UESAWA Yoshihiro Last updated: Oct 11, 2019 at 23:53
Name
UESAWA Yoshihiro Affiliation
Meiji Pharmaceutical University Section
Faculty of Pharmacy, Department of Pharmaceutics, Clinical Pharmaceutics Laboratory Job title
Associate professor Degree
Ph.D., Pharmaceutics(Kyoto University) Research funding number
90322528 ORCID ID
0000-0002-5773-991X
Academic & Professional Experience
Apr 2018
-
Today
Professor, Department of Medical Molecular Informatics, Meiji Pharmaceutical University
Apr 2013
-
Mar 2018
Meiji Pharmaceutical University
1992
-
2003
Meiji Pharmaceutical University, Research Associate
2001
-
2002
University of Dundee, Research Fellow
2003
- Meiji Pharmaceutical University, Assistant Professor
Education
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1992
Bioactive chemistry, Graduate School, Division of Pharmaceutical Sciences, Kyoto University
Awards & Honors
2016
Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones, 'Exceptional Quality Paper'（優秀論文）, International Institute of Anticancer Research (IIAR)
2015
ER-LBD, Tox21 DATA Challenge 2014 Winner, NIH
Winner: Yoshihiro Uesawa
2009
C型肝炎インターフェロン療法時の発熱に対する予測モデル式の構築～C型肝炎の治療で発熱しやすいひとはだれ？～, 講演ハイライト, 日本薬学会
Winner: UESAWA Yoshihiro, et al.
2009
First Pass Winner, "Environmental Toxicity Prediction Challenge" organized by ICANN'09: International Conference on Artificial Neural Networks, European Neural Network Society (ENNS) and CADASTER project
Quantitative Structure-Activity Relationship (QSAR) analysis using deep learning based on deep snap, a novel molecular image input technique, ポスター賞（Excellent Poster）
Published Papers
2-Styrylchromone derivatives as potent and selective monoamine oxidase B inhibitors
Takao K, Endo S, Nagai J, Kamauchi H, Takemura Y, Uesawa Y, Sugita Y
Bioorganic Chemistry 18;92(103285) 2019 [Refereed]
Prediction model with high-performance constitutive androstane receptor (CAR) using deepsnap-deep learning approach from the tox21 10K compound library
Matsuzaka Y, Uesawa Y
International Journal of Molecular Sciences 20(4855) 2019 [Refereed]
Analyses of respiratory depression associated with opioids in cancer patients based on the Japanese Adverse Drug Event Report Database
Sugawara H, Uchida M, Suzuki S, Suga Y, Uesawa Y, Nakagawa T, Takase H
Biol Pharm Bull 42 1185-1191 2019 [Refereed]
A nationwide survey of community pharmacist contributions to polypharmacy in opioidusing and non-using cancer patients in Japan
Suzuki S, Uchida M, Suga Y, Sugawara H, Kokubun H, Uesawa Y, Nakagawa T, Takase H
Biol Pharm Bull 42 1164-1171 2019 [Refereed]
Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives
Imanari K, Hashimoto M, Wakabayash H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H
Anticancer Res 39 3507-3518 2019 [Refereed]
A nationwide survey of hospital pharmacist’s interventions on polypharmacy in palliative care in Japan
Uchida M, Suzuki S, Sugawara H, Suga Y, Kokubun H, Uesawa Y, Nakagawa T, Takase H
J Pharm Health Care Sci 5(14) 1-13 2019 [Refereed]
QSAR prediction model to search for compounds with selective cytotoxicity against oral cell cancer
Nagai J, Imamura M, Sakagami H, Uesawa Y
Medicines 6(45) 2019 [Refereed][Invited]
Looking back our recent publications of the tumor-specificity of chromone derivatives
Sakagami H, Shi H, Nagai J, Uesawa Y, Takao K, Sugita Y
New Food Industry 61 11-18 2019
Current status of adverse events related with opioid analgesics in Japan: Assessment based on Japanese adverse drug event report database
Suga Y, Uchida M, Suzuki S, Sugawarad H, Torigoe K, Futamura A, Uesawa Y, Nakagawa T, Takase H
Biol. Pharm. Bull. 42 801-806 2019 [Refereed]
Optimization of a Deep-Learning Method Based on the Classification of Images Generated by Parameterized Deep Snap, a Novel Molecular-Image-Input Technique for Quantitative Structure–Activity Relationship (QSAR) Analysis
