2014年4月
PBDE: Structure-Activity Studies for the Inhibition of Hepatitis C Virus NS3 Helicase
MOLECULES
- 巻
- 19
- 号
- 4
- 開始ページ
- 4006
- 終了ページ
- 4020
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3390/molecules19044006
- 出版者・発行元
- MDPI AG
The helicase portion of the hepatitis C virus nonstructural protein 3 (NS3) is considered one of the most validated targets for developing direct acting antiviral agents. We isolated polybrominated diphenyl ether (PBDE) 1 from a marine sponge as an NS3 helicase inhibitor. In this study, we evaluated the inhibitory effects of PBDE (1) on the essential activities of NS3 protein such as RNA helicase, ATPase, and RNA binding activities. The structure-activity relationship analysis of PBDE (1) against the HCV ATPase revealed that the biphenyl ring, bromine, and phenolic hydroxyl group on the benzene backbone might be a basic scaffold for the inhibitory potency.
- リンク情報
- ID情報
-
- DOI : 10.3390/molecules19044006
- ISSN : 1420-3049
- PubMed ID : 24699145
- Web of Science ID : WOS:000336087800011