TAKAYAMA Kozo

J-GLOBAL         Last updated: Apr 9, 2019 at 13:29
 
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Name
TAKAYAMA Kozo
Affiliation
Josai University
Section
Faculty of Pharmaceutical Sciences Department of Pharmaceutical
Job title
Professor
Degree
Ph.D.

Research Areas

 
 

Academic & Professional Experience

 
Apr 2017
 - 
Today
Guest Professor, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University
 

Published Papers

 
Ito T, Kida C, Okada K, Ikeda J, Otomura K, Hayashi Y, Obata Y, Takayama K, Onuki Y
Langmuir : the ACS journal of surfaces and colloids   34(40) 12093-12099   Sep 2018   [Refereed]
Hayashi Y, Marumo Y, Takahashi T, Nakano Y, Kosugi A, Kumada S, Hirai D, Takayama K, Onuki Y
International journal of pharmaceutics   558 351-356   Mar 2019   [Refereed]
Yoshihiro Hayashi, Takuya Oishi, Kaede Shirotori, Yuki Marumo, Atsushi Kosugi, Shungo Kumada, Daijiro Hirai, Kozo Takayama, Yoshinori Onuki
Drug Development and Industrial Pharmacy   44(7) 1090-1098   Jul 2018   [Refereed]
© 2018 Informa UK Limited, trading as Taylor & Francis Group. Objectives: The aim of this study was to explore the potential of boosted tree (BT) to develop a correlation model between active pharmaceutical ingredient (API) characteristics and a...
Worranan Rangsimawong, Yasuko Obata, Praneet Opanasopit, Tanasait Ngawhirunpat, Kozo Takayama
AAPS PharmSciTech   19(3) 1093-1104   Apr 2018   [Refereed]
© 2017, American Association of Pharmaceutical Scientists. This study aimed to investigate the effect of low-frequency sonophoresis (SN) and limonene-containing PEGylated liposomes (PL) on the transdermal delivery of galantamine HBr (GLT). To eval...
Hiroaki Todo, Kazuki Sato, Kozo Takayama, Kenji Sugibayashi
Chemical and Pharmaceutical Bulletin   66(7) 748-756   Jan 2018   [Refereed]
© 2018 The Pharmaceutical Society of Japan. Direct compression is a popular choice as it provides the simplest way to prepare the tablet. It can be easily adopted when the active pharmaceutical ingredient (API) is unstable in water or to thermal d...
Yoshihiro Hayashi, Nobuto Okada, Kozo Takayama, Yasuko Obata, Yoshinori Onuki
Chemical and Pharmaceutical Bulletin   66(7) 727-731   Jan 2018   [Refereed]
© 2018 The Pharmaceutical Society of Japan. The mechanical strain distribution of scored tablets was simulated using the finite element method (FEM). The score was fabricated as a triangular runnel with the pole on the top surface of flat tablets....
Yu Fukuoka, El Sayed Khafagy, El Sayed Khafagy, Takahiro Goto, Noriyasu Kamei, Kozo Takayama, Kozo Takayama, Nicholas A. Peppas, Mariko Takeda-Morishita
Biological and Pharmaceutical Bulletin   41(5) 811-814   Jan 2018   [Refereed]
© 2018 The Pharmaceutical Society of Japan. In previous studies we showed that the complexation hydrogels based in poly(methacrylic acid-g-ethylene glycol) [P(MAA-g-EG)] rapidly release insulin in the intestine owing to their pH-dependent complexa...
Yoshihiro Hayashi, Atsushi Kosugi, Takahiro Miura, Kozo Takayama, Yoshinori Onuki
Chemical and Pharmaceutical Bulletin   66(5) 541-547   Jan 2018   [Refereed]
© 2018 The Pharmaceutical Society of Japan. The influence of granule size on simulation parameters and residual shear stress in tablets was determined by combining the finite element method (FEM) into the design of experiments (DoE). Lactose granu...
Todo H, Tamura M, Uchida T, Kurumada M, Motoki A, Sano T, Onuki Y, Takayama K, Sugibayashi K
Chemical & pharmaceutical bulletin   66(10) 959-966   2018   [Refereed]
Yoshihiro Hayashi, Takahiro Tsuji, Kaede Shirotori, Takuya Oishi, Atsushi Kosugi, Shungo Kumada, Daijiro Hirai, Kozo Takayama, Yoshinori Onuki
International Journal of Pharmaceutics   532 82-89   Oct 2017
© 2017 Elsevier B.V. In this study, we evaluated the correlation between the response surfaces for the tablet characteristics of placebo and active pharmaceutical ingredient (API)-containing tablets. The quantities of lactose, cornstarch, and micr...
Pratyusa Sahoo, Kok Hoong Leong, Shaik Nyamathulla, Yoshinori Onuki, Kozo Takayama, Lip Yong Chung
Reactive and Functional Polymers   119 145-155   Oct 2017
© 2017 Elsevier B.V. In designing an oral delivery method for insulin, we previously reported that pH-responsive carboxymethylated kappa-carrageenan-based microparticles protected insulin from acid degradation during transport through the gastroin...
Shingo Mori, Noriyasu Kamei, Yoji Murata, Kozo Takayama, Takashi Matozaki, Mariko Takeda-Morishita
Journal of Pharmaceutical Sciences   106 2904-2908   Sep 2017
© 2017 American Pharmacists Association® The stomach cancer–associated protein tyrosine phosphatase 1 (SAP-1) is a receptor-type protein tyrosine phosphatase that is specifically expressed on the apical membrane of the intestinal epithelium. SAP-1...
Kozo Takayama, Saori Otoguro, Nobuto Okada, Masato Hoshino, Naoto Yagi, Yasuko Obata
Yakugaku Zasshi   137 757-762   Jan 2017
© 2017 The Pharmaceutical Society of Japan. The purpose of this study was to determine the density distribution of scored and round-faced tablets using synchrotron X-ray computed tomography. The tablets were made by direct compression of standard ...
Yoshinori Onuki, Chiaki Funatani, Yoshihisa Yamamoto, Toshiro Fukami, Tatsuo Koide, Yoshihiro Hayashi, Kozo Takayama
Chemical and Pharmaceutical Bulletin   65 487-491   Jan 2017
© 2017 The Pharmaceutical Society of Japan. A moisturizing cream mixed with a steroid ointment is frequently prescribed to patients suffering from atopic dermatitis. However, there is a concern that the mixing operation causes destabilization. The...
Shinya Yoshida, Yasuko Obata, Yoshinori Onuki, Shunichi Utsumi, Noboru Ohta, Hiroshi Takahashi, Kozo Takayama
Chemical and Pharmaceutical Bulletin   65 134-142   Jan 2017
© 2017 The Pharmaceutical Society of Japan. l-Menthol increases drug partitioning on the surface of skin, diffusion of drugs in the skin, and lipid fluidity in the stratum corneum and alters the rigidly arranged lipid structure of intercellular li...
Kozo Takayama, Shota Kawai, Yasuko Obata, Hiroaki Todo, Kenji Sugibayashi
Chemical and pharmaceutical bulletin   65 967-972   Jan 2017
A large number of dissolution data were measured and integrated into a previously constructed tablet database composed of 14 kinds of compounds as model active pharmaceutical ingredients (APIs) with contents ranging from 10 to 80%. The database ha...
Shunichi Utsumi, Yasuko Obata, Kozo Takayama
Journal of Drug Delivery Science and Technology   35 200-206   Oct 2016
© 2016 Elsevier B.V. Attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR) is a powerful tool for evaluating the functional group interaction of intercellular lipids in the stratum corneum. However, as the large amide I an...
Onuki Y, Obata Y, Kawano K, Sano H, Matsumoto R, Hayashi Y, Takayama K
Molecular pharmaceutics   13(2) 369-378   Jan 2016   [Refereed]
Muto K, Kamei N, Yoshida M, Takayama K, Takeda-Morishita M
Journal of Pharmaceutical Sciences   105(6) 2014-2017   Jun 2016   [Refereed]
Yoshida M, Kamei N, Muto K, Kunisawa J, Takayama K, Peppas NA, Takeda-Morishita M
European Journal of Pharmaceutics and Biopharmaceutics      Nov 2016   [Refereed]

