Yoji Ikegami

Profile Information

Affiliation: Meiji Pharmaceutical University

Degree: Ph. D(Meiji Pharmaceutical University)
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J-GLOBAL ID: 200901092218180884
researchmap Member ID: 1000089377

Research Interests

Research Areas

Life sciences / Clinical pharmacy /

Education

Papers

Impact of Q141K on the Transport of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors by ABCG2.

Yutaka Inoue, Takashi Morita, Mari Onozuka, Ken-Ichi Saito, Kazumi Sano, Kazuhiko Hanada, Masami Kondo, Yoichi Nakamura, Tohru Kishino, Hiroshi Nakagawa, Yoji Ikegami

Cells, 8(7), Jul 23, 2019
第二世代BCR-ABLチロシンキナーゼ阻害薬の輸送に対するABCG2の遺伝子多型の影響

井上裕貴, 斎藤健一, 新井美砂, 大森丈彰, 小野塚真理, 近藤正巳, 佐野和美, 花田和彦, 中川大, 池上洋二

日本薬学会年会要旨集, 139年会(4) 106-106, Mar, 2019
マウスにおけるafatinibによる皮膚障害に対するminocycline外用剤の効果(II)

佐野和美, 杉崎俊亮, 高橋和哉, 清水憂佳, 永井拓海, 池上洋二, 中舘和彦, 花田和彦

日本薬学会年会要旨集, 139年会(4) 136-136, Mar, 2019
ABCG2の遺伝子変異が第二世代BCR-ABLチロシンキナーゼ阻害剤の輸送に及ぼす影響

井上裕貴, 斎藤健一, 関根清香, 柳下夏美, 深沼舞衣, 小野塚真理, 佐野和美, 花田和彦, 中川大, 池上洋二

日本薬学会年会要旨集, 138年会(4) 96-96, Mar, 2018
LogDを利用した15種のチロシンキナーゼ阻害剤のHPLC定量法の開発

南後菜月, 秋常仁志, 佐野和美, 植沢芳広, 池上洋二, 花田和彦

日本薬学会年会要旨集, 138年会(4) 140-140, Mar, 2018
慢性骨髄性白血病患者における第二世代BCR-ABLチロシンキナーゼ阻害剤の血中濃度解析

小野塚真理, 齋藤健一, 木村優花, 宮崎愛乃香, 井上裕貴, 佐野和美, 花田和彦, 井上嘉余子, 佐野元彦, 近藤正巳, 岸野亨, 池上洋二

日本薬学会年会要旨集, 138年会(4) 175-175, Mar, 2018
Investigation of Bioequivalence Between Brand-name and Generic Irinotecan Products.

Ken-Ichi Saito, Yutaka Inoue, Yoji Ikegami, Izumi Nanbo, Mari Onozuka, Kazumi Sano, Hisahiro Yoshida, Toshihiro Sakamoto, Emi Tatebayashi, Ken-Ichi Fujita, Yasutsuna Sasaki, Takaki Kitazawa

Anticancer research, 36(11) 5957-5963, Nov, 2016
Pharmacokinetic parameters of gefitinib predict efficacy and toxicity in patients with advanced non-small cell lung cancer harboring EGFR mutations.

Kosuke Mizoguchi, Yoichi Nakamura, Kazumi Sano, Shuntaro Sato, Yoji Ikegami, Kohei Motoshima, Shinnosuke Takemoto, Daiki Ogawara, Hiroaki Senju, Nanae Sugasaki, Takaya Ikeda, Hiroyuki Yamaguchi, Katsumi Nakatomi, Minoru Fukuda, Koichi Izumikawa, Hiroshi Mukae

Cancer chemotherapy and pharmacology, 78(2) 377-82, Aug, 2016
Molecular modeling of new camptothecin analogues to circumvent ABCG2-mediated drug resistance in cancer.

Hiroshi Nakagawa, Hikaru Saito, Yoji Ikegami, Sachiko Aida-Hyugaji, Seigo Sawada, Toshihisa Ishikawa

Cancer letters, 234(1) 81-9, Mar 8, 2006

Misc.

Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells

M Yoshikawa, Y Ikegami, S Hayasaka, K Ishi, A Ito, K Sano, T Suzuki, T Togawa, E Yoshida, H Soda, M Oka, S Kohno, S Sawada, T Ishikawa, S Tanabe

INTERNATIONAL JOURNAL OF CANCER, 110(6) 921-927, Jul, 2004
「ABCトランスポ―タ―と薬剤応答性」

癌と化学療法, 31(1-6), 2004
Reversal of breast cancer resistance protein (BCRP/ABCG2)-mediated drug resistance by novobiocin, a coumermycin antibiotic

K Shiozawa, M Oka, H Soda, M Yoshikawa, Y Ikegami, J Tsurutani, K Nakatomi, Y Nakamura, S Doi, T Kitazaki, Y Mizuta, K Murase, H Yoshida, DD Ross, S Kohno

INTERNATIONAL JOURNAL OF CANCER, 108(1) 146-151, Jan, 2004
Transport of SN-38 by the wild type of human ABC transporter ABCG2 and its inhibition by guercetin , a natural flavonoid.