Matsuzaka Y, Uesawa Y
Frontiers in Bioengineering and Biotechnology 7 1-15 2019 [Refereed][Invited]
Recent progress of basic studies of natural products and their dental application
Sakagami H, Watanabe T, Hoshino T, Suda N, Mori K, Yasui T, Yamauchi N, Kashiwagi H, Gomi T, Oizumi T, Nagai J, Uesawa Y, Takao K, Sugita Y
Medicines 6(1) e4 2019 [Refereed][Invited]
Direct-injection electron-ionization mass spectrometry metabolomics method for analyzing blueberry leaf metabolites that inhibit adult T-cell leukemia proliferation
Kai H, Uesawa Y, Kunitake H, Morishita K, Okada Y, Matsuno K
Planta Medica 85 81-87 2019 [Refereed]
Analysis of physicochemical properties of drugs included in anticholinergic rating scales
Nagai J, Kagaya H, Uesawa Y
CBI Journal 18 1-9 2018 [Refereed]
UESAWA Yoshihiro
Yakugaku Zasshi 138 185-190 2018 [Refereed][Invited]
UESAWA Yoshihiro
Bioorganic Chemistry 77 436-442 2018 [Refereed]
In Vitro Anti-tumor Activity of Azulene Amide Derivatives
TOSHIKI WADA1*, RYOTA MARUYAMA1*, YUTA IRIE1, MASASHI HASHIMOTO1, HIDETSUGU WAKABAYASHI1, NORIYUKI OKUDAIRA2, YOSHIHIRO UESAWA3, HAJIME KAGAYA3 and HIROSHI SAKAGAMI4
32(3) 479-486 2018 [Refereed]
Quantitative structure–cytotoxicity relationship of 2-azolylchromones
Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y
Anticancer Research 38 763-770 2018 [Refereed]
Quantitative structure–cytotoxicity relationship of cinnamic acid phenetyl esters
Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y
Anticancer Research 38 817-823 2018 [Refereed]
Quantitative structure-cytotoxicity relationship of furo[2,3b]chromones
Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y
Anticancer Research 38 3283-3290 2018 [Refereed]
Quantitative structure–cytotoxicity relationship of 2-(N-cyclicamino)chromone derivatives
Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y
Anticancer Research 38 3897-3906 2018 [Refereed]
Quantitative structure-cytotoxicity relationship of 3-(N-Cyclicamino)chromone derivatives
Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y
Anticancer Research 38 4459-4467 2018 [Refereed]
Quantitative structure-cytotoxicity relationship of pyrano[4,3-b]chromones
Nagai J, Shi H, Kubota Y, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y
38 4449-4457 2018 [Refereed]
UESAWA Yoshihiro
Bioorganic & Medicinal Chemistry Letters 28 3400-3403 2018 [Refereed]
Quantitative structure–activity relationship (QSAR) analysis uses structural, quantum chemical, and physicochemical features calculated from molecular geometry as explanatory variables predicting physiological activity. Recently, deep learning bas...
Risk Factors for Cancer Chemotherapy-Induced Hiccups (CIH)
Ryuichiro Hosoya, Ippei Tanaka, Reiko Ishii-Nozawa, Takeshi Amino, Tomoyuki Kamata, Seiichi Hino, Hajime Kagaya, Yoshihiro Uesawa
Pharmacology & Pharmacy 9(8) 331-343 2018 [Refereed]
High-throughput toxicity testing of drugs and chemicals by using artificial intelligence
UESAWA Yoshihiro
Chemical Industry 9 2018 [Invited]
Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates
Halise Inci Gul, Cem Yamali, Gulsen Gunesacar, Hiroshi Sakagami, Noriyuki Okudaira, Yoshihiro Uesawa, Hajime Kagaya
Medicinal Chemistry Research 27 2366-2378 2018 [Refereed]
Bananas decrease acetaminophen potency in in vitro assays
UESAWA Y, TSUJI N
Plos One 13(e0205612) 2018 [Refereed]
Analysis of adverse effects in palliative care with opioid based on JADER
UESAWA Yoshihiro
BIO Clinica 32(13) 67-72 Nov 2017 [Invited]
Nagai J, Uesawa Y, Kagaya H
Clinical Journal of Pain 33(8) 667-675 Aug 2017 [Refereed]
Quantitative Structure–Cytotoxicity Relationship of Chalcones
Sakagami H, Uesawa Y, et al.