Misc

 
Siew Hwei Yap, Noor Kamila Abdullah, Megan McStea, Kozo Takayama, Meng Li Chong, Elisa Crisci, Marie Larsson, Iskandar Azwa, Iskandar Azwa, Adeeba Kamarulzaman, Adeeba Kamarulzaman, Kok Hoong Leong, Yin Ling Woo, Yin Ling Woo, Reena Rajasuriar, Reena Rajasuriar, Reena Rajasuriar
PLoS ONE   12    Oct 2017
© 2017 Yap et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre...
小幡誉子, 内海俊一, 太田昇, 高山幸三
日本香粧品学会誌   40(3) 193‐194   Sep 2016
大成宏樹, 関谷匡俊, 奥山雅樹, 内海俊一, 小幡誉子, 高山幸三
日本香粧品学会誌   40(3) 192‐193   Sep 2016
小幡誉子, 高山幸三
オレオサイエンス   16(6) 279‐284   Jun 2016
大貫義則, 小幡誉子, 川野久美, 佐野啓, 松本玲奈, 林祥弘, 高山幸三
KEK Proceedings (Web)   (2016-2) 389 (WEB ONLY)   Jun 2016

Books etc

 
A novel method based on artificial neural networks for optimizing transdermal drug delivery systems
Handbook of Pharmaceutical Controlled Release Technology, Marcel Dekker, Inc.   2000   
Artificial neural network as a novel method to optimize pharmaceutical formulations(review)
┣DBPharm. Res.(/)-┫DB   1999   
Computer-aided design and optimization in pharmaceutical formulation and processing
Topics in pharmaceutical sciences 1993, Chap. 34, Medpharm   1994   
Development of new functionality materials for promoting drug transport across skin
New functionality materials, Vol.B, Synthesis and function control of biofunctionality materials, Elsevier   1993   
Development of new functionality materials for promoting drug transport across skin : New Functionality Materials, Vol. B
Elsevier Sci. Pub.   1993   

