2003年9月
Simple non-ion-paired high-performance liquid chromatographic method for simultaneous quantitation of carboxylate and lactone forms of 14 new camptothecin derivatives
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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- 巻
- 795
- 号
- 1
- 開始ページ
- 25
- 終了ページ
- 34
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S1570-0232(03)00485-9
- 出版者・発行元
- ELSEVIER SCIENCE BV
SN-38 (7-ethyl-10-hydroxycamptothecin) is an active metabolite derived from the semi-synthetic compound camptothecin (CPT) named Irinotecan (CPT-11). The antitumor activity of SN-38 is 1000-fold more potent than the parent CPT-11. Fourteen new derivatives of camptothecin have recently been developed by Yakult Honsha (Tokyo, Japan). Here we describe a simple and cost-effective high-performance liquid chromatography (HPLC) method without an ion-pairing agent, which allows the simultaneous determination of both lactone and carboxylate forms of SN-38 and other camptothecin derivatives. A weak linear relationship between the HPLC retention factors (In k') and the cellular concentrations of these compounds was observed. These results suggest that low-polarity compounds easily accumulate in cancer cells and may circumvent drug resistance. The HPLC analysis herein described is expected to greatly assist in derivative synthesis and chemical modification of camptothecin-based antitumor drugs. (C) 2003 Elsevier B.V. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/S1570-0232(03)00485-9
- CiNii Articles
- http://ci.nii.ac.jp/naid/10016516693
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/12957166
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000185270400004&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/S1570-0232(03)00485-9
- ISSN : 1570-0232
- CiNii Articles ID : 10016516693
- PubMed ID : 12957166
- Web of Science ID : WOS:000185270400004