Anticancer Research 37(3) 1091-1098 Mar 2017 [Refereed]
Evaluation of anti-HSV activity of licorice flavonoids based on QSAR analysis
UESAWA Yoshihiro, FUKUCHI Kunihiko, OHNO Hirokazu, YAMAMOTO Masaji, KAGAYA Hajime, SAKAGAMI Hiroshi
New Food Industry 59(2) 47-52 Feb 2017
Uesawa Y, Sakagami H, et al.
Anticancer Research 37 6169-6176 2017 [Refereed]
Search for New Type of Anticancer Drugs with High Tumor Specificity and Less Keratinocyte Toxicity
Sugita Y, Uesawa Y, et al.
Anticancer Research 37 5919-5924 2017 [Refereed]
Quantitative Structure–Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters
UESAWA Yoshihiro
Anticancer Research 37 6161-6168 2017 [Refereed]
Kano D, Nakagami Y, Kurihara H, Hosokawa S, Zenda S, Kusumoto M, Fujii H, Kaneta T, Saito S, Uesawa Y, Kagaya H
Journal of drug targeting 25(2) 172-178 2017 [Refereed]
Hishinuma S, Kosaka K, Akatsu C, Uesawa Y, Fukui H, Shoji M
Biochemical Pharmacology 15(128) 46-54 2017 [Refereed]
UESAWA Yoshihiro
Plos One 12(2) e0172057 2017 [Refereed]
Y Asako, Y Uesawa
Molecules 22(4) 1-10 2017 [Refereed]
Establishment of a direct-injection electron ionization–mass spectrometry metabolomics method and its application to lichen profiling
Hisahiro Kai, Kaoru Kinoshita, Hiroshi Harada, Yoshihiro Uesawa, Akihiro Maeda, Ryuichiro Suzuki, Yoshihito Okada, Kunio Takahashi, Koji Matsuno
Analytical Chemistry 20;89(12) 6408-6414 2017 [Refereed]
植沢芳広
日本緩和医療薬学雑誌 9(1) 1-10 Mar 2016 [Invited]
化合物の酵素活性、毒性、薬効、副作用といった生体内における挙動は、その化合物の分子構造によって規定されると考えることができる。薬物の体内動態も同様である。一方、紙に書き下すことのできる化合物の化学構造は、対象となる化合物・分子に関する情報の塊である。化学構造をひもとくことによって、その分子の有する構造的特徴や物理化学的性質を数値化することができる。このような構造情報と体内動態パラメーターの関係を数学的モデルとして表現する方法が、定量的構造動態相関(Quantitative Structur...
矢島愛理, 植沢芳広, 稲野寛, 益田典幸, 尾鳥勝也, 厚田幸一郎, 厚田幸一郎, 加賀谷肇
日本緩和医療薬学雑誌 9(1) 17-23 Mar 2016 [Refereed]
がん患者の疼痛緩和薬物治療における鎮痛薬の選択と投与設計において、クレアチニンクリアランス(CLcr)は基本的指標の一つである。CLcrは、血清クレアチニンと体重、性別等を用いて構築された種々CLcr予測式に基づいて推定することができる。CLcr予測式は蓄尿を必要としない一方、予測式構築時の母集団は一般的にがん患者と異なるため、病態の影響を被る可能性がある。そこで、呼吸器領域のがん患者集団を対象として、種々CLcr予測式の予測精度を比較するとともに、重回帰分析により最適なCLcr予測モデル...
Electron Ionization Mass Spectrometry-based Metabolomics Studies of Sophoraflavescens can Identify the Geographical Origin of Root Samples.
Suzuki R, Kai H, Uesawa Y, Matsuno K, Okada Y, Shirataki Y
Natural product communications 11(1) 73-75 Jan 2016 [Refereed]
Search for bioactive components from Ephedra species against adult T-cell leukemia using electron ionization MS- and NMR-based metabolomics
Kai, Uesawa, et al.