Research Grants & Projects

 
Non-empirical design method of pharmaceutical products based on deep learning and CAE simulation
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 2017 - Mar 2019    Investigator(s): Kozo TAKAYAMA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2011 - 2013    Investigator(s): Kozo TAKAYAMA
A tablet database was created in order for designing tablet formulations based on the quality by design concept. The contribution of active ingredients (APIs) to tablet properties such as tensile strength and disintegration time was clarified. Bef...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2007 - 2010    Investigator(s): Kozo TAKAYAMA
A nonlinear response surface method incorporating thin-plate spline interpolation (RSM-S) was developed and applied to the designing a sustained release matrix tablet formulation. A bootstrap (BS) resampling method was employed to estimate confide...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2011 - 2013    Investigator(s): Mariko TAKEDA
The purpose of this study was to establish non-invasive delivery systems for biodrugs based on new delivery tool: cell-penetrating peptides (CPPs) and to perform translational research, and the following results were obtained: 1) Elucidation of ma...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2006    Investigator(s): Kozo TAKAYAMA
The response surface method incorporating multivariate spline interpolation (RSM-S) is a powerful technique for the formulation optimization of pharmaceuticals. However, no satisfactory method has been developed to evaluate the reliability of the ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2008 - 2010    Investigator(s): Mariko MORISHITA
The purpose of this study was to investigate the safety and usefulness of functional peptides, which are expected as new tools to improve the bioavailability of oral and nasal administration of biologics, and was to clarify the mechanism of their ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2000 - 2002    Investigator(s): Kozo TAKAYAMA
A pharmaceutical formulation is composed of several formulation factors and process variables. Several responses relating to the effectiveness, usefulness, stability, as well as safety must be optimized simultaneously. Consequently, expertise and ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C), 基盤研究(C))
Project Year: 1995 - 1996    Investigator(s): Kozo TAKAYAMA
Solid fractal dimension of skin stratum corneum was determined in order to evaluate the pathological damages evoked by percutaneous absorption promoters such as d-limonene and Azone in the hairless rat. As a model dermatological system, alcoholic ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2000 - 2001    Investigator(s): Kenji SUGIBAYASHI
Three-dimensional cultured human skin model (LSE-high) was evaluated for prediction of skin permeation of drugs. Although the cumulative amount of drags that permeated through LSH-high was about 10-fold higher than those through the excised human ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1996 - 1997    Investigator(s): Tsuneji NAGAI
Thiomenthol derivatives were synthesized and their promoting activity on the percutaneous absorption of ketoprofen from hydrogels was evaluated in rats. The apparent penetration rate (R_p) of ketoprofen absorbed from the hydrogel was estimated by ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(B))
Project Year: 1994 - 1995    Investigator(s): Tsuneji NAGAI
The promoting effect of menthol ethylether derivative (MET) on the percutaneous absorption of ketoprofen from alcoholic hydrogels was evaluated in rats. The skin permeation of ketoprofen was analyzed by a membrane diffusion model, and the diffusio...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(B))
Project Year: 1988 - 1990    Investigator(s): T. NAGAI
The nasal bioavailability of interferon in two different powder dosage forms, i. e. mixed powder (MP) and freeze-dried powder (FP) dosage forms was examined. It was confirmed that the titers of sample MP and sample FP after preparation were differ...
Development of Transdermal Therapeutic Systems
Development of Optimization Method for Pharmaceutical Formulations
Computer-aided design and optimization for pharmaceuticals

Patents

 
森下 真莉子, 高山 幸三, 西尾 玲士, 柿澤 資訓
森下 真莉子, 高山 幸三, 西尾 玲士, 井田 伸夫
森下 真莉子, 高山 幸三, 西尾 玲士, 井田 伸夫
森下 真莉子, 高山 幸三, 西尾 玲士, 井田 伸夫
森下 真莉子, 高山 幸三, 西尾 玲士, 井田 伸夫
小幡 誉子, 足高 有理子, 高山 幸三
大槻 久美子, 奥村 剛宏, ▲高▼山 幸三
森下 真莉子, 高山 幸三, 西尾 玲士, 井田 伸夫
森下 真莉子, 高山 幸三, 西尾 玲士, 井田 伸夫
森下 真莉子, 高山 幸三, 井田 伸夫, 西尾 玲士, 青木 孝夫
森下 真莉子, 高山 幸三, 井田 伸夫, 西尾 玲士, 青木 孝夫
森下 真莉子, 高山 幸三, 井田 伸夫, 青木 孝夫, 柿澤 資訓, 西尾 玲士
森下 真莉子, 高山 幸三, 井田 伸夫, 青木 孝夫, 柿澤 資訓, 西尾 玲士