J. Experimental Therapeutics and oncology, 4 25-35, 2004
Simple non-ion-paired high-performance liquid chromatographic method for simultaneous quantitation of carboxylate and lactone forms of 14 new camptothecin derivatives

K Sano, M Yoshikawa, S Hayasaka, K Satake, Y Ikegami, H Yoshida, T Ishikawa, S Sawada, S Tanabe

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 795(1) 25-34, Sep, 2003
A functional study on the polymorphism of ATP-bcnding cassettee transporter ABCG2; critical role of Arg482 in methotrexate transporter

Biochem. J., 373(3) 767-774, 2003
Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4

M Yoshikawa, H Yabuuchi, A Kuroiwa, Y Ikegami, Y Sai, Tamai, I, A Tsuji, Y Matsuda, H Yoshida, T Ishikawa

GENE, 293(1-2) 67-75, Jun, 2002
「ポストゲノム時代の挑戦：ABCトランスポーターに基づく創薬分子デザイン」

化学工業, 53 1-7, 2002
Does ABCG2 Need a Heterodimer Partner? Expression and Functional Evaluation of ABCG2 (Arg 482)

Megumi Yoshikawa, Shiho Kasamatsu, Masa Yasunaga, Guizhi Wang, Hikaru Yabuuchi, Toshihisa Ishikawa, Yoji Ikegami, Hisahiro Yoshida, Shigeki Tarui

Drug Metabolism and Pharmacokinetics, 17(2) 130-135, 2002
Transport of 7-ethyl-10-hydroxycamptothecin (SN-38) by breast cancer resistance protein ABCG2 in human lung cancer cells

K Nakatomi, M Yoshikawa, M Oka, Y Ikegami, S Hayasaka, K Sano, K Shiozawa, S Kawabata, H Soda, T Ishikawa, S Tanabe, S Kohno

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 288(4) 827-832, Nov, 2001
Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells

S Kawabata, M Oka, K Shiozawa, K Tsukamoto, K Nakatomi, H Soda, M Fukuda, Y Ikegami, K Sugahara, Y Yamada, S Kamihira, LA Doyle, DD Ross, S Kohno

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 280(5) 1216-1223, Feb, 2001
「第(]G0003[)相解毒系ABCトランスポーターファミリーと抗癌剤感受性」

Cancer Frontier, 3 26-33, 2001
「医薬品開発研究におけるファーマコゲノミクスの利用」

石川智久, 薮内光, 笠松志保, 吉川恵美, 池上洋二

薬物動態, 16(4) 353-363, 2001
Metabolism of sulphobromophthalein (]G0001[) : positional isomers of sulphobromophthalein monoglutathione conjugate.

J. Pharm Phamacol., 53(7) 1015-1020, 2001
Induction of MRP1 and gamma-glutamylcysteine synthetase gene expression by interleukin 1 beta is mediated by nitric oxide-related signalings in human colorectal cancer cells

Y Ikegami, S Tatebe, YC Lin-Lee, QW Xie, T Ishikawa, MT Kuo

JOURNAL OF CELLULAR PHYSIOLOGY, 185(2) 293-301, Nov, 2000
Ion-pair reversed-phase high-performance liquid chromatography of adenine nucleotides and nucleoside using triethylamine as a counterion

T Uesugi, K Sano, Y Uesawa, Y Ikegami, K Mohri

JOURNAL OF CHROMATOGRAPHY B, 703(1-2) 63-74, Dec, 1997
HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF SULPHOBROMOPHTHALEIN AND ITS CONJUGATES

K SANO, KINOSITA, I, R MIHARA, Y IKEGAMI, T UESUGI

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 578(1) 63-70, Jul, 1992
Menogari, an anthracycline derivative, inhibits DNA topoisomerase (]G0002[) by stabilizing cleaveble complexes.

Jpn J. Cancer Res., 83 1018-1023, 1992
「真核細胞DNAトポイソメラーゼ(]G0001[)阻害剤の作用メカニズム」

日本農芸化学会誌, 65 1008-1010, 1991
Mode of Inhibition of Eukaryotic DNA topoisomerase (]G0001[) inhibitors.

Hiro-omi TAMURA, Yoji IKEGAMI

Nippon Nōgeikagaku Kaishi, 65(6) 1008-1010, 1991

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