Planta Medica 82(S01) 2016 [Refereed]
Fukuchi K, Uesawa Y, et al.
in vivo 30(6) 777-786 2016 [Refereed]
EI-MSによる地衣類縁種の分類法の検討（第2報
Kai Y, Uesawa Y, et al.
Lichenology 15(2) 117-117 2016 [Refereed]
UESAWA Yoshihiro
Frontiers in Environmental Science 4(9) 1-6 2016 [Refereed]
Random forest (RF) is a machine-learning ensemble method with high predictive performance. Majority voting in RF uses the discrimination results in numerous decision trees produced from bootstrapping data. For the same dataset, the bootstrapping p...
植沢芳広
ファルマシア 51(10) 952-956 Oct 2015 [Invited]
Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.
Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y
Anticancer research 35(10) 5341-5351 Oct 2015 [Refereed]
Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.
Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y
Anticancer research 35(10) 5299-5307 Oct 2015 [Refereed]
永井純子, 植沢芳広, 加賀谷肇
Palliat Care Res (Web) 10(3) 161-168 (J-STAGE)-168 Sep 2015 [Refereed]
オキシコドンの薬効および体内動態は性差等の患者背景に依存することから,副作用と患者背景因子の関係の把握は臨床上重要な知見を与える可能性がある.そこで,独立行政法人医薬品医療機器総合機構・医薬品副作用データベース(JADER)を用いた解析を試みた.オキシコドン投与患者において,主要な副作用症例の年齢・性別による発現傾向の変化を観察した.オキシコドンに関連する重要な有害事象は,モルヒネおよびフェンタニルと共通して臨床的に認知されている譫妄,悪心・嘔吐等の症状であった.女性において悪心,下痢など...
Construction of a model for predicting creatinine clearance in Japanese patients treated with Cisplatin therapy.
Yajima A, Uesawa Y, Ogawa C, Yatabe M, Kondo N, Saito S, Suzuki Y, Atsuda K, Kagaya H
Anticancer research 35(5) 2909-2914 May 2015 [Refereed]
永井純子, 植沢芳広, 加賀谷肇
Palliat Care Res (Web) 10(1) 113-119 (J-STAGE)-119 Mar 2015 [Refereed]
強オピオイドは,がん疼痛などの高度な痛みに適用される鎮痛薬である.強オピオイドを用いた疼痛緩和療法には多様な副作用が付随することから,適切な副作用管理を達成するための客観的根拠に基づくデータの解析が望まれる.そこで,本邦の副作用データベース(JADER)から,モルヒネ,フェンタニル,およびオキシコドンにおける副作用発現傾向を解析した.JADERから疼痛治療に用いた強オピオイドにより生じた副作用症例を抽出し,副作用の種類とその発現頻度を解析した.強オピオイドに共通する副作用の発現頻度は,薬物...
Takahashi M, Onozawa S, Ogawa R, Uesawa Y, Echizen H
Journal of clinical pharmacy and therapeutics 40(1) 91-97 Feb 2015 [Refereed]
Identification of the country of growth of Sophora flavescens using direct analysis in real time mass spectrometry (DART-MS).
Fukuda E, Uesawa Y, Baba M, Suzuki R, Fukuda T, Shirataki Y, Okada Y
Natural product communications 9(11) 1591-1594 Nov 2014 [Refereed]
植沢芳広, 加賀谷肇
がん患者と対症療法 25(1) 58-64 Oct 2014
オキシコドンは、モルヒネと類似した特徴を有しながら優れた経口バイオアベイラビリティを示すオピオイドである。本稿では、オキシコドンの薬効に影響を及ぼす併用薬を、薬物動態学的相互作用に焦点を当てて解説する。血球への移行性を考慮してオキシコドンの体内動態の正確な特徴づけを行い、本薬剤が肝臓に発現するCYP3A4の薬物代謝能に比較的影響を受けやすいことを明らかにする。さらに、CYP3A4活性の阻害薬となるイトラコナゾール、グレープフルーツジュースなど、およびCYP3A4誘導薬であるリファンピシンな...
Quantitative structure-cytotoxicity relationship of 3-styrylchromones.
Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H
Anticancer research 34(10) 5405-5411 Oct 2014 [Refereed]
植沢芳広, 加賀谷肇
日本緩和医療薬学雑誌 7(3) 55-61 Sep 2014 [Refereed]
オピオイドの物理化学的特徴と定常状態における分布容積(Vdss)の関係を把握することは、薬物体内動態的情報が不足しているオピオイドを評価するための重要な知見を与える。そこで、Vdssが既知である26種類のオピオイドの多様な物理化学的特徴を化学構造に基づいて算定するとともに、Vdss予測モデルの構築を目的として有意な相関を示す特徴を探索した。その結果、生理的pH条件下における電荷が、Vdssに対する最も有意な物理化学的変動要因であることを見出した。この知見は、新薬候補化合物、オピオイドの活性...
Quantitative structure-cytotoxicity relationship of piperic acid amides.
Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H
Anticancer research 34(9) 4877-4884 Sep 2014 [Refereed]
Hishinuma S, Sugawara K, Uesawa Y, Fukui H, Shoji M
Biochemical pharmacology 91(2) 231-241 Sep 2014 [Refereed]
Quantitative structure-cytotoxicity relationship of phenylpropanoid amides.
Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H
Anticancer research 34(7) 3543-3548 Jul 2014 [Refereed]
植沢芳広, 内田明宏, 小山茜, 宇田川三男, 武田直子, 富澤崇
医療薬学 40(4) 215-221 Apr 2014 [Refereed]
保険薬局で受付した処方箋284枚を対象に、患者の待ち時間を調査し、待ち時間予測モデルを構築・評価した。処方薬剤の種類は中央値2.7種類、混雑度は平均3.93人、薬剤師数は平均3.19人であった。中央値で「調剤時間」3分、「監査時間」3分、「待ち時間」7分であった。平均平方二乗誤差による評価では、「調剤時間」より「監査時間」が「待ち時間」に与える影響が大きかった。疑義照会を伴う処方箋は調剤時間を有意に延長させ、処方薬の種類数は調剤時間に有意に影響していた。「監査時間」「待ち時間」は混雑度と強...
Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones.
Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H
Anticancer research 34(4) 1743-1750 Apr 2014 [Refereed]
Uesawa Y, Hishinuma S, Shoji M
Journal of pharmacological sciences 124(2) 160-168 2014 [Refereed]
Application of mixture analysis to crude materials from natural resources (IV)[1(a-c)]: identification of Glycyrrhiza species by direct analysis in real time mass spectrometry (II).
Fukuda E, Uesawa Y, Baba M, Okada Y
Natural product communications 8(12) 1721-1724 Dec 2013 [Refereed]
Yajima A, Ogawa C, Yatabe M, Kondo N, Saito S, Suzuki Y, Uesawa Y
Die Pharmazie 68(9) 777-781 Sep 2013 [Refereed]
Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure.
Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M
Anticancer research 33(8) 3061-3068 Aug 2013 [Refereed]
植沢芳広, 越前宏俊, 和田義親
明治薬科大学研究紀要 (41) 14-17 Jun 2012
Uesawa Y, Mohri K
Die Pharmazie 67(3) 195-201 Mar 2012 [Refereed]
Application of mixture analysis to crude materials from natural resources (III): NMR spectral studies to analyze chalcones from Angelica keiskei.
Fukuda E, Baba M, Uesawa Y, Kamo O, Arifuku K, Tsubono K, Okada Y
Natural product communications 7(1) 21-23 Jan 2012 [Refereed]
QSAR analyses by using ChemBioOffice-a Review
UESAWA Yoshihiro
ChemBioNews 22(1) -UY000489 2012
Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives.
Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H
Anticancer research 31(12) 4231-4238 Dec 2011 [Refereed]
Application to classification of mulberry leaves using multivariate analysis of proton NMR metabolomic data.
Fukuda E, Yoshida M, Baba M, Uesawa Y, Suzuki R, Kamo O, Tsubono K, Arifuku K, Yatsunami K, Okada Y
Natural product communications 6(11) 1621-1625 Nov 2011 [Refereed]
Uesawa Y, Abe M, Fukuda E, Baba M, Okada Y, Mohri K
Die Pharmazie 66(7) 525-528 Jul 2011 [Refereed]
植沢芳広
明治薬科大学研究紀要 (40) 51-54 Jun 2011
Yoshihiro Uesawa, et al.
