論文

査読有り 招待有り
2017年5月1日

Bioactive peptides hidden in human salivary proteins

Journal of Oral Biosciences
  • Eiichi Saitoh
  • ,
  • Masayuki Taniguchi
  • ,
  • Akihito Ochiai
  • ,
  • Tetsuo Kato
  • ,
  • Akane Imai
  • ,
  • Satoko Isemura

59
2
開始ページ
71
終了ページ
79
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.job.2016.11.005
出版者・発行元
Japanese Association for Oral Biology

Background Extensive peptidomic studies of human saliva have resulted in considerable advances in the field of proteomics. As the next generation in salivary research, a comprehensive understanding of the biological functions of in vivo peptides generated by proteolysis in the oral cavity has been long awaited. A cyclopedic functional analysis of salivary peptides may bring promising therapeutic agents and novel clinical applications.Highlight: (1) This review article refers to bioactive peptides hidden in salivary parent proteins. (2) Functions of the peptides as anti-microbial, anti-viral, wound-closing, and anti-pain are described. (3) Biological significances of the repeated structures in salivary proline-rich proteins are emphasized. Conclusion Human salivary proteins have the ability to generate bioactive peptides upon proteolytic cleavage.

リンク情報
DOI
https://doi.org/10.1016/j.job.2016.11.005
ID情報
  • DOI : 10.1016/j.job.2016.11.005
  • ISSN : 1349-0079
  • SCOPUS ID : 85008145756

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