2017年5月1日
Bioactive peptides hidden in human salivary proteins
Journal of Oral Biosciences
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- 巻
- 59
- 号
- 2
- 開始ページ
- 71
- 終了ページ
- 79
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.job.2016.11.005
- 出版者・発行元
- Japanese Association for Oral Biology
Background Extensive peptidomic studies of human saliva have resulted in considerable advances in the field of proteomics. As the next generation in salivary research, a comprehensive understanding of the biological functions of in vivo peptides generated by proteolysis in the oral cavity has been long awaited. A cyclopedic functional analysis of salivary peptides may bring promising therapeutic agents and novel clinical applications.Highlight: (1) This review article refers to bioactive peptides hidden in salivary parent proteins. (2) Functions of the peptides as anti-microbial, anti-viral, wound-closing, and anti-pain are described. (3) Biological significances of the repeated structures in salivary proline-rich proteins are emphasized. Conclusion Human salivary proteins have the ability to generate bioactive peptides upon proteolytic cleavage.
- ID情報
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- DOI : 10.1016/j.job.2016.11.005
- ISSN : 1349-0079
- SCOPUS ID : 85008145756