The Pharmazie 2011 [Refereed]
Yoshihiro Uesawa, Takahiro Takeuchi and Kiminori Mohri
CURRENT PHARMACEUTICAL BIOTECHNOLOGY 2011 [Refereed][Invited]
in press
Bucolome N-Glucuronide Formation: Species Differences and Identification of Human UDP-Glucuronosyltransferase Isoforms
Humihisa Kanoh, Makiko Tada, Yoshihiro Uesawa, Kiminori Mohri*
Pharmacology & Pharmacy 2 361-369 2011 [Refereed]
Zhou Li, Kawano Michiyo, Thet May Maw, Kuroshita Reina, Chu Qing, Wang Qin-Tao, Sekine Keisuke, Zhang Chang-Hao, Kitajima Madoka, Oizumi Hiroshi, Oizumi Takaaki
In Vivo : International Journal of Experimental and Clinical Pathophysiology of Drug Research 24(5) 735-43 Sep 2010 [Refereed]
Previous studies have shown anti-inflammatory potential of alkaline extract of the leaves of Sasa senanensis Rehder (SE). The aim of the present study was to clarity the molecular entity of SE, using various fractionation methods. SE inhibited the...
植沢芳広, 東恭一郎, 古源寛
明治薬科大学研究紀要 (39) 34-38 Jun 2010
坂上宏, ZHOU Li, 河野みち代, THET May Maw, 長谷川秀夫, 田中庄二, 町野守, 天野滋, 黒下礼奈, 渡部茂, 金本大成, 寺久保繁美, 中島秀喜, 関根圭輔, 白瀧義明, 植沢芳広, 毛利公則, CHU Quing, WANG Qin‐Tad, 北嶋まどか, 大泉浩史, 大泉高明
New Food Ind 52(2) 1-10 Feb 2010
Identification of glycyrrhiza species by direct analysis in real time mass spectrometry
Natural Product Communications 5(11) 1755-1758 2010 [Refereed]
2010 in press
Yoshihiro Uesawa and Kiminori Mohri
Pharmaceuticals 3 411-447 2010 [Refereed][Invited]
Yoshihiro Uesawa, Takahiro Takeuchi and Kiminori Mohri
Die Pharmazie 65(5) 375-378 2010 [Refereed]
Y Uesawa, K Mohri
Pharmazie 65(1) 41-46 2010 [Refereed]
植沢芳広
CICSJ Bull (Div Chem Inf Comput Sci Chem Soc Jpn) 26 114-117 Aug 2009 [Refereed][Invited]
植沢芳広
明治薬科大学研究紀要 (38) 48-52 May 2009
E. Motegi, Y. Uesawa, Y. Dai, K. Ishii, and K. Mohri
YAKUGAKU ZASSHI 128(12) 1803-1810 Dec 2008 [Refereed]
To investigate the relation between tendency of feverishness and patient profile in pegylated interferon (peginterferon) and ribavirin combination therapy, we performed a retrospective survey of the medical charts of patients with chronic hepatiti...
植沢芳広
明治薬科大学研究紀要 (37) 77-80 May 2008
Uesawa Y, Yamada H, Mohri K
Die Pharmazie 63(2) 110-112 Feb 2008 [Refereed]
Yoshihiro Uesawa, Moeko Abe, Kiminori Mohri
Die Pharmazie 63(8) 598-600 2008 [Refereed]
Yoshihiro Uesawa and Kiminori Mohri
Biopharmaceutics & Drug Disposition 17;29(3) 185-188 2008 [Refereed]
Yoshihiro UESAWA and Kiminori MOHRI
PHARMAZIE 63 144-146 2008 [Refereed]
Uesawa Y, Yamada H, Mohri K
PHARMAZIE 63 110-112 2008 [Refereed]
植沢芳広, 毛利公則
薬学雑誌 128(1) 117-122 2008 [Refereed]
Banana reduces acetaminophen potency in liquid medications
Yoshihiro Uesawa, Tomoko Iwama, Naotaka Tsuji, Kiminoro Mohri
Yakugaku Zasshi 128(Suppl4) 62 2008
Archives of Toxicology 81(3) 163-8 2007 [Refereed]
