MISC

1999年

The ultrastructural patterns of mast cell degranulation in Kimura's disease

DERMATOLOGY
  • M Aoki
  • ,
  • S Kawana

199
1
開始ページ
35
終了ページ
39
記述言語
英語
掲載種別
DOI
10.1159/000018175
出版者・発行元
KARGER

Background: Although Kimura's disease has been considered an atopic disease because of the association of peripheral blood eosinophilia and elevated serum IgE, the mechanisms of these phenomena are still unknown. Objective: It is now established that mast cells are a source of cytokines that are involved in eosinophil recruitment or IgE production. In order to understand the role of mast cells in Kimura's disease, we conducted ultrastructural studies. Method: The 45 mast cells obtained from 2 patients with Kimura's disease were classified into two subgroups: S type, with a predominance of scroll or crystal subelements in their granules, and P type, predominantly possessing a particulate or filamentous substructure. Results: We observed numerous P type mast cells with focal losses of granule contents in the absence of granule extrusion in Kimura's disease. Conclusion: These results indicate the possibility that slow release of mediators or cytokines from mast cells by piecemeal degranulation may contribute to the pathomechanism of Kimura's disease.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1159/000018175
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000081975400008&DestApp=WOS_CPL

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