 American Chemical Society(ACS)

食品由来含硫化合物の生活習慣病予防に関する基礎的研究（日本栄養・食糧学会・学会賞受賞講演） [Invited]

関　泰一郎

第71回　日本栄養・食糧学会 19 May 2017 日本栄養・食糧学会

Macrophage promote the tissue remodeling and the recovery of liver functions during liver regeneration after carbon tetrachloride-induced liver injury.

Atsushi Miura, Yori Ozaki-Masuzawa, Takashi Hosono, Taiichiro Seki

The 10th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis(APSTH 2018) 29 Jun 2018

The food function of garlic: active principles and a molecular mechanism responsible for health promoting functions. [Invited]

Taiichiro Seki, Takashi Hosono, Yori Ozaki-Masuzawa

American Chemical Society Asia-Pacific International Chapter Conference. Agricultural and Food Chemistry Session. 6 Nov 2017 American Chemical Society

Garlic-derived compound diallyl trisulfide suppresses platelet aggregation by inhibiting both PI3K/Akt and cAMP pathways

Natsumi Nakaguchi, Yori Ozaki-Masuzawa, Takashi Hosono, Taiichiro Seki

ACS Asia-Pacific International Chapters Conference 6 Nov 2017 American Chemical Society

Association Memberships

日本農芸化学会(177) , 日本栄養・食糧学会(47) , 日本血栓止血学会(9) , 日本生化学会(181) , 日本生理学会(62) , 日本フードファクター学会(4) , 国際線溶学会(1) , 国際血栓止血学会(1) , 肝細胞研究会(2) , 日本香辛料研究会(2)

Research Grants & Projects

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Exosome,マイクロRNAに着目した機能性食品成分の新しい作用機構の解明　基盤研究（B）

Project Year: Apr 2016 - Mar 2019

機能性食品成分による新規血栓制御メカニズムの解明と食品の機能性評価への応用　基盤研究（B）

Project Year: Apr 2013 - Mar 2016

摂食リズムの形成による燃料基質のシフト、インスリン抵抗性改善の新しいメカニズム　萌芽（的）研究

Project Year: Apr 2015 - Mar 2018 Investigator(s): Seki, Taiichiro

リン酸化情報ハブに着目した機能性食品・栄養成分の作用メカニズムの解析　基盤研究(C)

Project Year: 2009 - 2011

食品由来多硫化アルケニルの生体内挙動とその分子標的に関する研究　基盤研究(B)

Project Year: 2008 - 2010

Patents

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PCT/JP2005/011182 : ES細胞を用いた肝細胞調製法

特開2006-14600 : 肝細胞増殖抑制剤

特願2004-192979 : Agarose plate for ES cell culture

特願2002-159194 : がん細胞増殖抑制剤

1331751 : Method for preparation of hepatocytes using ES cell

Nihon University