Use of ChemDraw for Education in a Life Science Course
Yoshihiro Uesawa
Bull Meiji Pharm Univ 36 67-69 2007
Biol. Pharm. Bull. 29(6) 1286-1289 2006 [Refereed]
Journal of Pharmacy and Pharmacology 58(8) 1067-72. 2006 [Refereed]
Biol Pharm Bull 29(11) 2274-2278 2006 [Refereed]
Misc
澤井祐香, 星祐樹, 菊地友佳子, 近藤沙織, 高井友子, 植沢芳広
日本薬学会年会要旨集(CD-ROM) 136th(4) ROMBUNNO.27AB-AM237-124 Mar 2016
明治薬科大学における臨床薬学の基礎を構築するための医薬品情報評価実習の取り組み 医薬品モノグラフの作成
清水 泰喜, 小川 竜一, 植沢 芳広, 佐藤 光利, 庄司 優, 宮沢 伸介, 山崎 紀子, 吉田 久博
日本薬学会年会要旨集 136年会(4) 224-224 Mar 2016
植沢芳広, 福島大介, 野澤(石井)玲子, 加賀谷肇
日本薬学会年会要旨集(CD-ROM) 136th(4) ROMBUNNO.27AB-PM098-175 Mar 2016
海野啓太, 植沢芳広, 永井純子, 加賀谷肇
日本薬学会年会要旨集(CD-ROM) 136th(4) ROMBUNNO.27AB-AM086-99 Mar 2016
阿部剛, 植沢芳広, 加賀谷肇
日本薬学会年会要旨集(CD-ROM) 136th(4) ROMBUNNO.27AB-AM085-98 Mar 2016
清水泰喜, 小川竜一, 植沢芳広, 佐藤光利, 庄司優, 宮沢伸介, 山崎紀子, 吉田久博
日本薬学会年会要旨集(CD-ROM) 136th ROMBUNNO.27AB-PM354S 2016
フォーカストセッション報告「計算毒性学の基本（多変量解析／パターン認識と人工知能）」
UESAWA Y, YUTA K
4(4) 6-6 2016
フォーカストセッション報告「計算毒性学とインシリコ創薬」
UESAWA Y, YUTA K, SONE H
4(4) 9-10 2016
フォーカストセッション報告「計算毒性学関連研究発表」
4(4) 8-8 2016
フォーカストセッション報告「計算毒性学関連トピックス（１）」
Yuta K, Uesawa Y
4(4) 12-13 2016
Books etc
QSAR Prediction Model to Search for Compounds with Selective Cytotoxicity Against Oral Cell Cancer, Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions
Nagai J, Imamura M, Sakagami H, Uesawa Y (Part:Joint Work)
MDPI Books 2019
Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs
UESAWA Yoshihiro (Part:Joint Work)
2017
Antihypertensive Drugs
UESAWA Yoshihiro
InTech 2012
Conference Activities & Talks
副作用データベースを用いて鎮痛薬の副作用を科学する [Invited]
NAGAI J, UESAWA Yoshihiro
Jun 2019
副作用データベースに基づく薬剤性肝障害誘発化合物識別システムの開発 [Invited]
UESAWA Yoshihiro
2019 BIOVIA USER CONFERENCE May 2019
AI-based QSAR modeling for prediction of active compounds in MIE/AOP [Invited]
Yoshihiro Uesawa
39th Annual Meeting of the Pharmaceutical Society of Japan 23 Mar 2019
The Development of Highly Accurate Toxicity Prediction Methods Using the JMP Machine Learning Function
UESAWA Yoshihiro
Japan Discovery Summit Nov 2016
大規模副作用情報に基づく副作用誘発化学構造の解析：アナフィラキシーを例として [Invited]
UESAWA Yoshihiro
UY000489 Oct 2016
High-performance prediction of adverse outcome pathways based on machine learning methods with chemical structures [Invited]
UESAWA Yoshihiro
UY000489 Oct 2016
毒性予測モデルの構築における化学構造の取扱い [Invited]
UESAWA Yoshihiro
CBI annual meeting 2016 Oct 2016
Tox21 Challenge To Build Predictive Models of Nuclear Receptor and Stress Response Pathways As Mediated by Exposure to Environmental Toxicants and Drugs [Invited]
UESAWA Yoshihiro
The Society of Toxicology 55th Annual Meeting and ToxExpo 2016
Research Grants & Projects
Glucuronidation
Public/Private Cooperative Joint Researches
Project Year: 2001 - 2004
Drug-Food interactions
Public/Private Cooperative Joint Researches
